KR102708936B1 - 유비퀴틴-특이적 프로테아제 1 억제제로서의 퓨리논 - Google Patents

유비퀴틴-특이적 프로테아제 1 억제제로서의 퓨리논 Download PDF

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KR102708936B1
KR102708936B1 KR1020187017482A KR20187017482A KR102708936B1 KR 102708936 B1 KR102708936 B1 KR 102708936B1 KR 1020187017482 A KR1020187017482 A KR 1020187017482A KR 20187017482 A KR20187017482 A KR 20187017482A KR 102708936 B1 KR102708936 B1 KR 102708936B1
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alkyl
halogen
heterocycloalkyl
alkoxy
optionally substituted
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KR20180095539A (ko
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알렉산드레 조셉 벅멜터
스테파노스 이오안니디스
브루스 팔로우스
개리 구스타프손
밍화 왕
저스틴 에이. 카라벨라
종궈 왕
에드워드 엘. 프리첸
지안 린
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포르마 세라퓨틱스 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020187017482A 2015-11-20 2016-11-18 유비퀴틴-특이적 프로테아제 1 억제제로서의 퓨리논 Active KR102708936B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258162P 2015-11-20 2015-11-20
US62/258,162 2015-11-20
PCT/US2016/062837 WO2017087837A1 (en) 2015-11-20 2016-11-18 Purinones as ubiquitin-specific protease 1 inhibitors

Publications (2)

Publication Number Publication Date
KR20180095539A KR20180095539A (ko) 2018-08-27
KR102708936B1 true KR102708936B1 (ko) 2024-09-25

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US (4) US10189841B2 (enExample)
EP (2) EP3696181A1 (enExample)
JP (3) JP6964343B2 (enExample)
KR (1) KR102708936B1 (enExample)
CN (2) CN108473495B (enExample)
AU (3) AU2016356694B2 (enExample)
BR (1) BR112018010216B1 (enExample)
CA (1) CA3005353A1 (enExample)
IL (3) IL300788A (enExample)
MX (2) MX2021001186A (enExample)
RU (1) RU2750151C2 (enExample)
SG (1) SG11201804098TA (enExample)
WO (1) WO2017087837A1 (enExample)

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