CN102740854A - 含有洛索洛芬的医药组合物 - Google Patents

含有洛索洛芬的医药组合物 Download PDF

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Publication number
CN102740854A
CN102740854A CN2011800077046A CN201180007704A CN102740854A CN 102740854 A CN102740854 A CN 102740854A CN 2011800077046 A CN2011800077046 A CN 2011800077046A CN 201180007704 A CN201180007704 A CN 201180007704A CN 102740854 A CN102740854 A CN 102740854A
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CN
China
Prior art keywords
salt
loxoprofen
loxoprofen sodium
powder body
white powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800077046A
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English (en)
Chinese (zh)
Inventor
薄井俊树
春原政明
高宫雅哉
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Kowa Co Ltd
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Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Publication of CN102740854A publication Critical patent/CN102740854A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011800077046A 2010-01-29 2011-01-31 含有洛索洛芬的医药组合物 Pending CN102740854A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP2010018015 2010-01-29
JP2010-018015 2010-01-29
JP2010149115 2010-06-30
JP2010-149089 2010-06-30
JP2010-149061 2010-06-30
JP2010-149115 2010-06-30
JP2010149061 2010-06-30
JP2010149089 2010-06-30
PCT/JP2011/051945 WO2011093498A1 (ja) 2010-01-29 2011-01-31 ロキソプロフェン含有医薬組成物

Publications (1)

Publication Number Publication Date
CN102740854A true CN102740854A (zh) 2012-10-17

Family

ID=44319475

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800077046A Pending CN102740854A (zh) 2010-01-29 2011-01-31 含有洛索洛芬的医药组合物

Country Status (4)

Country Link
JP (5) JP2012031131A (ja)
KR (1) KR20120112644A (ja)
CN (1) CN102740854A (ja)
WO (1) WO2011093498A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103333064A (zh) * 2013-07-17 2013-10-02 珠海金鸿药业股份有限公司 洛索洛芬钠化合物及其药物组合物
CN104225162A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的桂附地黄丸的制备方法
CN104225160A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的七味都气丸的制备方法
CN104225187A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的知柏地黄丸的制备方法
CN104225161A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的归芍地黄丸的制备方法
CN104224740A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的百合固金丸的制备方法
CN104257984A (zh) * 2014-09-28 2015-01-07 白杨 一种包衣处理的六味地黄丸的制备方法
CN104288433A (zh) * 2014-09-28 2015-01-21 白杨 一种包衣处理的枸菊地黄丸的制备方法
CN106580968A (zh) * 2016-11-22 2017-04-26 郑州仁宏医药科技有限公司 一种治疗牙齿肿痛的西药散剂及其制备方法
CN110831585A (zh) * 2017-06-16 2020-02-21 凯乌维·科恩 用于治疗疼痛的溴己新
CN113332252A (zh) * 2021-06-07 2021-09-03 大桐制药（中国）有限责任公司 一种洛索洛芬钠片的制备方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5525324B2 (ja) * 2009-04-28 2014-06-18 興和株式会社 ロキソプロフェン含有医薬製剤
JP5525323B2 (ja) * 2009-04-28 2014-06-18 興和株式会社 ロキソプロフェン含有医薬製剤
JP5624367B2 (ja) * 2009-05-28 2014-11-12 興和株式会社 ロキソプロフェン含有医薬製剤
TWI680757B (zh) * 2010-12-28 2020-01-01 日商興和股份有限公司 解熱鎮痛組成物
WO2013018766A1 (ja) * 2011-07-29 2013-02-07 興和株式会社 安定な医薬組成物
JP6008857B2 (ja) * 2011-07-29 2016-10-19 興和株式会社 ロキソプロフェンを含有する医薬組成物
WO2013047869A1 (ja) * 2011-09-29 2013-04-04 興和株式会社 ロキソプロフェン又はその塩を含有する医薬組成物
JP6114573B2 (ja) * 2012-02-29 2017-04-12 第一三共ヘルスケア株式会社 ロキソプロフェンナトリウムと制酸剤を含有する固形製剤
WO2014002599A1 (ja) * 2012-06-25 2014-01-03 興和株式会社 生薬等含有医薬組成物
JP6197513B2 (ja) * 2012-11-09 2017-09-20 大正製薬株式会社 医薬組成物
JP6149625B2 (ja) * 2012-11-09 2017-06-21 大正製薬株式会社 医薬組成物
JP6252177B2 (ja) * 2013-01-28 2017-12-27 大正製薬株式会社 固形製剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000143505A (ja) * 1998-11-06 2000-05-23 Sankyo Co Ltd ロキソプロフェンを含有する医薬組成物
EP1547587A1 (en) * 2002-08-22 2005-06-29 Ono Pharmaceutical Co., Ltd. Agent for reducing side effects of diclofenac
CN101052384A (zh) * 2004-11-05 2007-10-10 立德化学株式会社 含有非甾体类抗炎镇痛药的非水系透皮吸收制剂

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WO1996033704A1 (fr) * 1995-04-26 1996-10-31 Taisho Pharmaceutical Co., Ltd. Preparation pour administration orale
JP4828707B2 (ja) * 2000-02-28 2011-11-30 武田薬品工業株式会社 固形圧縮製剤
JP4853818B2 (ja) * 2005-08-24 2012-01-11 大正製薬株式会社 イブプロフェン及び塩酸アンブロキソール含有固形製剤
JP5465824B2 (ja) * 2006-03-24 2014-04-09 第一三共ヘルスケア株式会社 医薬用製剤およびその製造方法
WO2008069283A1 (ja) * 2006-12-06 2008-06-12 Nipro Patch Co., Ltd. 外用医薬組成物及び貼付剤
JP5232520B2 (ja) * 2007-04-17 2013-07-10 第一三共ヘルスケア株式会社 ロキソプロフェンを含有する抗アデノウイルス剤
JP2010215611A (ja) * 2009-01-28 2010-09-30 Kowa Co ロキソプロフェン含有医薬製剤
JP2010235599A (ja) * 2009-03-11 2010-10-21 Kowa Co ロキソプロフェン含有医薬製剤
JP2011006407A (ja) * 2009-05-28 2011-01-13 Kowa Co ロキソプロフェン含有医薬製剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000143505A (ja) * 1998-11-06 2000-05-23 Sankyo Co Ltd ロキソプロフェンを含有する医薬組成物
EP1547587A1 (en) * 2002-08-22 2005-06-29 Ono Pharmaceutical Co., Ltd. Agent for reducing side effects of diclofenac
CN101052384A (zh) * 2004-11-05 2007-10-10 立德化学株式会社 含有非甾体类抗炎镇痛药的非水系透皮吸收制剂

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103333064A (zh) * 2013-07-17 2013-10-02 珠海金鸿药业股份有限公司 洛索洛芬钠化合物及其药物组合物
CN103333064B (zh) * 2013-07-17 2014-04-23 珠海金鸿药业股份有限公司 洛索洛芬钠化合物及其药物组合物
CN104225162A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的桂附地黄丸的制备方法
CN104225160A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的七味都气丸的制备方法
CN104225187A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的知柏地黄丸的制备方法
CN104225161A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的归芍地黄丸的制备方法
CN104224740A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的百合固金丸的制备方法
CN104257984A (zh) * 2014-09-28 2015-01-07 白杨 一种包衣处理的六味地黄丸的制备方法
CN104288433A (zh) * 2014-09-28 2015-01-21 白杨 一种包衣处理的枸菊地黄丸的制备方法
CN106580968A (zh) * 2016-11-22 2017-04-26 郑州仁宏医药科技有限公司 一种治疗牙齿肿痛的西药散剂及其制备方法
CN110831585A (zh) * 2017-06-16 2020-02-21 凯乌维·科恩 用于治疗疼痛的溴己新
CN113332252A (zh) * 2021-06-07 2021-09-03 大桐制药（中国）有限责任公司 一种洛索洛芬钠片的制备方法

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Publication number Publication date
JP5575961B2 (ja) 2014-08-20
JP5809736B2 (ja) 2015-11-11
JPWO2011093498A1 (ja) 2013-06-06
JP2013237710A (ja) 2013-11-28
JP2014169345A (ja) 2014-09-18
KR20120112644A (ko) 2012-10-11
JP4787912B2 (ja) 2011-10-05
WO2011093498A1 (ja) 2011-08-04
JP2012031131A (ja) 2012-02-16
JP2012031147A (ja) 2012-02-16

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