KR20100027134A - C형 간염 바이러스 복제의 신규 펩티드 억제제 - Google Patents
C형 간염 바이러스 복제의 신규 펩티드 억제제 Download PDFInfo
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- KR20100027134A KR20100027134A KR1020097025827A KR20097025827A KR20100027134A KR 20100027134 A KR20100027134 A KR 20100027134A KR 1020097025827 A KR1020097025827 A KR 1020097025827A KR 20097025827 A KR20097025827 A KR 20097025827A KR 20100027134 A KR20100027134 A KR 20100027134A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
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| US60/917,300 | 2007-05-10 | ||
| US2304108P | 2008-01-23 | 2008-01-23 | |
| US61/023,041 | 2008-01-23 |
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| KR20100027134A true KR20100027134A (ko) | 2010-03-10 |
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|---|---|
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| EP (1) | EP2185524A1 (enExample) |
| JP (1) | JP2010526834A (enExample) |
| KR (1) | KR20100027134A (enExample) |
| CN (1) | CN101679277A (enExample) |
| AP (1) | AP2009005057A0 (enExample) |
| AR (1) | AR066528A1 (enExample) |
| AU (1) | AU2008251425A1 (enExample) |
| BR (1) | BRPI0811447A2 (enExample) |
| CA (1) | CA2686546A1 (enExample) |
| CL (1) | CL2008001381A1 (enExample) |
| CO (1) | CO6241100A2 (enExample) |
| EA (1) | EA200971041A1 (enExample) |
| EC (1) | ECSP099792A (enExample) |
| IL (1) | IL201842A0 (enExample) |
| MA (1) | MA31497B1 (enExample) |
| MX (1) | MX2009012093A (enExample) |
| NI (1) | NI200900205A (enExample) |
| TN (1) | TN2009000481A1 (enExample) |
| TW (1) | TW200902520A (enExample) |
| WO (1) | WO2008141227A1 (enExample) |
| ZA (1) | ZA200907858B (enExample) |
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| JP2003007697A (ja) * | 2001-06-21 | 2003-01-10 | Hitachi Kokusai Electric Inc | 半導体装置の製造方法、基板処理方法および基板処理装置 |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| GEP20105124B (en) | 2005-07-25 | 2010-11-25 | Array Biopharma Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
| BRPI0617274A2 (pt) * | 2005-10-11 | 2011-07-19 | Intermune Inc | compostos e métodos para a inibição de replicação viral de hepatite c |
| MX2009012093A (es) | 2007-05-10 | 2010-01-25 | Intermune Inc | Nuevos peptidos inhibidores de la replicacion del virus de la hepatitis c. |
| CN102046622A (zh) | 2008-04-15 | 2011-05-04 | 因特蒙公司 | 丙型肝炎病毒复制的新颖大环抑制剂 |
| US8163921B2 (en) * | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US20090285774A1 (en) * | 2008-05-15 | 2009-11-19 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| CA2740728A1 (en) * | 2008-10-15 | 2010-04-22 | Intermune, Inc. | Therapeutic antiviral peptides |
| AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| WO2010118078A1 (en) | 2009-04-08 | 2010-10-14 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors |
| US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
| CA2769652A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
| CN105001302A (zh) * | 2009-09-28 | 2015-10-28 | 英特穆恩公司 | C型肝炎病毒复制的环肽抑制剂 |
| WO2012047764A1 (en) * | 2010-10-04 | 2012-04-12 | Intermune, Inc. | Therapeutic antiviral peptides |
| WO2012092411A2 (en) | 2010-12-30 | 2012-07-05 | Enanta Pharmaceuticals, Inc. | Phenanthridine macrocyclic hepatitis c serine protease inhibitors |
| JP2014502620A (ja) | 2010-12-30 | 2014-02-03 | エナンタ ファーマシューティカルズ インコーポレイテッド | 大環状c型肝炎セリンプロテアーゼ阻害剤 |
| TW201309690A (zh) | 2011-02-10 | 2013-03-01 | Idenix Pharmaceuticals Inc | 巨環絲胺酸蛋白酶抑制劑,其醫藥組合物及其於治療hcv感染之用途 |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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-
2008
- 2008-05-09 MX MX2009012093A patent/MX2009012093A/es not_active Application Discontinuation
- 2008-05-09 CN CN200880018991A patent/CN101679277A/zh active Pending
- 2008-05-09 JP JP2010507704A patent/JP2010526834A/ja active Pending
- 2008-05-09 WO PCT/US2008/063304 patent/WO2008141227A1/en not_active Ceased
- 2008-05-09 CL CL2008001381A patent/CL2008001381A1/es unknown
- 2008-05-09 BR BRPI0811447-1A2A patent/BRPI0811447A2/pt not_active IP Right Cessation
- 2008-05-09 KR KR1020097025827A patent/KR20100027134A/ko not_active Withdrawn
- 2008-05-09 US US12/118,624 patent/US7932277B2/en not_active Expired - Fee Related
- 2008-05-09 EP EP08769417A patent/EP2185524A1/en not_active Withdrawn
- 2008-05-09 AU AU2008251425A patent/AU2008251425A1/en not_active Abandoned
- 2008-05-09 AR ARP080101992A patent/AR066528A1/es unknown
- 2008-05-09 AP AP2009005057A patent/AP2009005057A0/en unknown
- 2008-05-09 CA CA002686546A patent/CA2686546A1/en not_active Abandoned
- 2008-05-09 TW TW097117301A patent/TW200902520A/zh unknown
- 2008-05-09 EA EA200971041A patent/EA200971041A1/ru unknown
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2009
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- 2009-11-09 NI NI200900205A patent/NI200900205A/es unknown
- 2009-11-09 ZA ZA2009/07858A patent/ZA200907858B/en unknown
- 2009-11-10 TN TNP2009000481A patent/TN2009000481A1/fr unknown
- 2009-11-30 CO CO09136461A patent/CO6241100A2/es not_active Application Discontinuation
- 2009-12-07 MA MA32411A patent/MA31497B1/fr unknown
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Also Published As
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|---|---|
| CL2008001381A1 (es) | 2008-11-03 |
| IL201842A0 (en) | 2010-06-16 |
| NI200900205A (es) | 2010-10-11 |
| ECSP099792A (es) | 2010-01-29 |
| TW200902520A (en) | 2009-01-16 |
| ZA200907858B (en) | 2012-04-25 |
| CN101679277A (zh) | 2010-03-24 |
| WO2008141227A1 (en) | 2008-11-20 |
| US20090297476A1 (en) | 2009-12-03 |
| CO6241100A2 (es) | 2011-01-20 |
| EP2185524A1 (en) | 2010-05-19 |
| MA31497B1 (fr) | 2010-07-01 |
| US7932277B2 (en) | 2011-04-26 |
| MX2009012093A (es) | 2010-01-25 |
| TN2009000481A1 (en) | 2011-03-31 |
| AR066528A1 (es) | 2009-08-26 |
| JP2010526834A (ja) | 2010-08-05 |
| AU2008251425A1 (en) | 2008-11-20 |
| CA2686546A1 (en) | 2008-11-20 |
| BRPI0811447A2 (pt) | 2014-10-29 |
| EA200971041A1 (ru) | 2010-08-30 |
| AP2009005057A0 (en) | 2009-12-31 |
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