YU47594B - KRISTALNA SO (4-DI-N-PROPIL)AMINO-6-AMINOKARBONIL-1,3,4,5-TETRAHIDROBENZ/cd/INDOLA I POSTUPAK ZA NJENO DOBIJANJE - Google Patents

KRISTALNA SO (4-DI-N-PROPIL)AMINO-6-AMINOKARBONIL-1,3,4,5-TETRAHIDROBENZ/cd/INDOLA I POSTUPAK ZA NJENO DOBIJANJE

Info

Publication number
YU47594B
YU47594B YU32791A YU32791A YU47594B YU 47594 B YU47594 B YU 47594B YU 32791 A YU32791 A YU 32791A YU 32791 A YU32791 A YU 32791A YU 47594 B YU47594 B YU 47594B
Authority
YU
Yugoslavia
Prior art keywords
indola
aminocarbonyl
propyl
amino
obtaining
Prior art date
Application number
YU32791A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU32791A (sh
Inventor
T.J. Kress
D.L. Varie
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU32791A publication Critical patent/YU32791A/sh
Publication of YU47594B publication Critical patent/YU47594B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
YU32791A 1990-02-26 1991-02-25 KRISTALNA SO (4-DI-N-PROPIL)AMINO-6-AMINOKARBONIL-1,3,4,5-TETRAHIDROBENZ/cd/INDOLA I POSTUPAK ZA NJENO DOBIJANJE YU47594B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26

Publications (2)

Publication Number Publication Date
YU32791A YU32791A (sh) 1994-01-20
YU47594B true YU47594B (sh) 1995-10-24

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
YU32791A YU47594B (sh) 1990-02-26 1991-02-25 KRISTALNA SO (4-DI-N-PROPIL)AMINO-6-AMINOKARBONIL-1,3,4,5-TETRAHIDROBENZ/cd/INDOLA I POSTUPAK ZA NJENO DOBIJANJE

Country Status (28)

Country Link
US (1) US5397799A (enExample)
EP (1) EP0444852B1 (enExample)
JP (1) JP3157007B2 (enExample)
KR (1) KR100208114B1 (enExample)
CN (1) CN1027503C (enExample)
AT (1) ATE126506T1 (enExample)
AU (1) AU629453B2 (enExample)
BR (1) BR9100767A (enExample)
CA (1) CA2037099C (enExample)
CY (1) CY1887A (enExample)
DE (1) DE69112099T2 (enExample)
DK (1) DK0444852T3 (enExample)
ES (1) ES2077796T3 (enExample)
FI (1) FI95464C (enExample)
GR (1) GR3017940T3 (enExample)
HK (1) HK175495A (enExample)
HU (1) HU217118B (enExample)
IE (1) IE67801B1 (enExample)
IL (1) IL97306A (enExample)
LV (1) LV10251B (enExample)
NO (1) NO174149C (enExample)
NZ (1) NZ237181A (enExample)
PT (1) PT96852B (enExample)
RU (2) RU2034837C1 (enExample)
SG (1) SG69975A1 (enExample)
TW (1) TW219933B (enExample)
YU (1) YU47594B (enExample)
ZA (1) ZA911258B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5643934A (en) * 1991-03-28 1997-07-01 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz [CD]indoles
TW248556B (enExample) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
NZ623002A (en) 2006-06-26 2015-08-28 Akebia Therapeutics Inc Prolyl hydroxylase inhibitors and methods of use
CA2774039A1 (en) 2009-11-06 2011-05-12 Aerpio Therapeutics Inc. Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
CN103717214A (zh) 2011-06-06 2014-04-09 阿克比治疗有限公司 用于稳定低氧诱导因子-2α作为治疗癌症的方法的化合物和组合物
NO2686520T3 (enExample) 2011-06-06 2018-03-17
HUE066123T2 (hu) 2013-06-13 2024-07-28 Akebia Therapeutics Inc Készítmények és módszerek anémia kezelésére
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途
CA2974691A1 (en) 2015-01-23 2016-07-28 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
NZ735973A (en) 2015-04-01 2023-06-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
US12612367B2 (en) 2019-12-10 2026-04-28 Akebia Therapeutics, Inc. Method for producing nitrogen-containing heteroarylcarboxamide acetic acid derivative
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
CN1054589A (zh) 1991-09-18
RU2034837C1 (ru) 1995-05-10
HK175495A (en) 1995-11-24
PT96852B (pt) 1998-07-31
CA2037099C (en) 2001-09-11
EP0444852A2 (en) 1991-09-04
ATE126506T1 (de) 1995-09-15
NO910735L (no) 1991-08-27
EP0444852A3 (en) 1992-02-19
SG69975A1 (en) 2000-01-25
IE910625A1 (en) 1991-08-28
TW219933B (enExample) 1994-02-01
JP3157007B2 (ja) 2001-04-16
GR3017940T3 (en) 1996-02-29
ZA911258B (en) 1992-10-28
BR9100767A (pt) 1991-10-29
NO910735D0 (no) 1991-02-25
IL97306A0 (en) 1992-05-25
AU629453B2 (en) 1992-10-01
NO174149B (no) 1993-12-13
AU7197191A (en) 1991-08-29
FI95464C (fi) 1996-02-12
FI910895L (fi) 1991-08-27
DE69112099T2 (de) 1996-02-08
LV10251B (en) 1995-04-20
FI95464B (fi) 1995-10-31
KR910021375A (ko) 1991-12-20
HUT56542A (en) 1991-09-30
HU217118B (hu) 1999-11-29
PT96852A (pt) 1991-10-31
YU32791A (sh) 1994-01-20
LV10251A (lv) 1994-10-20
EP0444852B1 (en) 1995-08-16
ES2077796T3 (es) 1995-12-01
IL97306A (en) 1996-10-16
NZ237181A (en) 1992-06-25
FI910895A0 (fi) 1991-02-25
CN1027503C (zh) 1995-01-25
DK0444852T3 (da) 1995-12-11
CY1887A (en) 1996-04-05
DE69112099D1 (de) 1995-09-21
IE67801B1 (en) 1996-05-01
CA2037099A1 (en) 1991-08-27
KR100208114B1 (ko) 1999-07-15
US5397799A (en) 1995-03-14
RU2083561C1 (ru) 1997-07-10
JPH04217662A (ja) 1992-08-07
NO174149C (no) 1994-03-23

Similar Documents

Publication Publication Date Title
FI954944A7 (fi) Indolijohdannaisia 5-HT1-kaltaisina agonisteina käytettäväksi migreenin hoitoon
RU94036004A (ru) Промежуточные соединения для получения ароматических аминоспиртовых производных
ATE114151T1 (de) Benzocyclobutyl- oder indanyl-alkyl-amino-alkyl substituierte 3-benzazepin-2-ones, verwendbar in der behandlung von kardiovaskularen krankheiten.
MY131298A (en) 5-heteroyl indole derivatives
NO905608D0 (no) Fremgangsmaate for fremstilling av a-nor-steroid-3-karboksylsyrederivater.
NO900855D0 (no) Substituerte pyrroler.
DE69528273D1 (de) 1,2-substituierte imidazolylverbindungen zur behandlung von entzündungen
NO924433D0 (no) Isoksazol-4-karboksylsyreamider og hydroksyalkyliden-cyaneddiksyreamider, legemidler inneholdende disse forbindelsene og deres anvendelse
NO914092D0 (no) Fremgangsmaate for fremstilling av mercaptoacetylamidderivater
ATE187965T1 (de) Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzündungen
MX9102582A (es) Derivados de indol 3,7-disubstituidos, procedimiento para su preparacion y composicion farmaceutica que los contiene.
DK0598770T3 (da) Pyrazinderivater samt fremstilling og anvendelse deraf
DK0444852T3 (da) Krystallinsk salt af 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz(cd)indol
DK0533824T3 (da) Piperidylsubstituerede indoler
AU3582095A (en) Isothiourea derivatives as no synthase inhibitors
ATE81976T1 (de) 2-pyrimidinyl-1-piperazin-derivate zur behandlung von alkoholismus.
BG37839A3 (bg) Метод за получаване на производни на ортокондензиран пирол
ZA931099B (en) Heterocyclic compounds their use and preparation
PT89029A (pt) Processo para a preparacao de novos derivados substituidos de 20,21-dinoreburnamenina
NO880405D0 (no) Fremgangsmaate til fremstilling av 3-fenyl-7h-tiazolo-/3,2-b//1,2,4/-tiazine-7-oner.
EA199900710A1 (ru) Кристаллическая гидратированная натриевая соль (е)-4,6-дихлор-3-(2-оксо-1-фенилпирролидин-3-илиденметил)-1н-индол-2-карбоновой кислоты
YU46150B (sh) Racemski i optički aktivni derivati 14-hidrpksi-imino-eburnana kao i postupak za njihovo dobijanje
HUT36117A (en) Process for preparing indolo/2,3-a/quinolizine-oxime esters
ES2111760T3 (es) Utilizacion de cetogluconatos en fotografia.
SU1139143A1 (ru) Гидрохлорид 3-(2-диэтиламиноэтилтио)-9-метил-1,2,4-триазино/6,5-в/ индола, обладающий противогипоксической активностью