KR102684436B1 - Ep4 길항제 - Google Patents

Ep4 길항제 Download PDF

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Publication number
KR102684436B1
KR102684436B1 KR1020187013843A KR20187013843A KR102684436B1 KR 102684436 B1 KR102684436 B1 KR 102684436B1 KR 1020187013843 A KR1020187013843 A KR 1020187013843A KR 20187013843 A KR20187013843 A KR 20187013843A KR 102684436 B1 KR102684436 B1 KR 102684436B1
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trifluoromethyl
imidazo
pyrazole
ethyl
dihydro
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Korean (ko)
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KR20180083863A (ko
Inventor
완준 쟁
샤오지에 주
홍 두
마아르텐 포스테마
위민 장
징 리
로버트 유
형-욱 최
재문 이
프랑크 팽
다니엘 쿠스타
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에자이 알앤드디 매니지먼트 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020187013843A 2015-10-16 2016-10-14 Ep4 길항제 Active KR102684436B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562242734P 2015-10-16 2015-10-16
US201562242748P 2015-10-16 2015-10-16
US62/242,748 2015-10-16
US62/242,734 2015-10-16
BD2522016 2016-10-13
BD252/2016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (2)

Publication Number Publication Date
KR20180083863A KR20180083863A (ko) 2018-07-23
KR102684436B1 true KR102684436B1 (ko) 2024-07-15

Family

ID=58518017

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187013843A Active KR102684436B1 (ko) 2015-10-16 2016-10-14 Ep4 길항제

Country Status (11)

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US (3) US10316040B2 (https=)
EP (1) EP3362454B1 (https=)
JP (2) JP6860559B2 (https=)
KR (1) KR102684436B1 (https=)
CN (1) CN108473497B (https=)
AU (1) AU2016338679B2 (https=)
BR (1) BR112018007664B1 (https=)
CA (1) CA3002144C (https=)
IL (1) IL258737A (https=)
MX (1) MX390051B (https=)
WO (1) WO2017066633A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
CN110621671A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物
CN110621667A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 嘧啶衍生物
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
PL3625228T3 (pl) 2017-05-18 2021-12-20 Idorsia Pharmaceuticals Ltd Pochodne pirymidyny jako modulatory receptora pge2
US20200352906A1 (en) * 2018-02-05 2020-11-12 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic Carboxylic Acids for Treating Cancer or Inflammatory Diseases
KR20200129102A (ko) * 2018-03-02 2020-11-17 셴젠 이오노바 라이프 사이언스 시오., 엘티디. 헤테로비시클릭 카르복시산들 및 그의 염들
EP3889134B1 (en) 2019-01-22 2024-09-25 Keythera (Suzhou) Pharmaceuticals Co. Ltd. Compound for inhibiting pge2/ep4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004277337A (ja) 2003-03-14 2004-10-07 Sumitomo Pharmaceut Co Ltd ピラゾロ［１，５−ａ］ピリミジン誘導体
JP2008515981A (ja) 2004-10-12 2008-05-15 デコード ジェネティクス イーエイチエフ 閉塞性動脈疾患のためのカルボン酸ペリ置換二環式化合物
JP2009534430A (ja) 2006-04-24 2009-09-24 メルク フロスト カナダ リミテツド Ｅｐ４受容体アンタゴニストとしてのインドールアミド誘導体
JP2012500211A (ja) 2008-08-14 2012-01-05 ベータ・ファーマ・カナダ・インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのヘテロ環式アミド誘導体

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE294943C (https=)
GB8426447D0 (en) 1984-10-19 1984-11-28 Kodak Ltd Photographic colour couplers
JPS6296940A (ja) 1985-10-24 1987-05-06 Fuji Photo Film Co Ltd 熱現像感光材料
US4847256A (en) 1986-10-16 1989-07-11 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines
US4963553A (en) 1986-10-16 1990-10-16 American Cyanamid Co. 4-[(substituted) alkylcarbonyl]-4,5-dihydro- and -4,5,6,7-tetrahydro-7-[(substituted)phenyl]pyrazolo[1,5-a]pyrimidines
US5126340A (en) 1986-10-16 1992-06-30 American Cyanamid Company 4-[(substituted)alkylcarbonyl]-4,5-dihydro and -4,5,6,7-tetrahydro-7-[(substituted)-phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitriles
US5215982A (en) 1989-11-10 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DD294943A5 (de) 1990-06-05 1991-10-17 Wilhelm-Pieck-Uni. Rostock Direktorat Fuer Forschung,De Verfahren zur herstellung von kondensierten n-heterocyclen
JP2631160B2 (ja) 1990-11-06 1997-07-16 富士写真フイルム株式会社 シアンカプラー、シアン画像形成方法及びハロゲン化銀カラー写真感光材料
JPH04190348A (ja) 1990-11-26 1992-07-08 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
US5210200A (en) 1990-11-29 1993-05-11 Fuji Photo Film Co., Ltd. Heterocyclic dye compounds
US5880066A (en) 1990-12-11 1999-03-09 Monsanto Company Safened herbicidal sulfonamide compositions
US5484760A (en) 1990-12-31 1996-01-16 Monsanto Company Herbicide antidotes as safeners for reducing phytotoxicity resulting from synergistic interaction between herbicides and other pesticides
TW274551B (https=) 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
IL102183A (en) 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
TW284688B (https=) 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
JP2893100B2 (ja) 1991-11-27 1999-05-17 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料
JP2772884B2 (ja) 1992-01-28 1998-07-09 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料
JPH05341430A (ja) 1992-06-12 1993-12-24 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US5405969A (en) 1993-12-10 1995-04-11 Eastman Kodak Company Manufacture of thioether compounds
US6472416B1 (en) 1999-08-27 2002-10-29 Abbott Laboratories Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors
JP4233238B2 (ja) 2000-07-06 2009-03-04 富士フイルム株式会社 インク用着色微粒子分散物、それを用いたインクジェット記録用インクおよびインクジェット記録方法
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
EP1368355B1 (de) 2001-03-14 2006-06-07 Grünenthal GmbH Substituierte pyrazolo- und thiazolopyrimidine als analgetika
US6783558B2 (en) 2001-03-15 2004-08-31 Kao Corporation Hair coloring method and composition
WO2003004497A1 (en) 2001-07-05 2003-01-16 Sumitomo Pharmaceuticals Company, Limited Novel heterocyclic compound
JP2003222985A (ja) 2001-11-22 2003-08-08 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の感度を増加させる方法
JP2003327860A (ja) 2002-05-09 2003-11-19 Konica Minolta Holdings Inc 着色組成物、着色微粒子分散物、インクジェット用インク、インクジェット記録方法
KR101050700B1 (ko) 2002-08-26 2011-07-20 다케다 야쿠힌 고교 가부시키가이샤 칼슘 수용체 조절 화합물 및 이의 용도
JP2004091369A (ja) 2002-08-30 2004-03-25 Sumitomo Pharmaceut Co Ltd 新規ビフェニル化合物
AU2003274025A1 (en) 2002-10-17 2004-05-04 Syngenta Participations Ag Pyridine derivatives useful as herbicides
WO2004035563A1 (en) 2002-10-17 2004-04-29 Syngenta Participations Ag 3-heterocyclylpyridine derivatives useful as herbicides
JP4608869B2 (ja) 2002-12-12 2011-01-12 コニカミノルタホールディングス株式会社 光電変換材料用半導体、光電変換素子及び太陽電池
JP4419421B2 (ja) 2003-04-15 2010-02-24 コニカミノルタホールディングス株式会社 光電変換材料用半導体、光電変換素子及び太陽電池
JP4419424B2 (ja) 2003-04-17 2010-02-24 コニカミノルタホールディングス株式会社 光電変換材料用半導体、光電変換素子及び太陽電池
JP2004355960A (ja) 2003-05-29 2004-12-16 Konica Minolta Holdings Inc 光電変換材料用半導体、光電変換素子及び太陽電池
JP2005035932A (ja) 2003-07-15 2005-02-10 Fuji Photo Film Co Ltd ４−置換ピラゾロ［１，５−ａ］ピリミジンジオン誘導体の製造方法
US7419978B2 (en) 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
JP2005239611A (ja) 2004-02-25 2005-09-08 Takeda Chem Ind Ltd ピラゾロピリミジン誘導体およびその用途
US7288123B2 (en) 2004-08-26 2007-10-30 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
MX2007002257A (es) 2004-08-26 2009-02-12 Procter & Gamble Compuestos colorantes de queratina, composiciones colorantes de queratina que los contienen, y el uso de éstos.
ATE499344T1 (de) 2004-10-12 2011-03-15 Decode Genetics Ehf Peri-substituierte bicyclische sulfonamide gegen arterielle verschlusskrankheit
JP2006248195A (ja) 2005-03-14 2006-09-21 Fuji Photo Film Co Ltd 感熱記録材料
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
WO2007102531A1 (ja) 2006-03-08 2007-09-13 Takeda Pharmaceutical Company Limited 併用薬
WO2008019309A1 (en) 2006-08-04 2008-02-14 Metabasis Therapeutics, Inc. Novel inhibitors of fructose 1,6-bisphosphatase
JP5301469B2 (ja) 2007-02-26 2013-09-25 メルク カナダ インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのインドール及びインドリンシクロプロピルアミド誘導体
US8063249B1 (en) 2008-04-25 2011-11-22 Olema Pharmaceuticals, Inc. Substituted triphenyl butenes
JP2009282350A (ja) 2008-05-23 2009-12-03 Konica Minolta Business Technologies Inc 静電荷像現像用トナー
JP5151684B2 (ja) 2008-05-23 2013-02-27 コニカミノルタビジネステクノロジーズ株式会社 トナーの製造方法およびトナー
JP2010026048A (ja) 2008-07-16 2010-02-04 Konica Minolta Business Technologies Inc カラートナー
WO2010024258A1 (ja) 2008-08-29 2010-03-04 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体
CN102223798A (zh) 2008-09-24 2011-10-19 巴斯夫欧洲公司 用于防治无脊椎动物害虫的吡唑化合物
WO2010048559A2 (en) 2008-10-24 2010-04-29 Calcimedica Inc. Phenylpyrazole inhibitors of store operated calcium release
WO2010096115A1 (en) 2008-10-29 2010-08-26 Apath, Llc Compounds, compositions and methods for control of hepatitis c viral infections
US9776963B2 (en) 2008-11-10 2017-10-03 The Trustees Of The University Of Pennsylvania Small molecule CD4 mimetics and uses thereof
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
EP2504342A1 (en) 2009-11-23 2012-10-03 Pfizer Inc. Imidazo-pyrazoles as gpr119 inhibitors
ES2600355T3 (es) 2010-02-22 2017-02-08 Raqualia Pharma Inc. Uso de un antagonista del receptor EP4 en el tratamiento de dermatitis de contacto alérgica y psoriasis
MX2012009866A (es) 2010-02-26 2012-09-12 Mitsubishi Tanabe Pharma Corp Compuestos pirazolopirimidina y su uso como inhibidores de fosfodiesterasa 10.
WO2011156632A2 (en) 2010-06-09 2011-12-15 Georgetown University Compositions and methods of treatment for tumors in the nervous system
PE20140011A1 (es) 2010-09-03 2014-01-31 Forma Tm Llc Compuestos y composiciones novedosos para la inhibicion de nampt
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
CA2806121C (en) 2010-09-21 2018-10-09 Eisai R&D Management Co., Ltd. Pharmaceutical composition
WO2012103071A2 (en) 2011-01-25 2012-08-02 Eisai R&D Management Co., Ltd. Compounds and compositions
US9226929B2 (en) 2011-03-02 2016-01-05 Bayer Intellectual Property Gmbh Pharmaceutically active disubstituted triazine derivatives
JP2014511894A (ja) 2011-04-20 2014-05-19 グラクソ グループ リミテッド 抗結核化合物としてのテトラヒドロピラゾロ［１，５‐ａ］ピリミジン
EP2729445B1 (en) 2011-07-04 2015-10-21 Rottapharm Biotech S.r.l. Cyclic amine derivatives as ep4 receptor antagonists
WO2013036994A1 (en) 2011-09-16 2013-03-21 Biota Scientific Management Pty Ltd Compounds for the treatment of hcv
US9169205B2 (en) 2012-10-08 2015-10-27 Boehringer Ingelheim International Gmbh Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
CN102977106B (zh) 2012-12-12 2014-12-10 中国药科大学 一类具有外周镇痛作用的κ阿片受体激动剂
HRP20170217T1 (hr) 2013-04-25 2017-04-21 Beigene, Ltd. Fuzinirani heterociklički spojevi kao inhibitori protein kinaze
JP6409055B2 (ja) 2013-05-20 2018-10-17 ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーションＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｗａｓｈｉｎｇｔｏｎ Ｔｈｒｏｕｇｈ Ｉｔｓ Ｃｅｎｔｅｒ Ｆｏｒ Ｃｏｍｍｅｒｃｉａｌｉｚａｔｉｏｎ Ｃｄｐｋ１の５−アミノピラゾール−４−カルボキサミド阻害剤
JP5954278B2 (ja) 2013-08-09 2016-07-20 コニカミノルタ株式会社 静電荷像現像用トナー、その製造方法および画像形成方法
FR3014687B1 (fr) 2013-12-13 2016-11-25 Oreal Procede de coloration des matieres keratiniques a partir d'oligomeres et/ou de polymeres colores issus de coupleurs, composition et agent de coloration
KR102535283B1 (ko) 2014-05-23 2023-05-22 에자이 알앤드디 매니지먼트 가부시키가이샤 암의 치료를 위한 조합 요법
WO2016088903A1 (en) 2014-12-05 2016-06-09 Takeda Pharmaceutical Company Limited Heterocyclic compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004277337A (ja) 2003-03-14 2004-10-07 Sumitomo Pharmaceut Co Ltd ピラゾロ［１，５−ａ］ピリミジン誘導体
JP2008515981A (ja) 2004-10-12 2008-05-15 デコード ジェネティクス イーエイチエフ 閉塞性動脈疾患のためのカルボン酸ペリ置換二環式化合物
JP2009534430A (ja) 2006-04-24 2009-09-24 メルク フロスト カナダ リミテツド Ｅｐ４受容体アンタゴニストとしてのインドールアミド誘導体
JP2012500211A (ja) 2008-08-14 2012-01-05 ベータ・ファーマ・カナダ・インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのヘテロ環式アミド誘導体

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JP2021100969A (ja) 2021-07-08
JP6860559B2 (ja) 2021-04-14
US20180305362A1 (en) 2018-10-25
MX390051B (es) 2025-03-20
US10316040B2 (en) 2019-06-11
US10941148B2 (en) 2021-03-09
AU2016338679A1 (en) 2018-06-07
CN108473497B (zh) 2021-09-10
BR112018007664A2 (pt) 2018-11-06
KR20180083863A (ko) 2018-07-23
JP7090770B2 (ja) 2022-06-24
US20190315754A1 (en) 2019-10-17
CA3002144C (en) 2024-01-23
MX2018004664A (es) 2018-08-24
US20210347779A1 (en) 2021-11-11
EP3362454B1 (en) 2021-12-08
US11434246B2 (en) 2022-09-06
EP3362454A1 (en) 2018-08-22
WO2017066633A1 (en) 2017-04-20
BR112018007664B1 (pt) 2023-12-19
CA3002144A1 (en) 2017-04-20
JP2018530595A (ja) 2018-10-18
AU2016338679B2 (en) 2021-05-06
CN108473497A (zh) 2018-08-31
IL258737A (en) 2018-06-28

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