PT96852A - Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole - Google Patents

Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole

Info

Publication number
PT96852A
PT96852A PT96852A PT9685291A PT96852A PT 96852 A PT96852 A PT 96852A PT 96852 A PT96852 A PT 96852A PT 9685291 A PT9685291 A PT 9685291A PT 96852 A PT96852 A PT 96852A
Authority
PT
Portugal
Prior art keywords
tetrahydrobenz
aminocarbonyl
propyl
amino
indole
Prior art date
Application number
PT96852A
Other languages
English (en)
Other versions
PT96852B (pt
Inventor
Thomas Joseph Kress
David Lee Varie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT96852A publication Critical patent/PT96852A/pt
Publication of PT96852B publication Critical patent/PT96852B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT96852A 1990-02-26 1991-02-22 Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole PT96852B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26

Publications (2)

Publication Number Publication Date
PT96852A true PT96852A (pt) 1991-10-31
PT96852B PT96852B (pt) 1998-07-31

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96852A PT96852B (pt) 1990-02-26 1991-02-22 Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole

Country Status (28)

Country Link
US (1) US5397799A (pt)
EP (1) EP0444852B1 (pt)
JP (1) JP3157007B2 (pt)
KR (1) KR100208114B1 (pt)
CN (1) CN1027503C (pt)
AT (1) ATE126506T1 (pt)
AU (1) AU629453B2 (pt)
BR (1) BR9100767A (pt)
CA (1) CA2037099C (pt)
CY (1) CY1887A (pt)
DE (1) DE69112099T2 (pt)
DK (1) DK0444852T3 (pt)
ES (1) ES2077796T3 (pt)
FI (1) FI95464C (pt)
GR (1) GR3017940T3 (pt)
HK (1) HK175495A (pt)
HU (1) HU217118B (pt)
IE (1) IE67801B1 (pt)
IL (1) IL97306A (pt)
LV (1) LV10251B (pt)
NO (1) NO174149C (pt)
NZ (1) NZ237181A (pt)
PT (1) PT96852B (pt)
RU (2) RU2034837C1 (pt)
SG (1) SG69975A1 (pt)
TW (1) TW219933B (pt)
YU (1) YU47594B (pt)
ZA (1) ZA911258B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5641794A (en) * 1991-03-28 1997-06-24 Eli Lilly Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
TW248556B (pt) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
TR201900548T4 (tr) * 2006-06-26 2019-02-21 Akebia Therapeutics Inc Prolil hidroksilaz inhibitörleri ve kullanım yöntemleri.
US8309537B2 (en) 2009-11-06 2012-11-13 Aerpio Therapeutics Inc. Compositions and methods for treating colitis
NO2686520T3 (pt) 2011-06-06 2018-03-17
CA2837560C (en) 2011-06-06 2017-02-14 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
CN114404413A (zh) 2013-06-13 2022-04-29 阿克比治疗有限公司 用于治疗贫血症的组合物和方法
CA2930128A1 (en) 2013-11-15 2015-05-21 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
CN107427503A (zh) 2015-01-23 2017-12-01 阿克比治疗有限公司 2‑(5‑(3‑氟苯基)‑3‑羟基吡啶甲酰胺)乙酸的固体形式、其组合物及用途
LT3277270T (lt) 2015-04-01 2022-01-10 Akebia Therapeutics, Inc. Kompozicijos ir būdai skirti anemijos gydymui
TW202406895A (zh) 2018-05-09 2024-02-16 美商阿克比治療有限公司 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
AU7197191A (en) 1991-08-29
RU2083561C1 (ru) 1997-07-10
IL97306A0 (en) 1992-05-25
ZA911258B (en) 1992-10-28
NO174149C (no) 1994-03-23
IE910625A1 (en) 1991-08-28
DE69112099D1 (de) 1995-09-21
NO174149B (no) 1993-12-13
BR9100767A (pt) 1991-10-29
DE69112099T2 (de) 1996-02-08
EP0444852A2 (en) 1991-09-04
US5397799A (en) 1995-03-14
LV10251B (en) 1995-04-20
JPH04217662A (ja) 1992-08-07
FI95464B (fi) 1995-10-31
FI910895L (fi) 1991-08-27
RU2034837C1 (ru) 1995-05-10
ATE126506T1 (de) 1995-09-15
KR100208114B1 (ko) 1999-07-15
CN1027503C (zh) 1995-01-25
NZ237181A (en) 1992-06-25
JP3157007B2 (ja) 2001-04-16
LV10251A (lv) 1994-10-20
HU217118B (hu) 1999-11-29
GR3017940T3 (en) 1996-02-29
PT96852B (pt) 1998-07-31
SG69975A1 (en) 2000-01-25
AU629453B2 (en) 1992-10-01
CA2037099C (en) 2001-09-11
IE67801B1 (en) 1996-05-01
HUT56542A (en) 1991-09-30
NO910735L (no) 1991-08-27
CN1054589A (zh) 1991-09-18
YU32791A (sh) 1994-01-20
NO910735D0 (no) 1991-02-25
ES2077796T3 (es) 1995-12-01
KR910021375A (ko) 1991-12-20
EP0444852A3 (en) 1992-02-19
CA2037099A1 (en) 1991-08-27
FI95464C (fi) 1996-02-12
CY1887A (en) 1996-04-05
TW219933B (pt) 1994-02-01
DK0444852T3 (da) 1995-12-11
HK175495A (en) 1995-11-24
YU47594B (sh) 1995-10-24
IL97306A (en) 1996-10-16
FI910895A0 (fi) 1991-02-25
EP0444852B1 (en) 1995-08-16

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910704

FG3A Patent granted, date of granting

Effective date: 19980408

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20071008