KR101432460B1 - 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도 - Google Patents

스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도 Download PDF

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Publication number
KR101432460B1
KR101432460B1 KR1020137016857A KR20137016857A KR101432460B1 KR 101432460 B1 KR101432460 B1 KR 101432460B1 KR 1020137016857 A KR1020137016857 A KR 1020137016857A KR 20137016857 A KR20137016857 A KR 20137016857A KR 101432460 B1 KR101432460 B1 KR 101432460B1
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South Korea
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heteroaryl
heterocyclyl
aryl
alkyl
cycloalkyl
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Expired - Fee Related
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KR1020137016857A
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English (en)
Korean (ko)
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KR20130089279A (ko
Inventor
미카일 챠피브
술탄 초우두리
로버트 프레이저
지안민 푸
라젠더 캄보즈
두안지 호우
쉬펭 리우
메란 세이드 바게르자데
세르게이 스비리도브
사오이 쑨
?위 쑨
나가스리 차카
톰 시에
반드나 라이나
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제논 파마슈티칼스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020137016857A 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도 Expired - Fee Related KR101432460B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67089605P 2005-04-11 2005-04-11
US60/670,896 2005-04-11
PCT/US2006/014352 WO2006110917A2 (en) 2005-04-11 2006-04-11 Spiro-oxindole compounds and their uses as therapeutic agents

Related Parent Applications (1)

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KR1020077026134A Division KR101402557B1 (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020147009732A Division KR20140063803A (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도

Publications (2)

Publication Number Publication Date
KR20130089279A KR20130089279A (ko) 2013-08-09
KR101432460B1 true KR101432460B1 (ko) 2014-08-21

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ID=36952847

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020137016857A Expired - Fee Related KR101432460B1 (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도
KR1020167030733A Withdrawn KR20160130864A (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도
KR1020147009732A Ceased KR20140063803A (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도
KR1020077026134A Expired - Fee Related KR101402557B1 (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도
KR1020157020622A Withdrawn KR20150091542A (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도

Family Applications After (4)

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KR1020167030733A Withdrawn KR20160130864A (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도
KR1020147009732A Ceased KR20140063803A (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도
KR1020077026134A Expired - Fee Related KR101402557B1 (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도
KR1020157020622A Withdrawn KR20150091542A (ko) 2005-04-11 2006-04-11 스피로-옥스인돌 화합물 및 이들의 치료제로서의 용도

Country Status (30)

Country Link
US (4) US7700641B2 (https=)
EP (4) EP2752417B1 (https=)
JP (4) JP5118627B2 (https=)
KR (5) KR101432460B1 (https=)
CN (2) CN102153562B (https=)
AR (1) AR056968A1 (https=)
AT (1) ATE543825T1 (https=)
AU (1) AU2006235593B2 (https=)
BR (1) BRPI0607926A2 (https=)
CA (3) CA2853635C (https=)
DK (1) DK1888595T3 (https=)
EC (1) ECSP077852A (https=)
ES (2) ES2488618T3 (https=)
HK (1) HK1199874A1 (https=)
HR (1) HRP20070505B1 (https=)
IL (1) IL186616A (https=)
MA (1) MA29684B1 (https=)
MX (1) MX2007012636A (https=)
MY (2) MY158766A (https=)
NO (1) NO20074619L (https=)
NZ (1) NZ561210A (https=)
PL (1) PL1888595T3 (https=)
PT (1) PT1888595E (https=)
RS (1) RS52295B (https=)
RU (1) RU2415143C2 (https=)
SG (1) SG161262A1 (https=)
SI (1) SI1888595T1 (https=)
TN (1) TNSN07382A1 (https=)
TW (1) TWI374141B (https=)
WO (1) WO2006110917A2 (https=)

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AR056968A1 (es) 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
WO2008046087A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro compounds and their uses as therapeutic agents
AR063277A1 (es) * 2006-10-12 2009-01-14 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y usos como agentes terapeuticos
WO2008060789A2 (en) * 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
US20110294842A9 (en) * 2006-10-12 2011-12-01 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
AU2007307635A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
US7553833B2 (en) * 2007-05-17 2009-06-30 Hoffmann-La Roche Inc. 3,3-spiroindolinone derivatives
JP5055432B2 (ja) 2007-09-24 2012-10-24 コメンティス，インコーポレーテッド 治療のためのβ−セクレターゼ阻害剤としての（３−ヒドロキシ−４−アミノブタン−２−イル）−３−（２−チアゾール−２−イル−ピロリジン−１−カルボニル）ベンズアミド誘導体及び関連する化合物
CA2701203A1 (en) * 2007-10-04 2009-04-09 Merck Sharp & Dohme Corp. N-substituted oxindoline derivatives as calcium channel blockers
US20100204247A1 (en) * 2007-10-04 2010-08-12 Duffy Joseph L N-substituted oxindoline derivatives as calcium channel blockers
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