CY1117830T1 - Υποκατεστημενα παραγωγα τρικυκλικων οξεων ως αγωνιστες του υποδοχεα s1p1 χρησιμα στην αγωγη αυτοανοσων και φλεγμονοδων διαταραχων - Google Patents
Υποκατεστημενα παραγωγα τρικυκλικων οξεων ως αγωνιστες του υποδοχεα s1p1 χρησιμα στην αγωγη αυτοανοσων και φλεγμονοδων διαταραχωνInfo
- Publication number
- CY1117830T1 CY1117830T1 CY20161100713T CY161100713T CY1117830T1 CY 1117830 T1 CY1117830 T1 CY 1117830T1 CY 20161100713 T CY20161100713 T CY 20161100713T CY 161100713 T CY161100713 T CY 161100713T CY 1117830 T1 CY1117830 T1 CY 1117830T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- acid derivatives
- diseases
- substituted tricyclic
- autoimmune
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
Η παρούσα εφεύρεση σχετίζεται με ορισμένα υποκατεστημένα παράγωγα τρικυκλικών οξέων του Χημικού Τύπου (I) και φαρμακευτικώς αποδεκτά άλατα εξ' αυτών, τα οποία εκδηλώνουν χρήσιμες φαρμακολογικές ιδιότητες, για παράδειγμα, ως αγωνιστές του υποδοχέα S1Ρ1. Επίσης παρέχονται μέσω της παρούσας εφεύρεσης και φαρμακευτικές συνθέσεις περιέχοντας ενώσεις της εφεύρεσης, και μέθοδοι χρήσης των ενώσεων και συνθέσεων της εφεύρεσης στην αγωγή των S1P1-συσχετιζόμενων διαταραχών, για παράδειγμα, της ψωρίασης, της ρευματοειδούς αρθρίτιδας, της νόσου του Crohn, της απόρριψης μεταμοσχευμάτων, της πολλαπλής σκλήρυνσης, του συστημικού ερυθηματώδους λύκου, της ελκώδους κολίτιδας, του διαβήτη τύπου I, της ακμής, της μυοκαρδιακής ισχαιμίας-βλάβης επαναδιαπότισης, της υπερτασικής νεφροπάθειας, της σπειραματοσκλήρυνσης, της γαστρίτιδας, της πολυμυοσίτιδας, της θυρεοειδίτιδας, της λεύκης, της ηπατίτιδας, της χοληφόρου κίρρωσης, των μικροβιακών λοιμώξεων και συσχετιζόμενων παθήσεων, των ιικών λοιμώξεων και συσχετιζόμενων παθήσεων, των παθήσεων και διαταραχών που μεσολαβούνται από λεμφοκύτταρα, των αυτοάνοσων παθήσεων, των φλεγμονωδών παθήσεων, και του καρκίνου.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US19031108P | 2008-08-27 | 2008-08-27 | |
US26951909P | 2009-06-24 | 2009-06-24 | |
PCT/US2009/004851 WO2010027431A1 (en) | 2008-08-27 | 2009-08-26 | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
Publications (1)
Publication Number | Publication Date |
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CY1117830T1 true CY1117830T1 (el) | 2017-05-17 |
Family
ID=41491524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100713T CY1117830T1 (el) | 2008-08-27 | 2016-07-20 | Υποκατεστημενα παραγωγα τρικυκλικων οξεων ως αγωνιστες του υποδοχεα s1p1 χρησιμα στην αγωγη αυτοανοσων και φλεγμονοδων διαταραχων |
Country Status (24)
Country | Link |
---|---|
US (3) | US8415484B2 (el) |
EP (1) | EP2342205B1 (el) |
JP (2) | JP5726737B2 (el) |
KR (2) | KR101800595B1 (el) |
CN (2) | CN102197038B (el) |
AU (1) | AU2009288738B9 (el) |
BR (1) | BRPI0917923B1 (el) |
CA (1) | CA2733671C (el) |
CY (1) | CY1117830T1 (el) |
EA (1) | EA036955B1 (el) |
ES (1) | ES2583630T3 (el) |
HK (1) | HK1158624A1 (el) |
HR (1) | HRP20160890T1 (el) |
HU (1) | HUE031479T2 (el) |
IL (2) | IL211107A0 (el) |
MX (1) | MX2011002199A (el) |
NZ (1) | NZ591001A (el) |
PL (1) | PL2342205T4 (el) |
PT (1) | PT2342205T (el) |
RS (1) | RS54970B1 (el) |
SI (1) | SI2342205T1 (el) |
SM (1) | SMT201600318B (el) |
WO (1) | WO2010027431A1 (el) |
ZA (1) | ZA201101524B (el) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009115954A1 (en) * | 2008-03-17 | 2009-09-24 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective s1p1 receptor agonist |
HUE030424T2 (en) * | 2008-07-23 | 2017-05-29 | Arena Pharm Inc | Substituted 1,2,3,4-tetrahydrocyclopenta [b] indol-3-ylacetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
SI2342205T1 (sl) * | 2008-08-27 | 2016-09-30 | Arena Pharmaceuticals, Inc. | Substituirani triciklični kislinski derivati kot agonisti S1P1 receptorja, uporabni v zdravljenju avtoimunskih in vnetnih obolenj |
WO2011005295A1 (en) * | 2009-06-24 | 2011-01-13 | Arena Pharmaceuticals, Inc. | Modulators of the sphingosine-1-phosphate (s1p) receptor useful for the treatment of disorders related thereto |
ES2937386T3 (es) | 2010-01-27 | 2023-03-28 | Arena Pharm Inc | Procesos para la preparación de ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclopenta[b]indol-3-il)acético y sales del mismo |
WO2011109471A1 (en) | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
CN104710426B (zh) * | 2014-12-12 | 2017-08-01 | 常州大学 | 苯并吡咯里西啶生物碱及其制备方法和用途 |
CN104478885B (zh) * | 2014-12-12 | 2017-08-01 | 常州大学 | 9‑氨基‑9a‑烯丙基苯并吡咯里西啶生物碱的制备方法 |
EP3242666A1 (en) | 2015-01-06 | 2017-11-15 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
JP6838744B2 (ja) * | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ, インコーポレイテッド | S1P1レセプター関連障害における使用のための(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸(化合物1)の結晶性L−アルギニン塩 |
KR20190116416A (ko) | 2017-02-16 | 2019-10-14 | 아레나 파마슈티칼스, 인크. | 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법 |
CN110545848A (zh) * | 2017-02-16 | 2019-12-06 | 艾尼纳制药公司 | 用于治疗具有肠外表现的炎症性肠病的化合物和方法 |
WO2020051378A1 (en) | 2018-09-06 | 2020-03-12 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
EP3892616A4 (en) | 2018-12-06 | 2022-07-27 | Shanghai Jemincare Pharmaceuticals Co., Ltd. | AROMATIC RING DERIVATIVE AS IMMUNOREGULATION AND MANUFACTURING METHOD AND APPLICATION OF AN AROMATIC RING DERIVATIVE |
TWI731540B (zh) * | 2019-01-04 | 2021-06-21 | 大陸商蘇州亞盛藥業有限公司 | 製備磺胺類藥物的方法 |
CN112812052B (zh) * | 2021-02-02 | 2023-12-01 | 成都阿奇生物医药科技有限公司 | 一种治疗溃疡性结肠炎的化合物及其制备方法和用途 |
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EP2597089A1 (en) | 2009-10-29 | 2013-05-29 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
ES2937386T3 (es) | 2010-01-27 | 2023-03-28 | Arena Pharm Inc | Procesos para la preparación de ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclopenta[b]indol-3-il)acético y sales del mismo |
WO2011109471A1 (en) * | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
WO2012015758A2 (en) | 2010-07-30 | 2012-02-02 | Saint Louis University | Methods of treating pain |
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2009
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