WO2002018364A3 - Process for preparing 2-phenyl-3-aminobenzothiophenes - Google Patents

Process for preparing 2-phenyl-3-aminobenzothiophenes Download PDF

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Publication number
WO2002018364A3
WO2002018364A3 PCT/US2001/022608 US0122608W WO0218364A3 WO 2002018364 A3 WO2002018364 A3 WO 2002018364A3 US 0122608 W US0122608 W US 0122608W WO 0218364 A3 WO0218364 A3 WO 0218364A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
aminobenzothiophenes
phenyl
iii
compound
Prior art date
Application number
PCT/US2001/022608
Other languages
French (fr)
Other versions
WO2002018364A2 (en
Inventor
Preston Charles Conrad
John Paul Gardner
Original Assignee
Lilly Co Eli
Preston Charles Conrad
John Paul Gardner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Preston Charles Conrad, John Paul Gardner filed Critical Lilly Co Eli
Priority to AU2001286392A priority Critical patent/AU2001286392A1/en
Priority to US10/344,246 priority patent/US20040044224A1/en
Publication of WO2002018364A2 publication Critical patent/WO2002018364A2/en
Publication of WO2002018364A3 publication Critical patent/WO2002018364A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a one pot process for preparing a compound of formula I: I; from a compound of formula II and III: I; III.
PCT/US2001/022608 2000-08-25 2001-08-21 Process for preparing 2-phenyl-3-aminobenzothiophenes WO2002018364A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001286392A AU2001286392A1 (en) 2000-08-25 2001-08-21 Process for preparing 2-phenyl-3-aminobenzothiophenes
US10/344,246 US20040044224A1 (en) 2001-08-21 2001-08-21 Process for preparing 2-phenyl-3-aminobenzothiophenes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22819900P 2000-08-25 2000-08-25
US60/228,199 2000-08-25

Publications (2)

Publication Number Publication Date
WO2002018364A2 WO2002018364A2 (en) 2002-03-07
WO2002018364A3 true WO2002018364A3 (en) 2002-05-10

Family

ID=22856209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022608 WO2002018364A2 (en) 2000-08-25 2001-08-21 Process for preparing 2-phenyl-3-aminobenzothiophenes

Country Status (2)

Country Link
AU (1) AU2001286392A1 (en)
WO (1) WO2002018364A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157399A (en) * 1976-12-23 1979-06-05 Parcor Benzo(B)thiophenes
US4577046A (en) * 1984-06-11 1986-03-18 University Of New Mexico Deamination of aromatic amines
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US5723474A (en) * 1995-02-28 1998-03-03 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4157399A (en) * 1976-12-23 1979-06-05 Parcor Benzo(B)thiophenes
US4577046A (en) * 1984-06-11 1986-03-18 University Of New Mexico Deamination of aromatic amines
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US5723474A (en) * 1995-02-28 1998-03-03 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BECK J R: "A FACILE SYNTHESIS OF 2-PHENYLBENZOBTHIOPHENE-3-AMINE AND THE CORRESPONDING S-OXIDES", JOURNAL OF HETEROCYCLIC CHEMISTRY, HETEROCORPORATION. PROVO, US, May 1978 (1978-05-01), pages 513 - 514, XP000938993, ISSN: 0022-152X *
CORRAL C ET AL: "THE BEHAVIOUR OF VICINAL ALKYL AMINOTHIOPHENECARBOXYL-ATES IN THE SANDMEYER AND SCHIEMANN REACTIONS", HETEROCYCLES, XX, XX, vol. 23, no. 6, 1985, pages 1431 - 1435, XP000972048, ISSN: 0385-5414 *
LOMBARDINO J G ET AL: "PREPARATION AND ANTIINFLAMMATORY ACTIVITY OF SOME 2-ARYLBENZOBTHIOPEN-3(2H)-ONE 1,1-DIOXIDES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 13, March 1970 (1970-03-01), pages 206 - 210, XP000938994, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
AU2001286392A1 (en) 2002-03-13
WO2002018364A2 (en) 2002-03-07

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