RU92004575A - Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры - Google Patents
Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомерыInfo
- Publication number
- RU92004575A RU92004575A RU92004575/04A RU92004575A RU92004575A RU 92004575 A RU92004575 A RU 92004575A RU 92004575/04 A RU92004575/04 A RU 92004575/04A RU 92004575 A RU92004575 A RU 92004575A RU 92004575 A RU92004575 A RU 92004575A
- Authority
- RU
- Russia
- Prior art keywords
- tetrahydrobenz
- propyl
- amino
- aminocarbonil
- isomeres
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000011780 sodium chloride Substances 0.000 title 1
- YTOJFUORFUYGSV-UHFFFAOYSA-N 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide Chemical compound C1=C(C(N)=O)C(CC(N(CCC)CCC)C2)=C3C2=CNC3=C1 YTOJFUORFUYGSV-UHFFFAOYSA-N 0.000 claims 1
- QIAFMBKCNZACKA-UHFFFAOYSA-M N-benzoylglycinate Chemical compound [O-]C(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-M 0.000 claims 1
Claims (1)
- Предлагается метод получения и применение гиппурата 4-(ди-н-пропил)амино-6-аминокарбонил-1,3,4,5-тетрагидробенз[cd]индола.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48518590A | 1990-02-26 | 1990-02-26 | |
US485.185 | 1990-02-26 | ||
US485185 | 1990-02-26 |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU107654 Addition | |||
RU4894699 Division |
Publications (2)
Publication Number | Publication Date |
---|---|
RU92004575A true RU92004575A (ru) | 1995-09-27 |
RU2083561C1 RU2083561C1 (ru) | 1997-07-10 |
Family
ID=23927224
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU914894699A RU2034837C1 (ru) | 1990-02-26 | 1991-02-25 | Способ получения гиппурата 4-(ди-н-пропил)амино-6-аминокарбонил-1,3,4,5-тетрагидробенз(cd)индола |
RU9292004575A RU2083561C1 (ru) | 1990-02-26 | 1992-12-03 | Гиппурат 4-(ди-н-пропил)амино-6-аминокарбонил-1,3,4,5-тетрагидробенз [cd] индола и его 4r- и 4s-изомеры |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU914894699A RU2034837C1 (ru) | 1990-02-26 | 1991-02-25 | Способ получения гиппурата 4-(ди-н-пропил)амино-6-аминокарбонил-1,3,4,5-тетрагидробенз(cd)индола |
Country Status (28)
Country | Link |
---|---|
US (1) | US5397799A (ru) |
EP (1) | EP0444852B1 (ru) |
JP (1) | JP3157007B2 (ru) |
KR (1) | KR100208114B1 (ru) |
CN (1) | CN1027503C (ru) |
AT (1) | ATE126506T1 (ru) |
AU (1) | AU629453B2 (ru) |
BR (1) | BR9100767A (ru) |
CA (1) | CA2037099C (ru) |
CY (1) | CY1887A (ru) |
DE (1) | DE69112099T2 (ru) |
DK (1) | DK0444852T3 (ru) |
ES (1) | ES2077796T3 (ru) |
FI (1) | FI95464C (ru) |
GR (1) | GR3017940T3 (ru) |
HK (1) | HK175495A (ru) |
HU (1) | HU217118B (ru) |
IE (1) | IE67801B1 (ru) |
IL (1) | IL97306A (ru) |
LV (1) | LV10251B (ru) |
NO (1) | NO174149C (ru) |
NZ (1) | NZ237181A (ru) |
PT (1) | PT96852B (ru) |
RU (2) | RU2034837C1 (ru) |
SG (1) | SG69975A1 (ru) |
TW (1) | TW219933B (ru) |
YU (1) | YU47594B (ru) |
ZA (1) | ZA911258B (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5302612A (en) * | 1990-02-26 | 1994-04-12 | Eli Lilly And Company | 6-substituted-hexahydrobenz[cd]indoles |
IL97308A (en) * | 1990-02-26 | 1996-10-31 | Lilly Co Eli | Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them |
IL97309A (en) * | 1990-02-26 | 1996-11-14 | Lilly Co Eli | Intermediates for hexahydrobenz] [DC indoles and a process for making their pure enantiomers |
US5364856A (en) * | 1991-03-28 | 1994-11-15 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles |
US5665744A (en) * | 1991-03-28 | 1997-09-09 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenzn [cd] indoles |
TW248556B (ru) * | 1993-01-18 | 1995-06-01 | Takeda Pharm Industry Co | |
US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
EP3026044B8 (en) | 2006-06-26 | 2018-12-19 | Akebia Therapeutics, Inc. | Prolyl hydroxylase inhibitors and methods of use |
EP2496084B1 (en) | 2009-11-06 | 2015-06-10 | Aerpio Therapeutics Inc. | Compositions and methods for treating colitis |
CA2837560C (en) | 2011-06-06 | 2017-02-14 | Akebia Therapeutics Inc. | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
NO2686520T3 (ru) | 2011-06-06 | 2018-03-17 | ||
CN114404414A (zh) | 2013-06-13 | 2022-04-29 | 阿克比治疗有限公司 | 用于治疗贫血症的组合物和方法 |
TWI665190B (zh) | 2013-11-15 | 2019-07-11 | 阿克比治療有限公司 | {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式,其組合物及用途 |
US10150734B2 (en) | 2015-01-23 | 2018-12-11 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
BR112017021097B1 (pt) | 2015-04-01 | 2024-01-02 | Akebia Therapeutics, Inc | Formulação de dosagem oral e seu uso |
TW202406895A (zh) | 2018-05-09 | 2024-02-16 | 美商阿克比治療有限公司 | 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法 |
US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4110339A (en) * | 1977-11-25 | 1978-08-29 | Eli Lilly And Company | 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole |
US4576959A (en) * | 1984-02-06 | 1986-03-18 | Eli Lilly And Company | 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles |
US4745126A (en) * | 1987-03-12 | 1988-05-17 | Eli Lilly And Company | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides |
DE3809155A1 (de) * | 1988-03-18 | 1989-09-28 | Bayer Ag | 1,3,4,5-tetrahydrobenz-(c,d)-indole |
US5204340A (en) * | 1989-04-11 | 1993-04-20 | Eli Lilly And Company | Tetrahydrobenz(c,d)indole serotonin agonists |
US5229409A (en) * | 1990-08-15 | 1993-07-20 | Eli Lilly And Company | 6-substituted-tetrahydrobenz[cd]indoles |
-
1990
- 1990-06-26 TW TW079105258A patent/TW219933B/zh active
-
1991
- 1991-02-20 ZA ZA911258A patent/ZA911258B/xx unknown
- 1991-02-20 IL IL9730691A patent/IL97306A/en not_active IP Right Cessation
- 1991-02-21 NZ NZ237181A patent/NZ237181A/en unknown
- 1991-02-22 PT PT96852A patent/PT96852B/pt not_active IP Right Cessation
- 1991-02-22 JP JP05064391A patent/JP3157007B2/ja not_active Expired - Fee Related
- 1991-02-25 YU YU32791A patent/YU47594B/sh unknown
- 1991-02-25 HU HU91629A patent/HU217118B/hu unknown
- 1991-02-25 RU SU914894699A patent/RU2034837C1/ru not_active IP Right Cessation
- 1991-02-25 IE IE62591A patent/IE67801B1/en not_active IP Right Cessation
- 1991-02-25 AU AU71971/91A patent/AU629453B2/en not_active Ceased
- 1991-02-25 KR KR1019910003029A patent/KR100208114B1/ko not_active IP Right Cessation
- 1991-02-25 NO NO910735A patent/NO174149C/no unknown
- 1991-02-25 FI FI910895A patent/FI95464C/fi active
- 1991-02-26 BR BR919100767A patent/BR9100767A/pt not_active Application Discontinuation
- 1991-02-26 ES ES91301501T patent/ES2077796T3/es not_active Expired - Lifetime
- 1991-02-26 DE DE69112099T patent/DE69112099T2/de not_active Expired - Fee Related
- 1991-02-26 SG SG1996007257A patent/SG69975A1/en unknown
- 1991-02-26 EP EP91301501A patent/EP0444852B1/en not_active Expired - Lifetime
- 1991-02-26 AT AT91301501T patent/ATE126506T1/de not_active IP Right Cessation
- 1991-02-26 CN CN91101296A patent/CN1027503C/zh not_active Expired - Fee Related
- 1991-02-26 CA CA002037099A patent/CA2037099C/en not_active Expired - Fee Related
- 1991-02-26 DK DK91301501.2T patent/DK0444852T3/da active
-
1992
- 1992-12-03 RU RU9292004575A patent/RU2083561C1/ru not_active IP Right Cessation
-
1993
- 1993-05-19 US US08/064,539 patent/US5397799A/en not_active Expired - Lifetime
- 1993-06-08 LV LVP-93-509A patent/LV10251B/xx unknown
-
1995
- 1995-11-01 GR GR950403048T patent/GR3017940T3/el unknown
- 1995-11-16 HK HK175495A patent/HK175495A/xx not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY188796A patent/CY1887A/xx unknown
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