LU79547A1 - Procede de preparation de nouvelles compositions antibiotiques a base d'une tetracycline - Google Patents

Procede de preparation de nouvelles compositions antibiotiques a base d'une tetracycline

Info

Publication number
LU79547A1
LU79547A1 LU79547A LU79547A LU79547A1 LU 79547 A1 LU79547 A1 LU 79547A1 LU 79547 A LU79547 A LU 79547A LU 79547 A LU79547 A LU 79547A LU 79547 A1 LU79547 A1 LU 79547A1
Authority
LU
Luxembourg
Prior art keywords
tetracycline
preparation
compositions based
new antibiotic
antibiotic compositions
Prior art date
Application number
LU79547A
Other languages
English (en)
French (fr)
Inventor
W Armstrong
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of LU79547A1 publication Critical patent/LU79547A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LU79547A 1977-04-27 1978-04-27 Procede de preparation de nouvelles compositions antibiotiques a base d'une tetracycline LU79547A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
LU79547A1 true LU79547A1 (fr) 1979-11-07

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
LU79547A LU79547A1 (fr) 1977-04-27 1978-04-27 Procede de preparation de nouvelles compositions antibiotiques a base d'une tetracycline

Country Status (38)

Country Link
US (1) US4126680A (da)
JP (1) JPS53136514A (da)
AR (1) AR217844A1 (da)
AT (1) AT360148B (da)
AU (1) AU503139B1 (da)
BE (1) BE866419A (da)
BG (1) BG47943A3 (da)
CA (1) CA1100875A (da)
CH (1) CH630260A5 (da)
CS (1) CS199527B2 (da)
DD (1) DD135445A5 (da)
DE (1) DE2817335C3 (da)
DK (1) DK155977C (da)
EG (1) EG14348A (da)
ES (1) ES468749A1 (da)
FI (3) FI801197A7 (da)
FR (1) FR2388561A1 (da)
GB (1) GB1563478A (da)
GR (1) GR70062B (da)
HU (1) HU179050B (da)
IE (1) IE47049B1 (da)
IL (1) IL54581A0 (da)
IN (1) IN148197B (da)
IT (1) IT1094557B (da)
LU (1) LU79547A1 (da)
MX (1) MX6087E (da)
NL (1) NL7804455A (da)
NO (1) NO148280C (da)
NZ (1) NZ187046A (da)
OA (1) OA05949A (da)
PH (1) PH12962A (da)
PL (1) PL110459B1 (da)
PT (1) PT67895B (da)
RO (2) RO77953A (da)
SE (1) SE443507B (da)
YU (1) YU87178A (da)
ZA (1) ZA782400B (da)
ZM (1) ZM3878A1 (da)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
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US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (en) * 1993-04-20 1994-10-26 Nostras S.A. Antibiotic composition containing oxytetracycline and glycofurol
KR100764992B1 (ko) * 1999-09-14 2007-10-09 트러스티즈 오브 터프츠 칼리지 전이금속을 이용한 화학반응에 의한 치환 테트라사이클린 제조 방법 및 치환 테트라사이클린 화합물
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6833365B2 (en) 2000-01-24 2004-12-21 Trustees Of Tufts College Tetracycline compounds for treatment of Cryptosporidium parvum related disorders
MXPA02009482A (es) 2000-03-31 2004-05-14 Tufts College Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino.
AU2001259701A1 (en) * 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP1301466A2 (en) 2000-07-07 2003-04-16 Trustees Of Tufts College 7-substituted tetracycline compounds
SI1301467T1 (sl) 2000-07-07 2007-02-28 Tufts College 9-substituirane minociklinske spojine
EP2166000A1 (en) 2000-07-07 2010-03-24 Trustees Of Tufts College 7-, 8- and 9-substituted tetracycline compounds
EP1301465A2 (en) 2000-07-07 2003-04-16 Trustees Of Tufts College 13-substituted methacycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
AU2001271619B2 (en) 2001-03-13 2008-05-15 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
EP1381372A2 (en) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
EP1379255A2 (en) * 2001-03-14 2004-01-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
CA2444899C (en) 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2995610A1 (en) 2002-01-08 2016-03-16 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EA201000491A1 (ru) 2002-03-08 2010-08-30 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
CN101712632A (zh) 2002-03-21 2010-05-26 帕拉特克药品公司 取代的四环素化合物
CA2492273C (en) 2002-07-12 2013-02-05 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
AU2003287218C1 (en) 2002-10-24 2010-07-15 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP1656341A1 (en) 2003-07-09 2006-05-17 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2298323A3 (en) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CN103040773A (zh) * 2003-07-25 2013-04-17 沃纳奇尔科特有限责任公司 多西环素金属络合物固体剂型
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2295419A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2301912A3 (en) 2004-10-25 2012-07-11 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
EP1991236A2 (en) 2006-01-24 2008-11-19 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
PT2016045E (pt) * 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
EP2029749A2 (en) * 2006-05-15 2009-03-04 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
ES2315123B1 (es) * 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
PT2120963T (pt) 2006-12-21 2018-12-17 Paratek Pharm Innc Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele
EP2452935A3 (en) 2006-12-21 2012-08-29 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
EA016206B1 (ru) * 2007-03-23 2012-03-30 Моликьюлар Рисерч Сентер, Инк. Композиция и способ лечения воспалительных расстройств
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
JP2010523684A (ja) * 2007-04-12 2010-07-15 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法
EP2213655A1 (en) 2007-04-27 2010-08-04 Paratek Pharmaceuticals, Inc. Methods For Purifying Aminoalkyl Tetracycline Compounds
PT2176216E (pt) 2007-07-06 2012-07-27 Paratek Pharm Innc Métodos de síntese de minociclina substituída na posição 9
JP2011513404A (ja) * 2008-03-05 2011-04-28 パラテック ファーマシューティカルズ インコーポレイテッド ミノサイクリン化合物およびその使用方法
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CA2721399A1 (en) * 2008-04-14 2009-10-22 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
TWI585071B (zh) 2008-05-19 2017-06-01 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
WO2010017310A1 (en) 2008-08-06 2010-02-11 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
CN102215681A (zh) * 2008-09-19 2011-10-12 帕拉特克药品公司 用于治疗类风湿性关节炎的四环素化合物和相关的治疗方法
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PL2707003T3 (pl) 2011-05-12 2019-11-29 Paratek Pharm Innc Krystaliczne sole amidu kwasu (4s,4as,5ar,12as)-4-dimetyloamino-3,10,12,12a-tetrahydroksy-7-[(metoksy(metylo)amino)metylo]-1,11-diokso- 1,4,4a,5,5a,6,11,12a-oktahydronaftaceno- 2-karboksylowego i sposoby ich stosowania
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
ES2611185T3 (es) * 2013-05-20 2017-05-05 Fundación Comunidad Valenciana Centro De Investigación Principe Felipe Conjugados polímero-fármaco para el tratamiento de la amiloidosis
BR112017020358A2 (pt) 2015-03-23 2018-07-17 Biopharmx Inc composição farmacêutica de tetraciclina para uso dermatológico
RU2019113715A (ru) 2016-11-01 2020-12-03 Паратек Фармасьютикалс, Инк. 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп)
BR112020000968A2 (pt) 2017-07-21 2020-07-14 Almirall, Llc tratamento de lesões não inflamatórias
CN113655052B (zh) * 2021-08-03 2023-12-12 哈尔滨工程大学 基于高活性MgO对四环素类抗生素可视化检测的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
PL110459B1 (en) 1980-07-31
FI781300A7 (fi) 1978-10-28
FI801197A7 (fi) 1981-01-01
EG14348A (en) 1984-09-30
DK155977B (da) 1989-06-12
GB1563478A (en) 1980-03-26
BE866419A (fr) 1978-10-26
FR2388561A1 (fr) 1978-11-24
IE780828L (en) 1978-10-27
ZM3878A1 (en) 1978-11-21
MX6087E (es) 1984-11-08
IT7822720A0 (it) 1978-04-26
CA1100875A (en) 1981-05-12
ATA300478A (de) 1980-05-15
CS199527B2 (en) 1980-07-31
AU503139B1 (en) 1979-08-23
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
AR217844A1 (es) 1980-04-30
ES468749A1 (es) 1979-01-01
NO148280B (no) 1983-06-06
PH12962A (en) 1979-10-19
CH630260A5 (fr) 1982-06-15
GR70062B (da) 1982-07-26
YU87178A (en) 1984-04-30
NL7804455A (nl) 1978-10-31
RO75099A (ro) 1980-12-30
IN148197B (da) 1980-11-29
PT67895B (en) 1979-11-14
JPS5632290B2 (da) 1981-07-27
BG47943A3 (bg) 1990-10-15
IL54581A0 (en) 1978-07-31
RO77953A (ro) 1981-12-25
DE2817335C3 (de) 1982-04-22
SE443507B (sv) 1986-03-03
ZA782400B (en) 1979-04-25
FI801196A7 (fi) 1981-01-01
DD135445A5 (de) 1979-05-09
DE2817335B2 (de) 1981-06-11
HU179050B (en) 1982-08-28
NO781457L (no) 1978-10-30
AT360148B (de) 1980-12-29
DE2817335A1 (de) 1978-11-16
JPS53136514A (en) 1978-11-29
FR2388561B1 (da) 1980-07-18
IT1094557B (it) 1985-08-02
DK155977C (da) 1989-10-30
IE47049B1 (en) 1983-12-14
US4126680A (en) 1978-11-21
DK182578A (da) 1978-10-28
PT67895A (en) 1978-05-01
NO148280C (no) 1983-09-21
OA05949A (fr) 1981-06-30
NZ187046A (en) 1980-03-05

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