KR100208114B1 - 4-(디-n-프로필)아미노-6-아미노카보닐-1,3,4,5-테트라하이드로벤즈(cd)인돌의 결정형 염 - Google Patents

4-(디-n-프로필)아미노-6-아미노카보닐-1,3,4,5-테트라하이드로벤즈(cd)인돌의 결정형 염 Download PDF

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Publication number
KR100208114B1
KR100208114B1 KR1019910003029A KR910003029A KR100208114B1 KR 100208114 B1 KR100208114 B1 KR 100208114B1 KR 1019910003029 A KR1019910003029 A KR 1019910003029A KR 910003029 A KR910003029 A KR 910003029A KR 100208114 B1 KR100208114 B1 KR 100208114B1
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KR
South Korea
Prior art keywords
indole
amino
tetrahydrobenz
aminocarbonyl
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019910003029A
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English (en)
Korean (ko)
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KR910021375A (ko
Inventor
죠셉 크레스 토마스
리 배리 데이비드
Original Assignee
피터 지. 스트링거
일라이 릴리 앤드 컴퍼니
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Publication of KR910021375A publication Critical patent/KR910021375A/ko
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019910003029A 1990-02-26 1991-02-25 4-(디-n-프로필)아미노-6-아미노카보닐-1,3,4,5-테트라하이드로벤즈(cd)인돌의 결정형 염 Expired - Fee Related KR100208114B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26
US7/485185 1990-02-26
US07/485185 1990-02-26

Publications (2)

Publication Number Publication Date
KR910021375A KR910021375A (ko) 1991-12-20
KR100208114B1 true KR100208114B1 (ko) 1999-07-15

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910003029A Expired - Fee Related KR100208114B1 (ko) 1990-02-26 1991-02-25 4-(디-n-프로필)아미노-6-아미노카보닐-1,3,4,5-테트라하이드로벤즈(cd)인돌의 결정형 염

Country Status (28)

Country Link
US (1) US5397799A (enExample)
EP (1) EP0444852B1 (enExample)
JP (1) JP3157007B2 (enExample)
KR (1) KR100208114B1 (enExample)
CN (1) CN1027503C (enExample)
AT (1) ATE126506T1 (enExample)
AU (1) AU629453B2 (enExample)
BR (1) BR9100767A (enExample)
CA (1) CA2037099C (enExample)
CY (1) CY1887A (enExample)
DE (1) DE69112099T2 (enExample)
DK (1) DK0444852T3 (enExample)
ES (1) ES2077796T3 (enExample)
FI (1) FI95464C (enExample)
GR (1) GR3017940T3 (enExample)
HK (1) HK175495A (enExample)
HU (1) HU217118B (enExample)
IE (1) IE67801B1 (enExample)
IL (1) IL97306A (enExample)
LV (1) LV10251B (enExample)
NO (1) NO174149C (enExample)
NZ (1) NZ237181A (enExample)
PT (1) PT96852B (enExample)
RU (2) RU2034837C1 (enExample)
SG (1) SG69975A1 (enExample)
TW (1) TW219933B (enExample)
YU (1) YU47594B (enExample)
ZA (1) ZA911258B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5643934A (en) * 1991-03-28 1997-07-01 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz [CD]indoles
TW248556B (enExample) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
MX2009000286A (es) 2006-06-26 2009-03-20 Procter & Gamble Inhibidores de prolil hidroxilasa y metodos de uso.
MY160066A (en) 2009-11-06 2017-02-15 Aerpio Therapeutics Inc Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
MX2013014310A (es) 2011-06-06 2014-01-23 Akebia Therapeutics Inc Compuestos y composiciones para estabilizar el factor-2 alfa inducible por hipoxia como un metodo para tratar el cancer.
NO2686520T3 (enExample) 2011-06-06 2018-03-17
CN114404414A (zh) 2013-06-13 2022-04-29 阿克比治疗有限公司 用于治疗贫血症的组合物和方法
KR102495018B1 (ko) 2013-11-15 2023-02-06 아케비아 테라퓨틱스 인코포레이티드 ｛[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노｝아세트산의 고체형, 이의 조성물 및 용도
EP3247355A4 (en) 2015-01-23 2018-06-13 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
EA036920B1 (ru) 2015-04-01 2021-01-15 Экебиа Терапьютикс, Инк. Композиции и способы для лечения анемии
TW202406895A (zh) 2018-05-09 2024-02-16 美商阿克比治療有限公司 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
LV10251A (lv) 1994-10-20
DE69112099T2 (de) 1996-02-08
EP0444852A3 (en) 1992-02-19
FI910895A0 (fi) 1991-02-25
NO910735L (no) 1991-08-27
NO174149B (no) 1993-12-13
BR9100767A (pt) 1991-10-29
TW219933B (enExample) 1994-02-01
YU47594B (sh) 1995-10-24
NO910735D0 (no) 1991-02-25
FI95464C (fi) 1996-02-12
US5397799A (en) 1995-03-14
GR3017940T3 (en) 1996-02-29
SG69975A1 (en) 2000-01-25
RU2034837C1 (ru) 1995-05-10
DE69112099D1 (de) 1995-09-21
EP0444852B1 (en) 1995-08-16
DK0444852T3 (da) 1995-12-11
ATE126506T1 (de) 1995-09-15
HUT56542A (en) 1991-09-30
RU2083561C1 (ru) 1997-07-10
NZ237181A (en) 1992-06-25
JP3157007B2 (ja) 2001-04-16
FI910895L (fi) 1991-08-27
LV10251B (en) 1995-04-20
IL97306A0 (en) 1992-05-25
ES2077796T3 (es) 1995-12-01
EP0444852A2 (en) 1991-09-04
PT96852A (pt) 1991-10-31
CN1054589A (zh) 1991-09-18
KR910021375A (ko) 1991-12-20
AU7197191A (en) 1991-08-29
AU629453B2 (en) 1992-10-01
NO174149C (no) 1994-03-23
HK175495A (en) 1995-11-24
IE67801B1 (en) 1996-05-01
FI95464B (fi) 1995-10-31
ZA911258B (en) 1992-10-28
CA2037099C (en) 2001-09-11
CY1887A (en) 1996-04-05
JPH04217662A (ja) 1992-08-07
YU32791A (sh) 1994-01-20
PT96852B (pt) 1998-07-31
IL97306A (en) 1996-10-16
HU217118B (hu) 1999-11-29
CN1027503C (zh) 1995-01-25
CA2037099A1 (en) 1991-08-27
IE910625A1 (en) 1991-08-28

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