BE866419A - Nouvelles compositions antibiotiques a base d'une tetracycline - Google Patents

Nouvelles compositions antibiotiques a base d'une tetracycline

Info

Publication number
BE866419A
BE866419A BE187143A BE187143A BE866419A BE 866419 A BE866419 A BE 866419A BE 187143 A BE187143 A BE 187143A BE 187143 A BE187143 A BE 187143A BE 866419 A BE866419 A BE 866419A
Authority
BE
Belgium
Prior art keywords
tetracycline
compositions based
new antibiotic
antibiotic compositions
new
Prior art date
Application number
BE187143A
Other languages
English (en)
French (fr)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BE866419A publication Critical patent/BE866419A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BE187143A 1977-04-27 1978-04-26 Nouvelles compositions antibiotiques a base d'une tetracycline BE866419A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
BE866419A true BE866419A (fr) 1978-10-26

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
BE187143A BE866419A (fr) 1977-04-27 1978-04-26 Nouvelles compositions antibiotiques a base d'une tetracycline

Country Status (38)

Country Link
US (1) US4126680A (da)
JP (1) JPS53136514A (da)
AR (1) AR217844A1 (da)
AT (1) AT360148B (da)
AU (1) AU503139B1 (da)
BE (1) BE866419A (da)
BG (1) BG47943A3 (da)
CA (1) CA1100875A (da)
CH (1) CH630260A5 (da)
CS (1) CS199527B2 (da)
DD (1) DD135445A5 (da)
DE (1) DE2817335C3 (da)
DK (1) DK155977C (da)
EG (1) EG14348A (da)
ES (1) ES468749A1 (da)
FI (1) FI781300A (da)
FR (1) FR2388561A1 (da)
GB (1) GB1563478A (da)
GR (1) GR70062B (da)
HU (1) HU179050B (da)
IE (1) IE47049B1 (da)
IL (1) IL54581A0 (da)
IN (1) IN148197B (da)
IT (1) IT1094557B (da)
LU (1) LU79547A1 (da)
MX (1) MX6087E (da)
NL (1) NL7804455A (da)
NO (1) NO148280C (da)
NZ (1) NZ187046A (da)
OA (1) OA05949A (da)
PH (1) PH12962A (da)
PL (1) PL110459B1 (da)
PT (1) PT67895B (da)
RO (2) RO75099A (da)
SE (1) SE443507B (da)
YU (1) YU87178A (da)
ZA (1) ZA782400B (da)
ZM (1) ZM3878A1 (da)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (en) * 1993-04-20 1994-10-26 Nostras S.A. Antibiotic composition containing oxytetracycline and glycofurol
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
DK1240133T3 (da) 1999-09-14 2006-08-21 Tufts College Fremgangsmåde til fremstilling af substituerede tetracycliner med overgangsmetalbaserede kemiske metoder
EP1263442A1 (en) * 2000-01-24 2002-12-11 Trustees Of Tufts College TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS
US6818634B2 (en) * 2000-03-31 2004-11-16 Paratek Pharmaceuticals, Inc. 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
EP1286954B1 (en) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
WO2001098236A2 (en) 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
US6624168B2 (en) 2000-07-07 2003-09-23 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
HU229577B1 (en) 2000-07-07 2014-02-28 Tufts College 9-substituted minocycline derivatives
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
KR101083571B1 (ko) 2000-07-07 2011-11-14 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
CZ2003332A3 (cs) 2000-07-07 2003-05-14 Trustees Of Tufts College 13-Substituované methacyklinové sloučeniny
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP2298732A1 (en) * 2001-03-13 2011-03-23 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
US7045507B2 (en) 2001-03-14 2006-05-16 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
WO2002072022A2 (en) 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
DE60235083D1 (de) 2001-04-24 2010-03-04 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP1474380A4 (en) 2002-01-08 2007-04-18 Paratek Pharm Innc 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS
CN1649582A (zh) 2002-03-08 2005-08-03 帕拉特克药品公司 氨基－甲基取代的四环素类化合物
CA2479877C (en) 2002-03-21 2012-08-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CA2492273C (en) 2002-07-12 2013-02-05 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
WO2004038001A2 (en) 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
AU2004259659B2 (en) 2003-07-09 2011-11-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
WO2005009944A1 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CA2533150C (en) * 2003-07-25 2013-03-12 Warner Chilcott Company, Inc. A doxycycline metal complex in a solid dosage form
US7786099B2 (en) * 2004-01-15 2010-08-31 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
US7858601B2 (en) * 2004-10-25 2010-12-28 Paratek Pharmaceuticals, Inc. 4-substituted tetracyclines and methods of use thereof
WO2006047756A2 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CA2597212A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080242642A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
EP2298324A1 (en) 2006-01-24 2011-03-23 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
CA2649221A1 (en) * 2006-04-17 2007-10-25 Evgeny Tsiperman Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2857386B1 (en) * 2006-04-24 2017-02-22 Teva Pharmaceutical Industries Ltd Tigecycline crystalline forms and processes for preparation thereof
WO2007133797A2 (en) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
ES2315123B1 (es) * 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
KR101538175B1 (ko) 2006-12-21 2015-07-20 파라테크 파마슈티컬스, 인크. 박테리아, 바이러스 및 기생충 감염의 치료를 위한 테트라시클린 유도체
EP3488853A1 (en) 2006-12-21 2019-05-29 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
WO2008118744A1 (en) * 2007-03-23 2008-10-02 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
AU2008239606A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
JP2010525069A (ja) 2007-04-27 2010-07-22 パラテック ファーマシューティカルズ インコーポレイテッド アミノアルキルテトラサイクリン化合物の合成方法および精製方法
ATE555079T1 (de) 2007-07-06 2012-05-15 Paratek Pharm Innc Verfahren zur synthese von 9-substituiertem minocyclin
JP2011513404A (ja) * 2008-03-05 2011-04-28 パラテック ファーマシューティカルズ インコーポレイテッド ミノサイクリン化合物およびその使用方法
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
US20100022483A1 (en) * 2008-04-14 2010-01-28 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
TW202021946A (zh) * 2008-05-23 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
EP2341771A4 (en) * 2008-09-19 2012-08-15 Paratek Pharm Innc TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED THERAPEUTIC METHODS
CA2758322C (en) 2009-04-10 2019-04-02 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
EP3574908B8 (en) 2011-05-12 2024-09-11 Almirall LLC Pharmaceutical composition for oral administration comprising crystalline salts of (4s, 4as, 5ar, 12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2carboxylic acid amide
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
ES2611185T3 (es) * 2013-05-20 2017-05-05 Fundación Comunidad Valenciana Centro De Investigación Principe Felipe Conjugados polímero-fármaco para el tratamiento de la amiloidosis
CN107708665B (zh) 2015-03-23 2022-07-22 贝尔生物制药有限公司 用于皮肤病学用途的药用四环素组合物
JP7545803B2 (ja) 2016-11-01 2024-09-05 パラテック ファーマシューティカルズ，インコーポレイテッド ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用
EP3654988B1 (en) 2017-07-21 2023-09-06 Almirall, LLC Sarecycline for the treatment of non-inflammatory acne lesions
CN113655052B (zh) * 2021-08-03 2023-12-12 哈尔滨工程大学 基于高活性MgO对四环素类抗生素可视化检测的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
DK155977B (da) 1989-06-12
SE443507B (sv) 1986-03-03
PT67895B (en) 1979-11-14
FI781300A (fi) 1978-10-28
ZA782400B (en) 1979-04-25
DE2817335A1 (de) 1978-11-16
DE2817335C3 (de) 1982-04-22
CS199527B2 (en) 1980-07-31
ZM3878A1 (en) 1978-11-21
DD135445A5 (de) 1979-05-09
IN148197B (da) 1980-11-29
RO75099A (ro) 1980-12-30
IL54581A0 (en) 1978-07-31
DK155977C (da) 1989-10-30
GB1563478A (en) 1980-03-26
US4126680A (en) 1978-11-21
IE47049B1 (en) 1983-12-14
LU79547A1 (fr) 1979-11-07
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
FR2388561A1 (fr) 1978-11-24
BG47943A3 (en) 1990-10-15
GR70062B (da) 1982-07-26
NZ187046A (en) 1980-03-05
YU87178A (en) 1984-04-30
PL110459B1 (en) 1980-07-31
AT360148B (de) 1980-12-29
IT7822720A0 (it) 1978-04-26
HU179050B (en) 1982-08-28
CH630260A5 (fr) 1982-06-15
DK182578A (da) 1978-10-28
NO148280C (no) 1983-09-21
NO781457L (no) 1978-10-30
ATA300478A (de) 1980-05-15
JPS53136514A (en) 1978-11-29
OA05949A (fr) 1981-06-30
RO77953A (ro) 1981-12-25
AU503139B1 (en) 1979-08-23
EG14348A (en) 1984-09-30
ES468749A1 (es) 1979-01-01
IT1094557B (it) 1985-08-02
NL7804455A (nl) 1978-10-31
PH12962A (en) 1979-10-19
NO148280B (no) 1983-06-06
CA1100875A (en) 1981-05-12
AR217844A1 (es) 1980-04-30
MX6087E (es) 1984-11-08
JPS5632290B2 (da) 1981-07-27
FR2388561B1 (da) 1980-07-18
PT67895A (en) 1978-05-01
IE780828L (en) 1978-10-27
DE2817335B2 (de) 1981-06-11

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: PFIZER INC.

Effective date: 19940430