LT5138B - Epotilono analogo polimorfinės formos - Google Patents

Epotilono analogo polimorfinės formos Download PDF

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Publication number
LT5138B
LT5138B LT2003017A LT2003017A LT5138B LT 5138 B LT5138 B LT 5138B LT 2003017 A LT2003017 A LT 2003017A LT 2003017 A LT2003017 A LT 2003017A LT 5138 B LT5138 B LT 5138B
Authority
LT
Lithuania
Prior art keywords
crystalline
hours
mixture
formula
analogue
Prior art date
Application number
LT2003017A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2003017A (en
Inventor
John D. Dimarco
Jack Z. Gougoutas
Imre M. Vitez
Martha Davidovich
Michael Galella
Denis Favreau
Timothy M. Malloy
Zhenrong Guo
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22845469&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT5138(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of LT2003017A publication Critical patent/LT2003017A/xx
Publication of LT5138B publication Critical patent/LT5138B/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LT2003017A 2000-08-16 2003-02-25 Epotilono analogo polimorfinės formos LT5138B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22559000P 2000-08-16 2000-08-16

Publications (2)

Publication Number Publication Date
LT2003017A LT2003017A (en) 2004-03-25
LT5138B true LT5138B (lt) 2004-06-25

Family

ID=22845469

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2003017A LT5138B (lt) 2000-08-16 2003-02-25 Epotilono analogo polimorfinės formos

Country Status (42)

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US (4) US6689802B2 (sl)
EP (1) EP1309597B1 (sl)
JP (1) JP5046467B2 (sl)
KR (1) KR100810342B1 (sl)
CN (1) CN1269821C (sl)
AR (1) AR034259A1 (sl)
AT (1) ATE366735T1 (sl)
AU (2) AU2001281082B2 (sl)
BG (1) BG66132B1 (sl)
BR (1) BR0113234A (sl)
CA (1) CA2418109C (sl)
CY (1) CY1107758T1 (sl)
CZ (1) CZ305523B6 (sl)
DE (1) DE60129334T2 (sl)
DK (1) DK1309597T3 (sl)
EE (1) EE05273B1 (sl)
ES (1) ES2288518T3 (sl)
GE (1) GEP20053495B (sl)
HK (1) HK1052010A1 (sl)
HR (1) HRP20030190B1 (sl)
HU (1) HU229314B1 (sl)
IL (2) IL153993A0 (sl)
IS (1) IS2845B (sl)
LT (1) LT5138B (sl)
LV (1) LV13032B (sl)
MX (1) MXPA03001431A (sl)
MY (1) MY134129A (sl)
NO (1) NO328500B1 (sl)
NZ (1) NZ523722A (sl)
PE (1) PE20020290A1 (sl)
PL (1) PL205628B1 (sl)
PT (1) PT1309597E (sl)
RO (1) RO123296B1 (sl)
RU (1) RU2272039C2 (sl)
SI (1) SI21100B (sl)
SK (1) SK287876B6 (sl)
TW (1) TWI320040B (sl)
UA (1) UA75365C2 (sl)
UY (1) UY26886A1 (sl)
WO (1) WO2002014323A2 (sl)
YU (1) YU12103A (sl)
ZA (1) ZA200300522B (sl)

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US6518421B1 (en) * 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
AU2002245296B2 (en) * 2001-01-25 2006-12-21 Bristol-Myers Squibb Company Methods of administering epothilone analogs for the treatment of cancer
CZ20032022A3 (cs) * 2001-01-25 2004-04-14 Bristol-Myers Squibb Company Parenterální prostředek obsahující epothilonová analoga
RU2003128311A (ru) 2001-02-20 2005-03-10 Бристол-Маерс Сквибб Компани (Us) Способ лечения резистентных опухолей с применением аналогов эпотилона
CA2440555A1 (en) * 2001-03-14 2002-09-19 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
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JP2013527239A (ja) * 2010-06-01 2013-06-27 プラス・ケミカルス・エスアー イクサベピロンの固体形
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WO2014009426A2 (en) 2012-07-13 2014-01-16 Innate Pharma Screening of conjugated antibodies
EP3564259A3 (en) 2012-11-09 2020-02-12 Innate Pharma Recognition tags for tgase-mediated conjugation
CN103183681B (zh) * 2013-03-06 2016-01-13 浙江海正药业股份有限公司 伊沙匹隆的新晶型及其制备方法
US10611824B2 (en) 2013-03-15 2020-04-07 Innate Pharma Solid phase TGase-mediated conjugation of antibodies
EP3010547B1 (en) 2013-06-20 2021-04-21 Innate Pharma Enzymatic conjugation of polypeptides
WO2014202775A1 (en) 2013-06-21 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides
WO2019092148A1 (en) 2017-11-10 2019-05-16 Innate Pharma Antibodies with functionalized glutamine residues
AU2021212305A1 (en) 2020-01-31 2022-08-11 Allarity Therapeutics Europe ApS Methods for predicting ixabepilone responsiveness in cancer patients
CN112375085A (zh) * 2020-11-30 2021-02-19 湖北宏中药业股份有限公司 一种伊沙匹隆反应液的高收率高纯度处理方法
CN112409366A (zh) * 2020-11-30 2021-02-26 湖北宏中药业股份有限公司 一种伊沙匹隆二聚体的高收率制备方法
CN112457320A (zh) * 2020-11-30 2021-03-09 湖北宏中药业股份有限公司 一种提高伊沙匹隆合成反应速率的方法

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PE20020290A1 (es) 2002-04-03
US20020188014A1 (en) 2002-12-12
EE05273B1 (et) 2010-02-15
LT2003017A (en) 2004-03-25
TWI320040B (en) 2010-02-01
EP1309597B1 (en) 2007-07-11
HK1052010A1 (en) 2003-08-29
BG107467A (bg) 2003-09-30
NO20030707D0 (no) 2003-02-14
US7153879B2 (en) 2006-12-26
SK1342003A3 (en) 2003-09-11
KR20030022411A (ko) 2003-03-15
PT1309597E (pt) 2007-08-22
JP2004506638A (ja) 2004-03-04
HUP0300826A2 (hu) 2003-09-29
AU2001281082B2 (en) 2007-01-04
RO123296B1 (ro) 2011-06-30
ATE366735T1 (de) 2007-08-15
LV13032B (en) 2003-12-20
MXPA03001431A (es) 2004-05-04
CA2418109C (en) 2011-09-27
IS6714A (is) 2003-02-11
ES2288518T3 (es) 2008-01-16
IL153993A0 (en) 2003-07-31
PL365610A1 (en) 2005-01-10
CN1468243A (zh) 2004-01-14
IS2845B (is) 2013-08-15
SI21100B (sl) 2009-12-31
KR100810342B1 (ko) 2008-03-07
EE200300063A (et) 2004-12-15
CZ305523B6 (cs) 2015-11-18
BR0113234A (pt) 2004-02-25
BG66132B1 (bg) 2011-06-30
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