DE69112099T2 - Kristallinisches Salz von 4-(Di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indol. - Google Patents
Kristallinisches Salz von 4-(Di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indol.Info
- Publication number
- DE69112099T2 DE69112099T2 DE69112099T DE69112099T DE69112099T2 DE 69112099 T2 DE69112099 T2 DE 69112099T2 DE 69112099 T DE69112099 T DE 69112099T DE 69112099 T DE69112099 T DE 69112099T DE 69112099 T2 DE69112099 T2 DE 69112099T2
- Authority
- DE
- Germany
- Prior art keywords
- amino
- propyl
- tetrahydrobenz
- hippurate
- aminocarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48518590A | 1990-02-26 | 1990-02-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69112099D1 DE69112099D1 (de) | 1995-09-21 |
| DE69112099T2 true DE69112099T2 (de) | 1996-02-08 |
Family
ID=23927224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69112099T Expired - Fee Related DE69112099T2 (de) | 1990-02-26 | 1991-02-26 | Kristallinisches Salz von 4-(Di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indol. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5397799A (enExample) |
| EP (1) | EP0444852B1 (enExample) |
| JP (1) | JP3157007B2 (enExample) |
| KR (1) | KR100208114B1 (enExample) |
| CN (1) | CN1027503C (enExample) |
| AT (1) | ATE126506T1 (enExample) |
| AU (1) | AU629453B2 (enExample) |
| BR (1) | BR9100767A (enExample) |
| CA (1) | CA2037099C (enExample) |
| CY (1) | CY1887A (enExample) |
| DE (1) | DE69112099T2 (enExample) |
| DK (1) | DK0444852T3 (enExample) |
| ES (1) | ES2077796T3 (enExample) |
| FI (1) | FI95464C (enExample) |
| GR (1) | GR3017940T3 (enExample) |
| HK (1) | HK175495A (enExample) |
| HU (1) | HU217118B (enExample) |
| IE (1) | IE67801B1 (enExample) |
| IL (1) | IL97306A (enExample) |
| LV (1) | LV10251B (enExample) |
| NO (1) | NO174149C (enExample) |
| NZ (1) | NZ237181A (enExample) |
| PT (1) | PT96852B (enExample) |
| RU (2) | RU2034837C1 (enExample) |
| SG (1) | SG69975A1 (enExample) |
| TW (1) | TW219933B (enExample) |
| YU (1) | YU47594B (enExample) |
| ZA (1) | ZA911258B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL97308A (en) * | 1990-02-26 | 1996-10-31 | Lilly Co Eli | 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them |
| US5302612A (en) * | 1990-02-26 | 1994-04-12 | Eli Lilly And Company | 6-substituted-hexahydrobenz[cd]indoles |
| IL97309A (en) * | 1990-02-26 | 1996-11-14 | Lilly Co Eli | Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof |
| US5633273A (en) * | 1991-03-28 | 1997-05-27 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd] indoles |
| US5364856A (en) * | 1991-03-28 | 1994-11-15 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles |
| TW248556B (enExample) * | 1993-01-18 | 1995-06-01 | Takeda Pharm Industry Co | |
| UA53205C2 (en) * | 2002-04-03 | 2006-06-15 | Pharmatech Close Joint Stock C | Antidepressant formulation and method for its manufacture |
| US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
| ATE485264T1 (de) | 2006-06-26 | 2010-11-15 | Warner Chilcott Co Llc | Prolylhydroxylase-hemmer und verfahren zu ihrer anwendung |
| RS54010B1 (sr) * | 2009-11-06 | 2015-10-30 | Aerpio Therapeutics Inc. | Inhibitori prolil hidroksilaze |
| CA2837560C (en) | 2011-06-06 | 2017-02-14 | Akebia Therapeutics Inc. | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
| NO2686520T3 (enExample) | 2011-06-06 | 2018-03-17 | ||
| HUE066123T2 (hu) | 2013-06-13 | 2024-07-28 | Akebia Therapeutics Inc | Készítmények és módszerek anémia kezelésére |
| AU2014348523B2 (en) | 2013-11-15 | 2019-01-03 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| CA2974691A1 (en) | 2015-01-23 | 2016-07-28 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| MX374909B (es) | 2015-04-01 | 2025-03-06 | Akebia Therapeutics Inc | El uso del inhibidor de propil hidrolasa del factor inducible de hipoxia (hif) para el tratamiento o prevención de la anemia. |
| IL278533B1 (en) | 2018-05-09 | 2025-10-01 | Akebia Therapeutics Inc | Process for the preparation of 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110339A (en) * | 1977-11-25 | 1978-08-29 | Eli Lilly And Company | 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole |
| US4576959A (en) * | 1984-02-06 | 1986-03-18 | Eli Lilly And Company | 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles |
| US4745126A (en) * | 1987-03-12 | 1988-05-17 | Eli Lilly And Company | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides |
| DE3809155A1 (de) * | 1988-03-18 | 1989-09-28 | Bayer Ag | 1,3,4,5-tetrahydrobenz-(c,d)-indole |
| US5204340A (en) * | 1989-04-11 | 1993-04-20 | Eli Lilly And Company | Tetrahydrobenz(c,d)indole serotonin agonists |
| US5229409A (en) * | 1990-08-15 | 1993-07-20 | Eli Lilly And Company | 6-substituted-tetrahydrobenz[cd]indoles |
-
1990
- 1990-06-26 TW TW079105258A patent/TW219933B/zh active
-
1991
- 1991-02-20 ZA ZA911258A patent/ZA911258B/xx unknown
- 1991-02-20 IL IL9730691A patent/IL97306A/en not_active IP Right Cessation
- 1991-02-21 NZ NZ237181A patent/NZ237181A/en unknown
- 1991-02-22 PT PT96852A patent/PT96852B/pt not_active IP Right Cessation
- 1991-02-22 JP JP05064391A patent/JP3157007B2/ja not_active Expired - Fee Related
- 1991-02-25 AU AU71971/91A patent/AU629453B2/en not_active Ceased
- 1991-02-25 KR KR1019910003029A patent/KR100208114B1/ko not_active Expired - Fee Related
- 1991-02-25 RU SU914894699A patent/RU2034837C1/ru not_active IP Right Cessation
- 1991-02-25 FI FI910895A patent/FI95464C/fi active
- 1991-02-25 NO NO910735A patent/NO174149C/no unknown
- 1991-02-25 YU YU32791A patent/YU47594B/sh unknown
- 1991-02-25 HU HU91629A patent/HU217118B/hu unknown
- 1991-02-25 IE IE62591A patent/IE67801B1/en not_active IP Right Cessation
- 1991-02-26 DE DE69112099T patent/DE69112099T2/de not_active Expired - Fee Related
- 1991-02-26 CA CA002037099A patent/CA2037099C/en not_active Expired - Fee Related
- 1991-02-26 CN CN91101296A patent/CN1027503C/zh not_active Expired - Fee Related
- 1991-02-26 EP EP91301501A patent/EP0444852B1/en not_active Expired - Lifetime
- 1991-02-26 ES ES91301501T patent/ES2077796T3/es not_active Expired - Lifetime
- 1991-02-26 SG SG1996007257A patent/SG69975A1/en unknown
- 1991-02-26 DK DK91301501.2T patent/DK0444852T3/da active
- 1991-02-26 BR BR919100767A patent/BR9100767A/pt not_active Application Discontinuation
- 1991-02-26 AT AT91301501T patent/ATE126506T1/de not_active IP Right Cessation
-
1992
- 1992-12-03 RU RU9292004575A patent/RU2083561C1/ru not_active IP Right Cessation
-
1993
- 1993-05-19 US US08/064,539 patent/US5397799A/en not_active Expired - Lifetime
- 1993-06-08 LV LVP-93-509A patent/LV10251B/xx unknown
-
1995
- 1995-11-01 GR GR950403048T patent/GR3017940T3/el unknown
- 1995-11-16 HK HK175495A patent/HK175495A/en not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY188796A patent/CY1887A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |