IL258737A - Antagonists ep4 - Google Patents

Antagonists ep4

Info

Publication number
IL258737A
IL258737A IL258737A IL25873718A IL258737A IL 258737 A IL258737 A IL 258737A IL 258737 A IL258737 A IL 258737A IL 25873718 A IL25873718 A IL 25873718A IL 258737 A IL258737 A IL 258737A
Authority
IL
Israel
Prior art keywords
antagonists
Prior art date
Application number
IL258737A
Other languages
English (en)
Hebrew (he)
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of IL258737A publication Critical patent/IL258737A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL258737A 2015-10-16 2018-04-16 Antagonists ep4 IL258737A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562242734P 2015-10-16 2015-10-16
US201562242748P 2015-10-16 2015-10-16
BD2522016 2016-10-13
PCT/US2016/057135 WO2017066633A1 (en) 2015-10-16 2016-10-14 Ep4 antagonists

Publications (1)

Publication Number Publication Date
IL258737A true IL258737A (en) 2018-06-28

Family

ID=58518017

Family Applications (1)

Application Number Title Priority Date Filing Date
IL258737A IL258737A (en) 2015-10-16 2018-04-16 Antagonists ep4

Country Status (11)

Country Link
US (3) US10316040B2 (https=)
EP (1) EP3362454B1 (https=)
JP (2) JP6860559B2 (https=)
KR (1) KR102684436B1 (https=)
CN (1) CN108473497B (https=)
AU (1) AU2016338679B2 (https=)
BR (1) BR112018007664B1 (https=)
CA (1) CA3002144C (https=)
IL (1) IL258737A (https=)
MX (1) MX390051B (https=)
WO (1) WO2017066633A1 (https=)

Families Citing this family (10)

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CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
CN110621671A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物
CN110621667A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 嘧啶衍生物
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
PL3625228T3 (pl) 2017-05-18 2021-12-20 Idorsia Pharmaceuticals Ltd Pochodne pirymidyny jako modulatory receptora pge2
US20200352906A1 (en) * 2018-02-05 2020-11-12 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic Carboxylic Acids for Treating Cancer or Inflammatory Diseases
KR20200129102A (ko) * 2018-03-02 2020-11-17 셴젠 이오노바 라이프 사이언스 시오., 엘티디. 헤테로비시클릭 카르복시산들 및 그의 염들
EP3889134B1 (en) 2019-01-22 2024-09-25 Keythera (Suzhou) Pharmaceuticals Co. Ltd. Compound for inhibiting pge2/ep4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor

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Also Published As

Publication number Publication date
JP2021100969A (ja) 2021-07-08
JP6860559B2 (ja) 2021-04-14
US20180305362A1 (en) 2018-10-25
MX390051B (es) 2025-03-20
US10316040B2 (en) 2019-06-11
US10941148B2 (en) 2021-03-09
AU2016338679A1 (en) 2018-06-07
CN108473497B (zh) 2021-09-10
BR112018007664A2 (pt) 2018-11-06
KR20180083863A (ko) 2018-07-23
JP7090770B2 (ja) 2022-06-24
US20190315754A1 (en) 2019-10-17
CA3002144C (en) 2024-01-23
MX2018004664A (es) 2018-08-24
US20210347779A1 (en) 2021-11-11
EP3362454B1 (en) 2021-12-08
US11434246B2 (en) 2022-09-06
EP3362454A1 (en) 2018-08-22
WO2017066633A1 (en) 2017-04-20
BR112018007664B1 (pt) 2023-12-19
CA3002144A1 (en) 2017-04-20
JP2018530595A (ja) 2018-10-18
AU2016338679B2 (en) 2021-05-06
CN108473497A (zh) 2018-08-31
KR102684436B1 (ko) 2024-07-15

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