KR100948532B1 - 분지형 중합체 및 그의 공액체 - Google Patents
분지형 중합체 및 그의 공액체 Download PDFInfo
- Publication number
- KR100948532B1 KR100948532B1 KR1020047006961A KR20047006961A KR100948532B1 KR 100948532 B1 KR100948532 B1 KR 100948532B1 KR 1020047006961 A KR1020047006961 A KR 1020047006961A KR 20047006961 A KR20047006961 A KR 20047006961A KR 100948532 B1 KR100948532 B1 KR 100948532B1
- Authority
- KR
- South Korea
- Prior art keywords
- poly
- polymer
- branched
- group
- biologically active
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33761301P | 2001-11-07 | 2001-11-07 | |
US60/337,613 | 2001-11-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20050044364A KR20050044364A (ko) | 2005-05-12 |
KR100948532B1 true KR100948532B1 (ko) | 2010-03-23 |
Family
ID=23321254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047006961A KR100948532B1 (ko) | 2001-11-07 | 2002-11-07 | 분지형 중합체 및 그의 공액체 |
Country Status (8)
Families Citing this family (221)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1446438A2 (en) * | 2001-11-07 | 2004-08-18 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
EP1591467A1 (en) * | 2002-09-09 | 2005-11-02 | Nektar Therapeutics Al, Corporation | Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone |
CA2498167C (en) * | 2002-09-09 | 2012-03-20 | Nektar Therapeutics Al, Corporation | Water-soluble polymer alkanals |
ATE412684T1 (de) | 2002-09-09 | 2008-11-15 | Nektar Therapeutics Al Corp | Verfahren zur herstellung von wasserlöslichen polymerderivaten mit terminalen carboxylgruppen |
AU2003295432A1 (en) | 2002-11-12 | 2004-06-03 | Enzon Pharmaceuticals, Inc. | Prodrugs of vancomycin with hydrolysis resistant polymer linkers |
US7273845B2 (en) | 2002-11-12 | 2007-09-25 | Enzon Pharmaceuticals, Inc. | Polymeric prodrugs of vancomycin |
GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
US20090123367A1 (en) * | 2003-03-05 | 2009-05-14 | Delfmems | Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases |
PT2177620E (pt) * | 2003-03-05 | 2015-02-16 | Halozyme Inc | Glicoproteína hialuronidase solúvel (shasegp), processo para preparação da mesma, suas utilizações e composições farmacêuticas que a compreendem |
US7871607B2 (en) * | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
US20060104968A1 (en) * | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US20040249119A1 (en) * | 2003-06-05 | 2004-12-09 | Fox Martin Edward | Novel mPEG propionaldehyde precursor |
GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
JP2007501812A (ja) * | 2003-08-08 | 2007-02-01 | ノボ ノルディスク アクティーゼルスカブ | ペプチドのための結合剤として新しい構造上十分に定義された枝分れしたポリマーの合成および適用 |
EP1675620B1 (en) | 2003-10-09 | 2019-05-08 | Ambrx, Inc. | Polymer derivatives |
EP2264191A1 (en) * | 2003-11-21 | 2010-12-22 | ANP Technologies, Inc. | Asymmetrically branched polymer conjugates and microarray assays |
GB2429207A (en) | 2004-02-02 | 2007-02-21 | Ambrx Inc | Modified human interferon polypeptides and their uses |
WO2005108463A2 (en) | 2004-05-03 | 2005-11-17 | Nektar Therapeutics Al, Corporation | Branched polyethylen glycol derivates comprising an acetal or ketal branching point |
JP2008503217A (ja) * | 2004-06-18 | 2008-02-07 | アンブレツクス・インコーポレイテツド | 新規抗原結合ポリペプチド及びそれらの使用 |
US7579444B2 (en) * | 2004-06-30 | 2009-08-25 | Nektar Therapeutics Al, Corporation | Polymer-factor IX moiety conjugates |
EP1773375A1 (en) | 2004-07-14 | 2007-04-18 | University of Utah Research Foundation | Netrin-related compositions and uses |
EP1768700B1 (en) * | 2004-07-16 | 2010-12-15 | Nektar Therapeutics | Conjugates comprising gm-csf and a polymer |
BRPI0512396A (pt) * | 2004-07-21 | 2008-03-11 | Ambrx Inc | polipeptìdeos biossintéticos utilizando aminoácidos codificados não naturalmente |
JP4920593B2 (ja) * | 2004-10-25 | 2012-04-18 | インテザイン テクノロジーズ, インコーポレイテッド | ヘテロ二官能性ポリ(エチレングリコール)およびそれらの使用 |
SG158149A1 (en) | 2004-12-22 | 2010-01-29 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
MX2007007587A (es) * | 2004-12-22 | 2007-12-11 | Ambrx Inc | Formulaciones de la hormona del crecimiento humano que comprenden un aminoacido codificado de manera no natural. |
BRPI0519430A2 (pt) | 2004-12-22 | 2009-02-10 | Ambrx Inc | hormânio do crescimento humano modificado |
WO2006073846A2 (en) | 2004-12-22 | 2006-07-13 | Ambrx, Inc. | Methods for expression and purification of recombinant human growth hormone |
CN101087875B (zh) * | 2004-12-22 | 2012-08-22 | Ambrx公司 | 氨酰基-tRNA合成酶的组合物及其用途 |
KR20070092754A (ko) | 2004-12-27 | 2007-09-13 | 백스터 인터내셔널 인코포레이티드 | 중합체 - 폰 빌레브란트 인자 - 접합체 |
WO2006094530A1 (en) * | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
WO2006102484A2 (en) * | 2005-03-21 | 2006-09-28 | Anp Technologies, Inc. | Symmetrically branched polymer conjugates and microarray assays |
WO2006102659A2 (en) * | 2005-03-23 | 2006-09-28 | Nektar Therapeutics Al, Corporation | CONJUGATES OF AN hGH MOIETY AND A POLYMER |
AU2006242303A1 (en) * | 2005-05-02 | 2006-11-09 | Anp Technologies, Inc. | Polymer conjugate enhanced bioassays |
CA2609205A1 (en) | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Improved human interferon molecules and their uses |
EP1926768B1 (en) | 2005-07-18 | 2011-09-14 | Nektar Therapeutics | Branched functionalized polymers using branched polyol cores |
JP2007112924A (ja) * | 2005-10-21 | 2007-05-10 | National Institute For Materials Science | 高分子架橋剤及びこの架橋剤を用いたリポソーム又は細胞の架橋体 |
WO2007059312A2 (en) | 2005-11-16 | 2007-05-24 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
CU23556A1 (es) * | 2005-11-30 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico |
CA2630327C (en) | 2005-12-08 | 2015-05-26 | Tyco Healthcare Group Lp | Biocompatible surgical compositons |
CA2882445A1 (en) * | 2005-12-14 | 2007-06-21 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
WO2007075534A2 (en) * | 2005-12-16 | 2007-07-05 | Nektar Therapeutics Al, Corporation | Polymer conjugates of glp-1 |
US9234059B2 (en) * | 2008-07-16 | 2016-01-12 | Outlast Technologies, LLC | Articles containing functional polymeric phase change materials and methods of manufacturing the same |
US8404341B2 (en) * | 2006-01-26 | 2013-03-26 | Outlast Technologies, LLC | Microcapsules and other containment structures for articles incorporating functional polymeric phase change materials |
US20100016513A1 (en) * | 2008-07-16 | 2010-01-21 | Outlast Technologies, Inc. | Functional Polymeric Phase Change Materials and Methods of Manufacturing the Same |
US20070173154A1 (en) * | 2006-01-26 | 2007-07-26 | Outlast Technologies, Inc. | Coated articles formed of microcapsules with reactive functional groups |
US20100012883A1 (en) * | 2008-07-16 | 2010-01-21 | Outlast Technologies, Inc. | Functional Polymeric Phase Change Materials |
SI1988910T1 (en) * | 2006-02-28 | 2018-02-28 | Kodiak Sciences Inc. | Polymeric conjugates containing acryloyloxyethylphosphorylcholine and their preparations |
EP1834963A1 (en) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
EP2010222A1 (en) * | 2006-03-31 | 2009-01-07 | Baxter International Inc. | Pegylated factor viii |
US7985839B2 (en) * | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
US7982010B2 (en) * | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
US7560588B2 (en) | 2006-04-27 | 2009-07-14 | Intezyne Technologies, Inc. | Poly(ethylene glycol) containing chemically disparate endgroups |
US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
EP2444499A3 (en) * | 2006-05-02 | 2012-05-09 | Allozyne, Inc. | Amino acid substituted molecules |
WO2008019217A2 (en) | 2006-07-17 | 2008-02-14 | The Research Foundation Of State University Of New York | Stereoregular romp polymers |
CA2662753C (en) | 2006-09-08 | 2016-02-23 | Ambrx, Inc. | Hybrid suppressor trna for vertebrate cells |
EP2615108B1 (en) | 2006-09-08 | 2016-10-26 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and thier uses |
US8367065B2 (en) * | 2006-09-15 | 2013-02-05 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
KR20090057235A (ko) * | 2006-09-15 | 2009-06-04 | 엔존 파마슈티컬즈, 인코포레이티드 | 리신계 폴리머 링커 |
WO2008074032A1 (en) | 2006-12-15 | 2008-06-19 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
US20140011964A1 (en) * | 2007-02-28 | 2014-01-09 | Serina Therapeutics, Inc. | Activated Polyoxazolines and Conjugates and Compositions Comprising the Same |
KR20160121601A (ko) | 2007-03-30 | 2016-10-19 | 암브룩스, 인코포레이티드 | 변형된 fgf-21 폴리펩티드 및 그 용도 |
EP2076533B1 (en) | 2007-05-02 | 2014-10-08 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
CA2707840A1 (en) | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
EP2192914A4 (en) * | 2007-08-20 | 2014-05-07 | Belrose Pharma Inc | POLYMER BINDERS CONTAINING PYRIDYL DISULFIDE GROUPS |
US8946148B2 (en) | 2007-11-20 | 2015-02-03 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
US9345809B2 (en) | 2007-11-28 | 2016-05-24 | Fziomed, Inc. | Carboxymethylcellulose polyethylene glycol compositions for medical uses |
NZ586947A (en) | 2008-02-08 | 2012-11-30 | Ambrx Inc | Modified leptin polypeptides and their uses |
TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
PL2272875T3 (pl) * | 2008-04-03 | 2014-06-30 | Biosteed Gene Expression Tech Co Ltd | Hormon wzrostu modyfikowany dwuniciowym glikolem polietylenowym, sposoby otrzymywania i stosowania |
CA3096629A1 (en) | 2008-04-14 | 2009-10-22 | Halozyme, Inc. | Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions |
TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
US8476404B1 (en) * | 2008-07-04 | 2013-07-02 | Bhalchandra Shripad Lele | Selectively functionalized polyhydric compounds |
US8221910B2 (en) | 2008-07-16 | 2012-07-17 | Outlast Technologies, LLC | Thermal regulating building materials and other construction components containing polymeric phase change materials |
US20100015430A1 (en) * | 2008-07-16 | 2010-01-21 | Outlast Technologies, Inc. | Heat Regulating Article With Moisture Enhanced Temperature Control |
US10138283B2 (en) | 2008-07-23 | 2018-11-27 | Ambrx, Inc. | Modified bovine G-CSF polypeptides and their uses |
CA2732508C (en) | 2008-08-11 | 2016-03-15 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
WO2010033224A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
WO2010033217A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of cd-np peptides |
WO2010033223A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of opioid growth factor peptides |
WO2010033205A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of v681-like peptides |
US20110171162A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of thymosin alpha 1 peptides |
US20110165112A1 (en) * | 2008-09-19 | 2011-07-07 | Nektar Therapeutics | Polymer conjugates of c-peptides |
EP2337585A1 (en) * | 2008-09-19 | 2011-06-29 | Nektar Therapeutics | Polymer conjugates of glp-2-like peptides |
CA2737040C (en) * | 2008-09-19 | 2017-05-02 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
EP2344200A2 (en) * | 2008-09-19 | 2011-07-20 | Nektar Therapeutics | Modified therapeutics peptides, methods of their preparation and use |
US20110171166A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of osteocalcin peptides |
EP2340050A2 (en) * | 2008-09-19 | 2011-07-06 | Nektar Therapeutics | Polymer conjugates of aod-like peptides |
US20110171161A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of protegrin peptides |
US20110171163A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of ziconotide peptides |
NZ601659A (en) | 2008-09-26 | 2014-02-28 | Ambrx Inc | Modified animal erythropoietin polypeptides and their uses |
EA201170493A1 (ru) | 2008-09-26 | 2011-10-31 | Амбркс, Инк. | Микроорганизмы и вакцины, зависимые от репликации неприродных аминокислот |
JP4966434B2 (ja) * | 2008-10-15 | 2012-07-04 | バクスター・インターナショナル・インコーポレイテッド | 結合抗体の存在下における組換え血液凝固因子のpeg化 |
CA2915783C (en) | 2008-12-09 | 2020-07-21 | Halozyme, Inc. | Extended soluble ph20 polypeptides and uses thereof |
CN101870728A (zh) | 2009-04-23 | 2010-10-27 | 派格生物医药(苏州)有限公司 | 新型Exendin变体及其缀合物 |
TW201042257A (en) * | 2009-05-26 | 2010-12-01 | Baxter Int | Detection of antibody that binds to water soluble polymer-modified polypeptides |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
DK2459224T3 (en) * | 2009-07-27 | 2016-07-25 | Baxalta GmbH | Blodstørkningsproteinkonjugater |
AU2010277438B2 (en) | 2009-07-27 | 2015-08-20 | Baxalta GmbH | Glycopolysialylation of non-blood coagulation proteins |
EP3093029A1 (en) | 2009-07-27 | 2016-11-16 | Baxalta GmbH | Blood coagulation protein conjugates |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
JP5734985B2 (ja) | 2009-09-17 | 2015-06-17 | バクスター・ヘルスケヤー・ソシエテ・アノニムBaxter Healthcare SA | ヒアルロニダーゼおよび免疫グロブリンの安定な共製剤およびそれらの使用方法 |
US20110081398A1 (en) * | 2009-10-01 | 2011-04-07 | Tyco Healthcare Group Lp | Multi-mechanism surgical compositions |
US20110081701A1 (en) * | 2009-10-02 | 2011-04-07 | Timothy Sargeant | Surgical compositions |
US8968785B2 (en) * | 2009-10-02 | 2015-03-03 | Covidien Lp | Surgical compositions |
WO2011050052A2 (en) * | 2009-10-20 | 2011-04-28 | Georgia State University Research Foundation, Inc. | Protein agent for diabetes treatment and beta cell imaging |
WO2011081915A2 (en) * | 2009-12-15 | 2011-07-07 | Cebix Inc. | Methods for treating erectile dysfunction in patients with insulin-dependent diabetes |
WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
WO2011087810A1 (en) | 2009-12-21 | 2011-07-21 | Ambrx, Inc. | Modified porcine somatotropin polypeptides and their uses |
MX349301B (es) | 2009-12-21 | 2017-07-21 | Ambrx Inc | Polipéptidos de somatotropina bovina modificados y sus usos. |
EP2536753B1 (en) * | 2010-02-16 | 2017-12-20 | Novo Nordisk A/S | Factor viii molecules with reduced vwf binding |
WO2011146518A2 (en) * | 2010-05-17 | 2011-11-24 | Cebix Inc. | Pegylated c-peptide |
US10040761B2 (en) | 2010-06-25 | 2018-08-07 | Nof Corporation | Branched hetero polyethylene glycol and intermediate |
JP5825507B2 (ja) * | 2010-06-25 | 2015-12-02 | 日油株式会社 | 分岐型ヘテロポリエチレングリコール |
EP2595624B1 (en) | 2010-07-20 | 2018-01-31 | Halozyme, Inc. | Methods of treatment or prevention of the adverse side-effects associated with administration of an anti-hyaluronan agent |
JP6325818B2 (ja) | 2010-07-30 | 2018-05-16 | バクスアルタ ゲーエムベーハー | オキシム連結のための求核触媒 |
RS65223B1 (sr) | 2010-08-17 | 2024-03-29 | Ambrx Inc | Modifikovani polipeptidi relaksina i njihova primena |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
CN103189409B (zh) * | 2010-09-01 | 2015-11-25 | 巴斯夫欧洲公司 | 用于增溶微溶性活性成分的两亲物 |
US8841382B2 (en) | 2010-09-01 | 2014-09-23 | Basf Se | Hyperbranched polyethers/dendrimers for solubilzation of sparingly soluble active ingredients |
CN104788557A (zh) * | 2010-09-15 | 2015-07-22 | 诺沃—诺迪斯克有限公司 | 具有减少的细胞摄取的因子viii变体 |
TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
WO2012054822A1 (en) | 2010-10-22 | 2012-04-26 | Nektar Therapeutics | Pharmacologically active polymer-glp-1 conjugates |
US20140371258A1 (en) | 2010-12-17 | 2014-12-18 | Nektar Therapeutics | Water-Soluble Polymer Conjugates of Topotecan |
EP2654795B1 (en) | 2010-12-21 | 2018-03-07 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds |
US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
CA2822591C (en) | 2010-12-22 | 2020-12-29 | Baxter International Inc. | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
WO2012088506A1 (en) | 2010-12-23 | 2012-06-28 | Nektar Therapeutics | Polymer-semaxanib moiety conjugates |
JP6009457B2 (ja) | 2010-12-23 | 2016-10-19 | ネクター セラピューティクス | ポリマー−デスエチルスニチニブコンジュゲート |
JP6002149B2 (ja) | 2010-12-23 | 2016-10-05 | ネクター セラピューティクス | ポリマー−スニチニブコンジュゲート |
EP2907504B1 (en) | 2011-02-08 | 2017-06-28 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
US8673448B2 (en) | 2011-03-04 | 2014-03-18 | Outlast Technologies Llc | Articles containing precisely branched functional polymeric phase change materials |
MX343093B (es) | 2011-04-06 | 2016-10-25 | Stepan Co | Polimeros de uretano hidrofilos, de multiples brazos, metodos para prepararlos, y composiciones y procesos que los emplean. |
WO2012166555A1 (en) | 2011-05-27 | 2012-12-06 | Nektar Therapeutics | Water - soluble polymer - linked binding moiety and drug compounds |
EP2714093A1 (en) | 2011-05-27 | 2014-04-09 | Baxter International Inc. | Therapeutic proteins with increased half-life and methods of preparing same |
AU2012271361B2 (en) | 2011-06-17 | 2017-03-02 | Halozyme, Inc. | Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme |
US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
WO2013040501A1 (en) | 2011-09-16 | 2013-03-21 | Pharmathene, Inc. | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof |
JP6162707B2 (ja) | 2011-10-24 | 2017-07-12 | ハロザイム インコーポレイテッド | 抗ヒアルロナン剤治療のためのコンパニオン診断およびその使用方法 |
EP2780030A4 (en) | 2011-11-17 | 2015-11-18 | Cebix Ab | PEGYLATED C-PEPTIDE |
JP6067746B2 (ja) | 2011-12-30 | 2017-01-25 | ハロザイム インコーポレイテッド | Ph20ポリペプチド変異体、その製剤および使用 |
CA2869128C (en) | 2012-03-30 | 2022-07-26 | The Board Of Regents Of The University Of Oklahoma | High molecular weight heparosan polymers and methods of production and use thereof |
SI2833905T1 (en) | 2012-04-04 | 2018-08-31 | Halozyme, Inc. | Combination therapy with hyaluronidase and tumane-directed taxane |
AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
EP3505534A1 (en) | 2012-06-08 | 2019-07-03 | Sutro Biopharma, Inc. | Antibodies comprising sitespecific nonnatural amino acid residues, methods of their preparation and methods of their use |
US9732161B2 (en) | 2012-06-26 | 2017-08-15 | Sutro Biopharma, Inc. | Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
PL3584255T3 (pl) | 2012-08-31 | 2022-05-16 | Sutro Biopharma, Inc. | Modyfikowane aminokwasy zawierające grupę azydkową |
WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
DK2947111T3 (en) * | 2013-01-17 | 2018-05-07 | Xiamen Sinopeg Biotech Co Ltd | MONOFUNCTIONAL BRANCHED POLYETHYLENE LYCOL AND BIORELATED SUBSTANCE MODIFIED BY SAME |
KR102247959B1 (ko) | 2013-02-04 | 2021-05-06 | 더블유.엘. 고어 앤드 어소시에이트스, 인코포레이티드 | 기재용 코팅 |
US9272075B2 (en) | 2013-02-04 | 2016-03-01 | W.L. Gore & Associates, Inc. | Coating for substrate |
TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ph20玻尿酸酶變異體及其用途 |
US9764039B2 (en) | 2013-07-10 | 2017-09-19 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
JP6463361B2 (ja) | 2013-09-08 | 2019-01-30 | コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. | 第viii因子両性イオンポリマーコンジュゲート |
US9840493B2 (en) | 2013-10-11 | 2017-12-12 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
EA201690780A1 (ru) | 2013-10-15 | 2016-08-31 | Сиэтл Дженетикс, Инк. | Пегилированные лекарственные средства-линкеры для улучшенной фармакокинетики конъюгатов лиганд-лекарственное средство |
EP3092263B1 (en) * | 2014-01-10 | 2018-02-21 | ETH Zurich | Polyethylene glycol substituted acyl borates |
JP6106103B2 (ja) * | 2014-01-16 | 2017-03-29 | 信越化学工業株式会社 | 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法、並びにこれに用いる新規なアセタール基含有アルコール化合物及びそのアルカリ金属塩 |
JP6106104B2 (ja) | 2014-01-16 | 2017-03-29 | 信越化学工業株式会社 | 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法 |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
CN104109238A (zh) * | 2014-07-13 | 2014-10-22 | 成都市绿科华通科技有限公司 | 六方孔状功能聚乙二醇的制备方法 |
WO2016033555A1 (en) | 2014-08-28 | 2016-03-03 | Halozyme, Inc. | Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor |
KR101585795B1 (ko) * | 2014-10-14 | 2016-01-15 | 주식회사 파이토켐텍 | 활성 성분으로 디에칠렌글라이콜모노벤질에텔을 함유하는 보존제 조성물 |
KR102122463B1 (ko) | 2014-10-14 | 2020-06-15 | 할로자임, 아이엔씨 | 아데노신 디아미네이즈-2(ada2)의 조성물, 이의 변이체 및 이를 사용하는 방법 |
CN107208076A (zh) | 2014-10-17 | 2017-09-26 | 科达制药 | 丁酰胆碱酯酶两性离子聚合物缀合物 |
CA2965502A1 (en) | 2014-10-24 | 2016-04-28 | Bristol-Myers Squibb Company | Modified fgf-21 polypeptides and uses thereof |
DK3221331T3 (da) | 2014-11-19 | 2019-12-02 | Nzp Uk Ltd | 6-alkyl-7-hydroxy-4-en-3-on-steroider som mellemprodukter til fremstilling af steroide fxr-modulatorer |
JP6735748B2 (ja) | 2014-11-19 | 2020-08-05 | エヌゼットピー ユーケー リミテッド | ステロイドFXRモジュレーター製造のための中間体としての6α−アルキル−3,7−ジオン−ステロイド |
CA2968301C (en) | 2014-11-19 | 2023-05-16 | NZP UK Limited | 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators |
CA2968310A1 (en) | 2014-11-19 | 2016-05-26 | NZP UK Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
US10003053B2 (en) | 2015-02-04 | 2018-06-19 | Global Web Horizons, Llc | Systems, structures and materials for electrochemical device thermal management |
US10431858B2 (en) | 2015-02-04 | 2019-10-01 | Global Web Horizons, Llc | Systems, structures and materials for electrochemical device thermal management |
US10120948B2 (en) | 2015-10-13 | 2018-11-06 | Google Llc | Providing notifications based on geofencing search results |
TWI814699B (zh) | 2015-12-04 | 2023-09-11 | 美商思進公司 | 四級胺化妥布賴森(tubulysin)化合物之結合物 |
US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
CN106905120B (zh) * | 2015-12-21 | 2020-04-28 | 北京键凯科技股份有限公司 | Y型多缩乙二醇衍生物及其制备方法 |
RU2744860C2 (ru) | 2015-12-30 | 2021-03-16 | Кодиак Сайенсиз Инк. | Антитела и их конъюгаты |
CA3011455A1 (en) | 2016-01-27 | 2017-08-03 | Sutro Biopharma, Inc. | Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates |
WO2017165851A1 (en) | 2016-03-25 | 2017-09-28 | Seattle Genetics, Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
WO2018066692A1 (ja) * | 2016-10-07 | 2018-04-12 | 国立大学法人東京工業大学 | 分岐型ヘテロ単分散ポリエチレングリコール、その製造方法、及びその結合体 |
US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
TW201837051A (zh) | 2017-02-08 | 2018-10-16 | 美商必治妥美雅史谷比公司 | 包含藥物動力學增強劑之經修飾之鬆弛素(relaxin)多肽及其用途 |
IL269398B1 (en) | 2017-03-24 | 2024-01-01 | Seagen Inc | A process for the preparation of glucuronide-drug binders and their intermediates |
KR20200030063A (ko) | 2017-06-22 | 2020-03-19 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 변형된 막 유형 세린 프로테아제 1(mtsp-1) 폴리펩티드 및 사용 방법 |
AR112756A1 (es) | 2017-07-11 | 2019-12-11 | Synthorx Inc | Incorporación de nucleótidos no naturales, y su método |
EP3661955A4 (en) | 2017-08-03 | 2021-05-26 | Synthorx, Inc. | CYTOKINE CONJUGATES FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
EP3684814A1 (en) | 2017-09-18 | 2020-07-29 | Sutro Biopharma, Inc. | Anti-folate receptor alpha antibody conjugates and their uses |
WO2019222435A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
JP7441826B2 (ja) | 2018-09-11 | 2024-03-01 | アンブルックス,インコーポレイテッド | インターロイキン-2ポリペプチド抱合物およびその使用 |
WO2020060944A1 (en) | 2018-09-17 | 2020-03-26 | Sutro Biopharma, Inc. | Combination therapies with anti-folate receptor antibody conjugates |
CN110964116A (zh) | 2018-09-26 | 2020-04-07 | 北京辅仁瑞辉生物医药研究院有限公司 | GLP1-Fc融合蛋白及其缀合物 |
WO2020082057A1 (en) | 2018-10-19 | 2020-04-23 | Ambrx, Inc. | Interleukin-10 polypeptide conjugates, dimers thereof, and their uses |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
WO2020140101A1 (en) | 2018-12-28 | 2020-07-02 | Catalyst Biosciences, Inc. | Modified urokinase-type plasminogen activator polypeptides and methods of use |
CN114949240A (zh) | 2019-02-06 | 2022-08-30 | 新索思股份有限公司 | Il-2缀合物及其使用方法 |
SG11202108254YA (en) | 2019-02-12 | 2021-08-30 | Ambrx Inc | Compositions containing, methods and uses of antibody-tlr agonist conjugates |
US20220362394A1 (en) | 2019-05-03 | 2022-11-17 | Sutro Biopharma, Inc. | Anti-bcma antibody conjugates |
EP3980423A1 (en) | 2019-06-10 | 2022-04-13 | Sutro Biopharma, Inc. | 5h-pyrrolo[3,2-d]pyrimidine-2,4-diamino compounds and antibody conjugates thereof |
JP2022536800A (ja) | 2019-06-17 | 2022-08-18 | ストロ バイオファーマ インコーポレーテッド | Toll様受容体(tlr)7/8アゴニストとしての1-(4-(アミノメチル)ベンジル)-2-ブチル-2h-ピラゾロ[3,4-c]キノリン-4-アミン誘導体および関連化合物、ならびにがん療法および診断に使用するためのその抗体薬物コンジュゲート |
CN112175088B (zh) | 2019-07-02 | 2023-03-28 | 江苏晟斯生物制药有限公司 | 改进的fix融合蛋白、缀合物及其应用 |
AU2020347154A1 (en) | 2019-09-10 | 2022-03-03 | Synthorx, Inc. | IL-2 conjugates and methods of use to treat autoimmune diseases |
CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
AU2020380275A1 (en) | 2019-11-04 | 2022-04-14 | Synthorx, Inc. | Interleukin 10 conjugates and uses thereof |
EP4114852A1 (en) | 2020-03-03 | 2023-01-11 | Sutro Biopharma, Inc. | Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use |
KR20220151202A (ko) | 2020-03-11 | 2022-11-14 | 암브룩스, 인코포레이티드 | 인터류킨-2 폴리펩타이드 접합체 및 그의 사용 방법 |
CA3128035A1 (en) | 2020-08-13 | 2022-02-13 | Bioasis Technologies, Inc. | Combination therapies for delivery across the blood brain barrier |
TW202227449A (zh) | 2020-08-20 | 2022-07-16 | 美商Ambrx 公司 | 抗體-tlr促效劑偶聯物、其方法及用途 |
TW202228784A (zh) | 2020-09-23 | 2022-08-01 | 奧地利商艾柏力維亞生技有限公司 | 用以於一患者中螯合非預期的抗peg抗體的化合物 |
WO2022103983A2 (en) | 2020-11-11 | 2022-05-19 | Sutro Biopharma, Inc. | Fluorenylmethyloxycarbonyl and fluorenylmethylaminocarbonyl compounds, protein conjugates thereof, and methods for their use |
KR20240004342A (ko) | 2021-04-03 | 2024-01-11 | 암브룩스, 인코포레이티드 | 항-her2 항체-약물 접합체 및 이의 용도 |
KR20240004659A (ko) | 2021-04-30 | 2024-01-11 | 셀진 코포레이션 | 감마 세크레타제 억제제(gsi)와 병용하여 항-bcma 항체-약물 접합체(adc)를 사용하는 병용 요법 |
WO2024006272A1 (en) | 2022-06-27 | 2024-01-04 | Sutro Biopharma, Inc. | β-GLUCURONIDE LINKER-PAYLOADS, PROTEIN CONJUGATES THEREOF, AND METHODS THEREOF |
US20240058465A1 (en) | 2022-06-30 | 2024-02-22 | Sutro Biopharma, Inc. | Anti-ror1 antibody conjugates, compositions comprising anti ror1 antibody conjugates, and methods of making and using anti-ror1 antibody conjugates |
WO2024015229A1 (en) | 2022-07-15 | 2024-01-18 | Sutro Biopharma, Inc. | Protease/enzyme cleavable linker-payloads and protein conjugates |
WO2024044780A1 (en) | 2022-08-26 | 2024-02-29 | Sutro Biopharma, Inc. | Interleukin-18 variants and uses thereof |
CN115873231A (zh) * | 2022-12-17 | 2023-03-31 | 华南理工大学 | 一种聚乙二醇修饰的氨基糖苷类分子及其制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
JPH0367541A (ja) | 1989-08-04 | 1991-03-22 | Meiji Milk Prod Co Ltd | 洋菓子及びコーヒー兼用のホイップ性合成クリーム |
US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
US6191105B1 (en) * | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
EP0641853B1 (en) * | 1993-08-16 | 1998-10-21 | Nalco/Exxon Energy Chemicals L.P. | Method of demulsifying water-in-oil emulsions |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5605976A (en) * | 1995-05-15 | 1997-02-25 | Enzon, Inc. | Method of preparing polyalkylene oxide carboxylic acids |
US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
JP3067541B2 (ja) | 1994-08-23 | 2000-07-17 | 日本油脂株式会社 | グリセリンポリアルキレングリコールエーテル誘導体及びその製造方法 |
US5756593A (en) * | 1995-05-15 | 1998-05-26 | Enzon, Inc. | Method of preparing polyalkyene oxide carboxylic acids |
DE69636289T2 (de) * | 1995-12-18 | 2007-05-10 | Angiodevice International Gmbh | Vernetzten polymerisatmassen und verfahren für ihre verwendung |
US6258351B1 (en) * | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
EP0885913B1 (en) * | 1996-12-09 | 2003-04-16 | Daiso Co., Ltd. | Copolyether and solid polymer electrolyte |
US5746814A (en) * | 1997-05-07 | 1998-05-05 | Xerox Corporation | Decurling compositions |
US6056811A (en) * | 1997-08-25 | 2000-05-02 | Canon Kabushiki Kaisha | Water-based ink for ink-jet recording, ink-jet recording process, recording unit, ink cartridge and ink-jet recording apparatus |
JP3921781B2 (ja) * | 1998-02-12 | 2007-05-30 | 日本油脂株式会社 | カルボキシル基含有ポリオキシアルキレン化合物 |
ATE268609T1 (de) * | 1998-03-12 | 2004-06-15 | Nektar Therapeutics Al Corp | Polyethylenglycolderivate mit benachbarten reaktiven gruppen |
JP4055250B2 (ja) * | 1998-06-15 | 2008-03-05 | 日油株式会社 | アミノ基含有ポリオキシアルキレン化合物 |
US6328988B1 (en) | 1999-04-23 | 2001-12-11 | Rutgers, The State University Of New Jersey | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules |
US6348558B1 (en) * | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
WO2001049268A1 (en) | 2000-01-05 | 2001-07-12 | Imarx Therapeutics, Inc. | Pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
CA2436623C (en) | 2001-01-30 | 2011-08-02 | Kyowa Hakko Kogyo Co., Ltd. | Branched polyalkylene glycols |
EP1446438A2 (en) | 2001-11-07 | 2004-08-18 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
-
2002
- 2002-11-07 EP EP02789492A patent/EP1446438A2/en active Pending
- 2002-11-07 CA CA2466027A patent/CA2466027C/en not_active Expired - Lifetime
- 2002-11-07 US US10/290,082 patent/US7026440B2/en not_active Expired - Lifetime
- 2002-11-07 WO PCT/US2002/035759 patent/WO2003040211A2/en active Application Filing
- 2002-11-07 AU AU2002352524A patent/AU2002352524B2/en not_active Expired
- 2002-11-07 JP JP2003542253A patent/JP4758608B2/ja not_active Expired - Lifetime
- 2002-11-07 MX MXPA04004336A patent/MXPA04004336A/es active IP Right Grant
- 2002-11-07 KR KR1020047006961A patent/KR100948532B1/ko active IP Right Grant
-
2006
- 2006-01-20 US US11/336,695 patent/US7872072B2/en not_active Expired - Lifetime
-
2010
- 2010-12-08 US US12/963,170 patent/US8273833B2/en not_active Expired - Lifetime
-
2012
- 2012-08-24 US US13/593,861 patent/US8440816B2/en not_active Expired - Lifetime
-
2013
- 2013-04-18 US US13/865,912 patent/US8809453B2/en not_active Expired - Lifetime
-
2014
- 2014-07-17 US US14/334,223 patent/US9187569B2/en not_active Expired - Fee Related
-
2015
- 2015-10-13 US US14/882,265 patent/US20160032049A1/en not_active Abandoned
-
2019
- 2019-10-01 US US16/590,235 patent/US20200048412A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
Also Published As
Publication number | Publication date |
---|---|
MXPA04004336A (es) | 2005-05-16 |
US20160032049A1 (en) | 2016-02-04 |
WO2003040211A2 (en) | 2003-05-15 |
CA2466027A1 (en) | 2003-05-15 |
JP2005508421A (ja) | 2005-03-31 |
US8809453B2 (en) | 2014-08-19 |
US7872072B2 (en) | 2011-01-18 |
AU2002352524B2 (en) | 2007-10-04 |
CA2466027C (en) | 2013-01-08 |
US8440816B2 (en) | 2013-05-14 |
US9187569B2 (en) | 2015-11-17 |
EP1446438A2 (en) | 2004-08-18 |
US20060178475A1 (en) | 2006-08-10 |
US20200048412A1 (en) | 2020-02-13 |
US7026440B2 (en) | 2006-04-11 |
KR20050044364A (ko) | 2005-05-12 |
WO2003040211A3 (en) | 2003-07-03 |
US20120322134A1 (en) | 2012-12-20 |
US20140329994A1 (en) | 2014-11-06 |
JP4758608B2 (ja) | 2011-08-31 |
US20130295639A1 (en) | 2013-11-07 |
US20110077362A1 (en) | 2011-03-31 |
US8273833B2 (en) | 2012-09-25 |
US20030143596A1 (en) | 2003-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100948532B1 (ko) | 분지형 중합체 및 그의 공액체 | |
AU2002352524A1 (en) | Branched polymers and their conjugates | |
EP1259562B1 (en) | Sterically hindered derivatives of water soluble polymers | |
US8084572B2 (en) | Segmented polymers and their conjugates | |
US9040060B2 (en) | Hydrolytically degradable alkylene oxide based polymers | |
KR101178744B1 (ko) | 프로피온산-말단 중합체의 제조 방법 | |
JP5544085B2 (ja) | 重合体試薬と重合体試薬の組成物の調製方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
N231 | Notification of change of applicant | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20130227 Year of fee payment: 4 |
|
FPAY | Annual fee payment |
Payment date: 20140227 Year of fee payment: 5 |
|
FPAY | Annual fee payment |
Payment date: 20150227 Year of fee payment: 6 |
|
FPAY | Annual fee payment |
Payment date: 20151230 Year of fee payment: 7 |
|
FPAY | Annual fee payment |
Payment date: 20161229 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20171228 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20181227 Year of fee payment: 10 |