KR20120112644A

KR20120112644A - 록소프로펜 함유 의약 조성물

록소프로펜 함유 의약 조성물 Download PDF

Info

Publication number: KR20120112644A
Authority: KR; South Korea
Prior art keywords: salt; roxofene; white powder; hydrochloride; pharmaceutical composition
Prior art date: 2010-01-29

Application number

KR1020127019610A

Other languages

English (en)

Korean (ko)

Inventor

도시키 우스이

마사아키 스노하라

마사야 다카미야

Original Assignee

코와 가부시키가이샤

Priority date

2010-01-29

Filing date

2011-01-31

Publication date

2012-10-11

2011-01-31 Application filed by 코와 가부시키가이샤 filed Critical 코와 가부시키가이샤

2012-10-11 Publication of KR20120112644A publication Critical patent/KR20120112644A/ko

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 95
229960002373 loxoprofen Drugs 0.000 title description 12
YMBXTVYHTMGZDW-UHFFFAOYSA-N loxoprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1CC1C(=O)CCC1 YMBXTVYHTMGZDW-UHFFFAOYSA-N 0.000 title description 2
150000003839 salts Chemical class 0.000 claims abstract description 216
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims abstract description 134
229960004126 codeine Drugs 0.000 claims abstract description 71
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims abstract description 67
229960000428 carbinoxamine Drugs 0.000 claims abstract description 25
OJFSXZCBGQGRNV-UHFFFAOYSA-N carbinoxamine Chemical compound C=1C=CC=NC=1C(OCCN(C)C)C1=CC=C(Cl)C=C1 OJFSXZCBGQGRNV-UHFFFAOYSA-N 0.000 claims abstract description 25
229960003291 chlorphenamine Drugs 0.000 claims abstract description 23
SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 claims abstract description 23
102000016943 Muramidase Human genes 0.000 claims abstract description 22
108010014251 Muramidase Proteins 0.000 claims abstract description 22
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 22
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YNNUSGIPVFPVBX-NHCUHLMSSA-N clemastine Chemical compound CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-NHCUHLMSSA-N 0.000 claims abstract description 18
229960005174 ambroxol Drugs 0.000 claims abstract description 16
JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 claims abstract description 16
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OWQUZNMMYNAXSL-UHFFFAOYSA-N diphenylpyraline Chemical compound C1CN(C)CCC1OC(C=1C=CC=CC=1)C1=CC=CC=C1 OWQUZNMMYNAXSL-UHFFFAOYSA-N 0.000 claims abstract description 14
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 236
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BAZQYVYVKYOAGO-UHFFFAOYSA-M loxoprofen sodium hydrate Chemical compound O.O.[Na+].C1=CC(C(C([O-])=O)C)=CC=C1CC1C(=O)CCC1 BAZQYVYVKYOAGO-UHFFFAOYSA-M 0.000 description 11
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