MX2023011870A - Análogos de nucleósidos y de nucleótidos como agentes antivirales para coronavirus y otros virus. - Google Patents
Análogos de nucleósidos y de nucleótidos como agentes antivirales para coronavirus y otros virus.Info
- Publication number
- MX2023011870A MX2023011870A MX2023011870A MX2023011870A MX2023011870A MX 2023011870 A MX2023011870 A MX 2023011870A MX 2023011870 A MX2023011870 A MX 2023011870A MX 2023011870 A MX2023011870 A MX 2023011870A MX 2023011870 A MX2023011870 A MX 2023011870A
- Authority
- MX
- Mexico
- Prior art keywords
- corona
- viruses
- antiviral agents
- modified nucleosides
- sars
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 239000003443 antiviral agent Substances 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 241000315672 SARS coronavirus Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241001678559 COVID-19 virus Species 0.000 abstract 1
- 208000001528 Coronaviridae Infections Diseases 0.000 abstract 1
- 241000710831 Flavivirus Species 0.000 abstract 1
- 241000711467 Human coronavirus 229E Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000025370 Middle East respiratory syndrome Diseases 0.000 abstract 1
- 241000713112 Orthobunyavirus Species 0.000 abstract 1
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos, composiciones y métodos para prevenir, tratar o curar una infección por coronavirus en sujetos humanos u otros animales huéspedes. En una de las realizaciones, los compuestos se pueden usar para tratar una infección con un virus del síndrome respiratorio agudo grave, como, por ejemplo, coronavirus humano 229E, SARS, MERS, SARS-CoV-l (OC43) y SARS-CoV-2. En otra realización, los métodos se usan para tratar a un paciente infectado por un Flavivirus, Picornavirus, Togavirus o Bunyavirus.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163173354P | 2021-04-09 | 2021-04-09 | |
US202163175673P | 2021-04-16 | 2021-04-16 | |
US202163210246P | 2021-06-14 | 2021-06-14 | |
US202163288163P | 2021-12-10 | 2021-12-10 | |
US202263298836P | 2022-01-12 | 2022-01-12 | |
PCT/US2022/024289 WO2022217154A2 (en) | 2021-04-09 | 2022-04-11 | Modified nucleosides and nucleotides analogs as antiviral agents for corona and other viruses |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023011870A true MX2023011870A (es) | 2023-12-07 |
Family
ID=83546595
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023011903A MX2023011903A (es) | 2021-04-09 | 2022-04-11 | Tionucleosidos como agentes antivirales. |
MX2023011901A MX2023011901A (es) | 2021-04-09 | 2022-04-11 | Nucleosidos y analogos de nucleotidos como agentes antivirales. |
MX2023011870A MX2023011870A (es) | 2021-04-09 | 2022-04-11 | Análogos de nucleósidos y de nucleótidos como agentes antivirales para coronavirus y otros virus. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023011903A MX2023011903A (es) | 2021-04-09 | 2022-04-11 | Tionucleosidos como agentes antivirales. |
MX2023011901A MX2023011901A (es) | 2021-04-09 | 2022-04-11 | Nucleosidos y analogos de nucleotidos como agentes antivirales. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20240216413A1 (es) |
EP (3) | EP4319762A2 (es) |
JP (2) | JP2024514825A (es) |
KR (2) | KR20230170015A (es) |
AU (2) | AU2022254108A1 (es) |
BR (2) | BR112023020600A2 (es) |
CA (3) | CA3214904A1 (es) |
IL (2) | IL307478A (es) |
MX (3) | MX2023011903A (es) |
WO (3) | WO2022217154A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023512656A (ja) | 2020-01-27 | 2023-03-28 | ギリアード サイエンシーズ, インコーポレイテッド | SARS CoV-2感染を治療するための方法 |
TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
KR20220164784A (ko) | 2020-04-06 | 2022-12-13 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형 |
EP4157272A1 (en) | 2020-05-29 | 2023-04-05 | Gilead Sciences, Inc. | Remdesivir treatment methods |
TWI819321B (zh) | 2020-06-24 | 2023-10-21 | 美商基利科學股份有限公司 | 1'-氰基核苷類似物及其用途 |
TW202228722A (zh) | 2020-08-27 | 2022-08-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之化合物及方法 |
EP4320128A1 (en) | 2022-03-02 | 2024-02-14 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
CN116332996A (zh) * | 2023-05-04 | 2023-06-27 | 南京颐媛生物医学研究院有限公司 | 抗冠状病毒化合物及其制备方法和应用 |
CN116284135A (zh) * | 2023-05-04 | 2023-06-23 | 南京颐媛生物医学研究院有限公司 | 抗冠状病毒核苷类化合物的制备方法及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE74701B1 (en) * | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
US5128458A (en) * | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
US7339051B2 (en) * | 2003-04-28 | 2008-03-04 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (SARS) |
AU2004274021B2 (en) * | 2003-09-18 | 2009-08-13 | Isis Pharmaceuticals, Inc. | 4'-thionucleosides and oligomeric compounds |
RS52458B (en) * | 2005-02-04 | 2013-02-28 | Millennium Pharmaceuticals Inc. | E1 ENZYMING ENZYME INHIBITORS |
US20110130440A1 (en) * | 2008-03-26 | 2011-06-02 | Alnylam Pharmaceuticals, Inc. | Non-natural ribonucleotides, and methods of use thereof |
WO2012142523A2 (en) * | 2011-04-13 | 2012-10-18 | Gilead Sciences, Inc. | 1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment |
WO2014197578A1 (en) * | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
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2022
- 2022-04-11 WO PCT/US2022/024289 patent/WO2022217154A2/en active Application Filing
- 2022-04-11 AU AU2022254108A patent/AU2022254108A1/en active Pending
- 2022-04-11 EP EP22785599.6A patent/EP4319762A2/en active Pending
- 2022-04-11 IL IL307478A patent/IL307478A/en unknown
- 2022-04-11 WO PCT/US2022/024286 patent/WO2022217153A2/en active Application Filing
- 2022-04-11 MX MX2023011903A patent/MX2023011903A/es unknown
- 2022-04-11 MX MX2023011901A patent/MX2023011901A/es unknown
- 2022-04-11 MX MX2023011870A patent/MX2023011870A/es unknown
- 2022-04-11 CA CA3214904A patent/CA3214904A1/en active Pending
- 2022-04-11 AU AU2022253068A patent/AU2022253068A1/en active Pending
- 2022-04-11 EP EP22785600.2A patent/EP4319763A2/en active Pending
- 2022-04-11 BR BR112023020600A patent/BR112023020600A2/pt unknown
- 2022-04-11 CA CA3214918A patent/CA3214918A1/en active Pending
- 2022-04-11 KR KR1020237038196A patent/KR20230170015A/ko unknown
- 2022-04-11 WO PCT/US2022/024290 patent/WO2022217155A2/en active Application Filing
- 2022-04-11 IL IL307486A patent/IL307486A/en unknown
- 2022-04-11 CA CA3214726A patent/CA3214726A1/en active Pending
- 2022-04-11 US US18/285,789 patent/US20240216413A1/en active Pending
- 2022-04-11 KR KR1020237038195A patent/KR20240006536A/ko unknown
- 2022-04-11 JP JP2023561740A patent/JP2024514825A/ja active Pending
- 2022-04-11 EP EP22785601.0A patent/EP4319764A2/en active Pending
- 2022-04-11 JP JP2023562229A patent/JP2024513571A/ja active Pending
- 2022-04-11 BR BR112023020798A patent/BR112023020798A2/pt unknown
Also Published As
Publication number | Publication date |
---|---|
JP2024514825A (ja) | 2024-04-03 |
CA3214726A1 (en) | 2022-10-13 |
US20240216413A1 (en) | 2024-07-04 |
WO2022217155A3 (en) | 2022-11-17 |
BR112023020798A2 (pt) | 2023-12-19 |
WO2022217154A2 (en) | 2022-10-13 |
EP4319762A2 (en) | 2024-02-14 |
KR20240006536A (ko) | 2024-01-15 |
MX2023011903A (es) | 2024-01-08 |
AU2022253068A1 (en) | 2023-10-26 |
KR20230170015A (ko) | 2023-12-18 |
CA3214918A1 (en) | 2022-10-13 |
CA3214904A1 (en) | 2022-10-13 |
AU2022254108A1 (en) | 2023-10-26 |
IL307486A (en) | 2023-12-01 |
WO2022217153A2 (en) | 2022-10-13 |
WO2022217155A2 (en) | 2022-10-13 |
JP2024513571A (ja) | 2024-03-26 |
BR112023020600A2 (pt) | 2023-12-12 |
EP4319764A2 (en) | 2024-02-14 |
WO2022217153A3 (en) | 2022-11-17 |
IL307478A (en) | 2023-12-01 |
MX2023011901A (es) | 2024-01-05 |
EP4319763A2 (en) | 2024-02-14 |
WO2022217154A3 (en) | 2022-11-17 |
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