KR101376807B1 - 스티릴피리딘 유도체 및 그의 아밀로이드 플라크에 결합 및영상화를 위한 용도 - Google Patents

스티릴피리딘 유도체 및 그의 아밀로이드 플라크에 결합 및영상화를 위한 용도 Download PDF

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KR101376807B1
KR101376807B1 KR1020087023884A KR20087023884A KR101376807B1 KR 101376807 B1 KR101376807 B1 KR 101376807B1 KR 1020087023884 A KR1020087023884 A KR 1020087023884A KR 20087023884 A KR20087023884 A KR 20087023884A KR 101376807 B1 KR101376807 B1 KR 101376807B1
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KR20080106564A (ko
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행크. 에프. 쿵
메이-핑 쿵
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더 트러스티스 오브 더 유니버시티 오브 펜실바니아
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • A—HUMAN NECESSITIES
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    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

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  • Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Obesity (AREA)
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  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020087023884A 2006-03-30 2007-03-26 스티릴피리딘 유도체 및 그의 아밀로이드 플라크에 결합 및영상화를 위한 용도 Active KR101376807B1 (ko)

Applications Claiming Priority (3)

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US78715606P 2006-03-30 2006-03-30
US60/787,156 2006-03-30
PCT/US2007/007400 WO2007126733A2 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

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KR20080106564A KR20080106564A (ko) 2008-12-08
KR101376807B1 true KR101376807B1 (ko) 2014-03-20

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US20080038195A1 (en) 2008-02-14
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RS52222B (sr) 2012-10-31
HRP20170857T1 (hr) 2017-12-01
ES2378785T3 (es) 2012-04-17
IL193567A (en) 2014-03-31
WO2007126733A2 (en) 2007-11-08
WO2007126733A3 (en) 2008-03-06
EP2363392B1 (en) 2017-05-03
SI2363392T1 (sl) 2017-09-29
ZA200807955B (en) 2012-11-28
CY1113048T1 (el) 2015-11-04
JP2009532349A (ja) 2009-09-10
EP2363392A1 (en) 2011-09-07
LT2363392T (lt) 2017-07-25
CY2013024I2 (el) 2015-11-04
FR13C0034I2 (fr) 2014-03-07
SI1999109T1 (sl) 2012-04-30
US8506929B2 (en) 2013-08-13
KR20080106564A (ko) 2008-12-08
CR10329A (es) 2008-10-29
HUE032660T2 (en) 2017-10-30
CA2644530A1 (en) 2007-11-08
EA200870389A1 (ru) 2009-04-28
CY1119048T1 (el) 2018-01-10
DK1999109T3 (da) 2012-04-02
SG173338A1 (en) 2011-08-29
US20090123369A1 (en) 2009-05-14
MX2008012527A (es) 2008-10-14
AU2007243712B2 (en) 2013-01-10
EP2363391A1 (en) 2011-09-07
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
ECSP088783A (es) 2008-10-31
EA017898B1 (ru) 2013-04-30
US8840866B2 (en) 2014-09-23
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TW200838852A (en) 2008-10-01
EP1999109A2 (en) 2008-12-10
BE2013C044I2 (enExample) 2026-04-24
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NO2018030I1 (no) 2018-09-11
TWI399366B (zh) 2013-06-21
CN101522624B (zh) 2013-11-06
HRP20120135T1 (hr) 2012-03-31
ES2628882T3 (es) 2017-08-04
GT200800201A (es) 2009-08-20
AU2007243712A1 (en) 2007-11-08
CA2644530C (en) 2015-05-19
US7687052B2 (en) 2010-03-30
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FR13C0034I1 (enExample) 2013-08-09
DK2363392T3 (en) 2017-07-03
BRPI0710225B1 (pt) 2021-07-13
NZ570887A (en) 2011-05-27
BRPI0710225A2 (pt) 2011-08-02
ATE539060T1 (de) 2012-01-15
CY2013024I1 (el) 2015-11-04
HUS1300028I1 (hu) 2017-08-28
PT1999109E (pt) 2012-03-16
US20130129624A1 (en) 2013-05-23
CN101522624A (zh) 2009-09-02
IL193567A0 (en) 2009-05-04
LU92232I9 (enExample) 2019-01-15
JP5290954B2 (ja) 2013-09-18
RS56171B1 (sr) 2017-11-30

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