JP3157007B2 - テトラヒドロベンズインドール誘導体の結晶性塩 - Google Patents

テトラヒドロベンズインドール誘導体の結晶性塩

Info

Publication number
JP3157007B2
JP3157007B2 JP05064391A JP5064391A JP3157007B2 JP 3157007 B2 JP3157007 B2 JP 3157007B2 JP 05064391 A JP05064391 A JP 05064391A JP 5064391 A JP5064391 A JP 5064391A JP 3157007 B2 JP3157007 B2 JP 3157007B2
Authority
JP
Japan
Prior art keywords
compound
hippurate
indole
amino
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP05064391A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04217662A (ja
Inventor
トーマス・ジョゼフ・クレス
デイビット・リー・バリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH04217662A publication Critical patent/JPH04217662A/ja
Application granted granted Critical
Publication of JP3157007B2 publication Critical patent/JP3157007B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP05064391A 1990-02-26 1991-02-22 テトラヒドロベンズインドール誘導体の結晶性塩 Expired - Fee Related JP3157007B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26
US485,185 1990-02-26

Publications (2)

Publication Number Publication Date
JPH04217662A JPH04217662A (ja) 1992-08-07
JP3157007B2 true JP3157007B2 (ja) 2001-04-16

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
JP05064391A Expired - Fee Related JP3157007B2 (ja) 1990-02-26 1991-02-22 テトラヒドロベンズインドール誘導体の結晶性塩

Country Status (28)

Country Link
US (1) US5397799A (enExample)
EP (1) EP0444852B1 (enExample)
JP (1) JP3157007B2 (enExample)
KR (1) KR100208114B1 (enExample)
CN (1) CN1027503C (enExample)
AT (1) ATE126506T1 (enExample)
AU (1) AU629453B2 (enExample)
BR (1) BR9100767A (enExample)
CA (1) CA2037099C (enExample)
CY (1) CY1887A (enExample)
DE (1) DE69112099T2 (enExample)
DK (1) DK0444852T3 (enExample)
ES (1) ES2077796T3 (enExample)
FI (1) FI95464C (enExample)
GR (1) GR3017940T3 (enExample)
HK (1) HK175495A (enExample)
HU (1) HU217118B (enExample)
IE (1) IE67801B1 (enExample)
IL (1) IL97306A (enExample)
LV (1) LV10251B (enExample)
NO (1) NO174149C (enExample)
NZ (1) NZ237181A (enExample)
PT (1) PT96852B (enExample)
RU (2) RU2034837C1 (enExample)
SG (1) SG69975A1 (enExample)
TW (1) TW219933B (enExample)
YU (1) YU47594B (enExample)
ZA (1) ZA911258B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5656653A (en) * 1991-03-28 1997-08-12 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
TW248556B (enExample) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
PL3357911T3 (pl) 2006-06-26 2022-09-05 Akebia Therapeutics Inc. Inhibitory prolilohydroksylazy i sposoby ich użycia
CN102638983B (zh) 2009-11-06 2014-11-26 阿尔皮奥治疗学股份有限公司 用于治疗结肠炎的组合物和方法
CA2837560C (en) 2011-06-06 2017-02-14 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
NO2686520T3 (enExample) 2011-06-06 2018-03-17
PE20160194A1 (es) 2013-06-13 2016-04-20 Akebia Therapeutics Inc Composiciones y metodos para tratar anemia
TW201946625A (zh) 2013-11-15 2019-12-16 美商阿克比治療有限公司 {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式，其組合物及用途
AU2016209126A1 (en) 2015-01-23 2017-08-10 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
SG11201707994UA (en) 2015-04-01 2017-10-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
AU2019265629B2 (en) 2018-05-09 2024-09-12 Akebia Therapeutics, Inc. Process for preparing 2-((5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl)amino)acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
LV10251B (en) 1995-04-20
KR100208114B1 (ko) 1999-07-15
NO910735D0 (no) 1991-02-25
NZ237181A (en) 1992-06-25
GR3017940T3 (en) 1996-02-29
KR910021375A (ko) 1991-12-20
CA2037099A1 (en) 1991-08-27
US5397799A (en) 1995-03-14
LV10251A (lv) 1994-10-20
CA2037099C (en) 2001-09-11
RU2083561C1 (ru) 1997-07-10
EP0444852A3 (en) 1992-02-19
YU32791A (sh) 1994-01-20
DE69112099D1 (de) 1995-09-21
IL97306A0 (en) 1992-05-25
BR9100767A (pt) 1991-10-29
CY1887A (en) 1996-04-05
PT96852B (pt) 1998-07-31
NO174149B (no) 1993-12-13
ES2077796T3 (es) 1995-12-01
FI95464B (fi) 1995-10-31
YU47594B (sh) 1995-10-24
DE69112099T2 (de) 1996-02-08
IE910625A1 (en) 1991-08-28
JPH04217662A (ja) 1992-08-07
AU629453B2 (en) 1992-10-01
CN1027503C (zh) 1995-01-25
HU217118B (hu) 1999-11-29
DK0444852T3 (da) 1995-12-11
HK175495A (en) 1995-11-24
EP0444852B1 (en) 1995-08-16
PT96852A (pt) 1991-10-31
ZA911258B (en) 1992-10-28
HUT56542A (en) 1991-09-30
IL97306A (en) 1996-10-16
FI910895L (fi) 1991-08-27
SG69975A1 (en) 2000-01-25
FI95464C (fi) 1996-02-12
RU2034837C1 (ru) 1995-05-10
NO174149C (no) 1994-03-23
TW219933B (enExample) 1994-02-01
FI910895A0 (fi) 1991-02-25
ATE126506T1 (de) 1995-09-15
EP0444852A2 (en) 1991-09-04
NO910735L (no) 1991-08-27
CN1054589A (zh) 1991-09-18
IE67801B1 (en) 1996-05-01
AU7197191A (en) 1991-08-29

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