|
NL297170A
(enExample)
|
1963-04-04 |
1900-01-01 |
|
|
|
US3558618A
(en)
|
1968-04-01 |
1971-01-26 |
Dow Chemical Co |
Novel 4h-pyrazino(1,2-a)pyrimidine-4-ones
|
|
GB1383409A
(en)
|
1972-09-09 |
1974-02-12 |
Pfizer Ltd |
Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
|
|
US4122274A
(en)
|
1977-05-25 |
1978-10-24 |
Bristol-Myers Company |
3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
|
|
US4342870A
(en)
|
1980-03-28 |
1982-08-03 |
Janssen Pharmaceutica N.V. |
Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
|
|
JPS56150091A
(en)
|
1980-03-28 |
1981-11-20 |
Janssen Pharmaceutica Nv |
3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidine- 4-one derivative and its manufacture
|
|
FR2567518B1
(fr)
|
1984-07-11 |
1987-11-13 |
Sanofi Sa |
Nouveaux composes a noyau heterocyclique azote, leur preparation et les medicaments qui en contiennent
|
|
US5089633A
(en)
|
1987-04-28 |
1992-02-18 |
Georgia Tech Research Corporation |
Substituted isocoumarins
|
|
US5726182A
(en)
|
1990-05-02 |
1998-03-10 |
Abbott Laboratories |
Quinolizinone type compounds
|
|
WO1993023398A1
(en)
|
1992-05-13 |
1993-11-25 |
E.I. Du Pont De Nemours And Company |
Substituted pyrido[1,2-a]pyrimidinone derivatives as fungicides
|
|
FI955428A7
(fi)
|
1993-05-11 |
1996-01-04 |
The Univ Of North Carolina At |
Antisene-oligonukleotideja, jotka vastustavat poikkeavaa kietoutumista , ja menetelmiä niiden käyttämiseksi
|
|
AU6153096A
(en)
|
1995-06-06 |
1996-12-24 |
Abbott Laboratories |
Quinolizinone type compounds
|
|
US5916916A
(en)
|
1996-10-10 |
1999-06-29 |
Eli Lilly And Company |
1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
|
|
US5869500A
(en)
|
1996-12-13 |
1999-02-09 |
Hoffmann-La Roche Inc. |
Pyridone compounds useful in treating Alzheimer's disease
|
|
CA2269561C
(en)
|
1998-04-22 |
2007-06-05 |
Dainippon Ink And Chemicals, Inc. |
Naphthalene derivative and liquid crystal composition comprising the same
|
|
WO2000017197A1
(en)
|
1998-09-21 |
2000-03-30 |
Biochem Pharma Inc. |
Quinolizinones as integrin inhibitors
|
|
US6172216B1
(en)
|
1998-10-07 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of BCL-X expression
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
US6214986B1
(en)
|
1998-10-07 |
2001-04-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of bcl-x expression
|
|
ATE312820T1
(de)
|
1999-10-28 |
2005-12-15 |
Trine Pharmaceuticals Inc |
Pumpeninhibitoren zur freisetzung von medikamenten
|
|
ATE551325T1
(de)
|
2000-01-24 |
2012-04-15 |
Astrazeneca Ab |
Therapeutische morpholino-substituierte verbindungen
|
|
AU2002232536A1
(en)
|
2000-11-09 |
2002-05-21 |
Cold Spring Harbor Laboratory |
Chimeric molecules to modulate gene expression
|
|
US6774134B2
(en)
|
2000-12-20 |
2004-08-10 |
Bristol-Myers Squibb Company |
Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
|
|
KR100947185B1
(ko)
|
2000-12-21 |
2010-03-15 |
버텍스 파마슈티칼스 인코포레이티드 |
단백질 키나제 억제제로서 유용한 피라졸 화합물 및 이를 포함하는 조성물
|
|
EP1389463A4
(en)
|
2001-04-26 |
2008-09-17 |
Daiichi Seiyaku Co |
MEDICAMENT FOR INHIBITING A DRUG REMOVAL PUMP
|
|
US20030199526A1
(en)
|
2001-12-07 |
2003-10-23 |
Deborah Choquette |
Pyrimidine-based compounds useful as GSK-3 inhibitors
|
|
GB0205281D0
(en)
|
2002-03-06 |
2002-04-17 |
Novartis Ag |
Organic compounds
|
|
ATE548354T1
(de)
|
2002-07-24 |
2012-03-15 |
Ptc Therapeutics Inc |
Ureido-substituierte benzoesäureverbindungen und ihre verwendung für die nonsense-suppression und behandlung von erkrankungen
|
|
WO2004019002A2
(en)
*
|
2002-08-23 |
2004-03-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Fluorescent glycosides and methods for their use
|
|
DE60311853T2
(de)
|
2002-09-30 |
2007-06-21 |
Neurosearch A/S |
Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung
|
|
JP4820094B2
(ja)
|
2002-11-12 |
2011-11-24 |
アボット・ラボラトリーズ |
ヒスタミン−３受容体リガンドとしての２環式置換アミン
|
|
US20070078144A1
(en)
|
2003-01-29 |
2007-04-05 |
Stockwell Brent R |
Agents for treating neurodegenerative diseases
|
|
US20040224952A1
(en)
|
2003-05-07 |
2004-11-11 |
Cowart Marlon D. |
Fused bicyclic-substituted amines as histamine-3 receptor ligands
|
|
MXPA05013142A
(es)
|
2003-06-20 |
2006-03-17 |
Chiron Corp |
Compuestos de piridinio [1,2-a]pirimidin-4-ona como agentes anticancer.
|
|
GB0315494D0
(en)
|
2003-07-02 |
2003-08-06 |
Biofocus Plc |
Compounds which bind to the active site of protein kinase enzymes
|
|
US7511145B2
(en)
|
2003-08-01 |
2009-03-31 |
Genelabs Technologies, Inc. |
Bicyclic heteroaryl derivatives
|
|
US7160888B2
(en)
|
2003-08-22 |
2007-01-09 |
Warner Lambert Company Llc |
[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
|
|
US20050074801A1
(en)
|
2003-09-09 |
2005-04-07 |
Monia Brett P. |
Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
|
|
US20050245531A1
(en)
|
2003-12-22 |
2005-11-03 |
Abbott Laboratories |
Fused bicycloheterocycle substituted quinuclidine derivatives
|
|
US7655657B2
(en)
|
2003-12-22 |
2010-02-02 |
Abbott Laboratories |
Fused bicycloheterocycle substituted quinuclidine derivatives
|
|
US7309699B2
(en)
|
2003-12-22 |
2007-12-18 |
Abbott Laboratories |
3-Quinuclidinyl amino-substituted biaryl derivatives
|
|
US20050137203A1
(en)
|
2003-12-22 |
2005-06-23 |
Jianguo Ji |
3-quinuclidinyl amino-substituted biaryl derivatives
|
|
DE602004031258D1
(de)
|
2003-12-24 |
2011-03-10 |
Biota Scient Management |
Polycyclische mittel zur behandlung von infektione
|
|
SE0400184D0
(sv)
|
2004-01-30 |
2004-01-30 |
Fyrkloevern Scandinavia Ab |
New therapeutical use
|
|
TW200536830A
(en)
|
2004-02-06 |
2005-11-16 |
Chugai Pharmaceutical Co Ltd |
1-(2H)-isoquinolone derivative
|
|
EP1732560A4
(en)
|
2004-04-08 |
2010-08-18 |
Neurogen Corp |
SUBSTITUTED CINNOLINE-4-YLAMINE
|
|
CN101426772B
(zh)
|
2004-04-08 |
2014-01-08 |
塔尔基公司 |
激酶的苯并三嗪抑制物
|
|
US20080255162A1
(en)
|
2004-05-04 |
2008-10-16 |
Warner-Lambert Company Llc |
Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents
|
|
CA2595477A1
(en)
|
2005-01-21 |
2006-07-27 |
Janssen Pharmaceutica N.V. |
Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors
|
|
US7879992B2
(en)
|
2005-01-31 |
2011-02-01 |
Isis Pharmaceuticals, Inc. |
Modification of MyD88 splicing using modified oligonucleotides
|
|
GB0501999D0
(en)
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
JP2006219453A
(ja)
|
2005-02-14 |
2006-08-24 |
Tokyo Univ Of Pharmacy & Life Science |
キノリン環を母核とする金属識別型二波長性蛍光分子
|
|
US7563601B1
(en)
|
2005-06-01 |
2009-07-21 |
City Of Hope |
Artificial riboswitch for controlling pre-mRNA splicing
|
|
WO2006138418A2
(en)
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
EP1902028A2
(en)
|
2005-07-04 |
2008-03-26 |
Novo Nordisk A/S |
Histamine h3 receptor antagonists
|
|
US7473784B2
(en)
*
|
2005-08-01 |
2009-01-06 |
Bristol-Myers Squibb Company |
Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
|
|
US7576110B2
(en)
|
2005-09-22 |
2009-08-18 |
Abbott Laboratories |
Benzothiazole cyclobutyl amine derivatives
|
|
US8258109B2
(en)
|
2005-10-20 |
2012-09-04 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of LMNA expression
|
|
WO2007056580A2
(en)
|
2005-11-08 |
2007-05-18 |
Pharmadyn, Inc. |
Methods and compositions for treating diseases associated with pathogenic proteins
|
|
WO2007058894A2
(en)
|
2005-11-10 |
2007-05-24 |
The University Of North Carolina At Chapel Hill |
Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease
|
|
CA2632642A1
(en)
|
2005-12-06 |
2007-06-14 |
Neurosearch A/S |
Novel diazabicyclic aryl derivatives and their medical use
|
|
CA2634491A1
(en)
|
2005-12-21 |
2007-06-28 |
Painceptor Pharma Corporation |
Compositions and methods for modulating gated ion channels
|
|
EP3210633B1
(en)
|
2006-01-26 |
2019-06-19 |
Ionis Pharmaceuticals, Inc. |
Compositions and their uses directed to huntingtin
|
|
EP2388328A1
(en)
|
2006-01-27 |
2011-11-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
|
AR059339A1
(es)
|
2006-02-09 |
2008-03-26 |
Chugai Pharmaceutical Co Ltd |
Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
|
|
US8110681B2
(en)
|
2006-03-17 |
2012-02-07 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Compounds for the treatment of spinal muscular atrophy and other uses
|
|
EA015569B1
(ru)
*
|
2006-03-28 |
2011-10-31 |
ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Бензотиазолы, обладающие антагонистической активностью по отношению к h3-рецептору гистамина, и фармацевтические композиции, включающие эти соединения
|
|
WO2007130383A2
(en)
|
2006-04-28 |
2007-11-15 |
Northwestern University |
Compositions and treatments using pyridazine compounds and secretases
|
|
US20080247964A1
(en)
|
2006-05-08 |
2008-10-09 |
Yuelian Xu |
Substituted azaspiro derivatives
|
|
TW200812588A
(en)
|
2006-05-15 |
2008-03-16 |
Neurogen Corp |
CRF1 receptor ligands comprising heteroaryl fused bicycles
|
|
EP2029607A1
(en)
|
2006-05-23 |
2009-03-04 |
NeuroSearch A/S |
Novel 8,10-diaza-bicycloý4.3.1¨decane derivatives and their medical use
|
|
ES2344760T3
(es)
|
2006-07-20 |
2010-09-06 |
Amgen Inc. |
Compuestos de piridona sustituidos y metodo de uso.
|
|
WO2008013997A2
(en)
|
2006-07-27 |
2008-01-31 |
The Trustees Of Columbia University In The City Of New York |
Fluorescent substrates for monoamine transporters as optical false neurotransmitters
|
|
PT2066653E
(pt)
|
2006-08-03 |
2012-10-22 |
Rottapharm Spa |
Derivados de 6-1h-imidazo-quinazolina e quinolinas, novos potentes analgésicos e agentes anti-inflamatórios
|
|
WO2008020302A2
(en)
|
2006-08-17 |
2008-02-21 |
Pfizer Products Inc. |
Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
|
|
MX2009003892A
(es)
|
2006-10-25 |
2009-04-23 |
Neurosearch As |
Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico.
|
|
US8314119B2
(en)
|
2006-11-06 |
2012-11-20 |
Abbvie Inc. |
Azaadamantane derivatives and methods of use
|
|
MX2009006764A
(es)
|
2006-12-22 |
2009-11-26 |
Avexa Ltd |
Pirimidinonas biciclicas y usos de la misma.
|
|
WO2008083226A2
(en)
|
2006-12-28 |
2008-07-10 |
Navinta Llc |
Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
|
|
FR2914188B1
(fr)
|
2007-03-28 |
2012-06-22 |
Trophos |
Nouvelle composition a base d'oxime de cholest-4-en-3-one
|
|
EP2014656A3
(en)
|
2007-06-11 |
2011-08-24 |
High Point Pharmaceuticals, LLC |
New heteocyclic h3 antagonists
|
|
US8563550B2
(en)
|
2007-09-27 |
2013-10-22 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
Imidazolothiadiazoles for use as protein kinase inhibitors
|
|
EP2573080A1
(en)
|
2007-09-27 |
2013-03-27 |
The United States of America, as Represented by the Secretary, Department of Health and Human Services |
Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
|
|
US8153813B2
(en)
*
|
2007-12-20 |
2012-04-10 |
Abbott Laboratories |
Benzothiazole and benzooxazole derivatives and methods of use
|
|
WO2009114874A2
(en)
*
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Benzothiazole kinase inhibitors and methods of use
|
|
WO2009126635A1
(en)
*
|
2008-04-09 |
2009-10-15 |
Abbott Laboratories |
2-amino-benzothiazole derivates useful as inhibitors of rock kinases
|
|
US20090264433A1
(en)
|
2008-04-21 |
2009-10-22 |
Institute For Oneworld Health |
Compounds, Compositions and Methods Comprising Triazine Derivatives
|
|
US8633019B2
(en)
|
2008-05-27 |
2014-01-21 |
Ptc Therapeutics, Inc. |
Methods for treating spinal muscular atrophy
|
|
CA2728376C
(en)
|
2008-06-20 |
2015-05-12 |
Rottapharm S.P.A. |
6-1h-imidazo-quinazoline and quinolines derivatives/mao inhibitors for treating depression
|
|
EP2138493A1
(en)
|
2008-06-26 |
2009-12-30 |
Sanofi-Aventis |
Substituted pyrimidone derivatives
|
|
NZ590126A
(en)
|
2008-07-02 |
2012-11-30 |
Avexa Ltd |
Compounds having antiviral properties
|
|
US8986935B2
(en)
|
2008-08-13 |
2015-03-24 |
Ptc Therapeutics, Inc. |
Methods for treating spinal muscular atrophy
|
|
WO2010024903A1
(en)
*
|
2008-08-29 |
2010-03-04 |
Yangbo Feng |
BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS
|
|
AU2009303441A1
(en)
|
2008-10-16 |
2010-04-22 |
Schering Corporation |
Pyrrolidine, piperidine and piperazine derivatives and methods of use thereof
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
EP2379564A1
(en)
|
2008-12-19 |
2011-10-26 |
Schering Corporation |
Bicyclic heterocyclic derivatives and methods of use thereof
|
|
US8063032B2
(en)
|
2009-02-11 |
2011-11-22 |
Sunovion Pharmaceuticals Inc. |
Histamine H3 inverse agonists and antagonists and methods of use thereof
|
|
FR2945289A1
(fr)
|
2009-05-11 |
2010-11-12 |
Sanofi Aventis |
Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique
|
|
JP6073677B2
(ja)
|
2009-06-12 |
2017-02-01 |
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド |
縮合複素環式化合物およびそれらの使用
|
|
EP2443122B1
(en)
|
2009-06-19 |
2014-03-05 |
AbbVie Inc. |
Diazahomoadamantane derivatives and methods of use thereof
|
|
EP2475675B1
(en)
|
2009-09-11 |
2016-11-16 |
Ionis Pharmaceuticals, Inc. |
Modulation of huntingtin expression
|
|
WO2011050245A1
(en)
|
2009-10-23 |
2011-04-28 |
Yangbo Feng |
Bicyclic heteroaryls as kinase inhibitors
|
|
WO2011057204A2
(en)
|
2009-11-06 |
2011-05-12 |
The Johns Hopkins University |
Lrrk2-mediated neuronal toxicity
|
|
EP2501231B1
(en)
|
2009-11-20 |
2016-12-21 |
Merck Sharp & Dohme Corp. |
Quinolizidinone carboxamide m1 receptor positive allosteric modulators
|
|
CN102812023A
(zh)
|
2010-01-13 |
2012-12-05 |
韩国巴斯德研究所 |
抗感染吡啶并(1,2-a)嘧啶类
|
|
WO2011097643A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
US20130059902A1
(en)
|
2010-02-08 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Methods and compositions useful in treatment of diseases or conditions related to repeat expansion
|
|
CA2789038A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
MX2012012902A
(es)
*
|
2010-05-06 |
2012-12-17 |
Bristol Myers Squibb Co |
Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119.
|
|
CA2800509A1
(en)
|
2010-05-24 |
2011-12-01 |
Presidio Pharmaceuticals, Inc. |
Inhibitors of hcv ns5a
|
|
EP3031920B1
(en)
|
2010-07-19 |
2019-08-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dystrophia myotonica-protein kinase (dmpk) expression
|
|
WO2012019106A2
(en)
|
2010-08-06 |
2012-02-09 |
Board Of Regents Of The University Of Nebraska |
Positive and negative modulators of nmda receptors
|
|
WO2012075393A2
(en)
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
CN102617548A
(zh)
|
2011-01-31 |
2012-08-01 |
北京赛林泰医药技术有限公司 |
作为gpr受体激动剂的双环杂芳基化合物及其组合物和应用
|
|
WO2012104823A2
(en)
|
2011-02-04 |
2012-08-09 |
Novartis Ag |
Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
|
|
PH12013501628A1
(en)
|
2011-02-07 |
2019-10-11 |
Biogen Ma Inc |
S1p modulating agents
|
|
EP3467109A1
(en)
|
2011-02-08 |
2019-04-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
US8703763B2
(en)
|
2011-03-02 |
2014-04-22 |
Hoffmann-La Roche Inc. |
Bridged piperidine derivatives
|
|
US9447075B2
(en)
|
2011-08-02 |
2016-09-20 |
The Brigham And Women's Hospital, Inc. |
Pyridazine derivatives as EAAT2 activators
|
|
DK2742135T4
(da)
|
2011-08-11 |
2020-07-13 |
Ionis Pharmaceuticals Inc |
Bindingsmodificerede gapped oligomeriske forbindelser og anvendelser deraf
|
|
US8871756B2
(en)
|
2011-08-11 |
2014-10-28 |
Hoffmann-La Roche Inc. |
Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
|
|
EP2560008B1
(en)
*
|
2011-08-18 |
2016-11-30 |
Korea Institute of Science and Technology |
Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
|
|
US9976138B2
(en)
|
2011-08-29 |
2018-05-22 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
WO2013059606A1
(en)
|
2011-10-21 |
2013-04-25 |
Tufts Medical Center, Inc. |
Compounds and methods for the treatment of muscular disease, and related screening methods
|
|
GB201119538D0
(en)
|
2011-11-10 |
2011-12-21 |
Viral Ltd |
Pharmaceutical compounds
|
|
BR112014012815A8
(pt)
|
2011-11-28 |
2017-06-20 |
Novartis Ag |
derivados de trifluormetil-oxadiazol e uso dos mesmos no tratamento de doença
|
|
EP2797592B1
(en)
|
2011-12-30 |
2019-08-28 |
PTC Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
MX357834B
(es)
|
2012-01-26 |
2018-07-26 |
Ptc Therapeutics Inc |
Compuestos de tipo isocumarina sustituidos para tratar la atrofia muscular espinal.
|
|
PL2812004T3
(pl)
|
2012-02-10 |
2019-01-31 |
Ptc Therapeutics, Inc. |
Związki do leczenia rdzeniowego zaniku mięśni
|
|
US9371336B2
(en)
|
2012-03-01 |
2016-06-21 |
Ptc Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
EP2828247B1
(en)
|
2012-03-23 |
2019-01-16 |
PTC Therapeutics, Inc. |
4h-chromen-4-one derivatives for treating spinal muscular atrophy
|
|
US9199946B2
(en)
|
2012-04-03 |
2015-12-01 |
Bristol-Myers Squibb Company |
Pyrimidinone carboxamide inhibitors of endothelial lipase
|
|
SI3459942T1
(sl)
|
2012-04-24 |
2021-05-31 |
Vertex Pharmaceuticals Incorporated |
Inhibitorji DNA-PK
|
|
CN104302634B
(zh)
|
2012-05-15 |
2017-02-08 |
诺华股份有限公司 |
用于抑制abl1、abl2和bcr‑abl1的活性的苯甲酰胺衍生物
|
|
WO2014012050A2
(en)
|
2012-07-13 |
2014-01-16 |
Indiana University Research & Technology Corporation |
Compounds for treatment of spinal muscular atrophy
|
|
US8729263B2
(en)
|
2012-08-13 |
2014-05-20 |
Novartis Ag |
1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
|
|
WO2014059341A2
(en)
|
2012-10-12 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
|
EP3459549B1
(en)
|
2012-10-12 |
2022-04-06 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
WO2014066836A1
(en)
|
2012-10-25 |
2014-05-01 |
Usher Iii Initiative, Inc. |
Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
|
|
US9227976B2
(en)
|
2012-10-25 |
2016-01-05 |
Usher Iii Initiative, Inc. |
Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
|
|
JP6255711B2
(ja)
|
2012-11-01 |
2018-01-10 |
株式会社リコー |
エレクトロクロミック化合物、エレクトロクロミック組成物及び表示素子
|
|
US9040712B2
(en)
|
2013-01-23 |
2015-05-26 |
Novartis Ag |
Thiadiazole analogs thereof and methods for treating SMN-deficiency-related-conditions
|
|
ES2817050T3
(es)
|
2013-02-04 |
2021-04-06 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido selectivos y usos de los mismos
|
|
JP6427115B2
(ja)
|
2013-03-05 |
2018-11-21 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ |
癌などの疾患の処置のためのトリアゾロ［４，５−ｄ］ピリミジン誘導体
|
|
RU2015148926A
(ru)
|
2013-05-14 |
2017-06-15 |
Ф. Хоффманн-Ля Рош Аг |
Аза-оксо-индолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции
|
|
US20160145270A1
(en)
|
2013-06-25 |
2016-05-26 |
F. Hoffmann-La Roche Ag |
Compounds for treating spinal muscular atrophy
|
|
CA2918805C
(en)
|
2013-07-31 |
2023-02-28 |
Novartis Ag |
1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions
|
|
EP3035935B1
(en)
|
2013-08-19 |
2020-03-11 |
F. Hoffmann-La Roche AG |
Compounds for use in the prophylaxis and treatment of cancer
|
|
WO2015095446A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount of rna transcripts
|
|
WO2015095449A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount rna transcripts
|
|
US10195202B2
(en)
|
2013-12-19 |
2019-02-05 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount of RNA transcripts
|
|
PT3094728T
(pt)
|
2014-01-16 |
2022-05-19 |
Wave Life Sciences Ltd |
Desenho quiral
|
|
JP6473457B2
(ja)
|
2014-01-17 |
2019-02-20 |
ノバルティス アーゲー |
Ｓｈｐ２の活性を阻害するための１−（トリアジン−３−イル／ピリダジン−３−イル）−ピペリジン／ピペラジン誘導体およびその組成物
|
|
AR099134A1
(es)
|
2014-01-24 |
2016-06-29 |
Hoffmann La Roche |
Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
|
|
CA2940621C
(en)
|
2014-03-14 |
2022-03-15 |
Raqualia Pharma Inc. |
Azaspiro derivatives as trpm8 antagonists
|
|
AU2015231239B2
(en)
|
2014-03-19 |
2018-11-29 |
Amydis, Inc. |
Amyloid targeting agents and methods of using the same
|
|
PH12016502081B1
(en)
|
2014-05-15 |
2022-11-23 |
Hoffmann La Roche |
Compounds for treating spinal muscular atrophy
|
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
|
WO2015195811A2
(en)
|
2014-06-17 |
2015-12-23 |
Novozymes A/S |
Biological phosphorus removal from wastewater
|
|
KR102565544B1
(ko)
|
2014-06-25 |
2023-08-10 |
에프. 호프만-라 로슈 아게 |
척수성 근위축증을 치료하기 위한 이미다조[1,2-a]피라진-1일-벤즈아마이드 화합물
|
|
EP3212633B1
(en)
|
2014-10-31 |
2019-12-04 |
The General Hospital Corporation |
Potent gamma-secretase modulators
|
|
GB201419579D0
(en)
|
2014-11-03 |
2014-12-17 |
Iomet Pharma Ltd |
Pharmaceutical compound
|
|
BR112017011791A2
(pt)
|
2014-12-02 |
2018-02-27 |
Bayer Cropscience Aktiengesellschaft |
compostos bicíclicos como agentes de controle de pragas
|
|
US10174321B2
(en)
|
2014-12-24 |
2019-01-08 |
Uniqure Ip B.V. |
RNAI induced huntingtin gene suppression
|
|
WO2016115434A1
(en)
|
2015-01-16 |
2016-07-21 |
The General Hospital Corporation |
Compounds for improving mrna splicing
|
|
WO2016128343A1
(en)
|
2015-02-09 |
2016-08-18 |
F. Hoffmann-La Roche Ag |
Compounds for the treatment of cancer
|
|
GB201502567D0
(en)
|
2015-02-16 |
2015-04-01 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
WO2016144351A1
(en)
|
2015-03-11 |
2016-09-15 |
E. I. Du Pont De Nemours And Company |
Heterocycle-substituted bicyclic azole pesticides
|
|
GB201506933D0
(en)
|
2015-04-23 |
2015-06-10 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
JP6749343B2
(ja)
|
2015-05-20 |
2020-09-02 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
脊髄性筋萎縮症を処置するための化合物
|
|
EP4249472A3
(en)
|
2015-05-30 |
2023-12-13 |
PTC Therapeutics, Inc. |
Methods for modulating rna splicing
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
WO2017023987A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
|
WO2017059251A1
(en)
|
2015-10-02 |
2017-04-06 |
Incyte Corporation |
Heterocyclic compounds useful as pim kinase inhibitors
|
|
MX384868B
(es)
|
2015-11-12 |
2025-03-14 |
Hoffmann La Roche |
Composiciones para tratar atrofia muscular espinal.
|
|
MX2018005041A
(es)
|
2015-11-12 |
2018-08-01 |
Hoffmann La Roche |
Compuestos para tratar la esclerosis lateral amiotrofica.
|
|
US10383867B2
(en)
|
2015-11-28 |
2019-08-20 |
Russell Dahl |
Quinoline derivatives and their use for treating endoplasmic reticulum stress-related diseases and disorders
|
|
EP3848035B1
(en)
|
2015-12-10 |
2025-02-19 |
PTC Therapeutics, Inc. |
1,4-disubstituted pyridazine compounds for treating huntington's disease
|
|
CN108137579B
(zh)
|
2015-12-10 |
2022-01-07 |
豪夫迈·罗氏有限公司 |
桥连哌啶衍生物
|
|
RU2766139C2
(ru)
|
2016-03-11 |
2022-02-08 |
Ац Иммуне Са |
Бициклические соединения для диагностики и лечения
|
|
US10526345B2
(en)
*
|
2016-04-08 |
2020-01-07 |
Mankind Pharma Ltd. |
Compounds as GPR119 agonists
|
|
AR108325A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
|
MA45270A
(fr)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
CA3024706A1
(en)
|
2016-05-31 |
2017-12-07 |
Board Of Regents, The University Of Texas System |
Heterocyclic inhibitors of ptpn11
|
|
KR102494647B1
(ko)
*
|
2016-07-14 |
2023-01-31 |
브리스톨-마이어스 스큅 컴퍼니 |
비시클릭 헤테로아릴 치환된 화합물
|
|
WO2018022473A1
(en)
|
2016-07-25 |
2018-02-01 |
Wave Life Sciences Ltd. |
Phasing
|
|
TW202500565A
(zh)
|
2016-10-24 |
2025-01-01 |
美商傳達治療有限公司 |
Shp2磷酸酶抑制劑及其使用方法
|
|
EP3606562A4
(en)
|
2017-04-03 |
2020-11-11 |
Acceleron Pharma Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF SPINAL AMYOTROPHIA
|
|
WO2018218133A1
(en)
|
2017-05-26 |
2018-11-29 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
|
|
WO2018226622A1
(en)
|
2017-06-05 |
2018-12-13 |
Ptc Therapeutics, Inc. |
Compounds for treating huntington's disease
|
|
WO2019005993A1
(en)
|
2017-06-28 |
2019-01-03 |
Ptc Therapeutics, Inc. |
METHODS OF TREATING HUNTINGTON'S DISEASE
|
|
BR112019027717A2
(pt)
|
2017-06-28 |
2020-07-28 |
Ptc Therapeutics, Inc. |
métodos para tratar a doença de huntington
|
|
RU2020105929A
(ru)
|
2017-08-04 |
2021-09-06 |
Скайхоук Терапьютикс, Инк. |
Способы и композиции для модулирования сплайсинга
|
|
US20200392161A1
(en)
|
2018-02-21 |
2020-12-17 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of use thereof
|
|
KR20210015758A
(ko)
|
2018-03-21 |
2021-02-10 |
릴레이 테라퓨틱스, 인크. |
Shp2 포스파타제 억제제 및 그의 사용 방법
|
|
US12138263B2
(en)
|
2018-03-21 |
2024-11-12 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof
|
|
BR112020019373A2
(pt)
|
2018-03-27 |
2020-12-29 |
Ptc Therapeutics, Inc. |
Compostos para o tratamento da doença de hutington
|
|
RS65727B1
(sr)
|
2018-06-27 |
2024-08-30 |
Ptc Therapeutics Inc |
Heterociklična i heteroaril jedinjenja za lečenje hantingtonove bolesti
|
|
EP3814360B8
(en)
|
2018-06-27 |
2024-11-06 |
PTC Therapeutics, Inc. |
Heteroaryl compounds for treating huntington's disease
|
|
KR20210038845A
(ko)
|
2018-06-27 |
2021-04-08 |
피티씨 테라퓨틱스, 인크. |
헌팅턴병 치료를 위한 헤테로아릴 화합물
|
|
EP3937942A4
(en)
|
2019-03-15 |
2022-11-16 |
Skyhawk Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR CORRECTING ABERRANT SPLICING
|
|
EP3969446B1
(en)
|
2019-05-13 |
2023-09-27 |
PTC Therapeutics, Inc. |
Compounds for treating huntington's disease
|
|
WO2021007378A1
(en)
|
2019-07-11 |
2021-01-14 |
Ptc Therapeutics, Inc. |
Compounds for use in treating huntington's disease
|
|
CA3156848A1
(en)
|
2019-11-01 |
2021-05-06 |
Novartis Ag |
The use of a splicing modulator for a treatment slowing progression of huntington's disease
|
|
AU2021254418A1
(en)
|
2020-04-09 |
2022-11-03 |
Ptc Therapeutics, Inc. |
Compounds for treating Huntington's disease
|
|
IL302839A
(en)
|
2020-11-12 |
2023-07-01 |
Ptc Therapeutics Inc |
Novel rna transcript
|
|
AR126612A1
(es)
|
2021-07-30 |
2023-10-25 |
Ptc Therapeutics Inc |
Compuestos de heteroarilo para el tratamiento de la enfermedad de huntington
|