MX2018005925A - Purinonas como inhibidores de proteasa específica de ubiquitina 1. - Google Patents
Purinonas como inhibidores de proteasa específica de ubiquitina 1.Info
- Publication number
- MX2018005925A MX2018005925A MX2018005925A MX2018005925A MX2018005925A MX 2018005925 A MX2018005925 A MX 2018005925A MX 2018005925 A MX2018005925 A MX 2018005925A MX 2018005925 A MX2018005925 A MX 2018005925A MX 2018005925 A MX2018005925 A MX 2018005925A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- purinones
- ubiquitin
- specific protease
- usp1
- Prior art date
Links
- 101000607909 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Proteins 0.000 title abstract 3
- 102100039865 Ubiquitin carboxyl-terminal hydrolase 1 Human genes 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- UFZNZKGKBWOSJG-UHFFFAOYSA-N purin-2-one Chemical class O=C1N=CC2=NC=NC2=N1 UFZNZKGKBWOSJG-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La solicitud se refiere a inhibidores de USP1 útiles en el tratamiento de canceres, y otras enfermedades y trastornos asociados con USP1. Con la Formula: Donde R1, R2, R3, R4, R5, X1, X2, X3, X4, y n se describen en la presente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562258162P | 2015-11-20 | 2015-11-20 | |
PCT/US2016/062837 WO2017087837A1 (en) | 2015-11-20 | 2016-11-18 | Purinones as ubiquitin-specific protease 1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018005925A true MX2018005925A (es) | 2019-03-28 |
Family
ID=57472109
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018005925A MX2018005925A (es) | 2015-11-20 | 2016-11-18 | Purinonas como inhibidores de proteasa específica de ubiquitina 1. |
MX2021001186A MX2021001186A (es) | 2015-11-20 | 2016-11-18 | Purinonas como inhibidores de proteasa especifica de ubiquitina 1. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021001186A MX2021001186A (es) | 2015-11-20 | 2016-11-18 | Purinonas como inhibidores de proteasa especifica de ubiquitina 1. |
Country Status (13)
Country | Link |
---|---|
US (4) | US10189841B2 (es) |
EP (2) | EP3696181A1 (es) |
JP (3) | JP6964343B2 (es) |
KR (1) | KR20180095539A (es) |
CN (2) | CN114702495A (es) |
AU (3) | AU2016356694B2 (es) |
BR (1) | BR112018010216B1 (es) |
CA (1) | CA3005353A1 (es) |
IL (3) | IL300788A (es) |
MX (2) | MX2018005925A (es) |
RU (1) | RU2750151C2 (es) |
SG (1) | SG11201804098TA (es) |
WO (1) | WO2017087837A1 (es) |
Families Citing this family (34)
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KR102458689B1 (ko) * | 2020-07-08 | 2022-10-25 | 원광대학교산학협력단 | 피페리딘 화합물 및 이의 제조 방법 |
KR20220030134A (ko) * | 2020-09-02 | 2022-03-10 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 새로운 구조의 화합물 및 이를 포함하는 약제학적 조성물 |
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