CN108473497B - Ep4拮抗剂 - Google Patents

Ep4拮抗剂 Download PDF

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Publication number
CN108473497B
CN108473497B CN201680073562.6A CN201680073562A CN108473497B CN 108473497 B CN108473497 B CN 108473497B CN 201680073562 A CN201680073562 A CN 201680073562A CN 108473497 B CN108473497 B CN 108473497B
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CN
China
Prior art keywords
trifluoromethyl
pyrazole
imidazo
dihydro
ethyl
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CN201680073562.6A
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Chinese (zh)
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CN108473497A (zh
Inventor
郑完俊
朱潇杰
杜宏
马登·波斯特马
蒋益民
李静
罗伯特·于
崔亨旭
李在文
方家范
丹尼尔·喀斯特
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Sanitary Material R&d Management Co ltd
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Sanitary Material R&d Management Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201680073562.6A 2015-10-16 2016-10-14 Ep4拮抗剂 Active CN108473497B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562242748P 2015-10-16 2015-10-16
US201562242734P 2015-10-16 2015-10-16
US62/242,734 2015-10-16
US62/242,748 2015-10-16
BD2522016 2016-10-13
BD252/2016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (2)

Publication Number Publication Date
CN108473497A CN108473497A (zh) 2018-08-31
CN108473497B true CN108473497B (zh) 2021-09-10

Family

ID=58518017

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680073562.6A Active CN108473497B (zh) 2015-10-16 2016-10-14 Ep4拮抗剂

Country Status (11)

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US (3) US10316040B2 (https=)
EP (1) EP3362454B1 (https=)
JP (2) JP6860559B2 (https=)
KR (1) KR102684436B1 (https=)
CN (1) CN108473497B (https=)
AU (1) AU2016338679B2 (https=)
BR (1) BR112018007664B1 (https=)
CA (1) CA3002144C (https=)
IL (1) IL258737A (https=)
MX (1) MX390051B (https=)
WO (1) WO2017066633A1 (https=)

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US11839613B2 (en) 2017-05-18 2023-12-12 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
PE20191814A1 (es) 2017-05-18 2019-12-27 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
TW201900179A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 作為pge2受體調節劑之苯并呋喃及苯并噻吩衍生物
KR102612140B1 (ko) 2017-05-18 2023-12-08 이도르시아 파마슈티컬스 리미티드 피리미딘 유도체
CN111727044A (zh) * 2018-02-05 2020-09-29 深圳市原力生命科学有限公司 用于治疗癌症或炎性疾病的杂二环羧酸
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US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor

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US11434246B2 (en) 2022-09-06
MX2018004664A (es) 2018-08-24
CA3002144A1 (en) 2017-04-20
BR112018007664B1 (pt) 2023-12-19
US10941148B2 (en) 2021-03-09
JP2018530595A (ja) 2018-10-18
JP2021100969A (ja) 2021-07-08
US10316040B2 (en) 2019-06-11
JP6860559B2 (ja) 2021-04-14
BR112018007664A2 (pt) 2018-11-06
US20190315754A1 (en) 2019-10-17
CN108473497A (zh) 2018-08-31
KR20180083863A (ko) 2018-07-23
CA3002144C (en) 2024-01-23
WO2017066633A1 (en) 2017-04-20
IL258737A (en) 2018-06-28
EP3362454B1 (en) 2021-12-08
EP3362454A1 (en) 2018-08-22
JP7090770B2 (ja) 2022-06-24
MX390051B (es) 2025-03-20
US20210347779A1 (en) 2021-11-11
AU2016338679A1 (en) 2018-06-07
US20180305362A1 (en) 2018-10-25
KR102684436B1 (ko) 2024-07-15
AU2016338679B2 (en) 2021-05-06

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