KR100681724B1 - 티로신 키나제 억제제 및 이를 포함하는 약제학적 조성물 - Google Patents
티로신 키나제 억제제 및 이를 포함하는 약제학적 조성물 Download PDFInfo
- Publication number
- KR100681724B1 KR100681724B1 KR1020027004985A KR20027004985A KR100681724B1 KR 100681724 B1 KR100681724 B1 KR 100681724B1 KR 1020027004985 A KR1020027004985 A KR 1020027004985A KR 20027004985 A KR20027004985 A KR 20027004985A KR 100681724 B1 KR100681724 B1 KR 100681724B1
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- oxo
- indol
- ylmethyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 C**(CC1)Cc2c1cccc2 Chemical compound C**(CC1)Cc2c1cccc2 0.000 description 11
- CWXPZXBSDSIRCS-UHFFFAOYSA-N CC(C)(C)OC(N1CCNCC1)=O Chemical compound CC(C)(C)OC(N1CCNCC1)=O CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 description 1
- MCIJVHSZSCFULS-UHFFFAOYSA-N CC(N1CCN(Cc(cc2)cc3c2[nH]c(C2=Cc(cccc4)c4NC2=O)c3)CCC1)=O Chemical compound CC(N1CCN(Cc(cc2)cc3c2[nH]c(C2=Cc(cccc4)c4NC2=O)c3)CCC1)=O MCIJVHSZSCFULS-UHFFFAOYSA-N 0.000 description 1
- RFEHWDIKAGETSR-UHFFFAOYSA-N CC(c1ccc2[nH]c(C3=Cc4ccccc4NC3=O)cc2c1)N(CC1)CCN1S(C)(=O)=O Chemical compound CC(c1ccc2[nH]c(C3=Cc4ccccc4NC3=O)cc2c1)N(CC1)CCN1S(C)(=O)=O RFEHWDIKAGETSR-UHFFFAOYSA-N 0.000 description 1
- KNDFSRNKGXJFGN-ZIAGYGMSSA-O CCO[C@H]1C[N@H+](Cc2ccccc2)[C@@H](CO)C1 Chemical compound CCO[C@H]1C[N@H+](Cc2ccccc2)[C@@H](CO)C1 KNDFSRNKGXJFGN-ZIAGYGMSSA-O 0.000 description 1
- GPPXJGVECOPHES-UHFFFAOYSA-N CN(CCO)CCOC Chemical compound CN(CCO)CCOC GPPXJGVECOPHES-UHFFFAOYSA-N 0.000 description 1
- PFGZTGYXMOMDEB-UHFFFAOYSA-N COCCN(CCC(O)=O)CCO Chemical compound COCCN(CCC(O)=O)CCO PFGZTGYXMOMDEB-UHFFFAOYSA-N 0.000 description 1
- LCAYTGFTCJWLHH-UHFFFAOYSA-N COCCN(CCCO)Cc1ccccc1 Chemical compound COCCN(CCCO)Cc1ccccc1 LCAYTGFTCJWLHH-UHFFFAOYSA-N 0.000 description 1
- NFERSMBSJVXTNH-UHFFFAOYSA-N COCCN(CCOc1ccc2[nH]c(C3=Cc(cccc4)c4NC3=O)cc2c1)Cc(cn1)cnc1OC Chemical compound COCCN(CCOc1ccc2[nH]c(C3=Cc(cccc4)c4NC3=O)cc2c1)Cc(cn1)cnc1OC NFERSMBSJVXTNH-UHFFFAOYSA-N 0.000 description 1
- DGHJDQWMURFJPZ-UHFFFAOYSA-N COCCN(CCOc1ccc2[nH]c(C3=Cc4ccccc4NC3=O)cc2c1)Cc1ccccc1 Chemical compound COCCN(CCOc1ccc2[nH]c(C3=Cc4ccccc4NC3=O)cc2c1)Cc1ccccc1 DGHJDQWMURFJPZ-UHFFFAOYSA-N 0.000 description 1
- PJTBJZRAXNIMOQ-UHFFFAOYSA-N COCCNCCOc1ccc2[nH]c(C3=Cc4ccccc4NC3=O)cc2c1 Chemical compound COCCNCCOc1ccc2[nH]c(C3=Cc4ccccc4NC3=O)cc2c1 PJTBJZRAXNIMOQ-UHFFFAOYSA-N 0.000 description 1
- BESHXKNFMBEVAC-QWHCGFSZSA-N CO[C@H](C[C@H]1CO)CN1C(OCc1ccccc1)=O Chemical compound CO[C@H](C[C@H]1CO)CN1C(OCc1ccccc1)=O BESHXKNFMBEVAC-QWHCGFSZSA-N 0.000 description 1
- MERUNNHMVZFFRE-UHFFFAOYSA-N COc1ncc(C=O)cn1 Chemical compound COc1ncc(C=O)cn1 MERUNNHMVZFFRE-UHFFFAOYSA-N 0.000 description 1
- ZVSBMVDJXRCWBK-UHFFFAOYSA-N CS(N1CCN(Cc2ccc3[nH]c(C4=Cc(cccc5)c5NC4=O)cc3c2)CCC1)(=O)=O Chemical compound CS(N1CCN(Cc2ccc3[nH]c(C4=Cc(cccc5)c5NC4=O)cc3c2)CCC1)(=O)=O ZVSBMVDJXRCWBK-UHFFFAOYSA-N 0.000 description 1
- BKTSJPDIBUUXGO-UHFFFAOYSA-N NC1CN(Cc(cc2)cc3c2[nH]c(C2=Cc(cccc4)c4NC2=O)c3)CC1 Chemical compound NC1CN(Cc(cc2)cc3c2[nH]c(C2=Cc(cccc4)c4NC2=O)c3)CC1 BKTSJPDIBUUXGO-UHFFFAOYSA-N 0.000 description 1
- NBFJOZOCPMCWGZ-UHFFFAOYSA-N O/C(/C(F)(F)F)=[O]/C(CNCC1)N1C(COc1ccc2[nH]c(C3=Cc4ccccc4NC3=O)cc2c1)=O Chemical compound O/C(/C(F)(F)F)=[O]/C(CNCC1)N1C(COc1ccc2[nH]c(C3=Cc4ccccc4NC3=O)cc2c1)=O NBFJOZOCPMCWGZ-UHFFFAOYSA-N 0.000 description 1
- OBKDAJFWQHIAGH-UHFFFAOYSA-N O=C1Nc(cccc2)c2C=C1c1cc(cc(CNC2CC2)cc2)c2[nH]1 Chemical compound O=C1Nc(cccc2)c2C=C1c1cc(cc(CNC2CC2)cc2)c2[nH]1 OBKDAJFWQHIAGH-UHFFFAOYSA-N 0.000 description 1
- KLKXZRWSRHBDIV-UHFFFAOYSA-N O=C1Nc(cccc2)c2C=C1c1cc2cc(OCCCN3CCCCC3)ccc2[nH]1 Chemical compound O=C1Nc(cccc2)c2C=C1c1cc2cc(OCCCN3CCCCC3)ccc2[nH]1 KLKXZRWSRHBDIV-UHFFFAOYSA-N 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N O=C1Nc2ccccc2C=C1 Chemical compound O=C1Nc2ccccc2C=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- OGJAQJDKUZYXOF-UHFFFAOYSA-N OCC(CCN1)CC1/[O]=C(/C(F)(F)F)\O Chemical compound OCC(CCN1)CC1/[O]=C(/C(F)(F)F)\O OGJAQJDKUZYXOF-UHFFFAOYSA-N 0.000 description 1
- JJKYOTBAUFASAX-UHFFFAOYSA-N OCCN(CCC1)CC1C(O)=O Chemical compound OCCN(CCC1)CC1C(O)=O JJKYOTBAUFASAX-UHFFFAOYSA-N 0.000 description 1
- GOXNUYXRIQJIEF-UHFFFAOYSA-N OCCN(CCO1)C1=O Chemical compound OCCN(CCO1)C1=O GOXNUYXRIQJIEF-UHFFFAOYSA-N 0.000 description 1
- IMUKAXVWLZHUPS-UHFFFAOYSA-N ON1Nc(cccc2)c2C=C1c1cc2cc(C(N3CCNCC3)=O)ccc2[nH]1 Chemical compound ON1Nc(cccc2)c2C=C1c1cc2cc(C(N3CCNCC3)=O)ccc2[nH]1 IMUKAXVWLZHUPS-UHFFFAOYSA-N 0.000 description 1
- UTTCOAGPVHRUFO-GFCCVEGCSA-N O[C@H]1CN(Cc2ccccc2)CCC1 Chemical compound O[C@H]1CN(Cc2ccccc2)CCC1 UTTCOAGPVHRUFO-GFCCVEGCSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16035699P | 1999-10-19 | 1999-10-19 | |
| US60/160,356 | 1999-10-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20020038959A KR20020038959A (ko) | 2002-05-24 |
| KR100681724B1 true KR100681724B1 (ko) | 2007-02-28 |
Family
ID=22576544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020027004985A Expired - Fee Related KR100681724B1 (ko) | 1999-10-19 | 2000-10-16 | 티로신 키나제 억제제 및 이를 포함하는 약제학적 조성물 |
Country Status (39)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200101398A (ko) * | 2017-12-19 | 2020-08-27 | 브리스톨-마이어스 스큅 컴퍼니 | Tlr 억제제로서 유용한 아미드 치환된 인돌 화합물 |
Families Citing this family (179)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7354894B2 (en) * | 1998-08-18 | 2008-04-08 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
| KR100609646B1 (ko) * | 1998-08-18 | 2006-08-04 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Egf-r 길항물질의 투여에 의한 기도 점액생산의 방지 |
| US6846799B1 (en) * | 1998-08-18 | 2005-01-25 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
| SK288365B6 (sk) | 1999-02-10 | 2016-07-01 | Astrazeneca Ab | Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy |
| EP1226136B1 (en) * | 1999-10-19 | 2004-12-29 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6403581B1 (en) * | 2000-01-19 | 2002-06-11 | American Cyanamid Company | Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives |
| US6420382B2 (en) * | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| EP1289952A1 (en) | 2000-05-31 | 2003-03-12 | AstraZeneca AB | Indole derivatives with vascular damaging activity |
| US20020041880A1 (en) * | 2000-07-05 | 2002-04-11 | Defeo-Jones Deborah | Method of treating cancer |
| AR030357A1 (es) * | 2000-08-18 | 2003-08-20 | Lundbeck & Co As H | Derivados 4 -, 5 -, 6 - y 7-indol |
| JP4341949B2 (ja) | 2000-09-01 | 2009-10-14 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アザ複素環式誘導体およびその治療的使用 |
| PL211125B1 (pl) | 2000-09-11 | 2012-04-30 | Novartis Vaccines & Diagnostic | Pochodne chinolinonu jako inhibitory kinazy tyrozynowej, kompozycje je zawierające i ich zastosowanie |
| US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
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| EP0918522A4 (en) | 1996-05-20 | 1999-08-18 | Merck & Co Inc | GONADOLIBERIN ANTAGONISTS |
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| JP4516690B2 (ja) | 1998-08-11 | 2010-08-04 | ノバルティス アーゲー | 血管形成阻害活性を有するイソキノリン誘導体 |
| EP1226136B1 (en) * | 1999-10-19 | 2004-12-29 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200101398A (ko) * | 2017-12-19 | 2020-08-27 | 브리스톨-마이어스 스큅 컴퍼니 | Tlr 억제제로서 유용한 아미드 치환된 인돌 화합물 |
| KR102755258B1 (ko) | 2017-12-19 | 2025-01-15 | 브리스톨-마이어스 스큅 컴퍼니 | Tlr 억제제로서 유용한 아미드 치환된 인돌 화합물 |
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