ATE126506T1 - Kristallinisches salz von 4-(di-n-propyl)amino-6- aminocarbonyl-1,3,4,5-tetrahydrobenz(cd>indol. - Google Patents

Kristallinisches salz von 4-(di-n-propyl)amino-6- aminocarbonyl-1,3,4,5-tetrahydrobenz(cd>indol.

Info

Publication number
ATE126506T1
ATE126506T1 AT91301501T AT91301501T ATE126506T1 AT E126506 T1 ATE126506 T1 AT E126506T1 AT 91301501 T AT91301501 T AT 91301501T AT 91301501 T AT91301501 T AT 91301501T AT E126506 T1 ATE126506 T1 AT E126506T1
Authority
AT
Austria
Prior art keywords
aminocarbonyl
propyl
amino
tetrahydrobenze
indol
Prior art date
Application number
AT91301501T
Other languages
English (en)
Inventor
Thomas Joseph Kress
David Lee Varie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE126506T1 publication Critical patent/ATE126506T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91301501T 1990-02-26 1991-02-26 Kristallinisches salz von 4-(di-n-propyl)amino-6- aminocarbonyl-1,3,4,5-tetrahydrobenz(cd>indol. ATE126506T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26

Publications (1)

Publication Number Publication Date
ATE126506T1 true ATE126506T1 (de) 1995-09-15

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91301501T ATE126506T1 (de) 1990-02-26 1991-02-26 Kristallinisches salz von 4-(di-n-propyl)amino-6- aminocarbonyl-1,3,4,5-tetrahydrobenz(cd>indol.

Country Status (28)

Country Link
US (1) US5397799A (de)
EP (1) EP0444852B1 (de)
JP (1) JP3157007B2 (de)
KR (1) KR100208114B1 (de)
CN (1) CN1027503C (de)
AT (1) ATE126506T1 (de)
AU (1) AU629453B2 (de)
BR (1) BR9100767A (de)
CA (1) CA2037099C (de)
CY (1) CY1887A (de)
DE (1) DE69112099T2 (de)
DK (1) DK0444852T3 (de)
ES (1) ES2077796T3 (de)
FI (1) FI95464C (de)
GR (1) GR3017940T3 (de)
HK (1) HK175495A (de)
HU (1) HU217118B (de)
IE (1) IE67801B1 (de)
IL (1) IL97306A (de)
LV (1) LV10251B (de)
NO (1) NO174149C (de)
NZ (1) NZ237181A (de)
PT (1) PT96852B (de)
RU (2) RU2034837C1 (de)
SG (1) SG69975A1 (de)
TW (1) TW219933B (de)
YU (1) YU47594B (de)
ZA (1) ZA911258B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them
US5643910A (en) * 1991-03-28 1997-07-01 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[CD]indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
TW248556B (de) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
US7811595B2 (en) * 2006-06-26 2010-10-12 Warner Chilcott Company, Llc Prolyl hydroxylase inhibitors and methods of use
WO2011057112A1 (en) 2009-11-06 2011-05-12 Akebia Therapeutics Inc. Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
MX2013014310A (es) 2011-06-06 2014-01-23 Akebia Therapeutics Inc Compuestos y composiciones para estabilizar el factor-2 alfa inducible por hipoxia como un metodo para tratar el cancer.
NO2686520T3 (de) 2011-06-06 2018-03-17
SI3007695T1 (sl) 2013-06-13 2024-04-30 Akebia Therapeutics, Inc. Sestavki in metode za zdravljenje anemije
RU2016123382A (ru) 2013-11-15 2017-12-20 Экебиа Терапьютикс, Инк. Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения
WO2016118858A1 (en) 2015-01-23 2016-07-28 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
EP3277270B1 (de) 2015-04-01 2021-10-27 Akebia Therapeutics, Inc. Zusammensetzungen und verfahren zur behandlung von anämie
AR114886A1 (es) 2018-05-09 2020-10-28 Akebia Therapeutics Inc Proceso para preparar ácido 2-[[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino]acético
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
JP3157007B2 (ja) 2001-04-16
FI95464C (fi) 1996-02-12
DK0444852T3 (da) 1995-12-11
HU217118B (hu) 1999-11-29
IL97306A0 (en) 1992-05-25
GR3017940T3 (en) 1996-02-29
SG69975A1 (en) 2000-01-25
NO174149B (no) 1993-12-13
IL97306A (en) 1996-10-16
TW219933B (de) 1994-02-01
CN1054589A (zh) 1991-09-18
LV10251A (lv) 1994-10-20
AU7197191A (en) 1991-08-29
KR910021375A (ko) 1991-12-20
YU32791A (sh) 1994-01-20
EP0444852B1 (de) 1995-08-16
EP0444852A2 (de) 1991-09-04
AU629453B2 (en) 1992-10-01
NZ237181A (en) 1992-06-25
ZA911258B (en) 1992-10-28
DE69112099T2 (de) 1996-02-08
CN1027503C (zh) 1995-01-25
FI910895A (fi) 1991-08-27
YU47594B (sh) 1995-10-24
ES2077796T3 (es) 1995-12-01
FI95464B (fi) 1995-10-31
HUT56542A (en) 1991-09-30
KR100208114B1 (ko) 1999-07-15
RU2034837C1 (ru) 1995-05-10
NO910735L (no) 1991-08-27
CA2037099C (en) 2001-09-11
PT96852A (pt) 1991-10-31
CY1887A (en) 1996-04-05
BR9100767A (pt) 1991-10-29
NO910735D0 (no) 1991-02-25
IE67801B1 (en) 1996-05-01
CA2037099A1 (en) 1991-08-27
LV10251B (en) 1995-04-20
JPH04217662A (ja) 1992-08-07
EP0444852A3 (en) 1992-02-19
DE69112099D1 (de) 1995-09-21
FI910895A0 (fi) 1991-02-25
NO174149C (no) 1994-03-23
US5397799A (en) 1995-03-14
PT96852B (pt) 1998-07-31
HK175495A (en) 1995-11-24
IE910625A1 (en) 1991-08-28
RU2083561C1 (ru) 1997-07-10

Similar Documents

Publication Publication Date Title
ATE126506T1 (de) Kristallinisches salz von 4-(di-n-propyl)amino-6- aminocarbonyl-1,3,4,5-tetrahydrobenz(cd>indol.
IE782325L (en) TETRAHYDROBENZ £cd| INDOLES
ES2123521T3 (es) Derivados de indol.
RU92004575A (ru) Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры
DK29989D0 (da) Bifunktionelt vaekstmodulerende glycoprotein benaevnt amphiregulin
ATE180256T1 (de) 6-heterocyclisch-4-amino-1,3,4,5- tetrahydrobenz(cd>indole
ATE168687T1 (de) 6-heterocyclisch-4-amino-1,2,2a,3,4,5- hexahydrobenz(cd>indole
AU590603B2 (en) A method of preparing indoles or indole derivatives, coupled via position 4, 5, 6, or 7, the indoles or indole derivatives concerned, as well as the use thereof
AU6969687A (en) 2', 3', 4', 10'-tetrahydro-10'-substituted-10'-hydroxy-spiro ((cycloalkane or heterocyclic)-pyrimido(1,2a)indoles
CA2037100A1 (en) 6-substituted-hexahydrobenz ¢cd! indoles

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee