|
US8038994B2
(en)
|
1996-05-15 |
2011-10-18 |
Quest Pharmatech Inc. |
Combination therapy for treating disease
|
|
DK2283867T3
(da)
*
|
1999-06-25 |
2014-06-10 |
Immunogen Inc |
Fremgangsmåder til behandling ved anvendelse af anti-ErbB antistof-maytansinoidkonjugater
|
|
US6949245B1
(en)
|
1999-06-25 |
2005-09-27 |
Genentech, Inc. |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
|
|
TR200103756T2
(tr)
*
|
1999-06-25 |
2002-06-21 |
Genentech, Inc. |
Hümanize anti-ErbB2 antikorları ve anti-ErbB2 antikorlarıyla tedavi.
|
|
US6825333B1
(en)
|
1999-08-20 |
2004-11-30 |
Chiron Corporation |
EGFH2 genes and gene products
|
|
PT1210115E
(pt)
|
1999-08-27 |
2009-11-12 |
Genentech Inc |
Dosagens para tratamento com anticorpos anti-erbb2
|
|
AU775373B2
(en)
|
1999-10-01 |
2004-07-29 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
CN1447696A
(zh)
|
2000-05-19 |
2003-10-08 |
杰南技术公司 |
用于提高对ErbB拮抗剂癌症治疗的有效应答可能性的基因检测试验
|
|
EP1228766A1
(en)
*
|
2001-01-31 |
2002-08-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
PYK2 phosphorylation by HER3 induces tumor invasion
|
|
AU2002358246B2
(en)
*
|
2001-10-26 |
2008-02-28 |
Oncoquest Pharmaceuticals Inc. |
Combination therapy for treating disease
|
|
CA2481509A1
(en)
*
|
2002-04-11 |
2003-10-23 |
Suzanna Tatarewicz |
Her-2 receptor tyrosine kinase molecules and uses thereof
|
|
ITTO20020340A1
(it)
*
|
2002-04-19 |
2003-10-20 |
Biother Di Contardi Gabriella |
Localizzazione del recettore her2 mediante anticorpo umanizzato biotinilato.
|
|
US20050276812A1
(en)
*
|
2004-06-01 |
2005-12-15 |
Genentech, Inc. |
Antibody-drug conjugates and methods
|
|
WO2003101401A2
(en)
|
2002-06-03 |
2003-12-11 |
Chiron Corporation |
Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer
|
|
AT413486B
(de)
*
|
2002-07-03 |
2006-03-15 |
Igeneon Krebs Immuntherapie |
Verwendung eines antikörpers gerichtet gegen lewis-antigene
|
|
NO340576B1
(no)
*
|
2002-07-11 |
2017-05-15 |
Hoffmann La Roche |
Rekombinant, humanisert antistoff 2C4 (rhuMab 2C4) for anvendelse sammen med et andre, forskjellig vekstinhiberende anti-ErbB2-antistoff i en fremgangsmåte for behandling av kreft i en pasient og anvendelse derav for fremstilling av et medikament
|
|
BR0312534A
(pt)
*
|
2002-07-15 |
2007-03-13 |
Genentech Inc |
método de identificação de um tumor, método para a identificação de células de tumor, método para prever a resposta de um indivìduo diagnosticado com um tumor de her2-positivo, método para a identificação de um individuo responsivo ao tratamento com anticorpo anti-her2 e métodos de tratamento de um paciente e artigo de manufatura
|
|
NZ537277A
(en)
|
2002-07-18 |
2008-04-30 |
Crucell Holland Bv |
Recombinant production of mixtures of antibodies
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
EP2324846B1
(en)
*
|
2002-07-18 |
2014-11-12 |
Helix Biopharma Corp. |
Use of urease for inhibiting cancer cell growth
|
|
US7264800B2
(en)
|
2002-07-18 |
2007-09-04 |
Helix Biopharma Corporation |
Method and composition for inhibiting cancer cell growth
|
|
US7300655B2
(en)
|
2002-08-01 |
2007-11-27 |
Immunomedics, Inc. |
Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof
|
|
US20040033228A1
(en)
|
2002-08-16 |
2004-02-19 |
Hans-Juergen Krause |
Formulation of human antibodies for treating TNF-alpha associated disorders
|
|
WO2004032857A2
(en)
*
|
2002-10-08 |
2004-04-22 |
Immunomedics, Inc. |
Antibody therapy
|
|
JP4959136B2
(ja)
*
|
2002-12-13 |
2012-06-20 |
イミューノメディクス、インコーポレイテッド |
細胞内で開裂可能な結合を有する免疫接合体
|
|
WO2005003325A2
(en)
*
|
2003-03-11 |
2005-01-13 |
Dana Farber Cancer Institute |
Inhibition of viral pathogenesis
|
|
EP1631590B1
(en)
|
2003-04-23 |
2011-07-27 |
Medarex, Inc. |
Humanized antibodies to interferon alpha receptor-1 (ifnar-1)
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
AT500651B9
(de)
*
|
2003-05-27 |
2010-04-15 |
Altropus Gmbh |
Aktiv immunisierender antikörper
|
|
CA2527694C
(en)
|
2003-05-30 |
2015-07-14 |
Hendricus Renerus Jacobus Mattheus Hoogenboom |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
DK1648940T3
(en)
|
2003-07-28 |
2016-08-15 |
Genentech Inc |
Reduction of leaching of protein A during protein A affinity chromatography
|
|
US20070104714A1
(en)
*
|
2003-08-29 |
2007-05-10 |
Cedars-Sinai Medical Center |
Composition and method for the treatment of cancer and other physiologic conditins based on modulation of the ppar-gamma pathway and her-kinase axis
|
|
WO2005028498A2
(en)
*
|
2003-09-18 |
2005-03-31 |
Raven Biotechnologies, Inc. |
Kid3 and kid3 antibodies that bind thereto
|
|
AU2004292933B2
(en)
*
|
2003-11-28 |
2011-01-06 |
Glycorex Transplantation Ab |
Targeting of Erb antigens
|
|
RU2402568C2
(ru)
*
|
2004-02-06 |
2010-10-27 |
МорфоСис АГ |
Человеческие анти-cd38-антитела и их применение
|
|
RU2273475C2
(ru)
*
|
2004-04-06 |
2006-04-10 |
Государственное учреждение системы высшего и послевузовского профессионального образования "Сибирский государственный медицинский университет" (ГУ СВ ПО СибГМУ) |
Способ лечения диссеминированного колоректального рака
|
|
GT200500155A
(es)
*
|
2004-06-16 |
2006-05-15 |
|
Terapia del càncer resistente al platino
|
|
CA2574821C
(en)
|
2004-07-22 |
2013-07-09 |
Genentech, Inc. |
Her2 antibody composition
|
|
EP1791565B1
(en)
|
2004-09-23 |
2016-04-20 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
MX2007006529A
(es)
*
|
2004-12-07 |
2007-06-22 |
Genentech Inc |
Seleccionar pacientes para terapia con un inhibidor her.
|
|
AU2005325200A1
(en)
|
2005-01-21 |
2006-07-27 |
Genentech, Inc. |
Fixed dosing of HER antibodies
|
|
CN101163503B
(zh)
|
2005-02-23 |
2013-05-08 |
健泰科生物技术公司 |
使用her二聚化抑制剂在癌症患者中延长病情进展前时间或存活
|
|
AR053272A1
(es)
*
|
2005-05-11 |
2007-04-25 |
Hoffmann La Roche |
Determinacion de responsivos a la quimioterapia
|
|
CA2610709A1
(en)
|
2005-06-06 |
2006-12-14 |
Genentech, Inc. |
Transgenic models for different genes and their use for gene characterization
|
|
US7700299B2
(en)
|
2005-08-12 |
2010-04-20 |
Hoffmann-La Roche Inc. |
Method for predicting the response to a treatment
|
|
JP2009504183A
(ja)
|
2005-08-15 |
2009-02-05 |
ジェネンテック・インコーポレーテッド |
遺伝子破壊、それに関連する組成物および方法
|
|
KR101164820B1
(ko)
|
2005-09-22 |
2012-07-12 |
삼성전자주식회사 |
디스플레이장치
|
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
|
EP2002714A1
(en)
|
2005-11-21 |
2008-12-17 |
Genentech, Inc. |
Novel gene disruptions, compositions and methods relating thereto
|
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
ZA200807714B
(en)
|
2006-02-17 |
2010-01-27 |
Genentech Inc |
Gene disruptions, compositions and methods relating thereto
|
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
|
AR060358A1
(es)
|
2006-04-06 |
2008-06-11 |
Novartis Vaccines & Diagnostic |
Quinazolinas para la inhibicion de pdk 1
|
|
US20090288176A1
(en)
|
2006-04-19 |
2009-11-19 |
Genentech, Inc. |
Novel Gene Disruptions, Compositions and Methods Relating Thereto
|
|
KR20140085544A
(ko)
|
2006-05-30 |
2014-07-07 |
제넨테크, 인크. |
항체 및 면역접합체 및 이들의 용도
|
|
CN101495142A
(zh)
*
|
2006-06-05 |
2009-07-29 |
健泰科生物技术公司 |
延长EGF或TGF-α水平升高的癌症患者的存活
|
|
JP2010501498A
(ja)
|
2006-08-21 |
2010-01-21 |
エフ.ホフマン−ラ ロシュ アーゲー |
抗vegf抗体による腫瘍治療
|
|
WO2008031531A1
(en)
*
|
2006-09-15 |
2008-03-20 |
F. Hoffmann-La Roche Ag |
Tumor therapy with a combination of anti-her2 antibodies
|
|
NZ601022A
(en)
*
|
2006-10-12 |
2014-09-26 |
Chugai Pharmaceutical Co Ltd |
Diagnosis and treatment of cancer using anti-ereg antibody
|
|
RU2483080C2
(ru)
|
2006-10-27 |
2013-05-27 |
Дженентек, Инк. |
Антитела и иммуноконъюгаты и их применение
|
|
PL2132573T3
(pl)
|
2007-03-02 |
2014-09-30 |
Genentech Inc |
Prognozowanie odpowiedzi na inhibitor dimeryzacji HER oparte na niskiej ekspresji HER3
|
|
US9551033B2
(en)
|
2007-06-08 |
2017-01-24 |
Genentech, Inc. |
Gene expression markers of tumor resistance to HER2 inhibitor treatment
|
|
CA3006428A1
(en)
|
2007-06-08 |
2008-12-18 |
Genentech, Inc. |
Gene expression markers of tumor resistance to her2 inhibitor treatment
|
|
KR20100056438A
(ko)
*
|
2007-06-18 |
2010-05-27 |
메디뮨 엘엘씨 |
EphA2 및 ErbB2를 발현하는 세포의 상승적 치료 방법
|
|
KR20120044383A
(ko)
|
2007-07-16 |
2012-05-07 |
제넨테크, 인크. |
항-cd79b 항체 및 면역접합체 및 사용 방법
|
|
ES2528922T3
(es)
|
2007-07-16 |
2015-02-13 |
Genentech, Inc. |
Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso
|
|
JP5237382B2
(ja)
|
2007-10-30 |
2013-07-17 |
ジェネンテック, インコーポレイテッド |
陽イオン交換クロマトグラフィーによる抗体の精製
|
|
AU2008328781A1
(en)
|
2007-11-27 |
2009-06-04 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
|
PE20091523A1
(es)
|
2007-12-20 |
2009-10-29 |
Novartis Ag |
Derivados de tiazol como inhibidores de la enzima fosfatidilinositol 3-cinasa (pi3k)
|
|
US8574577B2
(en)
|
2008-01-03 |
2013-11-05 |
The Scripps Research Institute |
VEGF antibodies comprising modular recognition domains
|
|
US8557242B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
ERBB2 antibodies comprising modular recognition domains
|
|
US8454960B2
(en)
|
2008-01-03 |
2013-06-04 |
The Scripps Research Institute |
Multispecific antibody targeting and multivalency through modular recognition domains
|
|
EA201500156A3
(ru)
|
2008-01-03 |
2017-09-29 |
Дзе Скриппс Рисерч Инститьют |
Доставка антител посредством модульного домена распознавания
|
|
US8557243B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
EFGR antibodies comprising modular recognition domains
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
|
MY157403A
(en)
|
2008-01-31 |
2016-06-15 |
Genentech Inc |
Anti-cd79b antibodies and immunoconjugates and methods of use
|
|
AU2009223124B2
(en)
|
2008-03-14 |
2015-03-26 |
Genentech, Inc. |
Genetic variations associated with drug resistance
|
|
HUE035184T2
(en)
*
|
2008-03-18 |
2018-05-02 |
Genentech Inc |
Combinations of an anti-HER2 antibody-drug conjugate and docetaxel
|
|
KR20120127543A
(ko)
|
2008-05-23 |
2012-11-21 |
시와 코퍼레이션 |
재생을 촉진하는 방법, 조성물 및 장치
|
|
BRPI0812682A2
(pt)
|
2008-06-16 |
2010-06-22 |
Genentech Inc |
tratamento de cáncer de mama metastático
|
|
MX2011002372A
(es)
|
2008-09-10 |
2011-04-04 |
Genentech Inc |
Composiciones y metodos para la prevencion de la degradacion oxidativa de proteinas.
|
|
EP3939617B1
(en)
|
2009-02-13 |
2024-11-13 |
Immunomedics, Inc. |
Intermediates for preparing conjugates with an intracellularly-cleavable linkage
|
|
EP2408817B1
(en)
|
2009-03-20 |
2016-03-16 |
F.Hoffmann-La Roche Ag |
Bispecific anti-her antibodies
|
|
NZ595574A
(en)
|
2009-04-01 |
2013-11-29 |
Genentech Inc |
Anti-fcrh5 antibodies and immunoconjugates and methods of use
|
|
SG175080A1
(en)
|
2009-04-07 |
2011-11-28 |
Roche Glycart Ag |
Bispecific anti-erbb-2/anti-c-met antibodies
|
|
US20120121586A1
(en)
|
2009-05-29 |
2012-05-17 |
Astrid Kiermaier |
Modulators for her2 signaling in her2 expressing patients with gastric cancer
|
|
JP5808052B2
(ja)
|
2009-05-29 |
2015-11-10 |
中外製薬株式会社 |
Egfファミリーリガンドのアンタゴニストを成分とする医薬組成物
|
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
BR112012002974B1
(pt)
|
2009-08-11 |
2022-06-07 |
Genentech, Inc |
Processo para produzir um anticorpo em uma célula hospedeira de célula ovário de hamster chinês (cho) expressando o referido polipeptídeo
|
|
US20110047103A1
(en)
*
|
2009-08-15 |
2011-02-24 |
Genentech, Inc. |
Anti-angiogenesis therapy for the treatment of previously treated breast cancer
|
|
JP5787891B2
(ja)
|
2009-09-01 |
2015-09-30 |
ジェネンテック, インコーポレイテッド |
改変されたプロテインa溶離による向上したタンパク質精製
|
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
|
PL2486141T3
(pl)
|
2009-10-07 |
2018-07-31 |
Macrogenics, Inc. |
Polipeptydy zawierające regiony fc i mające w wyniku zmian w zakresie fukozylacji ulepszoną funkcję efektorową, i sposoby zastosowania tych polipeptydów
|
|
CA2777825A1
(en)
*
|
2009-10-28 |
2011-05-19 |
Abbott Biotherapeutics Corp. |
Anti-egfr antibodies and their uses
|
|
EP2496601B1
(en)
|
2009-11-05 |
2017-06-07 |
F. Hoffmann-La Roche AG |
Methods and composition for secretion of heterologous polypeptides
|
|
MX357972B
(es)
|
2009-11-13 |
2018-08-01 |
Amgen Inc |
Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
|
|
WO2011069104A2
(en)
|
2009-12-04 |
2011-06-09 |
Genentech, Inc. |
Multispecific antibodies, antibody analogs, compositions, and methods
|
|
US9115200B2
(en)
*
|
2010-02-04 |
2015-08-25 |
Toray Industries, Inc. |
Pharmaceutical composition for treating cancer using a monoclonal antibody having immunological reactivity with CAPRIN-1
|
|
ES2519348T3
(es)
|
2010-02-18 |
2014-11-06 |
Genentech, Inc. |
Antagonistas de neurregulina y uso de los mismos en el tratamiento del cáncer
|
|
US8609095B2
(en)
|
2010-03-04 |
2013-12-17 |
Symphogen A/S |
Anti-HER2 antibodies and compositions
|
|
CN106983862A
(zh)
|
2010-03-22 |
2017-07-28 |
弗·哈夫曼-拉罗切有限公司 |
对于稳定含有蛋白质的制剂有用的组合物和方法
|
|
JP2013525484A
(ja)
|
2010-05-03 |
2013-06-20 |
ジェネンテック, インコーポレイテッド |
タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法
|
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
|
US9714294B2
(en)
|
2010-05-27 |
2017-07-25 |
Genmab A/S |
Monoclonal antibodies against HER2 epitope
|
|
AU2011257121A1
(en)
|
2010-05-27 |
2013-01-10 |
Genmab A/S |
Monoclonal antibodies against HER2
|
|
CA2800728C
(en)
|
2010-05-28 |
2020-10-27 |
Genentech, Inc. |
Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
|
|
MX336109B
(es)
|
2010-06-03 |
2016-01-08 |
Genentech Inc |
Formacion de imagenes inmuno-tep de anticuerpos e inmunoconjugados y usos de lo mismo.
|
|
EP2579897A1
(en)
|
2010-06-08 |
2013-04-17 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
EP3586826B1
(en)
|
2010-06-24 |
2021-05-12 |
F. Hoffmann-La Roche AG |
Compositions and methods for stabilizing protein-containing formulations
|
|
US20120100166A1
(en)
|
2010-07-15 |
2012-04-26 |
Zyngenia, Inc. |
Ang-2 Binding Complexes and Uses Thereof
|
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
|
TW201302793A
(zh)
|
2010-09-03 |
2013-01-16 |
Glaxo Group Ltd |
新穎之抗原結合蛋白
|
|
US8721571B2
(en)
|
2010-11-22 |
2014-05-13 |
Siwa Corporation |
Selective removal of cells having accumulated agents
|
|
US20130245233A1
(en)
|
2010-11-24 |
2013-09-19 |
Ming Lei |
Multispecific Molecules
|
|
MX357821B
(es)
|
2010-12-21 |
2018-07-25 |
Hoffmann La Roche |
Preparación de anticuerpo enriquecida con isoforma y método para obtenerla.
|
|
WO2012085113A1
(en)
|
2010-12-23 |
2012-06-28 |
Roche Diagnostics Gmbh |
Binding agent
|
|
EP2655413B1
(en)
|
2010-12-23 |
2019-01-16 |
F.Hoffmann-La Roche Ag |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
|
AR085039A1
(es)
|
2011-01-31 |
2013-08-07 |
Novartis Ag |
DERIVADOS DE PURINA, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA PREPARACION DE MEDICAMENTOS PARA TRATAR ENFERMEDADES MODULADAS POR LA INHIBICION DE LA PI3K DE CLASE I Y/O mTOR
|
|
CN103649326B
(zh)
*
|
2011-03-08 |
2016-08-17 |
宾夕法尼亚大学理事会 |
用于治疗和诊断用途的抗体样蛋白
|
|
JP2014514314A
(ja)
|
2011-04-20 |
2014-06-19 |
ゲンマブ エー/エス |
Her2およびcd3に対する二重特異性抗体
|
|
AU2012258637B2
(en)
|
2011-05-24 |
2017-07-20 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
|
MX2014001766A
(es)
|
2011-08-17 |
2014-05-01 |
Genentech Inc |
Anticuerpos de neuregulina y sus usos.
|
|
ES2736005T3
(es)
|
2011-10-14 |
2019-12-23 |
Hoffmann La Roche |
Pertuzumab, Trastuzumab, Docetaxel y Carboplatino para el tratamiento del cáncer de mama en fase precoz
|
|
US9327023B2
(en)
|
2011-10-25 |
2016-05-03 |
The Regents Of The University Of Michigan |
HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
|
|
BR112014009890A2
(pt)
|
2011-10-28 |
2020-10-27 |
Novartis Ag |
derivados de purina e seu uso no tratamento de doença
|
|
WO2013078191A1
(en)
|
2011-11-23 |
2013-05-30 |
Medimmune, Llc |
Binding molecules specific for her3 and uses thereof
|
|
EP2785864A2
(en)
|
2011-11-30 |
2014-10-08 |
F. Hoffmann-La Roche AG |
Erbb3 mutations in cancer
|
|
US9376715B2
(en)
|
2011-12-09 |
2016-06-28 |
Roche Molecular Systems, Inc |
Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
|
|
CN104125963B
(zh)
|
2011-12-22 |
2018-08-17 |
弗·哈夫曼-拉罗切有限公司 |
使用离子交换膜层析改进下游蛋白质纯化步骤的方法
|
|
TWI593705B
(zh)
|
2011-12-28 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
|
|
EP3045543A3
(en)
|
2012-01-31 |
2016-10-12 |
Novartis AG |
Method of treating cancer
|
|
EP2638916A1
(en)
|
2012-03-16 |
2013-09-18 |
Covagen AG |
Novel binding molecules with antitumoral activity
|
|
MX2014011500A
(es)
|
2012-03-27 |
2014-12-05 |
Genentech Inc |
Diagnosticos y tratamientos relacionados a inhibidores her3.
|
|
SG11201406770WA
(en)
|
2012-04-20 |
2014-11-27 |
Merus B V |
Methods and means for the production of ig-like molecules
|
|
KR101505157B1
(ko)
*
|
2012-05-08 |
2015-03-24 |
주식회사 종근당 |
항―ErbB2 항체 변이체
|
|
WO2013173283A1
(en)
|
2012-05-16 |
2013-11-21 |
Novartis Ag |
Dosage regimen for a pi-3 kinase inhibitor
|
|
KR102291355B1
(ko)
|
2012-11-30 |
2021-08-19 |
에프. 호프만-라 로슈 아게 |
Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법
|
|
US20150329524A1
(en)
|
2013-01-10 |
2015-11-19 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Fatty acid synthase inhibitors
|
|
AR094403A1
(es)
|
2013-01-11 |
2015-07-29 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos anti-her3
|
|
EA201890895A1
(ru)
|
2013-03-15 |
2019-02-28 |
Зинджения, Инк. |
Мультивалентные и моновалентные мультиспецифические комплексы и их применение
|
|
CN104628846B
(zh)
|
2013-11-06 |
2019-12-06 |
三生国健药业(上海)股份有限公司 |
重组蛋白质的纯化方法
|
|
LT3480215T
(lt)
*
|
2013-11-19 |
2021-08-25 |
Remegen Co., Ltd. |
Anti-her2 antikūnas ir jo konjugatas
|
|
US10947319B2
(en)
|
2013-11-27 |
2021-03-16 |
Zymeworks Inc. |
Bispecific antigen-binding constructs targeting HER2
|
|
WO2015083101A1
(en)
|
2013-12-06 |
2015-06-11 |
Novartis Ag |
Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor
|
|
HUE044389T2
(hu)
|
2014-01-31 |
2019-10-28 |
Daiichi Sankyo Co Ltd |
Anti-HER2 antitest-hatóanyag konjugátum
|
|
US20160361309A1
(en)
|
2014-02-26 |
2016-12-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Methods of treating cancer patients responding to ezh2 inhibitor gsk126
|
|
PL3116999T3
(pl)
|
2014-03-14 |
2021-12-27 |
F.Hoffmann-La Roche Ag |
Sposoby i kompozycje do wydzielania polipeptydów heterologicznych
|
|
AU2015243377A1
(en)
|
2014-04-11 |
2016-09-15 |
Medimmune, Llc |
Bispecific HER2 antibodies
|
|
EP3191521A2
(en)
|
2014-09-12 |
2017-07-19 |
F. Hoffmann-La Roche AG |
Cysteine engineered antibodies and conjugates
|
|
JP6976847B2
(ja)
|
2014-09-19 |
2021-12-08 |
シワ コーポレイション |
炎症及び自己免疫障害を治療するための抗age抗体
|
|
US10385380B2
(en)
|
2014-10-02 |
2019-08-20 |
The Regents Of The University Of California |
Personalized protease assay to measure protease activity in neoplasms
|
|
DK3223848T3
(da)
|
2014-11-27 |
2025-03-03 |
Zymeworks Bc Inc |
Fremgangsmåder til anvendelse af bispecifikke antigenbindingskonstrukter målrettet her2
|
|
US10358502B2
(en)
|
2014-12-18 |
2019-07-23 |
Siwa Corporation |
Product and method for treating sarcopenia
|
|
US9993535B2
(en)
|
2014-12-18 |
2018-06-12 |
Siwa Corporation |
Method and composition for treating sarcopenia
|
|
MA41414A
(fr)
|
2015-01-28 |
2017-12-05 |
Centre Nat Rech Scient |
Protéines de liaison agonistes d' icos
|
|
KR101515535B1
(ko)
|
2015-01-28 |
2015-05-06 |
주식회사 종근당 |
항―ErbB2 항체 변이체
|
|
US11028182B2
(en)
|
2015-05-13 |
2021-06-08 |
Zymeworks Inc. |
Antigen-binding constructs targeting HER2
|
|
WO2017025871A1
(en)
|
2015-08-07 |
2017-02-16 |
Glaxosmithkline Intellectual Property Development Limited |
Combination therapy comprising anti ctla-4 antibodies
|
|
WO2017065837A1
(en)
*
|
2015-10-13 |
2017-04-20 |
Siwa Corporation |
Anti-age antibodies and methods of use thereof
|
|
US20180280370A1
(en)
|
2015-11-02 |
2018-10-04 |
Novartis Ag |
Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
|
|
CN106729743B
(zh)
|
2015-11-23 |
2021-09-21 |
四川科伦博泰生物医药股份有限公司 |
抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用
|
|
RU2018123717A
(ru)
|
2015-12-01 |
2020-01-14 |
Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед |
Комбинированные лечения, их применения и способы
|
|
GEP20217328B
(en)
|
2015-12-14 |
2021-12-10 |
Macrogenics Inc |
Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof
|
|
CN105646704B
(zh)
*
|
2015-12-28 |
2019-11-15 |
广西医科大学 |
抗p185erbB2人鼠嵌合抗体ChAb26、乳腺特异性表达载体、转基因FVB小鼠及其制备方法
|
|
WO2018191718A1
(en)
|
2017-04-13 |
2018-10-18 |
Siwa Corporation |
Humanized monoclonal advanced glycation end-product antibody
|
|
DK3677598T3
(da)
|
2016-02-19 |
2022-05-30 |
Siwa Corp |
Fremgangsmåde og sammensætning til behandling af cancer, drab på metastatiske cancerceller og forebyggelse af cancermetastaser under anvendelse af antistof mod avancerede glykeringsslutprodukter (age)
|
|
EP3429623A1
(en)
*
|
2016-03-15 |
2019-01-23 |
Merrimack Pharmaceuticals, Inc. |
Methods for treating er+, her2-, hrg+ breast cancer using combination therapies comprising an anti-erbb3 antibody
|
|
CN109311975A
(zh)
|
2016-04-15 |
2019-02-05 |
Siwa有限公司 |
用于治疗神经退行性紊乱的抗age抗体
|
|
WO2017194554A1
(en)
|
2016-05-10 |
2017-11-16 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Combinations therapies for the treatment of cancer
|
|
CN109476744B
(zh)
*
|
2016-05-12 |
2023-04-11 |
新加坡科技研究局 |
抗erbb-2抗体及其用途
|
|
WO2017222535A1
(en)
|
2016-06-23 |
2017-12-28 |
Siwa Corporation |
Vaccines for use in treating various diseases and disorders
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
WO2018066626A1
(ja)
|
2016-10-07 |
2018-04-12 |
第一三共株式会社 |
抗her2抗体-薬物コンジュゲート投与による耐性癌の治療
|
|
CA3046293A1
(en)
|
2016-12-12 |
2018-06-21 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and immune checkpoint inhibitor
|
|
CN110709419B
(zh)
*
|
2017-01-06 |
2023-11-28 |
博奥信生物技术(南京)有限公司 |
Erbb2抗体及其用途
|
|
US10961321B1
(en)
|
2017-01-06 |
2021-03-30 |
Siwa Corporation |
Methods and compositions for treating pain associated with inflammation
|
|
US10858449B1
(en)
|
2017-01-06 |
2020-12-08 |
Siwa Corporation |
Methods and compositions for treating osteoarthritis
|
|
US10995151B1
(en)
|
2017-01-06 |
2021-05-04 |
Siwa Corporation |
Methods and compositions for treating disease-related cachexia
|
|
US10925937B1
(en)
|
2017-01-06 |
2021-02-23 |
Siwa Corporation |
Vaccines for use in treating juvenile disorders associated with inflammation
|
|
BR112019017628A2
(pt)
|
2017-02-24 |
2020-07-07 |
Macrogenics, Inc. |
molécula de ligação a cd137 x ta, composições farmacêuticas, uso da molécula de ligação a cd137 x ta, molécula de ligação a cd137, uso da molécula de ligação a cd137, molécula de ligação a her2/neu, uso da molécula de ligação a her2/neu, e uso de uma composição
|
|
DK3589661T5
(da)
|
2017-03-02 |
2024-09-02 |
Genentech Inc |
Adjuvansbehandling af HER2-positiv brystcancer
|
|
EP3589286B1
(en)
|
2017-03-02 |
2022-08-03 |
ASLAN Pharmaceuticals Pte Ltd |
Dhodh inhibitor for treating haematological cancer
|
|
MA49279A
(fr)
|
2017-03-22 |
2020-02-05 |
Hoffmann La Roche |
Compositions d'anticorps optimisées pour le traitement de troubles oculaires
|
|
WO2018222135A1
(en)
|
2017-06-02 |
2018-12-06 |
Aslan Pharmaceuticals Pte Ltd |
Cancer therapy
|
|
CN107417791B
(zh)
*
|
2017-08-17 |
2020-09-22 |
合肥瀚科迈博生物技术有限公司 |
抗人ErbB2双特异性抗体、其制备方法及用途
|
|
AU2018320470B2
(en)
|
2017-08-23 |
2025-04-24 |
Daiichi Sankyo Company, Limited |
Antibody-drug conjugate preparation and lyophilization for same
|
|
US11945882B2
(en)
|
2017-08-31 |
2024-04-02 |
Daiichi Sankyo Company, Limited |
Method for producing antibody-drug conjugate
|
|
CA3074208C
(en)
|
2017-08-31 |
2023-10-03 |
Daiichi Sankyo Company, Limited |
Novel method for producing antibody-drug conjugate
|
|
CN107789631B
(zh)
*
|
2017-11-03 |
2021-03-16 |
合肥瀚科迈博生物技术有限公司 |
抗人ErbB2双表位抗体-药物偶联物及其应用
|
|
CA3085432A1
(en)
|
2017-12-12 |
2019-06-20 |
Macrogenics Inc. |
Bispecific cd16-binding molecules and their use in the treatment of disease
|
|
US11518801B1
(en)
|
2017-12-22 |
2022-12-06 |
Siwa Corporation |
Methods and compositions for treating diabetes and diabetic complications
|
|
US11685781B2
(en)
|
2018-02-15 |
2023-06-27 |
Macrogenics, Inc. |
Variant CD3-binding domains and their use in combination therapies for the treatment of disease
|
|
EP3560945A1
(en)
|
2018-04-27 |
2019-10-30 |
F. Hoffmann-La Roche AG |
Methods for purification of polypeptides using polysorbates
|
|
US20210205466A1
(en)
|
2018-05-28 |
2021-07-08 |
Daiichi Sankyo Company, Limited |
Treatment of her2-mutated cancer by administering anti-her2 antibody-drug conjugate
|
|
KR20210035854A
(ko)
|
2018-07-23 |
2021-04-01 |
트레비 테라퓨틱스, 인코포레이티드 |
만성 기침, 무호흡증 및 호흡곤란의 치료
|
|
AU2019311557A1
(en)
|
2018-07-25 |
2021-02-04 |
Daiichi Sankyo Company, Limited |
Effective method for manufacturing antibody-drug conjugate
|
|
AU2019311596A1
(en)
|
2018-07-27 |
2021-01-28 |
Daiichi Sankyo Company, Limited |
Protein recognizing drug moiety of antibody-drug conjugate
|
|
TWI822822B
(zh)
|
2018-07-31 |
2023-11-21 |
日商第一三共股份有限公司 |
抗體-藥物結合物之用途
|
|
JP7458981B2
(ja)
|
2018-08-06 |
2024-04-01 |
第一三共株式会社 |
抗体-薬物コンジュゲートとチューブリン阻害剤の組み合わせ
|
|
WO2020040245A1
(ja)
|
2018-08-23 |
2020-02-27 |
第一三共株式会社 |
抗体薬物複合体の感受性マーカー
|
|
KR20210064325A
(ko)
|
2018-09-25 |
2021-06-02 |
에이비에스씨아이, 엘엘씨 |
단백질 정제 방법
|
|
WO2020084503A1
(en)
|
2018-10-26 |
2020-04-30 |
Cadila Healthcare Limited |
A composition comprising antibody with reduced level of basic variants thereof
|
|
US20220023436A1
(en)
|
2018-12-11 |
2022-01-27 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate with parp inhibitor
|
|
MA54544A
(fr)
|
2018-12-19 |
2021-10-27 |
Incyte Corp |
Inhibiteurs de la voie jak1 pour le traitement d'une maladie gastro-intestinale
|
|
KR20210107069A
(ko)
|
2018-12-21 |
2021-08-31 |
다이이찌 산쿄 가부시키가이샤 |
항체-약물 컨쥬게이트와 키나아제 저해제의 조합
|
|
WO2020160375A1
(en)
|
2019-02-01 |
2020-08-06 |
Glaxosmithkline Intellectual Property Development Limited |
Combination treatments for cancer comprising belantamab mafodotin and an anti ox40 antibody and uses and methods thereof
|
|
TWI856084B
(zh)
|
2019-04-01 |
2024-09-21 |
美商建南德克公司 |
用於穩定含有蛋白質之配方之組合物及方法
|
|
CN112007169B
(zh)
*
|
2019-05-30 |
2022-03-08 |
湖南大学 |
一种核酸适配体药物偶联物及其制备方法和用途
|
|
CN110205302B
(zh)
*
|
2019-06-24 |
2021-03-23 |
扬州大学 |
一株分泌抗麦考酚酸单克隆抗体的细胞株、其单克隆抗体及其应用
|
|
AU2020308053A1
(en)
|
2019-06-26 |
2022-01-20 |
Glaxosmithkline Intellectual Property Development Limited |
IL1RAP binding proteins
|
|
CN110551214A
(zh)
*
|
2019-08-27 |
2019-12-10 |
杨澜 |
一种人源化抗Periostin单克隆抗体、及其制备方法和应用
|
|
EP4087569A4
(en)
|
2020-01-10 |
2024-01-24 |
Trevi Therapeutics, Inc. |
METHODS OF ADMINISTRATION OF NALBUPHINE
|
|
EP4096718A1
(en)
|
2020-01-28 |
2022-12-07 |
GlaxoSmithKline Intellectual Property Development Limited |
Combination treatments and uses and methods thereof
|
|
MX2022010228A
(es)
|
2020-02-21 |
2022-09-19 |
Macrogenics Inc |
Moleculas de union a cd137 y usos de las mismas.
|
|
WO2021260582A1
(en)
|
2020-06-24 |
2021-12-30 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and aurora b inhibitor
|
|
WO2021260583A1
(en)
|
2020-06-24 |
2021-12-30 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and dna-pk inhibitor
|
|
EP4171651A1
(en)
|
2020-06-24 |
2023-05-03 |
AstraZeneca UK Limited |
Combination of antibody-drug conjugate and atm inhibitor
|
|
EP4171654A1
(en)
|
2020-06-24 |
2023-05-03 |
AstraZeneca UK Limited |
Combination of antibody-drug conjugate and cdk9 inhibitor
|
|
TW202216208A
(zh)
|
2020-06-24 |
2022-05-01 |
英商阿斯特捷利康英國股份有限公司 |
抗體-藥物結合物及atr抑制劑之組合
|
|
US20230293714A1
(en)
|
2020-07-20 |
2023-09-21 |
Daiichi Sankyo Company, Limited |
Combination of anti-her2 antibody-drug conjugate with her dimerization inhibitor
|
|
CA3195117A1
(en)
|
2020-10-09 |
2022-04-14 |
Jerome Thomas Mettetal Ii |
Combination of antibody-drug conjugate and parp1 selective inhibitor
|
|
CA3198330A1
(en)
|
2020-11-11 |
2022-05-19 |
Mayumi SUE |
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|
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