SMT201600318B - Derivati dell'acido triciclico sostituiti come agonisti del recettore s1p1 utili nel trattamento di malattie autoimmuni e infiammatorie - Google Patents

Derivati dell'acido triciclico sostituiti come agonisti del recettore s1p1 utili nel trattamento di malattie autoimmuni e infiammatorie

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Publication number
SMT201600318B
SMT201600318B SM201600318T SM201600318T SMT201600318B SM T201600318 B SMT201600318 B SM T201600318B SM 201600318 T SM201600318 T SM 201600318T SM 201600318 T SM201600318 T SM 201600318T SM T201600318 B SMT201600318 B SM T201600318B
Authority
SM
San Marino
Prior art keywords
acid derivatives
inflammatory diseases
receptor agonists
treating autoimmune
agonists useful
Prior art date
Application number
SM201600318T
Other languages
English (en)
Inventor
Robert M Jones
Daniel J Buzard
Andrew M Kawasaki
Sun Hee Kim
Lars THORESEN
Juerg Lehmann
Xiuwen Zhu
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of SMT201600318B publication Critical patent/SMT201600318B/it

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/04—Ortho-condensed systems

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SM201600318T 2008-08-27 2016-09-14 Derivati dell'acido triciclico sostituiti come agonisti del recettore s1p1 utili nel trattamento di malattie autoimmuni e infiammatorie SMT201600318B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19031108P 2008-08-27 2008-08-27
US26951909P 2009-06-24 2009-06-24
PCT/US2009/004851 WO2010027431A1 (en) 2008-08-27 2009-08-26 Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders

Publications (1)

Publication Number Publication Date
SMT201600318B true SMT201600318B (it) 2016-11-10

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Application Number Title Priority Date Filing Date
SM201600318T SMT201600318B (it) 2008-08-27 2016-09-14 Derivati dell'acido triciclico sostituiti come agonisti del recettore s1p1 utili nel trattamento di malattie autoimmuni e infiammatorie

Country Status (23)

Country Link
US (3) US8415484B2 (it)
EP (1) EP2342205B1 (it)
JP (2) JP5726737B2 (it)
KR (2) KR20110058849A (it)
CN (2) CN105816453B (it)
AU (1) AU2009288738B9 (it)
BR (1) BRPI0917923B1 (it)
CA (1) CA2733671C (it)
CY (1) CY1117830T1 (it)
EA (1) EA036955B1 (it)
ES (1) ES2583630T3 (it)
HR (1) HRP20160890T1 (it)
HU (1) HUE031479T2 (it)
IL (2) IL211107A0 (it)
MX (1) MX2011002199A (it)
NZ (1) NZ591001A (it)
PL (1) PL2342205T3 (it)
PT (1) PT2342205T (it)
RS (1) RS54970B1 (it)
SI (1) SI2342205T1 (it)
SM (1) SMT201600318B (it)
WO (1) WO2010027431A1 (it)
ZA (1) ZA201101524B (it)

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NZ591001A (en) 2008-08-27 2012-11-30 Arena Pharm Inc Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
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CN105503882B (zh) * 2010-03-03 2019-07-05 艾尼纳制药公司 制备s1p1受体调节剂及其晶体形式的方法
CN104710426B (zh) * 2014-12-12 2017-08-01 常州大学 苯并吡咯里西啶生物碱及其制备方法和用途
CN104478885B (zh) * 2014-12-12 2017-08-01 常州大学 9‑氨基‑9a‑烯丙基苯并吡咯里西啶生物碱的制备方法
CN116850181A (zh) * 2015-01-06 2023-10-10 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
AU2016284162A1 (en) 2015-06-22 2018-02-01 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(Compound1) for use in SIP1 receptor-associated disorders
AU2018220521A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
CA3053416A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
WO2019236757A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
EP3892616A4 (en) * 2018-12-06 2022-07-27 Shanghai Jemincare Pharmaceuticals Co., Ltd. AROMATIC RING DERIVATIVE AS IMMUNOREGULATION AND MANUFACTURING METHOD AND APPLICATION OF AN AROMATIC RING DERIVATIVE
WO2020140957A1 (en) * 2019-01-04 2020-07-09 Ascentage Pharma (Suzhou) Co., Ltd. Method for preparing sulfonamides drugs
EP3908276B1 (en) * 2019-01-08 2025-06-11 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
WO2021213393A1 (en) * 2020-04-20 2021-10-28 Zebrapeutics Inc. Method of treating ship1-mediated diseases using pelorol derivatives
CN112812052B (zh) * 2021-02-02 2023-12-01 成都阿奇生物医药科技有限公司 一种治疗溃疡性结肠炎的化合物及其制备方法和用途

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