DK1309597T3 - Polymorfer af en epothilonanalog - Google Patents

Polymorfer af en epothilonanalog

Info

Publication number
DK1309597T3
DK1309597T3 DK01959536T DK01959536T DK1309597T3 DK 1309597 T3 DK1309597 T3 DK 1309597T3 DK 01959536 T DK01959536 T DK 01959536T DK 01959536 T DK01959536 T DK 01959536T DK 1309597 T3 DK1309597 T3 DK 1309597T3
Authority
DK
Denmark
Prior art keywords
polymorphs
epothilone analog
epothilone
analog
Prior art date
Application number
DK01959536T
Other languages
English (en)
Inventor
John D Dimarco
Jack Z Gougoutas
Imre M Vitez
Martha Davidovich
Michael Galella
Timothy M Malloy
Zhenrong Guo
Denis Favreau
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22845469&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1309597(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK1309597T3 publication Critical patent/DK1309597T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK01959536T 2000-08-16 2001-08-01 Polymorfer af en epothilonanalog DK1309597T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22559000P 2000-08-16 2000-08-16
PCT/US2001/024540 WO2002014323A2 (en) 2000-08-16 2001-08-01 Polymorphs of an epothilone analog

Publications (1)

Publication Number Publication Date
DK1309597T3 true DK1309597T3 (da) 2007-10-22

Family

ID=22845469

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01959536T DK1309597T3 (da) 2000-08-16 2001-08-01 Polymorfer af en epothilonanalog

Country Status (42)

Country Link
US (4) US6689802B2 (da)
EP (1) EP1309597B1 (da)
JP (1) JP5046467B2 (da)
KR (1) KR100810342B1 (da)
CN (1) CN1269821C (da)
AR (1) AR034259A1 (da)
AT (1) ATE366735T1 (da)
AU (2) AU2001281082B2 (da)
BG (1) BG66132B1 (da)
BR (1) BR0113234A (da)
CA (1) CA2418109C (da)
CY (1) CY1107758T1 (da)
CZ (1) CZ305523B6 (da)
DE (1) DE60129334T2 (da)
DK (1) DK1309597T3 (da)
EE (1) EE05273B1 (da)
ES (1) ES2288518T3 (da)
GE (1) GEP20053495B (da)
HK (1) HK1052010A1 (da)
HR (1) HRP20030190B1 (da)
HU (1) HU229314B1 (da)
IL (2) IL153993A0 (da)
IS (1) IS2845B (da)
LT (1) LT5138B (da)
LV (1) LV13032B (da)
MX (1) MXPA03001431A (da)
MY (1) MY134129A (da)
NO (1) NO328500B1 (da)
NZ (1) NZ523722A (da)
PE (1) PE20020290A1 (da)
PL (1) PL205628B1 (da)
PT (1) PT1309597E (da)
RO (1) RO123296B1 (da)
RU (1) RU2272039C2 (da)
SI (1) SI21100B (da)
SK (1) SK287876B6 (da)
TW (1) TWI320040B (da)
UA (1) UA75365C2 (da)
UY (1) UY26886A1 (da)
WO (1) WO2002014323A2 (da)
YU (1) YU12103A (da)
ZA (1) ZA200300522B (da)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043376A1 (en) * 1996-12-03 2005-02-24 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto, analogues and uses thereof
CA2273083C (en) 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6518421B1 (en) * 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
MXPA03006412A (es) * 2001-01-25 2003-10-15 Bristol Myers Squibb Co Metodos para administrar analogos de epotilona para tratamiento de cancer.
RU2003126171A (ru) * 2001-01-25 2005-02-27 Бристол-Маерс Сквибб Компани (Us) Парентеральный состав, содержащий аналоги эпотилона
MXPA03007394A (es) 2001-02-20 2003-12-04 Bristol Myers Squibb Co Tratamiento de tumores refractarios mediante uso de derivados de epotilona.
EP1383490B1 (en) * 2001-03-14 2012-04-25 Bristol-Myers Squibb Company Combination of an epothilone analog and chemotherapeutic agents for the treatment of proliferative diseases
DK1485090T3 (da) * 2002-03-08 2008-02-04 Novartis Ag Kombinationer omfattende et epothilonderivat og en imidazotetrazinon
US7649006B2 (en) * 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
ATE350383T1 (de) * 2002-08-23 2007-01-15 Sloan Kettering Inst Cancer Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US20050171167A1 (en) * 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US20090004277A1 (en) * 2004-05-18 2009-01-01 Franchini Miriam K Nanoparticle dispersion containing lactam compound
EP1640004A1 (en) * 2004-09-24 2006-03-29 Schering Aktiengesellschaft Use of epothilones in the treatment of bone metastases and bone tumors or cancers
EP1824458A1 (en) * 2004-11-18 2007-08-29 Bristol-Myers Squibb Company Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof
KR20070084325A (ko) 2004-11-18 2007-08-24 브리스톨-마이어스 스큅 컴퍼니 익사베필론을 포함하는 장용성 코팅된 비드 및 그의 제조방법
US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
EP1674098A1 (en) 2004-12-23 2006-06-28 Schering Aktiengesellschaft Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water
EP2634252B1 (en) 2005-02-11 2018-12-19 University of Southern California Method of expressing proteins with disulfide bridges
SI1698630T1 (sl) 2005-03-03 2015-01-30 Alfa Wassermann S.P.A. Nove polimorfne oblike rifaksimina, postopki za njihovo pripravo in njihova uporaba v medicinskih pripravkih
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
US7693596B2 (en) 2005-12-14 2010-04-06 Dell Products L.P. System and method for configuring information handling system integrated circuits
US20080286325A1 (en) * 2006-01-05 2008-11-20 Med Institute, Inc. Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent
US7919108B2 (en) * 2006-03-10 2011-04-05 Cook Incorporated Taxane coatings for implantable medical devices
US7875284B2 (en) * 2006-03-10 2011-01-25 Cook Incorporated Methods of manufacturing and modifying taxane coatings for implantable medical devices
WO2007117439A2 (en) 2006-03-31 2007-10-18 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
WO2007130501A2 (en) * 2006-05-01 2007-11-15 University Of Southern California Combination therapy for treatment of cancer
US8163792B2 (en) 2006-05-16 2012-04-24 Pharmascience Inc. IAP BIR domain binding compounds
CL2007002362A1 (es) 2006-08-16 2008-08-08 Novartis Ag Forma de cristal de la epotilona b; composicion farmaceutica que la comprende; y uso para el tratamiento de una enfermedad proliferativa, tal como un tumor.
US8463852B2 (en) * 2006-10-06 2013-06-11 Oracle International Corporation Groupware portlets for integrating a portal with groupware systems
WO2008103916A2 (en) * 2007-02-23 2008-08-28 The Trustees Of Columbia Univeristy In The City Of New York Compositions and methods for treating cancer or a neurotrophic disorder
EP2065054A1 (en) 2007-11-29 2009-06-03 Bayer Schering Pharma Aktiengesellschaft Combinations comprising a prostaglandin and uses thereof
EP2070521A1 (en) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Surface-modified nanoparticles
DE102007059752A1 (de) 2007-12-10 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
EP2210584A1 (en) 2009-01-27 2010-07-28 Bayer Schering Pharma Aktiengesellschaft Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer
SG10201501095WA (en) 2010-02-12 2015-04-29 Pharmascience Inc Iap bir domain binding compounds
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
KR20130086534A (ko) * 2010-06-01 2013-08-02 플러스 케미칼스, 에스.에이. 익사베필론의 고체 형태
CA2858806A1 (en) 2011-12-23 2013-06-27 Innate Pharma Enzymatic conjugation of polypeptides
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
EP2872894B1 (en) 2012-07-13 2019-04-17 Innate Pharma Screening of conjugated antibodies
EP3564259A3 (en) 2012-11-09 2020-02-12 Innate Pharma Recognition tags for tgase-mediated conjugation
CN103183681B (zh) * 2013-03-06 2016-01-13 浙江海正药业股份有限公司 伊沙匹隆的新晶型及其制备方法
US10611824B2 (en) 2013-03-15 2020-04-07 Innate Pharma Solid phase TGase-mediated conjugation of antibodies
EP3010547B1 (en) 2013-06-20 2021-04-21 Innate Pharma Enzymatic conjugation of polypeptides
CA2914189C (en) 2013-06-21 2023-03-14 Innate Pharma Enzymatic conjugation of polypeptides
WO2019092148A1 (en) 2017-11-10 2019-05-16 Innate Pharma Antibodies with functionalized glutamine residues
AU2021212305A1 (en) 2020-01-31 2022-08-11 Allarity Therapeutics Europe ApS Methods for predicting ixabepilone responsiveness in cancer patients
CN112409366A (zh) * 2020-11-30 2021-02-26 湖北宏中药业股份有限公司 一种伊沙匹隆二聚体的高收率制备方法
CN112375085A (zh) * 2020-11-30 2021-02-19 湖北宏中药业股份有限公司 一种伊沙匹隆反应液的高收率高纯度处理方法
CN112457320A (zh) * 2020-11-30 2021-03-09 湖北宏中药业股份有限公司 一种提高伊沙匹隆合成反应速率的方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1000809A (en) * 1960-11-02 1965-08-11 James Oakes & Company Riddings Pipe manufacture
DE2308418B2 (de) * 1972-06-21 1976-04-08 Petzetakis, Aristovoulos George, Moschaton, Piräus (Griechenland) Verfahren und vorrichtung zum herstellen eines insbesondere grosskalibrigen rohres aus thermoplastischem kunststoff
JPS5240337B2 (da) * 1973-01-29 1977-10-12
SE386365B (sv) * 1973-07-25 1976-08-09 L Brendling Behallare av plast, gummi eller annat bojligt material, spec. avsedd for uppsamling av urin och/eller fekalier
JPS6398413A (ja) * 1986-10-15 1988-04-28 Smc Corp 二重管およびその連続製造法
DE3927569A1 (de) * 1989-08-21 1991-02-28 Fritz Egger Gmbh Elektroabscheider zum abscheiden von schwebstoffen aus gasen
DE3939714A1 (de) * 1989-12-01 1991-06-06 Baedje K H Meteor Gummiwerke Schlauch
AU6431790A (en) * 1990-01-05 1991-08-05 Orscheln Co. Flexible synthetic plastic conduit
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
DE4206096A1 (de) * 1992-02-27 1993-09-02 Wolf Woco & Co Franz J Koaxialrohr
DE19542986A1 (de) 1995-11-17 1997-05-22 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Verwendung
PT1186606E (pt) 1995-11-17 2004-08-31 Biotechnolog Forschung Mbh Gbf Derivados do epotilone sua preparacao e utilizacao
DE19639456A1 (de) 1996-09-25 1998-03-26 Biotechnolog Forschung Gmbh Epothilon-Derivate, Herstellung und Mittel
NZ334821A (en) 1996-08-30 2000-12-22 Novartis Ag Method for producing epothilones
DE19645362A1 (de) 1996-10-28 1998-04-30 Ciba Geigy Ag Verfahren zur Herstellung von Epothilon A und B und Derivaten
DE19645361A1 (de) 1996-08-30 1998-04-30 Ciba Geigy Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II
DE19636343C1 (de) 1996-08-30 1997-10-23 Schering Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
DK1367057T3 (da) * 1996-11-18 2009-01-19 Biotechnolog Forschung Gmbh Epothiloner E og F
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
CA2273083C (en) 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
DE19701758A1 (de) 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr Epothilone-Synthesebausteine
CN1544436A (zh) 1997-02-25 2004-11-10 ���\���о����޹�˾��GBF�� 3,7-保护的环氧噻嗪酮-n-氧化物及其制备方法
DE19713970B4 (de) 1997-04-04 2006-08-31 R&D-Biopharmaceuticals Gmbh Epothilone-Synthesebausteine II - Prenylderivate
US6348551B1 (en) 1997-04-18 2002-02-19 Studiengesellschaft Kohle Mbh Selective olefin metathesis of bifunctional or polyfunctional substrates in compressed carbon dioxide as reaction medium
DE19720312A1 (de) 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
DE19821954A1 (de) 1997-05-15 1998-11-19 Biotechnolog Forschung Gmbh Verfahren zur Herstellung eines Epothilon-Derivats
DE19726627A1 (de) 1997-06-17 1998-12-24 Schering Ag Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
DK1001951T3 (da) 1997-07-16 2002-12-23 Schering Ag Thiazolderivater, fremgangsmåde til fremstilling deraf og anvendelse af disse
US7407975B2 (en) 1997-08-09 2008-08-05 Bayer Schering Pharma Ag Epothilone derivatives, method for producing same and their pharmaceutical use
DE19747580A1 (de) 1997-10-28 1999-04-29 Siemens Ag Rangierfeld mit Anschlußleiste
US6365749B1 (en) * 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
NZ506389A (en) 1998-02-05 2003-07-25 Novartis Ag Pharmaceutical compositions containing epothilone which can be optionally lyophilised
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE19807505A1 (de) 1998-02-21 1999-08-26 Roland Man Druckmasch Bogenrotationsdruckmaschine mit Druckeinheiten für den Mehrfarbendruck und wenigstens einer Beschichtungseinheit
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
CA2322157C (en) 1998-02-25 2012-05-29 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
AU5036999A (en) 1998-06-30 2000-01-17 Schering Aktiengesellschaft Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use
AU5325699A (en) * 1998-08-12 2000-03-06 Proteus Inc. Ribbed core dual wall structure
CA2352505C (en) 1998-12-22 2009-04-07 Novartis Ag Epothilone derivatives and their use as antitumor agents
AR023792A1 (es) 1999-04-30 2002-09-04 Bayer Schering Pharma Ag Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos
US6605559B1 (en) * 1999-09-29 2003-08-12 Daihatsu Motor Co., Ltd. Dimethyl ether reforming catalyst
US6518421B1 (en) 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
EP1353668B1 (en) 2001-01-25 2008-03-19 Bristol-Myers Squibb Company Processes for the preparation of pharmaceutical preparations containing epothilone analogues for the treatment of cancer
RU2003126171A (ru) * 2001-01-25 2005-02-27 Бристол-Маерс Сквибб Компани (Us) Парентеральный состав, содержащий аналоги эпотилона
US9317043B2 (en) 2013-12-19 2016-04-19 Google Inc. Path based power generation control for an aerial vehicle

Also Published As

Publication number Publication date
AR034259A1 (es) 2004-02-18
WO2002014323A2 (en) 2002-02-21
PT1309597E (pt) 2007-08-22
PE20020290A1 (es) 2002-04-03
HU229314B1 (en) 2013-10-28
HUP0300826A2 (hu) 2003-09-29
US20060063815A1 (en) 2006-03-23
IL153993A (en) 2009-07-20
HRP20030190A2 (en) 2003-04-30
YU12103A (sh) 2006-08-17
US6689802B2 (en) 2004-02-10
EP1309597B1 (en) 2007-07-11
HK1052010A1 (en) 2003-08-29
KR20030022411A (ko) 2003-03-15
LT2003017A (en) 2004-03-25
US20020188014A1 (en) 2002-12-12
SI21100A (sl) 2003-06-30
IS2845B (is) 2013-08-15
IL153993A0 (en) 2003-07-31
UA75365C2 (en) 2006-04-17
SK1342003A3 (en) 2003-09-11
CZ305523B6 (cs) 2015-11-18
KR100810342B1 (ko) 2008-03-07
CN1468243A (zh) 2004-01-14
BR0113234A (pt) 2004-02-25
CN1269821C (zh) 2006-08-16
BG66132B1 (bg) 2011-06-30
MY134129A (en) 2007-11-30
UY26886A1 (es) 2002-03-22
BG107467A (bg) 2003-09-30
JP5046467B2 (ja) 2012-10-10
PL365610A1 (en) 2005-01-10
NO328500B1 (no) 2010-03-01
USRE39251E1 (en) 2006-08-29
ZA200300522B (en) 2004-04-20
HUP0300826A3 (en) 2005-05-30
CA2418109C (en) 2011-09-27
IS6714A (is) 2003-02-11
AU2001281082B2 (en) 2007-01-04
EE05273B1 (et) 2010-02-15
MXPA03001431A (es) 2004-05-04
ATE366735T1 (de) 2007-08-15
DE60129334D1 (en) 2007-08-23
NZ523722A (en) 2005-04-29
SI21100B (sl) 2009-12-31
AU8108201A (en) 2002-02-25
SK287876B6 (sk) 2012-02-03
US7153879B2 (en) 2006-12-26
PL205628B1 (pl) 2010-05-31
RU2272039C2 (ru) 2006-03-20
DE60129334T2 (de) 2008-04-03
LV13032B (en) 2003-12-20
CZ2003418A3 (cs) 2004-01-14
US6982276B2 (en) 2006-01-03
JP2004506638A (ja) 2004-03-04
US20040157897A1 (en) 2004-08-12
GEP20053495B (en) 2005-04-25
WO2002014323A3 (en) 2002-05-02
CA2418109A1 (en) 2002-02-21
EE200300063A (et) 2004-12-15
RO123296B1 (ro) 2011-06-30
ES2288518T3 (es) 2008-01-16
TWI320040B (en) 2010-02-01
CY1107758T1 (el) 2013-06-19
NO20030707L (no) 2003-04-15
EP1309597A2 (en) 2003-05-14
HRP20030190B1 (en) 2011-07-31
NO20030707D0 (no) 2003-02-14
LT5138B (lt) 2004-06-25

Similar Documents

Publication Publication Date Title
DK1309597T3 (da) Polymorfer af en epothilonanalog
DK1438306T3 (da) Derivater af UK-2A
AR028567A1 (es) Nuevos derivados de fenil-propargileter
AR028596A1 (es) Nuevos derivados de fenilglicina
DK1169314T3 (da) Krystallinsk base af citalopram
CY2004011I1 (el) Aσυμμετρη συνθεση της πρεγαβαλινης
DE60121480D1 (de) Umformung von dünnwandigen Körpern
ATE430129T1 (de) Substituierte thioacetamide
PT1250321E (pt) Composicao de gliburida
ID30187A (id) Dongkrak jenis pantagraf
DE60134817D1 (de) Isolierter Konverter
DK1840125T3 (da) Mellemprodukter til fremstilling af dioxan-2-alkylcarbamater
PT1345624E (pt) Inducao de tolerancia
PT1322592E (pt) Derivados substituidos de 1-aminobutan-3-ol
IS6620A (is) Nýr fjölgervingur V af tórasemíði
FR2816486B1 (fr) Bague
FR2851121B1 (fr) Dechaumeuse de precision
FR2810531B1 (fr) Trocart de coelio-chirurgie
DK1080082T3 (da) Mellemprodukter til fremstillingen af epothiloner og fremgangsmåde til deres fremstilling
UA4579S (uk) Дозиметр-радіометр гамма-бета-випромінювань
FI20002366A (fi) Välituotteet
ID30572A (id) Oksidasi ikatan-ikatan karbon-boron
IDP000026456A (id) Senyawa-senyawa siklopropanakarboksilat ester
FI20000271A0 (fi) Puupalkki
FI20012395A0 (fi) Mittausyhteen huuhtelu