JP2015504057A5 - - Google Patents
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- Publication number
- JP2015504057A5 JP2015504057A5 JP2014550478A JP2014550478A JP2015504057A5 JP 2015504057 A5 JP2015504057 A5 JP 2015504057A5 JP 2014550478 A JP2014550478 A JP 2014550478A JP 2014550478 A JP2014550478 A JP 2014550478A JP 2015504057 A5 JP2015504057 A5 JP 2015504057A5
- Authority
- JP
- Japan
- Prior art keywords
- chromen
- pyrazin
- pyridin
- methylimidazo
- dimethylimidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161582064P | 2011-12-30 | 2011-12-30 | |
| US61/582,064 | 2011-12-30 | ||
| PCT/US2012/071899 WO2013101974A1 (en) | 2011-12-30 | 2012-12-28 | Compounds for treating spinal muscular atrophy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504057A JP2015504057A (ja) | 2015-02-05 |
| JP2015504057A5 true JP2015504057A5 (enExample) | 2016-02-12 |
| JP6193881B2 JP6193881B2 (ja) | 2017-09-06 |
Family
ID=48698624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550478A Active JP6193881B2 (ja) | 2011-12-30 | 2012-12-28 | 脊髄性筋萎縮症を治療するための化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9617268B2 (enExample) |
| EP (1) | EP2797592B1 (enExample) |
| JP (1) | JP6193881B2 (enExample) |
| KR (1) | KR102057351B1 (enExample) |
| CN (1) | CN104244944B (enExample) |
| BR (1) | BR112014016287B1 (enExample) |
| CA (1) | CA2861609C (enExample) |
| EA (1) | EA029984B1 (enExample) |
| MX (1) | MX352861B (enExample) |
| WO (1) | WO2013101974A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX357834B (es) | 2012-01-26 | 2018-07-26 | Ptc Therapeutics Inc | Compuestos de tipo isocumarina sustituidos para tratar la atrofia muscular espinal. |
| EP3406252B1 (en) | 2012-02-10 | 2020-05-13 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| US9371336B2 (en) | 2012-03-01 | 2016-06-21 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| EP2828247B1 (en) | 2012-03-23 | 2019-01-16 | PTC Therapeutics, Inc. | 4h-chromen-4-one derivatives for treating spinal muscular atrophy |
| JP2016503051A (ja) * | 2012-12-24 | 2016-02-01 | ラモット・アット・テル−アヴィヴ・ユニヴァーシティ・リミテッド | ナンセンス変異に起因する遺伝性疾患を治療する作用剤、及びこれを同定する方法 |
| CN103360269B (zh) * | 2013-07-16 | 2015-07-08 | 临海市联盛化学有限公司 | 一种3-氯-2-氨基苯酚的制备方法 |
| CA2915764A1 (en) | 2013-08-19 | 2015-02-26 | F. Hoffmann-La Roche Ag | Screening method |
| WO2015095449A1 (en) * | 2013-12-19 | 2015-06-25 | Ptc Therapeutics, Inc. | Methods for modulating the amount rna transcripts |
| WO2015105657A1 (en) | 2013-12-19 | 2015-07-16 | Ptc Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| BR112016023811B8 (pt) | 2014-04-22 | 2023-01-10 | Piqur Therapeutics Ag | Método para fabricação para derivados de triazina, pirimidina e piridina, seus intermediários e seus métodos de fabricação |
| AU2015261046C1 (en) * | 2014-05-15 | 2019-07-25 | F. Hoffmann-La Roche Ag | Compounds for treating spinal muscular atrophy |
| US10882868B2 (en) | 2014-05-15 | 2021-01-05 | Hoffmann-La Roche Inc. | Compounds for treating spinal muscular atrophy |
| MX375925B (es) * | 2014-06-25 | 2025-03-07 | Hoffmann La Roche | Compuestos imidazo[1,2-a]pirazin-1-il-benzamida para tratar atrofia muscular espinal. |
| CN104744376A (zh) * | 2015-03-14 | 2015-07-01 | 长沙深橙生物科技有限公司 | 一种2-异丙基嘧啶衍生物的制备方法 |
| CN104803921A (zh) * | 2015-03-14 | 2015-07-29 | 长沙深橙生物科技有限公司 | 一种苯取代嘧啶衍生物的制备方法 |
| EP3310169B1 (en) | 2015-05-30 | 2023-05-17 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| AR106652A1 (es) * | 2015-11-12 | 2018-02-07 | Hoffmann La Roche | Compuestos para tratar la esclerosis lateral amiotrófica |
| AU2016353961B2 (en) | 2015-11-12 | 2019-08-29 | F. Hoffmann-La Roche Ag | Compositions for treating spinal muscular atrophy |
| EP3377476B1 (en) * | 2015-11-16 | 2022-10-26 | PTC Therapeutics, Inc. | Hydrogen isotope-enriched analogues of 1,2,4-oxadiazole benzoic acid compounds, compositions and uses thereof |
| CA3119019C (en) | 2015-12-10 | 2024-06-11 | Ptc Therapeutics, Inc. | Compounds and methods for treating huntington's disease |
| EP3386978B1 (en) | 2015-12-10 | 2021-01-27 | H. Hoffnabb-La Roche Ag | Bridged piperidine derivatives |
| JP2019509272A (ja) * | 2016-02-23 | 2019-04-04 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | 脊髄性筋萎縮症の治療のための併用療法 |
| WO2018068759A1 (zh) | 2016-10-14 | 2018-04-19 | 江苏恒瑞医药股份有限公司 | 五元杂芳环并桥环类衍生物、其制备方法及其在医药上的应用 |
| JP2019535789A (ja) | 2016-11-28 | 2019-12-12 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを調節する方法 |
| EP4151627A1 (en) | 2017-06-05 | 2023-03-22 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| CN111372611A (zh) | 2017-06-14 | 2020-07-03 | Ptc医疗公司 | 修饰rna剪接的方法 |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| CN111163838B (zh) | 2017-06-28 | 2023-03-28 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| MX2020001425A (es) | 2017-08-04 | 2020-08-06 | Skyhawk Therapeutics Inc | Metodos y composiciones para modular el empalme. |
| HRP20251594T1 (hr) * | 2017-09-22 | 2026-01-30 | F. Hoffmann - La Roche Ag | Postupak priprave derivata 7-(4,7-diazaspiro[2.5]oktan-7-il)-2-(2,8-dimetilimidazo[1,2-b]piridazin-6-il)pirido[1,2-a]pirimidin-4-ona |
| CN112135825A (zh) | 2018-03-13 | 2020-12-25 | 夏尔人类遗传性治疗公司 | 血浆激肽释放酶抑制剂及其用途 |
| BR112020019373A2 (pt) | 2018-03-27 | 2020-12-29 | Ptc Therapeutics, Inc. | Compostos para o tratamento da doença de hutington |
| IL279688B2 (en) | 2018-06-27 | 2025-01-01 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
| KR20210038845A (ko) | 2018-06-27 | 2021-04-08 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료를 위한 헤테로아릴 화합물 |
| WO2020005882A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| WO2020004594A1 (ja) | 2018-06-27 | 2020-01-02 | 株式会社リボルナバイオサイエンス | 脊髄性筋萎縮症の予防または治療剤 |
| WO2020146449A1 (en) * | 2019-01-08 | 2020-07-16 | Texas Tech University System | Small molecule analogs of the protein e4orf1 in the treatment and prevention of metabolic disorders |
| WO2020163248A1 (en) | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| KR102913697B1 (ko) | 2019-02-05 | 2026-01-15 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| WO2020163541A1 (en) | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| JP7603594B2 (ja) | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| KR102925385B1 (ko) | 2019-02-06 | 2026-02-11 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| CN112654681B (zh) * | 2019-03-01 | 2023-01-06 | 伊卢米纳剑桥有限公司 | 环外胺取代的香豆素化合物及其作为荧光标记物的用途 |
| CN109943092A (zh) * | 2019-04-09 | 2019-06-28 | 浙江工业大学 | 具有高荧光量子产率的咪唑类香豆素类染料及其合成方法 |
| CA3139821A1 (en) | 2019-05-13 | 2020-11-19 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| US11129829B2 (en) | 2019-06-17 | 2021-09-28 | Skyhawk Therapeutics, Inc. | Methods for modulating splicing |
| WO2021055589A1 (en) | 2019-09-18 | 2021-03-25 | Shire Human Genetic Therapies, Inc. | Heteroaryl plasma kallikrein inhibitors |
| CN114728962B (zh) | 2019-09-18 | 2025-09-19 | 武田药品工业有限公司 | 血浆激肽释放酶抑制剂及其用途 |
| CN110862395B (zh) * | 2019-11-13 | 2020-09-29 | 株洲千金药业股份有限公司 | 一种制备他达拉非重要杂质的原料化合物的制备方法 |
| CN114315807B (zh) * | 2022-01-05 | 2023-09-15 | 江南大学 | 一种吡啶鎓盐光引发剂及其制备方法和应用 |
| AU2024286618A1 (en) * | 2023-06-09 | 2025-10-30 | F. Hoffmann-La Roche Ag | Inducible gene expression system |
| US12180195B1 (en) | 2023-11-01 | 2024-12-31 | King Faisal University | 6-(6-bromo-2-oxo-2H-chromen-3-yl)-4-(2,4-dichlorophenyl)-2-alkoxynicotinonitrile as an antimicrobial compound |
| WO2025111409A1 (en) * | 2023-11-21 | 2025-05-30 | Biogen Ma Inc. | Heterocyclic compounds of formula (i) for use in the treatment of spinal muscular atrophy via modulation of smn2 splicing |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1020636B (de) | 1954-11-12 | 1957-12-12 | Geigy Ag J R | Verfahren zur Herstellung von 3-Phenyl-7-acylamino-cumarinen |
| CH419146A (de) | 1961-04-27 | 1966-08-31 | Geigy Ag J R | Verfahren zur Herstellung von 3-Phenyl-7-pyrazolyl-cumarinen |
| US3311636A (en) * | 1963-03-14 | 1967-03-28 | Upjohn Co | Organic chemical compounds and process |
| DE1245306B (de) | 1963-05-11 | 1967-07-27 | Bayer Ag | Aufhellungsmittel |
| DE1794396C2 (de) * | 1966-03-19 | 1975-04-10 | Bayer Ag, 5090 Leverkusen | Aufhellungsmittel |
| CH505089A (de) * | 1968-08-23 | 1971-03-31 | Bayer Ag | Verfahren zur Herstellung von 3-substituierten-7-Aminocumarinen |
| JPS5023687B2 (enExample) | 1972-03-07 | 1975-08-09 | ||
| CH620322B (de) | 1976-03-26 | Ciba Geigy Ag | Verwendung von 3-phenyl-7-(v-triazol-2-yl)-cumarinen zum optischen aufhellen von organischen materialien. | |
| FR2361680A1 (fr) | 1976-08-11 | 1978-03-10 | Du Pont | Plaques d'impression planographiques et leur preparation |
| DE2807761A1 (de) * | 1978-02-23 | 1979-08-30 | Basf Ag | Cumarinderivate |
| DE2815956A1 (de) * | 1978-04-13 | 1979-10-18 | Bayer Ag | Verfahren zur herstellung von in 2-stellung substituierten triazolen-1,2,3 |
| DE2950291A1 (de) * | 1979-12-14 | 1981-06-19 | Basf Ag, 6700 Ludwigshafen | Neue cumarinverbindungen und verfahren zur herstellung von cumarinverbindungen |
| JPS56140990A (en) | 1980-04-07 | 1981-11-04 | Showa Kagaku Kogyo Kk | 3-phenylcoumarin derivative bearing dicarbonylimide group |
| DE3101141A1 (de) * | 1981-01-16 | 1982-09-02 | Bayer Ag, 5090 Leverkusen | Triazolylcumarinverbindungen, sowie deren herstellung und verwendung als optiche aufheller, scintillatoren und laserfarbstoffe |
| JPS62267285A (ja) | 1986-05-16 | 1987-11-19 | Kyorin Pharmaceut Co Ltd | 新規ピラゾロピリジン誘導体 |
| EP0428939B1 (de) * | 1989-11-21 | 1996-01-17 | Bayer Ag | Cumarinderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und Thiazolyl-essigsäurederivate als Zwischenprodukte |
| DK0429907T3 (da) | 1989-11-21 | 1994-10-03 | Bayer Ag | Optisk biosensor |
| EP0448241A3 (en) | 1990-02-28 | 1992-03-04 | Konica Corporation | Light-sensitive silver halide photographic material |
| CA2123740C (en) * | 1993-05-19 | 2002-12-17 | Hee-Gwon Chae | Electric vacuum cleaner |
| JPH073179A (ja) | 1993-06-15 | 1995-01-06 | Nippon Kayaku Co Ltd | インクジェットプリント用インク組成物及びこれを用いる染色法 |
| BR0214967A (pt) * | 2001-12-14 | 2005-05-10 | Novo Nordisk As | Composto, sal famaceuticamente aceitável, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratar um distúrbio de um paciente |
| GB0205281D0 (en) | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
| CN1180016C (zh) * | 2002-04-04 | 2004-12-15 | 中国石化上海石油化工股份有限公司 | 用于制造增白聚丙烯纤维的增白聚丙烯母粒 |
| KR100863667B1 (ko) * | 2002-09-11 | 2008-10-15 | 가부시끼가이샤 구레하 | 아민 화합물 및 그 용도 |
| US7399767B2 (en) * | 2005-01-21 | 2008-07-15 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors |
| AR059339A1 (es) | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| US8337941B2 (en) * | 2006-07-27 | 2012-12-25 | The Trustees Of Columbia University In The City Of New York | Fluorescent substrates for monoamine transporters as optical false neurotransmitters |
| JP2010513392A (ja) * | 2006-12-20 | 2010-04-30 | ノイロサーチ アクティーゼルスカブ | 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用 |
| EP2242754A1 (en) | 2008-02-05 | 2010-10-27 | NeuroSearch A/S | Novel 9-aza-bicyclo[3.3.1]non-3-yloxy chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| DE102008018132A1 (de) | 2008-04-09 | 2009-10-15 | Henkel Ag & Co. Kgaa | Kationische Direktzieher und Mittel zum Färben von keratinhaltigen Fasern |
| US8633019B2 (en) | 2008-05-27 | 2014-01-21 | Ptc Therapeutics, Inc. | Methods for treating spinal muscular atrophy |
| WO2010019236A1 (en) | 2008-08-13 | 2010-02-18 | Ptc Therapeutics, Inc | Methods for treating spinal muscular atrophy |
| EP2340292B1 (de) | 2008-10-29 | 2013-05-29 | Merck Patent GmbH | Flüssigkristallanzeige |
| MX357834B (es) | 2012-01-26 | 2018-07-26 | Ptc Therapeutics Inc | Compuestos de tipo isocumarina sustituidos para tratar la atrofia muscular espinal. |
| EP3406252B1 (en) | 2012-02-10 | 2020-05-13 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| US9371336B2 (en) | 2012-03-01 | 2016-06-21 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| EP2828247B1 (en) | 2012-03-23 | 2019-01-16 | PTC Therapeutics, Inc. | 4h-chromen-4-one derivatives for treating spinal muscular atrophy |
-
2012
- 2012-12-28 MX MX2014007877A patent/MX352861B/es active IP Right Grant
- 2012-12-28 BR BR112014016287-5A patent/BR112014016287B1/pt active IP Right Grant
- 2012-12-28 EP EP12862080.4A patent/EP2797592B1/en active Active
- 2012-12-28 JP JP2014550478A patent/JP6193881B2/ja active Active
- 2012-12-28 WO PCT/US2012/071899 patent/WO2013101974A1/en not_active Ceased
- 2012-12-28 CA CA2861609A patent/CA2861609C/en active Active
- 2012-12-28 KR KR1020147021262A patent/KR102057351B1/ko active Active
- 2012-12-28 US US14/369,294 patent/US9617268B2/en not_active Ceased
- 2012-12-28 CN CN201280071056.5A patent/CN104244944B/zh active Active
- 2012-12-28 EA EA201491296A patent/EA029984B1/ru not_active IP Right Cessation
- 2012-12-28 US US15/695,299 patent/USRE47689E1/en active Active
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