GT200800201A - Derivados de estirilpiridina y sus usos para union a placas amiloides y obtención de imagenes de las mismas. - Google Patents

Derivados de estirilpiridina y sus usos para union a placas amiloides y obtención de imagenes de las mismas.

Info

Publication number
GT200800201A
GT200800201A GT200800201A GT200800201A GT200800201A GT 200800201 A GT200800201 A GT 200800201A GT 200800201 A GT200800201 A GT 200800201A GT 200800201 A GT200800201 A GT 200800201A GT 200800201 A GT200800201 A GT 200800201A
Authority
GT
Guatemala
Prior art keywords
amiloid
obtaining images
stirilpiridina
joining
derivatives
Prior art date
Application number
GT200800201A
Other languages
English (en)
Spanish (es)
Inventor
Hank F Kung
Mei-Ping Kung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200800201A publication Critical patent/GT200800201A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GT200800201A 2006-03-30 2008-09-30 Derivados de estirilpiridina y sus usos para union a placas amiloides y obtención de imagenes de las mismas. GT200800201A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30

Publications (1)

Publication Number Publication Date
GT200800201A true GT200800201A (es) 2009-08-20

Family

ID=38326579

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200800201A GT200800201A (es) 2006-03-30 2008-09-30 Derivados de estirilpiridina y sus usos para union a placas amiloides y obtención de imagenes de las mismas.

Country Status (35)

Country Link
US (3) US7687052B2 (enExample)
EP (3) EP2363392B1 (enExample)
JP (1) JP5290954B2 (enExample)
KR (1) KR101376807B1 (enExample)
CN (1) CN101522624B (enExample)
AT (1) ATE539060T1 (enExample)
AU (1) AU2007243712B2 (enExample)
BE (1) BE2013C044I2 (enExample)
BR (1) BRPI0710225B1 (enExample)
CA (1) CA2644530C (enExample)
CR (1) CR10329A (enExample)
CY (3) CY1113048T1 (enExample)
DK (2) DK2363392T3 (enExample)
EA (1) EA017898B1 (enExample)
EC (1) ECSP088783A (enExample)
ES (2) ES2628882T3 (enExample)
FR (1) FR13C0034I2 (enExample)
GT (1) GT200800201A (enExample)
HR (2) HRP20120135T1 (enExample)
HU (2) HUE032660T2 (enExample)
IL (1) IL193567A (enExample)
LT (1) LT2363392T (enExample)
LU (1) LU92232I2 (enExample)
MX (1) MX2008012527A (enExample)
NO (2) NO342090B1 (enExample)
NZ (1) NZ570887A (enExample)
PL (2) PL1999109T3 (enExample)
PT (2) PT2363392T (enExample)
RS (2) RS56171B1 (enExample)
SG (1) SG173338A1 (enExample)
SI (2) SI2363392T1 (enExample)
TW (1) TWI399366B (enExample)
UA (1) UA97802C2 (enExample)
WO (1) WO2007126733A2 (enExample)
ZA (1) ZA200807955B (enExample)

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PL1999109T3 (pl) 2006-03-30 2012-05-31 Univ Pennsylvania Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych
CA2699965A1 (en) * 2007-07-04 2009-01-08 Tohoku University Pet probe having an alkoxy group substituted by fluorine and hydroxy group
US8557222B2 (en) * 2008-04-04 2013-10-15 Avid Radiopharmaceuticals, Inc. Radiopharmaceutical imaging of neurodegenerative diseases
AU2009335049B2 (en) * 2008-12-31 2015-07-16 Avid Radiopharmaceuticals, Inc. Synthesis of 18F-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof
US8968701B2 (en) * 2009-07-10 2015-03-03 Piramal Imaging Sa Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
US20120263646A1 (en) 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
AU2010334929B2 (en) * 2009-12-23 2015-04-23 Lantheus Biosciences Ltd. Formulations suitable for pet imaging with hydrophobic pet agents
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
CA2801530C (en) 2010-06-04 2017-09-12 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
BR112012030946A2 (pt) * 2010-06-04 2016-11-01 Piramal Imaging Sa método para a produção de ligante para amiloide beta marcado com f-18
EA201201647A1 (ru) * 2010-06-04 2013-05-30 Пирамаль Имэджинг Са Способ получения f-18 меченных лигандов бета-амилоида
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
CN101891674B (zh) * 2010-06-24 2012-11-14 山东大学 4-苯乙烯基吡啶类化合物及其制备方法与应用
EP3263136A1 (en) * 2010-10-12 2018-01-03 Mayo Foundation for Medical Education and Research Imaging of meningiomas using stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
WO2012145169A2 (en) 2011-04-21 2012-10-26 The Regents Of The University Of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
CA2852840A1 (en) 2011-10-19 2013-04-25 Piramal Imaging Sa Improved method for production of f-18 labeled a.beta. ligands
CA2869398C (en) 2012-04-10 2019-10-22 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
JP6099045B2 (ja) * 2013-04-30 2017-03-22 国立大学法人京都大学 トリアゾロピリミジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
MX376163B (es) * 2014-05-13 2025-03-07 Hoffmann La Roche Compuestos heterocíclicos deuterados y su uso como agentes formadores de imágenes.
JP7114074B2 (ja) * 2015-08-18 2022-08-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 画像化のためのニトロキシドを含むアミロイド結合剤およびその治療的使用
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
KR20250107902A (ko) 2022-11-14 2025-07-14 일라이 릴리 앤드 캄파니 플로르베타피르 전구체 av-105의 다형체 형태

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Also Published As

Publication number Publication date
LU92232I2 (fr) 2013-08-26
US20080038195A1 (en) 2008-02-14
UA97802C2 (uk) 2012-03-26
RS52222B (sr) 2012-10-31
HRP20170857T1 (hr) 2017-12-01
ES2378785T3 (es) 2012-04-17
IL193567A (en) 2014-03-31
WO2007126733A2 (en) 2007-11-08
WO2007126733A3 (en) 2008-03-06
EP2363392B1 (en) 2017-05-03
SI2363392T1 (sl) 2017-09-29
ZA200807955B (en) 2012-11-28
CY1113048T1 (el) 2015-11-04
JP2009532349A (ja) 2009-09-10
EP2363392A1 (en) 2011-09-07
LT2363392T (lt) 2017-07-25
CY2013024I2 (el) 2015-11-04
FR13C0034I2 (fr) 2014-03-07
SI1999109T1 (sl) 2012-04-30
US8506929B2 (en) 2013-08-13
KR20080106564A (ko) 2008-12-08
CR10329A (es) 2008-10-29
HUE032660T2 (en) 2017-10-30
CA2644530A1 (en) 2007-11-08
EA200870389A1 (ru) 2009-04-28
CY1119048T1 (el) 2018-01-10
DK1999109T3 (da) 2012-04-02
SG173338A1 (en) 2011-08-29
US20090123369A1 (en) 2009-05-14
MX2008012527A (es) 2008-10-14
AU2007243712B2 (en) 2013-01-10
EP2363391A1 (en) 2011-09-07
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
ECSP088783A (es) 2008-10-31
EA017898B1 (ru) 2013-04-30
US8840866B2 (en) 2014-09-23
PL2363392T3 (pl) 2017-10-31
TW200838852A (en) 2008-10-01
EP1999109A2 (en) 2008-12-10
BE2013C044I2 (enExample) 2026-04-24
EP1999109B1 (en) 2011-12-28
NO2018030I1 (no) 2018-09-11
TWI399366B (zh) 2013-06-21
CN101522624B (zh) 2013-11-06
HRP20120135T1 (hr) 2012-03-31
ES2628882T3 (es) 2017-08-04
KR101376807B1 (ko) 2014-03-20
AU2007243712A1 (en) 2007-11-08
CA2644530C (en) 2015-05-19
US7687052B2 (en) 2010-03-30
NO20084590L (no) 2008-12-29
NO342090B1 (no) 2018-03-19
FR13C0034I1 (enExample) 2013-08-09
DK2363392T3 (en) 2017-07-03
BRPI0710225B1 (pt) 2021-07-13
NZ570887A (en) 2011-05-27
BRPI0710225A2 (pt) 2011-08-02
ATE539060T1 (de) 2012-01-15
CY2013024I1 (el) 2015-11-04
HUS1300028I1 (hu) 2017-08-28
PT1999109E (pt) 2012-03-16
US20130129624A1 (en) 2013-05-23
CN101522624A (zh) 2009-09-02
IL193567A0 (en) 2009-05-04
LU92232I9 (enExample) 2019-01-15
JP5290954B2 (ja) 2013-09-18
RS56171B1 (sr) 2017-11-30

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