MD3653F2 - Forme polimorfe de rifaximina, procedee deobtinere a lor si utilizarea acestora in calitatede antibiotic - Google Patents

Forme polimorfe de rifaximina, procedee deobtinere a lor si utilizarea acestora in calitatede antibiotic Download PDF

Info

Publication number
MD3653F2
MD3653F2 MDA20060080A MD20060080A MD3653F2 MD 3653 F2 MD3653 F2 MD 3653F2 MD A20060080 A MDA20060080 A MD A20060080A MD 20060080 A MD20060080 A MD 20060080A MD 3653 F2 MD3653 F2 MD 3653F2
Authority
MD
Moldova
Prior art keywords
rifaximin
water content
2theta
ray powder
polymorphic forms
Prior art date
Application number
MDA20060080A
Other languages
English (en)
Other versions
MD20060080A (ro
MD3653G8 (ro
Inventor
Giuseppe C. Viscomi
Manuela Campana
Dario Braga
Donatella Confortini
Vincenzo Cannata
Paolo Righi
Gofftredo Rosini
Original Assignee
Alfa Wassermann S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33187382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD3653(F2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alfa Wassermann S.P.A. filed Critical Alfa Wassermann S.P.A.
Publication of MD20060080A publication Critical patent/MD20060080A/ro
Publication of MD3653F2 publication Critical patent/MD3653F2/ro
Publication of MD3653G8 publication Critical patent/MD3653G8/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B6/00—Heating by electric, magnetic or electromagnetic fields
    • H05B6/02—Induction heating
    • H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
    • H05B6/12—Cooking devices
    • H05B6/1209—Cooking devices induction cooking plates or the like and devices to be used in combination with them
    • H05B6/1236—Cooking devices induction cooking plates or the like and devices to be used in combination with them adapted to induce current in a coil to supply power to a device and electrical heating devices powered in this way
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B6/00—Heating by electric, magnetic or electromagnetic fields
    • H05B6/02—Induction heating
    • H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
    • H05B6/12—Cooking devices
    • H05B6/1209—Cooking devices induction cooking plates or the like and devices to be used in combination with them
    • H05B6/1245—Cooking devices induction cooking plates or the like and devices to be used in combination with them with special coil arrangements
    • H05B6/1263—Cooking devices induction cooking plates or the like and devices to be used in combination with them with special coil arrangements using coil cooling arrangements

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

Inventia se refera la forme polimorfe de rifaximina, si anume la formele Alpha, Beta, Gamma.Forma polimorfa Alpha de rifaximina are un continut de apa mai mic de 4,5% si o difractograma a pulberii curaze X manifestand varfuri la valorile unghiurilor de difractie 2Theta 6,6°; 7,4o; 7,9°; 8,8o; 10,5°; 11,1o; 11,8°; 12,9°; 17,6°; 18,5°; 19,7°; 21,0°; 21,4°; 22,1°.Forma polimorfa Beta de rifaximina are un continut de apa mai mare de 4,5% si o difractograma a pulberii cu raze X manifestand varfuri la valorile unghiurilor de difractie 2Theta 5,4°; 6,4°; 7,0°; 7,8°; 9,0°; 10,4°; 13,1°; 14,4°; 17,1°; 17,9°; 18,3°; 20,9°.Forma polimorfa Gamma de rifaximina are un continut de apa intre 1,0% si 2,0% si o difractograma a pulberii cu raze X manifestand, in general, un profil amorf si cateva varfuri semnificative la valorile unghiurilor de difractie 2Theta 5,0°; 7,1°; 8,4°.Inventia se refera de asemenea la procedee de obtinere a lor, la care prin incalzire se dilueaza rifaximina bruta in alcool etilic si se initiaza cristalizarea produsului prinadaugarea apei la o temperatura anumita, pe parcursul unui anumit interval de timp, dupa care se realizeaza uscarea sub control, pana cand produsul finit ajunge la un anumit continut de apa.Formele polimorfe obtinute de rifaximina se utilizeaza in calitate de preparate medicamentoase cu actiune antibiotica pentru administrare orala si locala.
MDA20060080A 2003-11-07 2004-11-04 Forme polimorfe de rifaximină, procedee de obţinere a lor şi utilizarea acestora în calitate de antibiotic MD3653G8 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002144A ITMI20032144A1 (it) 2003-11-07 2003-11-07 Forme polimorfe di rifaximina, processi per ottenerle e
PCT/EP2004/012490 WO2005044823A2 (en) 2003-11-07 2004-11-04 Polymorphous forms of rifaximin as antibiotics

Publications (3)

Publication Number Publication Date
MD20060080A MD20060080A (ro) 2006-11-30
MD3653F2 true MD3653F2 (ro) 2008-07-31
MD3653G8 MD3653G8 (ro) 2016-08-31

Family

ID=33187382

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20060080A MD3653G8 (ro) 2003-11-07 2004-11-04 Forme polimorfe de rifaximină, procedee de obţinere a lor şi utilizarea acestora în calitate de antibiotic

Country Status (37)

Country Link
US (5) US7045620B2 (ro)
EP (6) EP1676848B1 (ro)
JP (5) JP2005139161A (ro)
KR (4) KR20050043589A (ro)
CN (4) CN1613858A (ro)
AR (3) AR043547A1 (ro)
AT (3) ATE421966T1 (ro)
AU (2) AU2004200964A1 (ro)
BR (2) BRPI0402382A (ro)
CA (2) CA2460384A1 (ro)
CL (1) CL2004000498A1 (ro)
CO (1) CO5560083A1 (ro)
CY (3) CY1108017T1 (ro)
DE (4) DE602004006367C5 (ro)
DK (3) DK1557421T3 (ro)
ES (3) ES2244364T3 (ro)
HR (2) HRP20040265A2 (ro)
IL (2) IL160798A0 (ro)
IT (1) ITMI20032144A1 (ro)
JO (1) JO2470B1 (ro)
MA (1) MA27069A1 (ro)
MD (1) MD3653G8 (ro)
ME (1) ME00424B (ro)
MX (2) MXPA04002353A (ro)
NO (1) NO334950B1 (ro)
NZ (1) NZ531622A (ro)
PL (3) PL1557421T3 (ro)
PT (3) PT1557421E (ro)
RS (4) RS54568B1 (ro)
RU (1) RU2270200C2 (ro)
SI (3) SI1676848T1 (ro)
TN (2) TNSN04044A1 (ro)
TW (1) TWI285107B (ro)
UA (1) UA86384C2 (ro)
WO (1) WO2005044823A2 (ro)
YU (1) YU24804A (ro)
ZA (1) ZA200401948B (ro)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4081G2 (ro) * 2005-03-03 2011-07-31 Alfa Wassermann S.P.A. Forme polimorfe de rifaximină, procedee de obţinere şi utilizare a acestora în calitate de preparate medicamentoase cu activitate antibiotică

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7923553B2 (en) * 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7906542B2 (en) * 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US7902206B2 (en) * 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
ITBO20050123A1 (it) * 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
PT2054066E (pt) 2006-08-02 2015-07-16 Salix Pharmaceuticals Inc Métodos para tratamento de enterite por radiação
ITMI20061692A1 (it) * 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
US8633234B2 (en) * 2006-09-22 2014-01-21 Cipla Limited Rifaximin
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US8383151B2 (en) * 2007-07-06 2013-02-26 Lupin Limited Pharmaceutical compositions of rifaximin
AU2016203925B2 (en) * 2007-07-06 2016-10-20 Lupin Limited Pharmaceutical compositions of rifaximin
ES2389358T5 (es) * 2007-07-06 2016-01-19 Lupin Ltd. Composiciones farmacéuticas de rifaximina
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
SG10201607926VA (en) * 2008-02-25 2016-11-29 Salix Pharmaceuticals Ltd Forms of rifaximin and uses thereof
US8486956B2 (en) * 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
KR20100122937A (ko) 2008-02-26 2010-11-23 샐릭스 파마슈티컬스 리미티드 장 질환의 치료 방법
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
AU2009244190B2 (en) 2008-05-07 2016-02-25 Salix Pharmaceuticals, Ltd. Methods of treating bowel disease by administering a bowel cleanser and an antibiotic
AU2009297562B2 (en) 2008-09-26 2015-04-23 Alfasigma S.P.A. Agent for preventing and/or treating functional gastrointestinal disorder
US7928115B2 (en) * 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
US20100317681A1 (en) * 2009-06-15 2010-12-16 Salix Pharmaceuticals, Ltd. Modulation of systemic exposure to rifaximin
ES2770308T3 (es) 2008-10-02 2020-07-01 Salix Pharmaceuticals Ltd Procedimientos de tratamiento de encefalopatía hepática
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
KR20110107806A (ko) 2008-12-10 2011-10-04 시플라 리미티드 리팍시민 복합체
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
BRPI1010028A2 (pt) * 2009-06-02 2019-02-12 Salix Pharmaceuticals, Ltd. métodos de tratamento de encefalopatia hepática
EP2475392A4 (en) * 2009-09-13 2013-01-09 Salix Pharmaceuticals Ltd METHOD FOR TREATING IRRITATION SYNDROME
KR20190000931A (ko) * 2009-10-27 2019-01-03 루핀 리미티드 리팍시민의 고형 분산물
WO2011061748A1 (en) * 2009-11-19 2011-05-26 Strides Arcolab Limited Rifaximin premix
KR20120117788A (ko) 2009-11-23 2012-10-24 시플라 리미티드 국소용 폼 조성물
US8952159B2 (en) † 2009-12-28 2015-02-10 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
EP3650022A1 (en) 2010-02-18 2020-05-13 Salix Pharmaceuticals, Ltd. Methods for treating rifampin resistant clostridium difficilis infections
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
US8513275B2 (en) * 2010-06-03 2013-08-20 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
CA2802874A1 (en) * 2010-06-16 2011-12-22 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
EP3750526A1 (en) * 2010-07-12 2020-12-16 Salix Pharmaceuticals, Inc. Formulations of rifaximin and uses thereof
US8759513B2 (en) 2010-09-13 2014-06-24 Sequent Scientific Limited Polymorphic form of rifaximin and process for its preparation
IT1403847B1 (it) * 2010-09-22 2013-11-08 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina e loro uso.
WO2012060675A1 (es) * 2010-11-05 2012-05-10 Interquim, S.A. De C.V. Proceso para la preparación de rifaximina amorfa
WO2012076832A1 (en) * 2010-12-09 2012-06-14 Cipla Limited Suppositories comprising rifaximin
MX350448B (es) 2011-02-11 2017-09-07 Salix Pharmaceuticals Ltd Formas de rifaximina y usos de las mismas.
AU2012251385A1 (en) 2011-05-02 2013-11-21 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
ITMI20110890A1 (it) * 2011-05-19 2012-11-20 A M S A Anonima Materie Sint & Affini S P A Polimorfo di rifaximina e processo per la sua preparazione
WO2012155981A1 (en) 2011-05-19 2012-11-22 Friulchem Spa New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
PL2773205T3 (pl) 2011-11-02 2024-09-02 Salix Pharmaceuticals, Inc. Ryfaksymina w leczeniu ustępującej biegunki z przewagą zespołu jelita drażliwego
JP2013184902A (ja) * 2012-03-06 2013-09-19 Aska Pharmaceutical Co Ltd リファキシミン含有結晶
CA2876737A1 (en) 2012-06-13 2013-12-19 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
US9849090B2 (en) 2012-12-12 2017-12-26 Sun Pharmaceutical Industries Limited Pharmaceutical compositions of rifaximin
WO2014140988A1 (en) 2013-03-15 2014-09-18 Alfa Wassermann S.P.A. Rifaximin for use in the treating of vaginal infections.
EP2971062A2 (en) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Method for diagnosing vaginal infections
ES2829285T3 (es) 2013-04-12 2021-05-31 Alfasigma Spa Administración de AINE y composiciones, métodos y sistemas relacionados
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
EP2927235B1 (en) 2014-03-31 2017-02-08 Euticals S.P.A. Polymorphic mixture of rifaximin and its use for the preparation of solid formulations
EP3134415A4 (en) 2014-04-19 2017-10-25 Granules India Limited An improved process for the preparation of rifamycin derivatives
WO2015171493A1 (en) 2014-05-04 2015-11-12 Salix Pharmaceuticals, Inc. Ibs microbiota and uses thereof
PL3143027T3 (pl) 2014-05-12 2019-11-29 Alfasigma Spa Nowe solwatowane krystaliczne postaci rifaksyminy, ich wytwarzanie, kompozycje i zastosowania
MX381919B (es) * 2014-06-30 2025-03-13 Salix Pharmaceuticals Inc Métodos para repetir tratamiento de síndrome del intestino irritable (ibs).
CN104083324B (zh) * 2014-07-10 2017-05-10 青岛动保国家工程技术研究中心有限公司 一种利福昔明的兽用悬乳剂及其制备方法和应用
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
CN104274391B (zh) * 2014-10-08 2017-02-01 哈尔滨坤盟医药科技有限公司 一种含利福昔明的药物制剂
WO2017021975A1 (en) * 2015-08-06 2017-02-09 Msn Laboratories Private Limited Process for the preparation of crystalline forms of rifaximin
US10842782B2 (en) 2016-03-24 2020-11-24 Sandoz Ag Storage stable composition comprising rifaximin alpha
US10576065B2 (en) 2016-03-24 2020-03-03 Sandoz Ag Pharmaceutical composition containing rifaximin alpha and delta
US9988398B2 (en) * 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
EP4137132A1 (en) 2016-09-30 2023-02-22 Salix Pharmaceuticals, Inc. Solid dispersion forms of rifaximin
CN106632396B (zh) * 2017-01-06 2019-01-11 成都樵枫科技发展有限公司 γ晶型利福昔明的制备方法和用途
SI3416627T1 (sl) 2017-04-26 2020-03-31 Sandoz Ag Peroralna odmerna oblika, ki obsega rifaksimin v obliki beta
RU2020102511A (ru) 2017-06-26 2021-07-27 Биофер С.П.А. Соединения пиридо-имидазо рифамицина в качестве антибактериального средства
KR20210105381A (ko) * 2018-12-19 2021-08-26 프리울켐 에스.피.에이. 리팍시민 정제의 제조 방법 및 리팍시민 정제
CA3142214A1 (en) 2019-06-03 2020-12-10 Bausch Health Ireland Limited Use of methylnaltrexone and rifaximin for treatment of increased gut permeability or associated disorders
EP4034091A1 (en) 2019-09-24 2022-08-03 Bausch Health Ireland Limited Rifaximin liquid formulations
WO2021191312A1 (en) 2020-03-24 2021-09-30 Bausch Health Ireland Limited Methods of treating covid-19 with rifaximin
WO2021229480A1 (en) * 2020-05-15 2021-11-18 Atra Pharmaceuticals Limited Polymorph of rifaximin, process for the preparation thereof and pharmaceutical composition containing rifaximin
AU2021298178A1 (en) 2020-06-26 2023-02-02 Bausch Health Ireland Limited Targeted release rifaximin compositions
WO2022090490A1 (en) 2020-10-29 2022-05-05 Bausch Health Ireland Limited Rifaximin liquid formulations for use in the treatment of sickle cell disease

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241785A (en) * 1978-07-24 1980-12-30 Peerless Of America, Inc. Heat exchangers and method of making same
IT1154655B (it) * 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica
CA1215976A (en) 1984-05-15 1986-12-30 Vincenzo Cannata New process for the synthesis of imidazo rifamycins
IT1199374B (it) 1984-05-15 1988-12-30 Alfa Farmaceutici Spa Processo per la preparazione di pirido-imidazo-rifamicine
IT1199413B (it) 1984-09-26 1988-12-30 Alfa Farmaceutici Spa Processo per la preparazione di pirido-imidazo-rifamicine
GB8816620D0 (en) * 1988-07-13 1988-08-17 Lepetit Spa Rifapentine hydrohalides
EP0536197B1 (en) * 1990-06-29 1995-07-26 GRUPPO LEPETIT S.p.A. Pure crystalline form of rifapentine
AU2930501A (en) * 2000-01-07 2001-07-24 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
UA75365C2 (en) * 2000-08-16 2006-04-17 Bristol Myers Squibb Co Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
EP1330427A1 (en) * 2000-10-31 2003-07-30 Ciba SC Holding AG Crystalline forms of venlafaxine hydrochloride
IL156055A0 (en) * 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US20050262269A1 (en) 2004-05-20 2005-11-24 Pike Jimmy D System and method for information handling system PCI express advanced switching
DK1698630T3 (da) 2005-03-03 2014-12-08 Alfa Wassermann Spa Nye polymorfe former af rifaximin, fremgangsmåde for deres fremstilling og anvendelse deraf i de medicinske præparater
US8633234B2 (en) * 2006-09-22 2014-01-21 Cipla Limited Rifaximin
WO2008115572A1 (en) 2007-03-21 2008-09-25 Theraquest Biosciences, Inc. Methods and compositions of nsaids
ITMI20071241A1 (it) 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
ES2389358T5 (es) 2007-07-06 2016-01-19 Lupin Ltd. Composiciones farmacéuticas de rifaximina
US8383151B2 (en) * 2007-07-06 2013-02-26 Lupin Limited Pharmaceutical compositions of rifaximin
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
JP2011500552A (ja) 2007-10-10 2011-01-06 ルピン・リミテッド 胃腸障害を処置するための医薬用組み合わせおよび組成物
SG10201607926VA (en) 2008-02-25 2016-11-29 Salix Pharmaceuticals Ltd Forms of rifaximin and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4081G2 (ro) * 2005-03-03 2011-07-31 Alfa Wassermann S.P.A. Forme polimorfe de rifaximină, procedee de obţinere şi utilizare a acestora în calitate de preparate medicamentoase cu activitate antibiotică

Also Published As

Publication number Publication date
DE602004006367C5 (de) 2019-04-04
MXPA04002353A (es) 2005-05-11
AR081992A2 (es) 2012-10-31
US8173801B2 (en) 2012-05-08
AU2004200964A1 (en) 2005-05-26
NO334950B1 (no) 2014-08-04
AU2004287601A1 (en) 2005-05-19
EP2208730A1 (en) 2010-07-21
ES2320160T3 (es) 2009-05-19
HRP20040265A2 (en) 2004-12-31
DE602004006367T2 (de) 2007-09-06
DK1557421T3 (da) 2007-09-17
ITMI20032144A1 (it) 2005-05-08
SI1557421T1 (sl) 2007-08-31
KR20070113326A (ko) 2007-11-28
BRPI0402382A (pt) 2005-06-28
JP2007509904A (ja) 2007-04-19
HK1073657A1 (en) 2005-10-14
RS54569B1 (sr) 2016-06-30
SI1676847T1 (sl) 2009-06-30
CA2460384A1 (en) 2005-05-07
WO2005044823A2 (en) 2005-05-19
ATE421965T1 (de) 2009-02-15
CO5560083A1 (es) 2005-09-30
TW200515913A (en) 2005-05-16
CN101260114B (zh) 2012-11-28
DE602004019296D1 (de) 2009-03-19
KR100883216B1 (ko) 2009-02-13
CN1613858A (zh) 2005-05-11
CY1108909T1 (el) 2014-07-02
HK1092150A1 (en) 2007-02-02
ES2320161T3 (es) 2009-05-19
EP1557421B1 (en) 2007-05-09
US7915275B2 (en) 2011-03-29
RU2004108953A (ru) 2005-10-27
MD20060080A (ro) 2006-11-30
JP5199576B2 (ja) 2013-05-15
EP2210893A1 (en) 2010-07-28
IL160798A0 (en) 2004-08-31
ES2244364T3 (es) 2007-12-01
CN101260114A (zh) 2008-09-10
RS54568B1 (sr) 2016-06-30
PT1557421E (pt) 2007-07-31
US8404704B2 (en) 2013-03-26
US20050101598A1 (en) 2005-05-12
ATE361927T1 (de) 2007-06-15
PT1676847E (pt) 2009-04-09
RS20150292A1 (sr) 2015-10-30
KR20070113327A (ko) 2007-11-28
YU24804A (sh) 2006-08-17
UA86384C2 (uk) 2009-04-27
EP1557421A1 (en) 2005-07-27
IL174271A (en) 2010-12-30
RS20060168A (sr) 2008-09-29
MD3653G8 (ro) 2016-08-31
DK1676847T3 (da) 2009-05-11
CN101260115B (zh) 2011-11-23
BRPI0407149A8 (pt) 2019-01-15
NO20061110L (no) 2006-04-19
JP5635376B2 (ja) 2014-12-03
ME00424B (me) 2011-10-10
MXPA06002644A (es) 2006-06-06
RS20150291A1 (sr) 2015-10-30
DK1676848T3 (da) 2009-05-11
EP1676847B1 (en) 2009-01-28
JP2005139161A (ja) 2005-06-02
HRP20060093B1 (hr) 2015-12-18
KR20060110737A (ko) 2006-10-25
AR043547A1 (es) 2005-08-03
EP1676848B1 (en) 2009-01-28
KR20050043589A (ko) 2005-05-11
TNSN04044A1 (en) 2006-06-01
EP1676847A1 (en) 2006-07-05
ES2244364T1 (es) 2005-12-16
TWI285107B (en) 2007-08-11
ATE421966T1 (de) 2009-02-15
CN101260115A (zh) 2008-09-10
CL2004000498A1 (es) 2005-03-11
CY1108964T1 (el) 2014-07-02
CA2538546C (en) 2011-04-19
CN1886408B (zh) 2010-06-09
DE602004019298D1 (de) 2009-03-19
RS54571B1 (sr) 2016-06-30
US20110160449A1 (en) 2011-06-30
US7045620B2 (en) 2006-05-16
WO2005044823A3 (en) 2005-10-27
BRPI0407149A (pt) 2006-02-07
JO2470B1 (en) 2009-01-20
AU2004287601B8 (en) 2009-03-05
CN1886408A (zh) 2006-12-27
CY1108017T1 (el) 2013-09-04
AU2004287601B2 (en) 2009-02-26
HRP20060093A2 (en) 2006-05-31
ZA200401948B (en) 2004-04-29
HK1092151A1 (en) 2007-02-02
DE602004006367D1 (de) 2007-06-21
PL1676847T3 (pl) 2009-07-31
IL174271A0 (en) 2006-08-01
EP1682556A2 (en) 2006-07-26
CA2538546A1 (en) 2005-05-19
KR100867751B1 (ko) 2008-11-10
PT1676848E (pt) 2009-04-09
US20050272754A1 (en) 2005-12-08
EP1676848A1 (en) 2006-07-05
US20080132530A1 (en) 2008-06-05
KR100855084B1 (ko) 2008-08-29
NZ531622A (en) 2004-10-29
RU2270200C2 (ru) 2006-02-20
ES2320160T4 (es) 2011-03-09
TNSN06069A1 (en) 2007-10-03
JP2011057698A (ja) 2011-03-24
JP2014177500A (ja) 2014-09-25
SI1676848T1 (sl) 2009-06-30
MA27069A1 (fr) 2004-12-20
JP2011046738A (ja) 2011-03-10
AR081991A2 (es) 2012-10-31
PL1676848T3 (pl) 2009-07-31
US20120059023A1 (en) 2012-03-08
PL1557421T3 (pl) 2007-08-31
DE04005541T1 (de) 2005-12-29

Similar Documents

Publication Publication Date Title
MD3653F2 (ro) Forme polimorfe de rifaximina, procedee deobtinere a lor si utilizarea acestora in calitatede antibiotic
HRP20070433A2 (en) New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal
LV12735A (en) Manufacture and pharmaceutical compositions thereof
NO20043038L (no) Polymorfe former av klopidogrel-hydrogensulfat
HUE037560T2 (hu) Glikolipid-származékok, eljárás elõállításukra, szintézis-köztitermékeik, és eljárás a köztitermékek elõállítására
NZ585880A (en) Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
NZ596872A (en) Improved method for synthesizing pirfenidone
CA2600203A1 (en) New salt and polymorphs of a dpp-iv inhibitor
GEP20094577B (en) New crystalline form iv of agomelatine, a process for its preparation and pharmaceutical compositions containing it
HUP0302336A2 (hu) 5-Klór-3-(4-metánszulfonilfenil)-6'-metil-[2,3']bipiridinil tiszta formában és eljárás előállítására
GEP20094576B (en) New cyrstalline form iii of agomelatine, a process for its preparation and pharmaceutical compositions containing it
MX2010007294A (es) Dutasterida solida y cristalina y procesos para la preparacion de la misma.
TW200504003A (en) Method for producing ditrimethylolpropane
WO2005044824A3 (en) Processes for the preparation of highly pure 3-(2-substituted vinyl) cephalosporin
WO2004009608A3 (en) Novel amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a, process for preparing the same, and use thereof
EP1598356A4 (en) PROCESS FOR THE PREPARATION OF IRINOTECANHYDROCHLORIDE POLYMORPHES
WO2009115287A1 (de) Thiostrepton-derivate
WO2008006720A3 (en) Crystalline nemorubicin hydrochloride
NO20055495L (no) 4-(4-trans-hydroksysykloheksyl)amino-2-fenyl-7H-pyrrolo[2,3-d]-pyrimidinhydrogenmesylat og dets polymorfe former
AR064728A1 (es) Formas amorfas y cristalinas de rimonabant, procesos para su preparacion y composiciones farmaceuticas que las contienen.
Ganapathi et al. A Facile Synthesis and Characterization of Biologically Active Halogen Substituted 1-Acetyl 3, 5-Diphenylpyrazole Derivatives. SOJ Mater Sci Eng 3 (3): 1-2
RU2003113228A (ru) Способ получения смеси z-и е-изомеров аджоена в соотношении 2:1.
MY144578A (en) New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
WO2005061524A2 (en) Process for the preparation of form ii clarithromycin
CN108503585A (zh) PeniciloneB的氨基酸衍生物及其作为抗菌药物的应用

Legal Events

Date Code Title Description
FG4A Patent for invention issued
FG4A Patent for invention issued
TC4A Change of name of proprietor (patent for invention)

Owner name: ALFASIGMA S.P.A., IT VIALE SARCA N.223, MILANO (MI

Free format text: PREVIOUS NAME OF PROPRIETOR: ALFA WASSERMANN S.P.A., IT VIA ENRICO FERMI, 1, I-65020 ALANNO (PE), ITALIA