KR102911165B1 - 1'-시아노 뉴클레오시드 유사체 및 이의 용도 - Google Patents

1'-시아노 뉴클레오시드 유사체 및 이의 용도

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Publication number
KR102911165B1
KR102911165B1 KR1020237002629A KR20237002629A KR102911165B1 KR 102911165 B1 KR102911165 B1 KR 102911165B1 KR 1020237002629 A KR1020237002629 A KR 1020237002629A KR 20237002629 A KR20237002629 A KR 20237002629A KR 102911165 B1 KR102911165 B1 KR 102911165B1
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Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
alkyl
cycloalkyl
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KR1020237002629A
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English (en)
Korean (ko)
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KR20230028486A (ko
Inventor
다니엘 에이치. 변
병권 천
마이클 오. 클라크
페트르 잔사
라오 브이. 칼라
드미트리 콜툰
리차드 엘. 맥만
타오 디. 페리
더스틴 에스. 지젤
스코트 피. 시모노비치
Original Assignee
길리애드 사이언시즈, 인코포레이티드
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Publication of KR20230028486A publication Critical patent/KR20230028486A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237002629A 2020-06-24 2021-06-23 1'-시아노 뉴클레오시드 유사체 및 이의 용도 Active KR102911165B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063043349P 2020-06-24 2020-06-24
US63/043,349 2020-06-24
US202163139648P 2021-01-20 2021-01-20
US63/139,648 2021-01-20
PCT/US2021/038645 WO2021262826A2 (en) 2020-06-24 2021-06-23 1'-cyano nucleoside analogs and uses thereof

Publications (2)

Publication Number Publication Date
KR20230028486A KR20230028486A (ko) 2023-02-28
KR102911165B1 true KR102911165B1 (ko) 2026-01-13

Family

ID=76959096

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237002629A Active KR102911165B1 (ko) 2020-06-24 2021-06-23 1'-시아노 뉴클레오시드 유사체 및 이의 용도

Country Status (18)

Country Link
US (3) US11939347B2 (https=)
EP (1) EP4172160A2 (https=)
JP (1) JP2023531524A (https=)
KR (1) KR102911165B1 (https=)
CN (2) CN121800834A (https=)
AU (2) AU2021296841B2 (https=)
BR (1) BR112022026321A2 (https=)
CA (1) CA3187821A1 (https=)
CL (1) CL2022003733A1 (https=)
CO (1) CO2022018715A2 (https=)
CR (1) CR20220675A (https=)
DO (1) DOP2022000293A (https=)
IL (1) IL299202A (https=)
MX (1) MX2022016405A (https=)
PE (1) PE20230618A1 (https=)
PH (1) PH12022553530A1 (https=)
TW (1) TWI819321B (https=)
WO (1) WO2021262826A2 (https=)

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WO2019014247A1 (en) 2017-07-11 2019-01-17 Gilead Sciences, Inc. COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS
JP2023512656A (ja) 2020-01-27 2023-03-28 ギリアード サイエンシーズ， インコーポレイテッド ＳＡＲＳ ＣｏＶ－２感染を治療するための方法
KR20220153619A (ko) 2020-03-12 2022-11-18 길리애드 사이언시즈, 인코포레이티드 1'-시아노 뉴클레오사이드의 제조 방법
TW202203941A (zh) 2020-05-29 2022-02-01 美商基利科學股份有限公司 瑞德西韋之治療方法
PE20230618A1 (es) 2020-06-24 2023-04-14 Gilead Sciences Inc Analogos de nucleosido de 1'-ciano y usos de los mismos
IL300453A (en) 2020-08-27 2023-04-01 Gilead Sciences Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
WO2022166581A1 (zh) * 2021-02-07 2022-08-11 石家庄迪斯凯威医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
KR20240154647A (ko) 2022-03-02 2024-10-25 길리애드 사이언시즈, 인코포레이티드 바이러스성 감염 치료를 위한 화합물 및 방법
WO2023207942A1 (zh) * 2022-04-25 2023-11-02 北京沐华生物科技有限责任公司 用于治疗或预防冠状病毒感染的核苷类药物及其用途
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof
EP4617278A1 (en) * 2022-12-09 2025-09-17 Shenzhen TargetRx, Inc. Nucleotide analog, and composition and use thereof
CN116410228B (zh) * 2023-05-04 2025-10-31 南京颐媛生物医学研究院有限公司 一种抗冠状病毒核苷类化合物的制备方法及其应用
CN116332996B (zh) * 2023-05-04 2025-04-01 南京颐媛生物医学研究院有限公司 L-呋喃核糖型抗冠状病毒化合物及其制备方法和应用
CN116284135B (zh) * 2023-05-04 2025-03-21 南京颐媛生物医学研究院有限公司 抗冠状病毒核苷类化合物的制备方法及其应用

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