KR101800595B1 - 자가면역 및 염증성 장애의 치료에 유용한, ｓ1ｐ1 수용체 효능제로서의 치환된 트리시클릭 산 유도체 - Google Patents

자가면역 및 염증성 장애의 치료에 유용한, ｓ1ｐ1 수용체 효능제로서의 치환된 트리시클릭 산 유도체 Download PDF

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KR101800595B1
KR101800595B1 KR1020177014649A KR20177014649A KR101800595B1 KR 101800595 B1 KR101800595 B1 KR 101800595B1 KR 1020177014649 A KR1020177014649 A KR 1020177014649A KR 20177014649 A KR20177014649 A KR 20177014649A KR 101800595 B1 KR101800595 B1 KR 101800595B1
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pyrrolo
acetic acid
indol
dihydro
cyano
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KR20170063992A (ko
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로버트 엠. 존스
대니얼 제이. 버자드
앤드류 엠. 가와사키
선 희 김
라르스 토레센
위르크 레만
시우웬 주
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아레나 파마슈티칼스, 인크.
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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KR1020177014649A 2008-08-27 2009-08-26 자가면역 및 염증성 장애의 치료에 유용한, ｓ1ｐ1 수용체 효능제로서의 치환된 트리시클릭 산 유도체 Active KR101800595B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19031108P 2008-08-27 2008-08-27
US61/190,311 2008-08-27
US26951909P 2009-06-24 2009-06-24
US61/269,519 2009-06-24
PCT/US2009/004851 WO2010027431A1 (en) 2008-08-27 2009-08-26 Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders

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KR1020117006863A Division KR20110058849A (ko) 2008-08-27 2009-08-26 자가면역 및 염증성 장애의 치료에 유용한, ｓ1ｐ1 수용체 효능제로서의 치환된 트리시클릭 산 유도체

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KR20170063992A KR20170063992A (ko) 2017-06-08
KR101800595B1 true KR101800595B1 (ko) 2017-11-22

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KR1020177014649A Active KR101800595B1 (ko) 2008-08-27 2009-08-26 자가면역 및 염증성 장애의 치료에 유용한, ｓ1ｐ1 수용체 효능제로서의 치환된 트리시클릭 산 유도체
KR1020117006863A Ceased KR20110058849A (ko) 2008-08-27 2009-08-26 자가면역 및 염증성 장애의 치료에 유용한, ｓ1ｐ1 수용체 효능제로서의 치환된 트리시클릭 산 유도체

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US (3) US8415484B2 (enrdf_load_stackoverflow)
EP (1) EP2342205B1 (enrdf_load_stackoverflow)
JP (2) JP5726737B2 (enrdf_load_stackoverflow)
KR (2) KR101800595B1 (enrdf_load_stackoverflow)
CN (2) CN105816453B (enrdf_load_stackoverflow)
AU (1) AU2009288738B9 (enrdf_load_stackoverflow)
BR (1) BRPI0917923B1 (enrdf_load_stackoverflow)
CA (1) CA2733671C (enrdf_load_stackoverflow)
CY (1) CY1117830T1 (enrdf_load_stackoverflow)
EA (1) EA036955B1 (enrdf_load_stackoverflow)
ES (1) ES2583630T3 (enrdf_load_stackoverflow)
HR (1) HRP20160890T1 (enrdf_load_stackoverflow)
HU (1) HUE031479T2 (enrdf_load_stackoverflow)
IL (2) IL211107A0 (enrdf_load_stackoverflow)
MX (1) MX2011002199A (enrdf_load_stackoverflow)
NZ (1) NZ591001A (enrdf_load_stackoverflow)
PL (1) PL2342205T4 (enrdf_load_stackoverflow)
PT (1) PT2342205T (enrdf_load_stackoverflow)
RS (1) RS54970B1 (enrdf_load_stackoverflow)
SI (1) SI2342205T1 (enrdf_load_stackoverflow)
SM (1) SMT201600318B (enrdf_load_stackoverflow)
WO (1) WO2010027431A1 (enrdf_load_stackoverflow)
ZA (1) ZA201101524B (enrdf_load_stackoverflow)

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CN104800208A (zh) * 2008-03-17 2015-07-29 埃科特莱茵药品有限公司 选择性s1p1受体激动剂的给药方案
WO2010011316A1 (en) 2008-07-23 2010-01-28 Arena Pharmaceuticals, Inc. SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
NZ591001A (en) 2008-08-27 2012-11-30 Arena Pharm Inc Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
WO2011005295A1 (en) * 2009-06-24 2011-01-13 Arena Pharmaceuticals, Inc. Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto
CN103221391B (zh) 2010-01-27 2018-07-06 艾尼纳制药公司 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法
US9085581B2 (en) * 2010-03-03 2015-07-21 Arena Pharmaceuticals, Inc. Processes for the preparation of S1P1 receptor modulators and crystalline forms thereof
CN104478885B (zh) * 2014-12-12 2017-08-01 常州大学 9‑氨基‑9a‑烯丙基苯并吡咯里西啶生物碱的制备方法
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