MXPA04002679A - Derivados de sulfuro de diarilo, sales de los mismos y agentes inmunosupresores que utilizan los mismos. - Google Patents

Derivados de sulfuro de diarilo, sales de los mismos y agentes inmunosupresores que utilizan los mismos.

Info

Publication number
MXPA04002679A
MXPA04002679A MXPA04002679A MXPA04002679A MXPA04002679A MX PA04002679 A MXPA04002679 A MX PA04002679A MX PA04002679 A MXPA04002679 A MX PA04002679A MX PA04002679 A MXPA04002679 A MX PA04002679A MX PA04002679 A MXPA04002679 A MX PA04002679A
Authority
MX
Mexico
Prior art keywords
sulfide derivative
immunosuppressant
diaryl sulfide
addition salt
diaryl
Prior art date
Application number
MXPA04002679A
Other languages
English (en)
Inventor
Shinji Kudou
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of MXPA04002679A publication Critical patent/MXPA04002679A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

La presente invencion proporciona derivados de sulfuro de diarilo que exhiben efectos inmunosupresores significativos con menos efectos secundarios. Los derivados de diarilo de la presente invencion se representan por la siguiente formula general (1): (ver formula) Un ejemplo es 2-amino-2 -[4-(3-benciloxifeniltio) -2 -clorofenil]propil-1, 3- propandiol.
MXPA04002679A 2001-09-27 2002-09-25 Derivados de sulfuro de diarilo, sales de los mismos y agentes inmunosupresores que utilizan los mismos. MXPA04002679A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001297411 2001-09-27
JP2002216192 2002-07-25
PCT/JP2002/009865 WO2003029205A1 (fr) 2001-09-27 2002-09-25 Derive de sulfure de diaryle, son sel d'addition et immunosuppresseur

Publications (1)

Publication Number Publication Date
MXPA04002679A true MXPA04002679A (es) 2004-07-30

Family

ID=26623111

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04002679A MXPA04002679A (es) 2001-09-27 2002-09-25 Derivados de sulfuro de diarilo, sales de los mismos y agentes inmunosupresores que utilizan los mismos.

Country Status (15)

Country Link
US (1) US6960692B2 (es)
EP (1) EP1431284B1 (es)
JP (2) JP4217620B2 (es)
KR (1) KR100913269B1 (es)
CN (1) CN1329372C (es)
AU (1) AU2002332289B2 (es)
BR (1) BRPI0212894B8 (es)
CA (1) CA2461212C (es)
CY (1) CY1107272T1 (es)
DE (1) DE60223699T2 (es)
DK (1) DK1431284T3 (es)
ES (1) ES2292809T3 (es)
MX (1) MXPA04002679A (es)
PT (1) PT1431284E (es)
WO (1) WO2003029205A1 (es)

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Also Published As

Publication number Publication date
BR0212894A (pt) 2004-10-13
CA2461212C (en) 2010-08-17
DE60223699T2 (de) 2008-10-30
EP1431284B1 (en) 2007-11-21
JP4217620B2 (ja) 2009-02-04
JP2009040794A (ja) 2009-02-26
DK1431284T3 (da) 2008-02-18
EP1431284A4 (en) 2006-03-01
CN1561331A (zh) 2005-01-05
EP1431284A1 (en) 2004-06-23
BRPI0212894B8 (pt) 2021-05-25
AU2002332289B2 (en) 2007-05-10
PT1431284E (pt) 2008-01-21
DE60223699D1 (en) 2008-01-03
US20040254222A1 (en) 2004-12-16
WO2003029205A1 (fr) 2003-04-10
BRPI0212894B1 (pt) 2019-07-30
KR100913269B1 (ko) 2009-08-21
CN1329372C (zh) 2007-08-01
US6960692B2 (en) 2005-11-01
CY1107272T1 (el) 2012-11-21
CA2461212A1 (en) 2003-04-10
KR20040037107A (ko) 2004-05-04
JPWO2003029205A1 (ja) 2005-01-13
ES2292809T3 (es) 2008-03-16
JP4917589B2 (ja) 2012-04-18

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