KR100713311B1 - 알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ - Google Patents

알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ Download PDF

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Publication number
KR100713311B1
KR100713311B1 KR1020007010698A KR20007010698A KR100713311B1 KR 100713311 B1 KR100713311 B1 KR 100713311B1 KR 1020007010698 A KR1020007010698 A KR 1020007010698A KR 20007010698 A KR20007010698 A KR 20007010698A KR 100713311 B1 KR100713311 B1 KR 100713311B1
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South Korea
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disease
pharmaceutical composition
composition according
animal
anzuroginin
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Expired - Fee Related
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KR1020007010698A
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English (en)
Korean (ko)
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KR20010042205A (ko
Inventor
종킨 지아
예어 후
이안 루빈
조나단 브로스토프
브라이언 화이틀
웨이준 왕
필 건닝
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파이토팜 피엘씨
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Priority claimed from GBGB9806513.9A external-priority patent/GB9806513D0/en
Priority claimed from GBGB9905275.5A external-priority patent/GB9905275D0/en
Application filed by 파이토팜 피엘씨 filed Critical 파이토팜 피엘씨
Publication of KR20010042205A publication Critical patent/KR20010042205A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/944—Acetylcholine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
KR1020007010698A 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ Expired - Fee Related KR100713311B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9806513.9 1998-03-26
GBGB9806513.9A GB9806513D0 (en) 1998-03-26 1998-03-26 Membrane-bound receptors
GB9905275.5 1999-03-08
GBGB9905275.5A GB9905275D0 (en) 1999-03-08 1999-03-08 Treatment of conditions associated with membrane-bound receptors and their function

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020067027786A Division KR20070007214A (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및안주로게닌-ｄ

Publications (2)

Publication Number Publication Date
KR20010042205A KR20010042205A (ko) 2001-05-25
KR100713311B1 true KR100713311B1 (ko) 2007-05-04

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ID=26313369

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1020007010698A Expired - Fee Related KR100713311B1 (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ
KR1020097000085A Expired - Fee Related KR101092050B1 (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ
KR1020077027370A Ceased KR20070117001A (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및안주로게닌-ｄ
KR1020067027786A Ceased KR20070007214A (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및안주로게닌-ｄ
KR1020097000581A Ceased KR20090009997A (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ
KR1020007010677A Expired - Fee Related KR100632052B1 (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스테로이드계 사포게닌 및 이의 유도체

Family Applications After (5)

Application Number Title Priority Date Filing Date
KR1020097000085A Expired - Fee Related KR101092050B1 (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ
KR1020077027370A Ceased KR20070117001A (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및안주로게닌-ｄ
KR1020067027786A Ceased KR20070007214A (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및안주로게닌-ｄ
KR1020097000581A Ceased KR20090009997A (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스밀라게닌 및 안주로게닌-ｄ
KR1020007010677A Expired - Fee Related KR100632052B1 (ko) 1998-03-26 1999-03-26 알츠하이머병을 치료하기 위한 스테로이드계 사포게닌 및 이의 유도체

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US (2) US6812213B2 (enExample)
EP (3) EP1719512B1 (enExample)
JP (4) JP3768100B2 (enExample)
KR (6) KR100713311B1 (enExample)
CN (3) CN1198622C (enExample)
AT (3) ATE337788T1 (enExample)
AU (2) AU748138B2 (enExample)
BR (2) BR9909110A (enExample)
CA (2) CA2325633C (enExample)
CY (1) CY1105653T1 (enExample)
DE (3) DE69943415D1 (enExample)
DK (2) DK1719512T3 (enExample)
ES (2) ES2272060T3 (enExample)
GB (1) GB2335599B (enExample)
HR (2) HRP20000637A2 (enExample)
HU (2) HUP0103654A2 (enExample)
ID (2) ID26989A (enExample)
IL (4) IL138663A0 (enExample)
IS (2) IS5637A (enExample)
MX (1) MXPA00009437A (enExample)
NO (4) NO20004803L (enExample)
NZ (1) NZ507355A (enExample)
PL (3) PL207723B1 (enExample)
PT (1) PT1066042E (enExample)
RU (1) RU2297228C2 (enExample)
TR (2) TR200002774T2 (enExample)
WO (2) WO1999048507A2 (enExample)

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GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
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EP1809298A4 (en) * 2004-10-14 2008-06-18 Univ Georgetown NEUROPROTECTIVE PHARMACEUTICAL SPIROSTENOL COMPOSITIONS
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KR101027384B1 (ko) * 2009-06-29 2011-04-11 에이디엠이십일 주식회사 플랫와이퍼블레이드와 와이퍼아암의 연결장치
AU2010207597A1 (en) 2009-01-24 2011-08-18 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
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CN102389438A (zh) * 2011-06-30 2012-03-28 北京师范大学 黄芪甲苷的应用
JP5789339B2 (ja) * 2013-01-21 2015-10-07 レジリオ株式会社 アルツハイマー病等を含む神経疾患の１，２５ｄ３−ｍａｒｒｓが関与する治療薬及び治療法
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