JP2015504057A5 - - Google Patents
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- JP2015504057A5 JP2015504057A5 JP2014550478A JP2014550478A JP2015504057A5 JP 2015504057 A5 JP2015504057 A5 JP 2015504057A5 JP 2014550478 A JP2014550478 A JP 2014550478A JP 2014550478 A JP2014550478 A JP 2014550478A JP 2015504057 A5 JP2015504057 A5 JP 2015504057A5
- Authority
- JP
- Japan
- Prior art keywords
- chromen
- pyrazin
- pyridin
- methylimidazo
- dimethylimidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161582064P | 2011-12-30 | 2011-12-30 | |
| US61/582,064 | 2011-12-30 | ||
| PCT/US2012/071899 WO2013101974A1 (en) | 2011-12-30 | 2012-12-28 | Compounds for treating spinal muscular atrophy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504057A JP2015504057A (ja) | 2015-02-05 |
| JP2015504057A5 true JP2015504057A5 (enExample) | 2016-02-12 |
| JP6193881B2 JP6193881B2 (ja) | 2017-09-06 |
Family
ID=48698624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550478A Active JP6193881B2 (ja) | 2011-12-30 | 2012-12-28 | 脊髄性筋萎縮症を治療するための化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9617268B2 (enExample) |
| EP (1) | EP2797592B1 (enExample) |
| JP (1) | JP6193881B2 (enExample) |
| KR (1) | KR102057351B1 (enExample) |
| CN (1) | CN104244944B (enExample) |
| BR (1) | BR112014016287B1 (enExample) |
| CA (1) | CA2861609C (enExample) |
| EA (1) | EA029984B1 (enExample) |
| MX (1) | MX352861B (enExample) |
| WO (1) | WO2013101974A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2809322T3 (pl) | 2012-01-26 | 2019-11-29 | Ptc Therapeutics Inc | Związki do leczenia zaniku mięśni pochodzenia rdzeniowego |
| DK2812004T3 (en) | 2012-02-10 | 2018-10-15 | Ptc Therapeutics Inc | COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY |
| CN104302181B (zh) | 2012-03-01 | 2017-09-15 | Ptc医疗公司 | 用于治疗脊髓性肌萎缩的化合物 |
| KR102109992B1 (ko) | 2012-03-23 | 2020-05-13 | 피티씨 테라퓨틱스, 인크. | 척수성 근위축증을 치료하기 위한 화합물 |
| KR20150098675A (ko) * | 2012-12-24 | 2015-08-28 | 라모트 앳 텔-아비브 유니버시티 리미티드 | 넌센스 돌연변이로부터 생긴 유전적 질환을 치료하기 위한 물질 및 이를 확인하는 방법 |
| CN103360269B (zh) * | 2013-07-16 | 2015-07-08 | 临海市联盛化学有限公司 | 一种3-氯-2-氨基苯酚的制备方法 |
| WO2015024876A2 (en) | 2013-08-19 | 2015-02-26 | F. Hoffmann-La Roche Ag | Screening method |
| WO2015095449A1 (en) * | 2013-12-19 | 2015-06-25 | Ptc Therapeutics, Inc. | Methods for modulating the amount rna transcripts |
| EP3082820B1 (en) | 2013-12-19 | 2022-07-20 | PTC Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| ES2713452T3 (es) | 2014-04-22 | 2019-05-21 | Univ Basel | Proceso de fabricación para derivados de triazina, pirimidina y piridina |
| US10882868B2 (en) | 2014-05-15 | 2021-01-05 | Hoffmann-La Roche Inc. | Compounds for treating spinal muscular atrophy |
| SI3143025T1 (sl) * | 2014-05-15 | 2020-01-31 | F. Hoffmann-La Roche Ag | Spojine za zdravljenje spinalne mišične atrofije |
| BR112016026951B1 (pt) * | 2014-06-25 | 2022-09-20 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]pirazin-1-il-benzamida, seu uso, e composições farmacêuticas |
| CN104803921A (zh) * | 2015-03-14 | 2015-07-29 | 长沙深橙生物科技有限公司 | 一种苯取代嘧啶衍生物的制备方法 |
| CN104744376A (zh) * | 2015-03-14 | 2015-07-01 | 长沙深橙生物科技有限公司 | 一种2-异丙基嘧啶衍生物的制备方法 |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| JP6659841B2 (ja) | 2015-11-12 | 2020-03-04 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 脊髄性筋萎縮症を処置するための組成物 |
| WO2017081111A1 (en) * | 2015-11-12 | 2017-05-18 | F. Hoffmann-La Roche Ag | Compounds for treating amyotrophic lateral sclerosis |
| US20200262800A1 (en) * | 2015-11-16 | 2020-08-20 | Ptc Therapeutics, Inc. | Hydrogen isotope-enriched analogues of 1,2,4-oxadiazole benzoic acid compounds, compositions and uses thereof |
| WO2017097728A1 (en) | 2015-12-10 | 2017-06-15 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
| IL294124B2 (en) | 2015-12-10 | 2024-02-01 | Ptc Therapeutics Inc | Methods for treating huntington's disease |
| AU2017223706A1 (en) * | 2016-02-23 | 2018-09-20 | Indiana University Research & Technology Corporation | Combination therapies for treatment of spinal muscular atrophy |
| JP2019534266A (ja) | 2016-10-14 | 2019-11-28 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ５員ヘテロアリール環の架橋した環誘導体、その製造方法およびその医学的使用 |
| EA201991309A1 (ru) | 2016-11-28 | 2019-11-29 | Способы модуляции сплайсинга рнк | |
| US11407753B2 (en) | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| KR20200017476A (ko) | 2017-06-14 | 2020-02-18 | 피티씨 테라퓨틱스, 인크. | Rna 스플라이싱의 변경 방법 |
| US11382918B2 (en) | 2017-06-28 | 2022-07-12 | Ptc Therapeutics, Inc. | Methods for treating Huntington's Disease |
| WO2019005993A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| WO2019028440A1 (en) | 2017-08-04 | 2019-02-07 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICING |
| HRP20251594T1 (hr) * | 2017-09-22 | 2026-01-30 | F. Hoffmann - La Roche Ag | Postupak priprave derivata 7-(4,7-diazaspiro[2.5]oktan-7-il)-2-(2,8-dimetilimidazo[1,2-b]piridazin-6-il)pirido[1,2-a]pirimidin-4-ona |
| EP3765459A1 (en) | 2018-03-13 | 2021-01-20 | Shire Human Genetic Therapies, Inc. | Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof |
| MX2020009957A (es) | 2018-03-27 | 2021-01-15 | Ptc Therapeutics Inc | Compuestos para el tratamiento de enfermedad de hungtinton. |
| PL3814357T3 (pl) | 2018-06-27 | 2024-09-16 | Ptc Therapeutics, Inc. | Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona |
| EP3814345B8 (en) | 2018-06-27 | 2024-10-30 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| BR112020026637A2 (pt) | 2018-06-27 | 2021-03-30 | Reborna Biosciences, Inc. | Agente profilático ou terapêutico para atrofia muscular espinhal |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| WO2020146449A1 (en) * | 2019-01-08 | 2020-07-16 | Texas Tech University System | Small molecule analogs of the protein e4orf1 in the treatment and prevention of metabolic disorders |
| WO2020163248A1 (en) | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| EP3920915A4 (en) | 2019-02-05 | 2022-10-05 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICE |
| CN114126613A (zh) | 2019-02-05 | 2022-03-01 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| WO2020163544A1 (en) | 2019-02-06 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| CN113661162A (zh) | 2019-02-06 | 2021-11-16 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| BR112020026528B1 (pt) * | 2019-03-01 | 2024-02-15 | Illumina Cambridge Limited | Composto de cumarina substituído com amina exocíclica, nucleotídeo ou oligonucleotídeo, kit, método de sequenciamento e método para sintetizar o referido composto |
| CN109943092A (zh) * | 2019-04-09 | 2019-06-28 | 浙江工业大学 | 具有高荧光量子产率的咪唑类香豆素类染料及其合成方法 |
| WO2020231977A1 (en) | 2019-05-13 | 2020-11-19 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| US11129829B2 (en) | 2019-06-17 | 2021-09-28 | Skyhawk Therapeutics, Inc. | Methods for modulating splicing |
| EP4031245A1 (en) | 2019-09-18 | 2022-07-27 | Takeda Pharmaceutical Company Limited | Heteroaryl plasma kallikrein inhibitors |
| DK4031547T3 (da) | 2019-09-18 | 2024-09-09 | Takeda Pharmaceuticals Co | Plasmakallikreininhibitorer og anvendelser deraf |
| CN110862395B (zh) * | 2019-11-13 | 2020-09-29 | 株洲千金药业股份有限公司 | 一种制备他达拉非重要杂质的原料化合物的制备方法 |
| CN114315807B (zh) * | 2022-01-05 | 2023-09-15 | 江南大学 | 一种吡啶鎓盐光引发剂及其制备方法和应用 |
| WO2024251925A1 (en) * | 2023-06-09 | 2024-12-12 | F. Hoffmann-La Roche Ag | Inducible gene expression system |
| US12180195B1 (en) | 2023-11-01 | 2024-12-31 | King Faisal University | 6-(6-bromo-2-oxo-2H-chromen-3-yl)-4-(2,4-dichlorophenyl)-2-alkoxynicotinonitrile as an antimicrobial compound |
| WO2025111409A1 (en) * | 2023-11-21 | 2025-05-30 | Biogen Ma Inc. | Heterocyclic compounds of formula (i) for use in the treatment of spinal muscular atrophy via modulation of smn2 splicing |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1020636B (de) | 1954-11-12 | 1957-12-12 | Geigy Ag J R | Verfahren zur Herstellung von 3-Phenyl-7-acylamino-cumarinen |
| CH419146A (de) * | 1961-04-27 | 1966-08-31 | Geigy Ag J R | Verfahren zur Herstellung von 3-Phenyl-7-pyrazolyl-cumarinen |
| US3311636A (en) * | 1963-03-14 | 1967-03-28 | Upjohn Co | Organic chemical compounds and process |
| DE1245306B (de) | 1963-05-11 | 1967-07-27 | Bayer Ag | Aufhellungsmittel |
| DE1594845C3 (de) | 1966-03-19 | 1982-05-19 | Bayer Ag, 5090 Leverkusen | Substituierte v-Triazol-(2)-yl-cumarinverbindungen und deren Verwendung als Aufhellungsmittel |
| CH505089A (de) * | 1968-08-23 | 1971-03-31 | Bayer Ag | Verfahren zur Herstellung von 3-substituierten-7-Aminocumarinen |
| JPS5023687B2 (enExample) | 1972-03-07 | 1975-08-09 | ||
| CH620322B (de) | 1976-03-26 | Ciba Geigy Ag | Verwendung von 3-phenyl-7-(v-triazol-2-yl)-cumarinen zum optischen aufhellen von organischen materialien. | |
| FR2361680A1 (fr) | 1976-08-11 | 1978-03-10 | Du Pont | Plaques d'impression planographiques et leur preparation |
| DE2807761A1 (de) * | 1978-02-23 | 1979-08-30 | Basf Ag | Cumarinderivate |
| DE2815956A1 (de) * | 1978-04-13 | 1979-10-18 | Bayer Ag | Verfahren zur herstellung von in 2-stellung substituierten triazolen-1,2,3 |
| DE2950291A1 (de) | 1979-12-14 | 1981-06-19 | Basf Ag, 6700 Ludwigshafen | Neue cumarinverbindungen und verfahren zur herstellung von cumarinverbindungen |
| JPS56140990A (en) | 1980-04-07 | 1981-11-04 | Showa Kagaku Kogyo Kk | 3-phenylcoumarin derivative bearing dicarbonylimide group |
| DE3101141A1 (de) | 1981-01-16 | 1982-09-02 | Bayer Ag, 5090 Leverkusen | Triazolylcumarinverbindungen, sowie deren herstellung und verwendung als optiche aufheller, scintillatoren und laserfarbstoffe |
| JPS62267285A (ja) | 1986-05-16 | 1987-11-19 | Kyorin Pharmaceut Co Ltd | 新規ピラゾロピリジン誘導体 |
| EP0428939B1 (de) * | 1989-11-21 | 1996-01-17 | Bayer Ag | Cumarinderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und Thiazolyl-essigsäurederivate als Zwischenprodukte |
| ATE106566T1 (de) | 1989-11-21 | 1994-06-15 | Bayer Ag | Optischer biosensor. |
| EP0448241A3 (en) | 1990-02-28 | 1992-03-04 | Konica Corporation | Light-sensitive silver halide photographic material |
| CA2123740C (en) * | 1993-05-19 | 2002-12-17 | Hee-Gwon Chae | Electric vacuum cleaner |
| JPH073179A (ja) | 1993-06-15 | 1995-01-06 | Nippon Kayaku Co Ltd | インクジェットプリント用インク組成物及びこれを用いる染色法 |
| EP1458374A2 (en) | 2001-12-14 | 2004-09-22 | Novo Nordisk A/S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
| CN1180016C (zh) * | 2002-04-04 | 2004-12-15 | 中国石化上海石油化工股份有限公司 | 用于制造增白聚丙烯纤维的增白聚丙烯母粒 |
| AU2003261974A1 (en) * | 2002-09-11 | 2004-04-30 | Kureha Chemical Industry Company, Limited | Amine compounds and use thereof |
| AU2006206446A1 (en) | 2005-01-21 | 2006-07-27 | Janssen Pharmaceutica N.V. | Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors |
| AR059339A1 (es) * | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| US8337941B2 (en) * | 2006-07-27 | 2012-12-25 | The Trustees Of Columbia University In The City Of New York | Fluorescent substrates for monoamine transporters as optical false neurotransmitters |
| WO2008074798A1 (en) | 2006-12-20 | 2008-06-26 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2011511031A (ja) | 2008-02-05 | 2011-04-07 | ノイロサーチ アクティーゼルスカブ | 新規な９−アザ−ビシクロ［３．３．１］ノン−３−イルオキシクロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用 |
| DE102008018132A1 (de) | 2008-04-09 | 2009-10-15 | Henkel Ag & Co. Kgaa | Kationische Direktzieher und Mittel zum Färben von keratinhaltigen Fasern |
| WO2009151546A2 (en) | 2008-05-27 | 2009-12-17 | Ptc Therapeutics, Inc. | Methods for treating spinal muscular atrophy |
| WO2010019243A1 (en) | 2008-08-13 | 2010-02-18 | Ptc Therapeutics, Inc. | Methods for treating viral infections |
| CN102197109B (zh) * | 2008-10-29 | 2014-05-14 | 默克专利股份有限公司 | 液晶显示器 |
| PL2809322T3 (pl) | 2012-01-26 | 2019-11-29 | Ptc Therapeutics Inc | Związki do leczenia zaniku mięśni pochodzenia rdzeniowego |
| DK2812004T3 (en) | 2012-02-10 | 2018-10-15 | Ptc Therapeutics Inc | COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY |
| CN104302181B (zh) | 2012-03-01 | 2017-09-15 | Ptc医疗公司 | 用于治疗脊髓性肌萎缩的化合物 |
| KR102109992B1 (ko) | 2012-03-23 | 2020-05-13 | 피티씨 테라퓨틱스, 인크. | 척수성 근위축증을 치료하기 위한 화합물 |
-
2012
- 2012-12-28 KR KR1020147021262A patent/KR102057351B1/ko active Active
- 2012-12-28 MX MX2014007877A patent/MX352861B/es active IP Right Grant
- 2012-12-28 EA EA201491296A patent/EA029984B1/ru not_active IP Right Cessation
- 2012-12-28 US US14/369,294 patent/US9617268B2/en not_active Ceased
- 2012-12-28 BR BR112014016287-5A patent/BR112014016287B1/pt active IP Right Grant
- 2012-12-28 CN CN201280071056.5A patent/CN104244944B/zh active Active
- 2012-12-28 CA CA2861609A patent/CA2861609C/en active Active
- 2012-12-28 EP EP12862080.4A patent/EP2797592B1/en active Active
- 2012-12-28 WO PCT/US2012/071899 patent/WO2013101974A1/en not_active Ceased
- 2012-12-28 JP JP2014550478A patent/JP6193881B2/ja active Active
- 2012-12-28 US US15/695,299 patent/USRE47689E1/en active Active
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