JP2015504057A5 - - Google Patents

Info

Publication number

JP2015504057A5

JP2015504057A5 JP2014550478A JP2014550478A JP2015504057A5 JP 2015504057 A5 JP2015504057 A5 JP 2015504057A5 JP 2014550478 A JP2014550478 A JP 2014550478A JP 2014550478 A JP2014550478 A JP 2014550478A JP 2015504057 A5 JP2015504057 A5 JP 2015504057A5

Authority

JP

Japan

Prior art keywords

chromen

pyrazin

pyridin

methylimidazo

dimethylimidazo

Prior art date

2012-12-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000000217 alkyl group Chemical group 0.000 claims 110
• 125000003282 alkyl amino group Chemical group 0.000 claims 29
• -1 amino, hydroxy Chemical group 0.000 claims 25
• 125000003545 alkoxy group Chemical group 0.000 claims 24
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 24
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 21
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 18
• 125000000623 heterocyclic group Chemical group 0.000 claims 15
• 150000001875 compounds Chemical class 0.000 claims 12
• 125000001072 heteroaryl group Chemical group 0.000 claims 10
• 125000003118 aryl group Chemical group 0.000 claims 5
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 5
• 229910052736 halogen Inorganic materials 0.000 claims 5
• 150000002367 halogens Chemical class 0.000 claims 5
• 208000002320 spinal muscular atrophy Diseases 0.000 claims 5
• 125000001424 substituent group Chemical group 0.000 claims 5
• 210000005260 human cell Anatomy 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 125000003342 alkenyl group Chemical group 0.000 claims 3
• 125000000304 alkynyl group Chemical group 0.000 claims 3
• 125000004093 cyano group Chemical group *C#N 0.000 claims 3
• 125000000753 cycloalkyl group Chemical group 0.000 claims 3
• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 3
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 2
• WQSWVLPIWLGLBO-UHFFFAOYSA-N 3-(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C(C)=CSC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 WQSWVLPIWLGLBO-UHFFFAOYSA-N 0.000 claims 2
• 125000004939 6-pyridyl group Chemical group N1=CC=CC=C1* 0.000 claims 2
• TUJVMUVNOXASGN-XLIONFOSSA-N 7-[(4ar,7ar)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C([C@@H]1C2)CCN[C@H]1CN2C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=N1 TUJVMUVNOXASGN-XLIONFOSSA-N 0.000 claims 2
• SBIQSXJVVHYVRK-GCJKJVERSA-N 7-[(4ar,7ar)-1-methyl-3,4,4a,5,7,7a-hexahydro-2h-pyrrolo[3,4-b]pyridin-6-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@H]4CCCN([C@H]4C3)C)=CN21 SBIQSXJVVHYVRK-GCJKJVERSA-N 0.000 claims 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
• 125000004414 alkyl thio group Chemical group 0.000 claims 2
• 239000012458 free base Substances 0.000 claims 2
• 125000005241 heteroarylamino group Chemical group 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
• FWXSKRXGYQVFET-UHFFFAOYSA-N 1-[3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-2-oxochromen-7-yl]piperidine-4-carbonitrile Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(C#N)CC1 FWXSKRXGYQVFET-UHFFFAOYSA-N 0.000 claims 1
• HNEGJTWNOOWEMH-UHFFFAOYSA-N 1-fluoropropane Chemical group [CH2]CCF HNEGJTWNOOWEMH-UHFFFAOYSA-N 0.000 claims 1
• WOFBBPJJNUWCLE-UHFFFAOYSA-N 2-[3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-2-oxochromen-7-yl]-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one Chemical compound C1CN2C(=O)CCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=N1 WOFBBPJJNUWCLE-UHFFFAOYSA-N 0.000 claims 1
• BBKBZMAPFDPOFS-UHFFFAOYSA-N 2-[7-(4-methylpiperazin-1-yl)-2-oxochromen-3-yl]imidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=CC(=CN3C=2)C#N)C(=O)O2)C2=C1 BBKBZMAPFDPOFS-UHFFFAOYSA-N 0.000 claims 1
• HVFYUCPIVWAAMY-CQSZACIVSA-N 2-[7-[(3r)-3,4-dimethylpiperazin-1-yl]-2-oxochromen-3-yl]-6-methyl-7h-imidazo[1,2-a]pyrazin-8-one Chemical compound C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(=O)NC(C)=CN3C=2)C(=O)O2)C2=C1 HVFYUCPIVWAAMY-CQSZACIVSA-N 0.000 claims 1
• FQMXPTKOHBNJLC-UHFFFAOYSA-N 2-oxo-n-phenyl-7-piperazin-1-ylchromene-3-carboxamide Chemical compound C=1C2=CC=C(N3CCNCC3)C=C2OC(=O)C=1C(=O)NC1=CC=CC=C1 FQMXPTKOHBNJLC-UHFFFAOYSA-N 0.000 claims 1
• VNMNDYAZYIOOMY-UHFFFAOYSA-N 2-oxo-n-phenyl-7-piperazin-1-ylchromene-3-carboxamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C=1C2=CC=C(N3CCNCC3)C=C2OC(=O)C=1C(=O)NC1=CC=CC=C1 VNMNDYAZYIOOMY-UHFFFAOYSA-N 0.000 claims 1
• BILGPXGIOPANRF-CYBMUJFWSA-N 3-(1,3-benzodioxol-5-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2C=C3OCOC3=CC=2)C(=O)O2)C2=C1 BILGPXGIOPANRF-CYBMUJFWSA-N 0.000 claims 1
• ADVXHRRETMBNAM-OKILXGFUSA-N 3-(1,3-benzodioxol-5-yl)-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2C=C3OCOC3=CC=2)C(=O)O2)C2=C1 ADVXHRRETMBNAM-OKILXGFUSA-N 0.000 claims 1
• BILGPXGIOPANRF-ZDUSSCGKSA-N 3-(1,3-benzodioxol-5-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=C3OCOC3=CC=2)C(=O)O2)C2=C1 BILGPXGIOPANRF-ZDUSSCGKSA-N 0.000 claims 1
• LDEAIBTVXBTRDN-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3C=C4OCOC4=CC=3)C(=O)OC=2C=C1N1CCNCC1 LDEAIBTVXBTRDN-UHFFFAOYSA-N 0.000 claims 1
• LRFLPGXWTDMCFY-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-4-methyl-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C(C)=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1N1CCNCC1 LRFLPGXWTDMCFY-UHFFFAOYSA-N 0.000 claims 1
• MSYMDGYUVMVKMW-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-5-fluoro-7-piperazin-1-ylchromen-2-one Chemical compound C=1C=2OC(=O)C(C=3SC4=CC=CC=C4N=3)=CC=2C(F)=CC=1N1CCNCC1 MSYMDGYUVMVKMW-UHFFFAOYSA-N 0.000 claims 1
• VFZHTHMWTDNCIX-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-6-fluoro-7-piperazin-1-ylchromen-2-one Chemical compound FC1=CC=2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1N1CCNCC1 VFZHTHMWTDNCIX-UHFFFAOYSA-N 0.000 claims 1
• ZWURFUFPDIBZRL-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2SC3=CC=CC=C3N=2)C(=O)O2)C2=C1 ZWURFUFPDIBZRL-UHFFFAOYSA-N 0.000 claims 1
• CKQYPOSBCXTFDJ-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2SC3=CC=CC=C3N=2)C(=O)O2)C2=C1 CKQYPOSBCXTFDJ-UHFFFAOYSA-N 0.000 claims 1
• REMDTBRMDKFLOA-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-(4-propan-2-ylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C=2SC3=CC=CC=C3N=2)C(=O)O2)C2=C1 REMDTBRMDKFLOA-UHFFFAOYSA-N 0.000 claims 1
• RXZTVKWOXVXVBG-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-(diethylaminomethyl)chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CN(CC)CC)=NC2=C1 RXZTVKWOXVXVBG-UHFFFAOYSA-N 0.000 claims 1
• ROPBCBSPHRORDA-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-(methylaminomethyl)chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CNC)=NC2=C1 ROPBCBSPHRORDA-UHFFFAOYSA-N 0.000 claims 1
• GFJWYBWMBVNDCC-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-(piperidin-1-ylmethyl)chromen-2-one Chemical compound C1=CC=2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1CN1CCCCC1 GFJWYBWMBVNDCC-UHFFFAOYSA-N 0.000 claims 1
• FHAWVHBQONANQP-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-[(1,3-dihydroxypropan-2-ylamino)methyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CNC(CO)CO)=NC2=C1 FHAWVHBQONANQP-UHFFFAOYSA-N 0.000 claims 1
• UDMKQFJESZFRLG-MRXNPFEDSA-N 3-(1,3-benzothiazol-2-yl)-7-[(3r)-1-ethylpyrrolidin-3-yl]oxychromen-2-one Chemical compound C1N(CC)CC[C@H]1OC1=CC=C(C=C(C=2SC3=CC=CC=C3N=2)C(=O)O2)C2=C1 UDMKQFJESZFRLG-MRXNPFEDSA-N 0.000 claims 1
• GIAXDRAJMQBDJB-CQSZACIVSA-N 3-(1,3-benzothiazol-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound C1=CC=2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1O[C@@H]1CCNC1 GIAXDRAJMQBDJB-CQSZACIVSA-N 0.000 claims 1
• GIAXDRAJMQBDJB-AWEZNQCLSA-N 3-(1,3-benzothiazol-2-yl)-7-[(3s)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound C1=CC=2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1O[C@H]1CCNC1 GIAXDRAJMQBDJB-AWEZNQCLSA-N 0.000 claims 1
• NWTZUIITADOPAW-OKILXGFUSA-N 3-(1,3-benzothiazol-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2SC3=CC=CC=C3N=2)C(=O)O2)C2=C1 NWTZUIITADOPAW-OKILXGFUSA-N 0.000 claims 1
• IDMHOQRNLKLQMQ-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-[(dimethylamino)methyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CN(C)C)=NC2=C1 IDMHOQRNLKLQMQ-UHFFFAOYSA-N 0.000 claims 1
• NIAOIOJBSPVJOZ-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-[(propan-2-ylamino)methyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CNC(C)C)=NC2=C1 NIAOIOJBSPVJOZ-UHFFFAOYSA-N 0.000 claims 1
• MOOFZYJSACRJIL-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-[1-(dimethylamino)ethyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)C(N(C)C)C)=NC2=C1 MOOFZYJSACRJIL-UHFFFAOYSA-N 0.000 claims 1
• QCPVOGQGOOWHNC-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-[1-(propan-2-ylamino)ethyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)C(C)NC(C)C)=NC2=C1 QCPVOGQGOOWHNC-UHFFFAOYSA-N 0.000 claims 1
• SMOUATFKGOZYKM-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-[2-(dimethylamino)ethyl-methylamino]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)N(C)CCN(C)C)=NC2=C1 SMOUATFKGOZYKM-UHFFFAOYSA-N 0.000 claims 1
• WETBFBCGHJMOQN-AWEZNQCLSA-N 3-(1,3-benzothiazol-2-yl)-7-[[(2s)-pyrrolidin-2-yl]methoxy]chromen-2-one Chemical compound C1=CC=2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1OC[C@@H]1CCCN1 WETBFBCGHJMOQN-AWEZNQCLSA-N 0.000 claims 1
• YUAOWRFSXFUQLY-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-[[2-hydroxyethyl(methyl)amino]methyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CN(CCO)C)=NC2=C1 YUAOWRFSXFUQLY-UHFFFAOYSA-N 0.000 claims 1
• LRAGEJPCNKMCHP-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1N1CCNCC1 LRAGEJPCNKMCHP-UHFFFAOYSA-N 0.000 claims 1
• QYCFAUOAVDAYBW-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.C1=CC=2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1N1CCNCC1 QYCFAUOAVDAYBW-UHFFFAOYSA-N 0.000 claims 1
• VAXJPLNOPJBLDV-UHFFFAOYSA-N 3-(1,3-benzothiazol-2-yl)-7-piperidin-4-yloxychromen-2-one Chemical compound C1=CC=2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC=2C=C1OC1CCNCC1 VAXJPLNOPJBLDV-UHFFFAOYSA-N 0.000 claims 1
• ZWVYYRZVLRHFBB-UHFFFAOYSA-N 3-(1,3-benzoxazol-2-yl)-5-fluoro-7-piperazin-1-ylchromen-2-one Chemical compound C=1C=2OC(=O)C(C=3OC4=CC=CC=C4N=3)=CC=2C(F)=CC=1N1CCNCC1 ZWVYYRZVLRHFBB-UHFFFAOYSA-N 0.000 claims 1
• ZVIIRSMUXVNKAH-UHFFFAOYSA-N 3-(1,3-benzoxazol-2-yl)-7-(2,5-diazabicyclo[2.2.1]heptan-2-yl)chromen-2-one Chemical compound C1=CC=C2OC(C3=CC=4C=CC(=CC=4OC3=O)N3C4CC(NC4)C3)=NC2=C1 ZVIIRSMUXVNKAH-UHFFFAOYSA-N 0.000 claims 1
• LBTVDRJXNXRFNC-UHFFFAOYSA-N 3-(1,3-benzoxazol-2-yl)-7-(2,5-dimethylpiperazin-1-yl)chromen-2-one Chemical compound CC1CNC(C)CN1C1=CC=C(C=C(C=2OC3=CC=CC=C3N=2)C(=O)O2)C2=C1 LBTVDRJXNXRFNC-UHFFFAOYSA-N 0.000 claims 1
• JCOIBAGUIYWMQB-UHFFFAOYSA-N 3-(1,3-benzoxazol-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2OC3=CC=CC=C3N=2)C(=O)O2)C2=C1 JCOIBAGUIYWMQB-UHFFFAOYSA-N 0.000 claims 1
• ZQCXIHIZPYMIAH-OKILXGFUSA-N 3-(1,3-benzoxazol-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=CC=CC=C3N=2)C(=O)O2)C2=C1 ZQCXIHIZPYMIAH-OKILXGFUSA-N 0.000 claims 1
• LUNJVRYOYXREQE-UHFFFAOYSA-N 3-(1,3-benzoxazol-2-yl)-7-[2-(dimethylamino)ethyl-methylamino]chromen-2-one Chemical compound C1=CC=C2OC(C3=CC4=CC=C(C=C4OC3=O)N(C)CCN(C)C)=NC2=C1 LUNJVRYOYXREQE-UHFFFAOYSA-N 0.000 claims 1
• NPUFOYJMPPMWRN-UHFFFAOYSA-N 3-(1,3-benzoxazol-2-yl)-7-[3-(dimethylamino)pyrrolidin-1-yl]chromen-2-one Chemical compound C1C(N(C)C)CCN1C1=CC=C(C=C(C=2OC3=CC=CC=C3N=2)C(=O)O2)C2=C1 NPUFOYJMPPMWRN-UHFFFAOYSA-N 0.000 claims 1
• BVIVWYWNONLRRS-UHFFFAOYSA-N 3-(1,3-benzoxazol-2-yl)-7-piperidin-4-yloxychromen-2-one Chemical compound C1=CC=2C=C(C=3OC4=CC=CC=C4N=3)C(=O)OC=2C=C1OC1CCNCC1 BVIVWYWNONLRRS-UHFFFAOYSA-N 0.000 claims 1
• JVMXXZOLNCOSSD-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-(3-morpholin-4-ylpyrrolidin-1-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(C1)CCC1N1CCOCC1 JVMXXZOLNCOSSD-UHFFFAOYSA-N 0.000 claims 1
• MGOHZJPAODRTQJ-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-(4-ethyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(CC)CCCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 MGOHZJPAODRTQJ-UHFFFAOYSA-N 0.000 claims 1
• JBMUQEWBNORSBM-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-(4-ethylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 JBMUQEWBNORSBM-UHFFFAOYSA-N 0.000 claims 1
• REQGENVMPLBRPE-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 REQGENVMPLBRPE-UHFFFAOYSA-N 0.000 claims 1
• HIPDOPGKEBQKTJ-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 HIPDOPGKEBQKTJ-UHFFFAOYSA-N 0.000 claims 1
• SPDQAFVITZQLOV-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-(4-propan-2-yl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 SPDQAFVITZQLOV-UHFFFAOYSA-N 0.000 claims 1
• AMGXZAFVSBBFLG-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-(4-propan-2-ylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 AMGXZAFVSBBFLG-UHFFFAOYSA-N 0.000 claims 1
• GKRVTSBZSDWFRC-GOSISDBHSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[(3r)-3-methyl-4-propan-2-ylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N(C(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 GKRVTSBZSDWFRC-GOSISDBHSA-N 0.000 claims 1
• YNWUFPVEPMLDSV-CQSZACIVSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 YNWUFPVEPMLDSV-CQSZACIVSA-N 0.000 claims 1
• FLELDXNSFPYLTF-DNQXCXABSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[(3r,4r)-3-hydroxy-4-pyrrolidin-1-ylpyrrolidin-1-yl]chromen-2-one Chemical compound N1([C@H]2[C@H](O)CN(C2)C2=CC=C3C=C(C(OC3=C2)=O)C2=CN3C=C(N=C(C)C3=C2)C)CCCC1 FLELDXNSFPYLTF-DNQXCXABSA-N 0.000 claims 1
• RNMJDQZEZOOOHH-FQEVSTJZSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[(3s)-3-(propan-2-ylamino)pyrrolidin-1-yl]chromen-2-one Chemical compound C1[C@@H](NC(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 RNMJDQZEZOOOHH-FQEVSTJZSA-N 0.000 claims 1
• GKRVTSBZSDWFRC-SFHVURJKSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[(3s)-3-methyl-4-propan-2-ylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@H](C)N(C(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 GKRVTSBZSDWFRC-SFHVURJKSA-N 0.000 claims 1
• YNWUFPVEPMLDSV-AWEZNQCLSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 YNWUFPVEPMLDSV-AWEZNQCLSA-N 0.000 claims 1
• SKAJCENUUXAOPG-KRWDZBQOSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[(3s)-4-ethyl-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@H](C)N(CC)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 SKAJCENUUXAOPG-KRWDZBQOSA-N 0.000 claims 1
• CVEZOFPKKKXEQZ-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[4-(2-hydroxyethyl)piperazin-1-yl]chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(CCO)CC1 CVEZOFPKKKXEQZ-UHFFFAOYSA-N 0.000 claims 1
• HPCZQIQVMKEOHQ-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[4-[(propan-2-ylamino)methyl]piperidin-1-yl]chromen-2-one Chemical compound C1CC(CNC(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 HPCZQIQVMKEOHQ-UHFFFAOYSA-N 0.000 claims 1
• XEWLVRQNCSDGCW-UHFFFAOYSA-N 3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 XEWLVRQNCSDGCW-UHFFFAOYSA-N 0.000 claims 1
• CVJFQHMBWSRJPL-GASCZTMLSA-N 3-(1-benzofuran-2-yl)-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=CC=CC=C3C=2)C(=O)O2)C2=C1 CVJFQHMBWSRJPL-GASCZTMLSA-N 0.000 claims 1
• JLNCOBYGEQONOK-AWEZNQCLSA-N 3-(1-benzofuran-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=CC=CC=C3C=2)C(=O)O2)C2=C1 JLNCOBYGEQONOK-AWEZNQCLSA-N 0.000 claims 1
• GMNMZZOYYDWFCT-UHFFFAOYSA-N 3-(1-benzofuran-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3OC4=CC=CC=C4C=3)C(=O)OC=2C=C1N1CCNCC1 GMNMZZOYYDWFCT-UHFFFAOYSA-N 0.000 claims 1
• JMHFWXQYVOEBPN-CQSZACIVSA-N 3-(1-benzothiophen-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2SC3=CC=CC=C3C=2)C(=O)O2)C2=C1 JMHFWXQYVOEBPN-CQSZACIVSA-N 0.000 claims 1
• VOFJANAKVGPKFT-GASCZTMLSA-N 3-(1-benzothiophen-2-yl)-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2SC3=CC=CC=C3C=2)C(=O)O2)C2=C1 VOFJANAKVGPKFT-GASCZTMLSA-N 0.000 claims 1
• JMHFWXQYVOEBPN-AWEZNQCLSA-N 3-(1-benzothiophen-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2SC3=CC=CC=C3C=2)C(=O)O2)C2=C1 JMHFWXQYVOEBPN-AWEZNQCLSA-N 0.000 claims 1
• IUFHYKXTORMEGD-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3SC4=CC=CC=C4C=3)C(=O)OC=2C=C1N1CCNCC1 IUFHYKXTORMEGD-UHFFFAOYSA-N 0.000 claims 1
• ACRRVVLPWYRDLU-UHFFFAOYSA-N 3-(1-methylindol-3-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2C3=CC=CC=C3N(C)C=2)C(=O)O2)C2=C1 ACRRVVLPWYRDLU-UHFFFAOYSA-N 0.000 claims 1
• GCBQYDRMVZAOJT-UHFFFAOYSA-N 3-(1-methylindol-3-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C12=CC=CC=C2N(C)C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 GCBQYDRMVZAOJT-UHFFFAOYSA-N 0.000 claims 1
• PNGVEWCCODASIJ-UHFFFAOYSA-N 3-(1-methylpyrazol-3-yl)-7-piperazin-1-ylchromen-2-one Chemical compound CN1C=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 PNGVEWCCODASIJ-UHFFFAOYSA-N 0.000 claims 1
• AMDLERZRXZSMTH-UHFFFAOYSA-N 3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C2C(C)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 AMDLERZRXZSMTH-UHFFFAOYSA-N 0.000 claims 1
• FNIUCQMBPLANSZ-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-5-fluoro-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC(F)=C(C=C(C=2NC3=CC=CC=C3N=2)C(=O)O2)C2=C1 FNIUCQMBPLANSZ-UHFFFAOYSA-N 0.000 claims 1
• WHMUFHGVEJQWJB-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-5-fluoro-7-piperazin-1-ylchromen-2-one Chemical compound C=1C=2OC(=O)C(C=3NC4=CC=CC=C4N=3)=CC=2C(F)=CC=1N1CCNCC1 WHMUFHGVEJQWJB-UHFFFAOYSA-N 0.000 claims 1
• DJBOGEGRNODZAV-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(1,4-diazepan-1-yl)-5-fluorochromen-2-one Chemical compound C=1C=2OC(=O)C(C=3NC4=CC=CC=C4N=3)=CC=2C(F)=CC=1N1CCCNCC1 DJBOGEGRNODZAV-UHFFFAOYSA-N 0.000 claims 1
• FFUILIUOFWYWOZ-BETUJISGSA-N 3-(1h-benzimidazol-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-5-fluorochromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC(F)=C(C=C(C=2NC3=CC=CC=C3N=2)C(=O)O2)C2=C1 FFUILIUOFWYWOZ-BETUJISGSA-N 0.000 claims 1
• GRURVWXGLZNMEX-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-[(dimethylamino)methyl]chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)CN(C)C)=NC2=C1 GRURVWXGLZNMEX-UHFFFAOYSA-N 0.000 claims 1
• RJVBZWFQMSANIQ-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3NC4=CC=CC=C4N=3)C(=O)OC=2C=C1N1CCNCC1 RJVBZWFQMSANIQ-UHFFFAOYSA-N 0.000 claims 1
• RGKUROUVCDMXCE-UHFFFAOYSA-N 3-(1h-indazol-5-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3C=C4C=NNC4=CC=3)C(=O)OC=2C=C1N1CCNCC1 RGKUROUVCDMXCE-UHFFFAOYSA-N 0.000 claims 1
• NMUWOVHSXQTVHL-LBPRGKRZSA-N 3-(2,3-difluorophenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C(=C(F)C=CC=2)F)C(=O)O2)C2=C1 NMUWOVHSXQTVHL-LBPRGKRZSA-N 0.000 claims 1
• YKSLJUASHAWFMM-GASCZTMLSA-N 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2C=C3OCCOC3=CC=2)C(=O)O2)C2=C1 YKSLJUASHAWFMM-GASCZTMLSA-N 0.000 claims 1
• VJLIRVMECHJKOM-AWEZNQCLSA-N 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=C3OCCOC3=CC=2)C(=O)O2)C2=C1 VJLIRVMECHJKOM-AWEZNQCLSA-N 0.000 claims 1
• SODZKKCPTSGQEF-CQSZACIVSA-N 3-(2,4-dimethoxyphenyl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound COC1=CC(OC)=CC=C1C1=CC2=CC=C(N3C[C@@H](C)NCC3)C=C2OC1=O SODZKKCPTSGQEF-CQSZACIVSA-N 0.000 claims 1
• SODZKKCPTSGQEF-AWEZNQCLSA-N 3-(2,4-dimethoxyphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound COC1=CC(OC)=CC=C1C1=CC2=CC=C(N3C[C@H](C)NCC3)C=C2OC1=O SODZKKCPTSGQEF-AWEZNQCLSA-N 0.000 claims 1
• DMDXCSJKZSRFMF-UHFFFAOYSA-N 3-(2,4-dimethoxyphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound COC1=CC(OC)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O DMDXCSJKZSRFMF-UHFFFAOYSA-N 0.000 claims 1
• XYKHECGJXLXGOP-UHFFFAOYSA-N 3-(2,4-dimethylthieno[2,3-d]pyrimidin-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound S1C2=NC(C)=NC(C)=C2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 XYKHECGJXLXGOP-UHFFFAOYSA-N 0.000 claims 1
• BLFTYTWRHRWDPP-LBPRGKRZSA-N 3-(2-chloro-4-fluorophenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C(=CC(F)=CC=2)Cl)C(=O)O2)C2=C1 BLFTYTWRHRWDPP-LBPRGKRZSA-N 0.000 claims 1
• XCFNYYIPDTWIQX-UHFFFAOYSA-N 3-(2-chloroimidazo[2,1-b][1,3]thiazol-6-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3SC(Cl)=CN3C=2)C(=O)O2)C2=C1 XCFNYYIPDTWIQX-UHFFFAOYSA-N 0.000 claims 1
• LDIBOKGSQDKWLD-UHFFFAOYSA-N 3-(2-chloroimidazo[2,1-b][1,3]thiazol-6-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3SC(Cl)=CN3C=2)C(=O)O2)C2=C1 LDIBOKGSQDKWLD-UHFFFAOYSA-N 0.000 claims 1
• QULUEZUGARIMRI-TXEJJXNPSA-N 3-(2-chloroimidazo[2,1-b][1,3]thiazol-6-yl)-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3SC(Cl)=CN3C=2)C(=O)O2)C2=C1 QULUEZUGARIMRI-TXEJJXNPSA-N 0.000 claims 1
• ZKOAUYICAVULIN-UHFFFAOYSA-N 3-(2-chloroimidazo[2,1-b][1,3]thiazol-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2SC(Cl)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 ZKOAUYICAVULIN-UHFFFAOYSA-N 0.000 claims 1
• SBTHZOICXFRIEG-UHFFFAOYSA-N 3-(2-chloropyridin-4-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=NC(Cl)=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 SBTHZOICXFRIEG-UHFFFAOYSA-N 0.000 claims 1
• ISDAXYVZMFDGQI-UHFFFAOYSA-N 3-(2-cyclopropylpyrimidin-4-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C(N=CC=2)C2CC2)C(=O)O2)C2=C1 ISDAXYVZMFDGQI-UHFFFAOYSA-N 0.000 claims 1
• BWGMUGGNLAEUNA-UHFFFAOYSA-N 3-(2-cyclopropylpyrimidin-4-yl)-7-piperazin-1-ylchromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C(N=1)=CC=NC=1C1CC1 BWGMUGGNLAEUNA-UHFFFAOYSA-N 0.000 claims 1
• RCNGOFQCICCVQG-UHFFFAOYSA-N 3-(2-cyclopropylpyrimidin-4-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C(N=1)=CC=NC=1C1CC1 RCNGOFQCICCVQG-UHFFFAOYSA-N 0.000 claims 1
• BQRNODIATSXVLK-UHFFFAOYSA-N 3-(2-ethoxypyridin-3-yl)-7-piperazin-1-ylchromen-2-one Chemical compound CCOC1=NC=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O BQRNODIATSXVLK-UHFFFAOYSA-N 0.000 claims 1
• MRELCFZFQZXGLB-UHFFFAOYSA-N 3-(2-ethylimidazo[2,1-b][1,3]thiazol-6-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound N1=C2SC(CC)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCN(C)CC1 MRELCFZFQZXGLB-UHFFFAOYSA-N 0.000 claims 1
• GNCZUYTWEBETBQ-UHFFFAOYSA-N 3-(2-ethylimidazo[2,1-b][1,3]thiazol-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2SC(CC)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 GNCZUYTWEBETBQ-UHFFFAOYSA-N 0.000 claims 1
• PXMOUDIYAKXWEQ-UHFFFAOYSA-N 3-(2-methoxypyridin-4-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1=NC(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCN(C)CC2)=O)=C1 PXMOUDIYAKXWEQ-UHFFFAOYSA-N 0.000 claims 1
• ZWYMDGCXCSIRKQ-UHFFFAOYSA-N 3-(2-methyl-1,3-benzothiazol-6-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2C=C3SC(C)=NC3=CC=2)C(=O)O2)C2=C1 ZWYMDGCXCSIRKQ-UHFFFAOYSA-N 0.000 claims 1
• OIUJGWSAGBDYIX-ZDUSSCGKSA-N 3-(2-methyl-1,3-benzothiazol-6-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=C3SC(C)=NC3=CC=2)C(=O)O2)C2=C1 OIUJGWSAGBDYIX-ZDUSSCGKSA-N 0.000 claims 1
• VZKLHXMFPSJIPL-UHFFFAOYSA-N 3-(2-methyl-1,3-benzoxazol-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C2OC(C)=NC2=CC=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 VZKLHXMFPSJIPL-UHFFFAOYSA-N 0.000 claims 1
• ZMRLZDBTYFMSNZ-UHFFFAOYSA-N 3-(2-methylimidazo[1,2-a]pyridin-6-yl)-7-(1-methylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(C)CCC1C1=CC=C(C=C(C2=CN3C=C(C)N=C3C=C2)C(=O)O2)C2=C1 ZMRLZDBTYFMSNZ-UHFFFAOYSA-N 0.000 claims 1
• PDLVGZNNOZZEFQ-UHFFFAOYSA-N 3-(2-methylimidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C3C=C2)C(=O)O2)C2=C1 PDLVGZNNOZZEFQ-UHFFFAOYSA-N 0.000 claims 1
• YZHGZMXMKFXEKZ-CQSZACIVSA-N 3-(2-methylimidazo[1,2-a]pyridin-6-yl)-7-[(3R)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound CC=1N=C2N(C=C(C=C2)C=2C(OC3=CC(=CC=C3C=2)N2C[C@H](NCC2)C)=O)C=1 YZHGZMXMKFXEKZ-CQSZACIVSA-N 0.000 claims 1
• YZHGZMXMKFXEKZ-AWEZNQCLSA-N 3-(2-methylimidazo[1,2-a]pyridin-6-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=C3C=C2)C(=O)O2)C2=C1 YZHGZMXMKFXEKZ-AWEZNQCLSA-N 0.000 claims 1
• KCINMJOCDZWTKK-UHFFFAOYSA-N 3-(2-methylimidazo[1,2-a]pyridin-6-yl)-7-[1-(oxetan-3-yl)piperidin-4-yl]chromen-2-one Chemical compound C1=CC2=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C(CC1)CCN1C1COC1 KCINMJOCDZWTKK-UHFFFAOYSA-N 0.000 claims 1
• SPTBDFVKNYMQTI-UHFFFAOYSA-N 3-(2-methylimidazo[1,2-a]pyridin-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC2=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 SPTBDFVKNYMQTI-UHFFFAOYSA-N 0.000 claims 1
• QBLRLFLJOALTIW-UHFFFAOYSA-N 3-(2-methylimidazo[1,2-a]pyridin-6-yl)-7-piperidin-4-ylchromen-2-one Chemical compound C1=CC2=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCNCC1 QBLRLFLJOALTIW-UHFFFAOYSA-N 0.000 claims 1
• JKOOQDCSNOIRQC-UHFFFAOYSA-N 3-(2-methylimidazo[1,2-a]pyrimidin-6-yl)-7-(1-methylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(C)CCC1C1=CC=C(C=C(C2=CN3C=C(C)N=C3N=C2)C(=O)O2)C2=C1 JKOOQDCSNOIRQC-UHFFFAOYSA-N 0.000 claims 1
• MVPHIIFWPSAYSU-CYBMUJFWSA-N 3-(2-methylimidazo[1,2-a]pyrimidin-6-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=C3N=C2)C(=O)O2)C2=C1 MVPHIIFWPSAYSU-CYBMUJFWSA-N 0.000 claims 1
• VAQVMDFZGPMYOB-UHFFFAOYSA-N 3-(2-methylimidazo[1,2-a]pyrimidin-6-yl)-7-piperidin-4-ylchromen-2-one Chemical compound C1=NC2=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCNCC1 VAQVMDFZGPMYOB-UHFFFAOYSA-N 0.000 claims 1
• CJRXMCAZTMLHSQ-UHFFFAOYSA-N 3-(2-methylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3SC(C)=NN3C=2)C(=O)O2)C2=C1 CJRXMCAZTMLHSQ-UHFFFAOYSA-N 0.000 claims 1
• ZKGBXLMNHXDSEI-LLVKDONJSA-N 3-(2-methylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3SC(C)=NN3C=2)C(=O)O2)C2=C1 ZKGBXLMNHXDSEI-LLVKDONJSA-N 0.000 claims 1
• ZKGBXLMNHXDSEI-NSHDSACASA-N 3-(2-methylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3SC(C)=NN3C=2)C(=O)O2)C2=C1 ZKGBXLMNHXDSEI-NSHDSACASA-N 0.000 claims 1
• WWHNAQGXBJZYQT-UHFFFAOYSA-N 3-(2-methylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2SC(C)=NN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 WWHNAQGXBJZYQT-UHFFFAOYSA-N 0.000 claims 1
• BYIKEZGWSJOFNP-UHFFFAOYSA-N 3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3SC(C)=CN3C=2)C(=O)O2)C2=C1 BYIKEZGWSJOFNP-UHFFFAOYSA-N 0.000 claims 1
• XYPCLOBMTMSYEX-PFEQFJNWSA-N 3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-[(3R)-pyrrolidin-3-yl]oxychromen-2-one hydrochloride Chemical compound Cl.Cc1cn2cc(nc2s1)-c1cc2ccc(O[C@@H]3CCNC3)cc2oc1=O XYPCLOBMTMSYEX-PFEQFJNWSA-N 0.000 claims 1
• ARDVPMWNDITSEH-GFCCVEGCSA-N 3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3SC(C)=CN3C=2)C(=O)O2)C2=C1 ARDVPMWNDITSEH-GFCCVEGCSA-N 0.000 claims 1
• AWQRTEDIWFEIGY-CQSZACIVSA-N 3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound N1=C2SC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 AWQRTEDIWFEIGY-CQSZACIVSA-N 0.000 claims 1
• ARDVPMWNDITSEH-LBPRGKRZSA-N 3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3SC(C)=CN3C=2)C(=O)O2)C2=C1 ARDVPMWNDITSEH-LBPRGKRZSA-N 0.000 claims 1
• OPRXTKZTNVTHGV-UHFFFAOYSA-N 3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2SC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 OPRXTKZTNVTHGV-UHFFFAOYSA-N 0.000 claims 1
• OKCBQWIXCPNJQG-UHFFFAOYSA-N 3-(2-methylindazol-5-yl)-7-(1-methylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(C)CCC1C1=CC=C(C=C(C2=CC3=CN(C)N=C3C=C2)C(=O)O2)C2=C1 OKCBQWIXCPNJQG-UHFFFAOYSA-N 0.000 claims 1
• SXHROWZEEPONNN-UHFFFAOYSA-N 3-(2-methylindazol-5-yl)-7-piperidin-4-ylchromen-2-one Chemical compound C1=CC2=NN(C)C=C2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCNCC1 SXHROWZEEPONNN-UHFFFAOYSA-N 0.000 claims 1
• NOWWUBJQPOYWIS-UHFFFAOYSA-N 3-(2-methylpyrimidin-4-yl)-7-piperazin-1-ylchromen-2-one Chemical compound CC1=NC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 NOWWUBJQPOYWIS-UHFFFAOYSA-N 0.000 claims 1
• MNYDYSBCLNGXEO-UHFFFAOYSA-N 3-(2-methylpyrimidin-4-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.CC1=NC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 MNYDYSBCLNGXEO-UHFFFAOYSA-N 0.000 claims 1
• IWUCVJSLAJEIPL-UHFFFAOYSA-N 3-(2-methylpyrrolo[1,2-b]pyridazin-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2N=C(C)C=CC2=CC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 IWUCVJSLAJEIPL-UHFFFAOYSA-N 0.000 claims 1
• YEKVFNIGULRKIW-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-5-fluoro-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=C(F)C=C(N3CCN(C)CCC3)C=C2OC1=O YEKVFNIGULRKIW-UHFFFAOYSA-N 0.000 claims 1
• MVIKYKUWAPIZDX-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-5-fluoro-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=C(F)C=C(N3CCN(C)CC3)C=C2OC1=O MVIKYKUWAPIZDX-UHFFFAOYSA-N 0.000 claims 1
• AOMJIVHBPYRRJY-CYBMUJFWSA-N 3-(3,4-dimethoxyphenyl)-5-fluoro-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=C(F)C=C(N3C[C@@H](C)NCC3)C=C2OC1=O AOMJIVHBPYRRJY-CYBMUJFWSA-N 0.000 claims 1
• AOMJIVHBPYRRJY-ZDUSSCGKSA-N 3-(3,4-dimethoxyphenyl)-5-fluoro-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=C(F)C=C(N3C[C@H](C)NCC3)C=C2OC1=O AOMJIVHBPYRRJY-ZDUSSCGKSA-N 0.000 claims 1
• BIDBGICGDLXUJF-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-5-fluoro-7-piperazin-1-ylchromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=C(F)C=C(N3CCNCC3)C=C2OC1=O BIDBGICGDLXUJF-UHFFFAOYSA-N 0.000 claims 1
• PJLAUDNSXWPPMG-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=CC=C(N3CCN(C)CC3)C=C2OC1=O PJLAUDNSXWPPMG-UHFFFAOYSA-N 0.000 claims 1
• VHCXTQBVWGLPTE-AWEZNQCLSA-N 3-(3,4-dimethoxyphenyl)-7-[(2s)-2-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=CC=C(N3[C@H](CNCC3)C)C=C2OC1=O VHCXTQBVWGLPTE-AWEZNQCLSA-N 0.000 claims 1
• ICDHRMXICPHMJH-CQSZACIVSA-N 3-(3,4-dimethoxyphenyl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=CC=C(N3C[C@@H](C)NCC3)C=C2OC1=O ICDHRMXICPHMJH-CQSZACIVSA-N 0.000 claims 1
• MSWDUNUXNIYQPF-GASCZTMLSA-N 3-(3,4-dimethoxyphenyl)-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=CC=C(N3C[C@@H](C)N[C@@H](C)C3)C=C2OC1=O MSWDUNUXNIYQPF-GASCZTMLSA-N 0.000 claims 1
• ICDHRMXICPHMJH-AWEZNQCLSA-N 3-(3,4-dimethoxyphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=CC=C(N3C[C@H](C)NCC3)C=C2OC1=O ICDHRMXICPHMJH-AWEZNQCLSA-N 0.000 claims 1
• MGJUPRGMKHMAOC-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O MGJUPRGMKHMAOC-UHFFFAOYSA-N 0.000 claims 1
• PEKPNRLISHVNJT-BETUJISGSA-N 3-(3,5-difluoro-2-methoxyphenyl)-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound COC1=C(F)C=C(F)C=C1C1=CC2=CC=C(N3C[C@@H](C)N[C@@H](C)C3)C=C2OC1=O PEKPNRLISHVNJT-BETUJISGSA-N 0.000 claims 1
• WCEHTAMRHVRLOS-LBPRGKRZSA-N 3-(3,5-difluoro-2-methoxyphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound COC1=C(F)C=C(F)C=C1C1=CC2=CC=C(N3C[C@H](C)NCC3)C=C2OC1=O WCEHTAMRHVRLOS-LBPRGKRZSA-N 0.000 claims 1
• YESRBAXEBHOGSB-UHFFFAOYSA-N 3-(3,5-difluoro-2-methoxyphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound COC1=C(F)C=C(F)C=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O YESRBAXEBHOGSB-UHFFFAOYSA-N 0.000 claims 1
• ZUPUGIMFOQGVFZ-UHFFFAOYSA-N 3-(3,5-difluorophenyl)-5-fluoro-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC(F)=C(C=C(C=2C=C(F)C=C(F)C=2)C(=O)O2)C2=C1 ZUPUGIMFOQGVFZ-UHFFFAOYSA-N 0.000 claims 1
• AQUIWQHEIZHTMS-UHFFFAOYSA-N 3-(3,5-difluorophenyl)-5-fluoro-7-piperazin-1-ylchromen-2-one Chemical compound FC1=CC(F)=CC(C=2C(OC3=CC(=CC(F)=C3C=2)N2CCNCC2)=O)=C1 AQUIWQHEIZHTMS-UHFFFAOYSA-N 0.000 claims 1
• PJSQGQKJPANNMY-UHFFFAOYSA-N 3-(3,5-difluorophenyl)-7-piperazin-1-ylchromen-2-one Chemical compound FC1=CC(F)=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 PJSQGQKJPANNMY-UHFFFAOYSA-N 0.000 claims 1
• DULFFWCUMHUQGP-UHFFFAOYSA-N 3-(3,5-dimethoxyphenyl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound COC1=CC(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCN(C)CCC2)=O)=C1 DULFFWCUMHUQGP-UHFFFAOYSA-N 0.000 claims 1
• JRBBKNQXUYZDQC-CQSZACIVSA-N 3-(3,5-dimethoxyphenyl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound COC1=CC(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2C[C@@H](C)NCC2)=O)=C1 JRBBKNQXUYZDQC-CQSZACIVSA-N 0.000 claims 1
• JRBBKNQXUYZDQC-AWEZNQCLSA-N 3-(3,5-dimethoxyphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound COC1=CC(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2C[C@H](C)NCC2)=O)=C1 JRBBKNQXUYZDQC-AWEZNQCLSA-N 0.000 claims 1
• LBTPNJHJSXUHJZ-LBPRGKRZSA-N 3-(3-chloro-4-fluorophenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=C(Cl)C(F)=CC=2)C(=O)O2)C2=C1 LBTPNJHJSXUHJZ-LBPRGKRZSA-N 0.000 claims 1
• SVVRFDMDGSFPPE-UHFFFAOYSA-N 3-(3-chloro-4-fluorophenyl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C(Cl)C(F)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O SVVRFDMDGSFPPE-UHFFFAOYSA-N 0.000 claims 1
• UEMZTGKIKUWTSP-ZDUSSCGKSA-N 3-(3-chlorophenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=C(Cl)C=CC=2)C(=O)O2)C2=C1 UEMZTGKIKUWTSP-ZDUSSCGKSA-N 0.000 claims 1
• JORDQUBBAFOHSX-ZDUSSCGKSA-N 3-(3-fluoro-4-methoxyphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(F)C(OC)=CC=C1C1=CC2=CC=C(N3C[C@H](C)NCC3)C=C2OC1=O JORDQUBBAFOHSX-ZDUSSCGKSA-N 0.000 claims 1
• QQJARXUHYGJSOF-UHFFFAOYSA-N 3-(3-fluoro-4-methoxyphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C(F)C(OC)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O QQJARXUHYGJSOF-UHFFFAOYSA-N 0.000 claims 1
• UKYKSANGDBIQHG-UHFFFAOYSA-N 3-(3-fluorophenyl)-7-piperazin-1-ylchromen-2-one Chemical compound FC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 UKYKSANGDBIQHG-UHFFFAOYSA-N 0.000 claims 1
• SAIAMBXSBSGCEN-UHFFFAOYSA-N 3-(3-fluoropyridin-4-yl)-7-piperazin-1-ylchromen-2-one Chemical compound FC1=CN=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O SAIAMBXSBSGCEN-UHFFFAOYSA-N 0.000 claims 1
• RXCNALNDLPMIDI-HNNXBMFYSA-N 3-(3-methoxy-4-methylphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(C)C(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2C[C@H](C)NCC2)=O)=C1 RXCNALNDLPMIDI-HNNXBMFYSA-N 0.000 claims 1
• MJKASFXQACDLDM-UHFFFAOYSA-N 3-(3-methoxy-4-methylphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C(C)C(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 MJKASFXQACDLDM-UHFFFAOYSA-N 0.000 claims 1
• VBGZGDSCDTYCSA-UHFFFAOYSA-N 3-(3-methoxyphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 VBGZGDSCDTYCSA-UHFFFAOYSA-N 0.000 claims 1
• VIKTWYXZYRKART-UHFFFAOYSA-N 3-(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3SC=C(C)N3C=2)C(=O)O2)C2=C1 VIKTWYXZYRKART-UHFFFAOYSA-N 0.000 claims 1
• YTOBFUMSSMQYJJ-UHFFFAOYSA-N 3-(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.C=1N2C(C)=CSC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 YTOBFUMSSMQYJJ-UHFFFAOYSA-N 0.000 claims 1
• VBXSUEQDSUUOGC-HNNXBMFYSA-N 3-(3-methylphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=C(C)C=CC=2)C(=O)O2)C2=C1 VBXSUEQDSUUOGC-HNNXBMFYSA-N 0.000 claims 1
• WNGCACMCSURNMJ-UHFFFAOYSA-N 3-(3-methylphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound CC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 WNGCACMCSURNMJ-UHFFFAOYSA-N 0.000 claims 1
• PEORPOMLVKJPED-UHFFFAOYSA-N 3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)-7-(4-propan-2-yl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 PEORPOMLVKJPED-UHFFFAOYSA-N 0.000 claims 1
• HDWUUVRIEFDADR-UHFFFAOYSA-N 3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)-7-(4-propan-2-ylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 HDWUUVRIEFDADR-UHFFFAOYSA-N 0.000 claims 1
• KBPXVWOSIBICJA-UHFFFAOYSA-N 3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 KBPXVWOSIBICJA-UHFFFAOYSA-N 0.000 claims 1
• BNLHZDHHJCZMLH-UHFFFAOYSA-N 3-(4,6-dimethylfuro[3,2-c]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2OC3=CC(C)=NC(C)=C3C=2)C(=O)O2)C2=C1 BNLHZDHHJCZMLH-UHFFFAOYSA-N 0.000 claims 1
• BBKYDIKYPNASOX-UHFFFAOYSA-N 3-(4,6-dimethylfuro[3,2-c]pyridin-2-yl)-7-(4-propan-2-ylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C=2OC3=CC(C)=NC(C)=C3C=2)C(=O)O2)C2=C1 BBKYDIKYPNASOX-UHFFFAOYSA-N 0.000 claims 1
• LHBMLGVCTWSPQS-UHFFFAOYSA-N 3-(4,6-dimethylfuro[3,2-c]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1C=2C(C)=NC(C)=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 LHBMLGVCTWSPQS-UHFFFAOYSA-N 0.000 claims 1
• QKNQDWKREMNVNQ-UHFFFAOYSA-N 3-(4,6-dimethylpyrazolo[1,5-a]pyrazin-2-yl)-7-(1-ethylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(CC)CCC1C1=CC=C(C=C(C2=NN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 QKNQDWKREMNVNQ-UHFFFAOYSA-N 0.000 claims 1
• HTDXMSLJIJDZQG-UHFFFAOYSA-N 3-(4,6-dimethylthieno[3,2-c]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2SC3=CC(C)=NC(C)=C3C=2)C(=O)O2)C2=C1 HTDXMSLJIJDZQG-UHFFFAOYSA-N 0.000 claims 1
• UGBOOYSXAWHDIR-UHFFFAOYSA-N 3-(4,6-dimethylthieno[3,2-c]pyridin-2-yl)-7-[4-(2-methoxyethyl)piperazin-1-yl]chromen-2-one Chemical compound C1CN(CCOC)CCN1C1=CC=C(C=C(C=2SC3=CC(C)=NC(C)=C3C=2)C(=O)O2)C2=C1 UGBOOYSXAWHDIR-UHFFFAOYSA-N 0.000 claims 1
• WTORVDUMXQIRBU-UHFFFAOYSA-N 3-(4,6-dimethylthieno[3,2-c]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1C=2C(C)=NC(C)=CC=2SC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 WTORVDUMXQIRBU-UHFFFAOYSA-N 0.000 claims 1
• LDVLEMKDSCDREY-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2SC3=CC=CC(Cl)=C3N=2)C(=O)O2)C2=C1 LDVLEMKDSCDREY-UHFFFAOYSA-N 0.000 claims 1
• VYZBILNTXUKWNO-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-(4-methylpiperazine-1-carbonyl)chromen-2-one Chemical compound C1CN(C)CCN1C(=O)C1=CC=C(C=C(C=2SC3=CC=CC(Cl)=C3N=2)C(=O)O2)C2=C1 VYZBILNTXUKWNO-UHFFFAOYSA-N 0.000 claims 1
• YMYHBVROWLVNOM-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-(diethylaminomethyl)chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CN(CC)CC)=NC2=C1Cl YMYHBVROWLVNOM-UHFFFAOYSA-N 0.000 claims 1
• MJYXUZMTPCPRDZ-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-(piperazin-1-ylmethyl)chromen-2-one Chemical compound N=1C=2C(Cl)=CC=CC=2SC=1C(C(OC1=C2)=O)=CC1=CC=C2CN1CCNCC1 MJYXUZMTPCPRDZ-UHFFFAOYSA-N 0.000 claims 1
• AROIFFAQOJBNGS-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-(piperidin-1-ylmethyl)chromen-2-one Chemical compound N=1C=2C(Cl)=CC=CC=2SC=1C(C(OC1=C2)=O)=CC1=CC=C2CN1CCCCC1 AROIFFAQOJBNGS-UHFFFAOYSA-N 0.000 claims 1
• UVJXQAIGXIPNQV-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[(1-hydroxypropan-2-ylamino)methyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CNC(CO)C)=NC2=C1Cl UVJXQAIGXIPNQV-UHFFFAOYSA-N 0.000 claims 1
• BLTGHANAKDJFOG-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[(3-hydroxypyrrolidin-1-yl)methyl]chromen-2-one Chemical compound C1C(O)CCN1CC1=CC=C(C=C(C=2SC3=CC=CC(Cl)=C3N=2)C(=O)O2)C2=C1 BLTGHANAKDJFOG-UHFFFAOYSA-N 0.000 claims 1
• NEHSOIGXWZCDTB-BETUJISGSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2SC3=CC=CC(Cl)=C3N=2)C(=O)O2)C2=C1 NEHSOIGXWZCDTB-BETUJISGSA-N 0.000 claims 1
• PIXUBVJJNQVGMV-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[(4-hydroxypiperidin-1-yl)methyl]chromen-2-one Chemical compound C1CC(O)CCN1CC1=CC=C(C=C(C=2SC3=CC=CC(Cl)=C3N=2)C(=O)O2)C2=C1 PIXUBVJJNQVGMV-UHFFFAOYSA-N 0.000 claims 1
• XWPDAWFLDBMPGO-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[(dimethylamino)methyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CN(C)C)=NC2=C1Cl XWPDAWFLDBMPGO-UHFFFAOYSA-N 0.000 claims 1
• MZGLCUFVGDKWTL-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[(propan-2-ylamino)methyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CNC(C)C)=NC2=C1Cl MZGLCUFVGDKWTL-UHFFFAOYSA-N 0.000 claims 1
• SOYYJSSCMJQKQR-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[2-(propan-2-ylamino)ethyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CCNC(C)C)=NC2=C1Cl SOYYJSSCMJQKQR-UHFFFAOYSA-N 0.000 claims 1
• IIKNIFUKXBYVKX-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[3-(propan-2-ylamino)propyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CCCNC(C)C)=NC2=C1Cl IIKNIFUKXBYVKX-UHFFFAOYSA-N 0.000 claims 1
• DTBCGVUNKPYREE-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-[[2-hydroxyethyl(methyl)amino]methyl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CN(CCO)C)=NC2=C1Cl DTBCGVUNKPYREE-UHFFFAOYSA-N 0.000 claims 1
• QJZJRAWXHLZIQG-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N=1C=2C(Cl)=CC=CC=2SC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 QJZJRAWXHLZIQG-UHFFFAOYSA-N 0.000 claims 1
• CMHBSVQATLLBTQ-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-piperazin-1-ylchromen-2-one hydrochloride Chemical compound Cl.Clc1cccc2sc(nc12)-c1cc2ccc(cc2oc1=O)N1CCNCC1 CMHBSVQATLLBTQ-UHFFFAOYSA-N 0.000 claims 1
• JZBXIJYYMJMZKO-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-piperidin-4-ylchromen-2-one Chemical compound N=1C=2C(Cl)=CC=CC=2SC=1C(C(OC1=C2)=O)=CC1=CC=C2C1CCNCC1 JZBXIJYYMJMZKO-UHFFFAOYSA-N 0.000 claims 1
• OLQGKJREKJAPTD-UHFFFAOYSA-N 3-(4-chloro-1,3-benzothiazol-2-yl)-7-piperidin-4-ylchromen-2-one;hydrochloride Chemical compound Cl.N=1C=2C(Cl)=CC=CC=2SC=1C(C(OC1=C2)=O)=CC1=CC=C2C1CCNCC1 OLQGKJREKJAPTD-UHFFFAOYSA-N 0.000 claims 1
• MNQYASZTVCEHMD-UHFFFAOYSA-N 3-(4-chloro-1,3-benzoxazol-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2OC3=CC=CC(Cl)=C3N=2)C(=O)O2)C2=C1 MNQYASZTVCEHMD-UHFFFAOYSA-N 0.000 claims 1
• BZUBPVJZBWSMHD-BETUJISGSA-N 3-(4-chloro-1,3-benzoxazol-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=CC=CC(Cl)=C3N=2)C(=O)O2)C2=C1 BZUBPVJZBWSMHD-BETUJISGSA-N 0.000 claims 1
• HVMRGMKSPRPLQS-UHFFFAOYSA-N 3-(4-chloro-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N=1C=2C(Cl)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 HVMRGMKSPRPLQS-UHFFFAOYSA-N 0.000 claims 1
• GURKFFYMWAYAGU-UHFFFAOYSA-N 3-(4-chloro-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.N=1C=2C(Cl)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 GURKFFYMWAYAGU-UHFFFAOYSA-N 0.000 claims 1
• PNEMSENVPGDPJJ-UHFFFAOYSA-N 3-(4-chloropyridin-3-yl)-7-piperazin-1-ylchromen-2-one Chemical compound ClC1=CC=NC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O PNEMSENVPGDPJJ-UHFFFAOYSA-N 0.000 claims 1
• GWZQYCUXLDGCGU-UHFFFAOYSA-N 3-(4-fluoro-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N=1C=2C(F)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 GWZQYCUXLDGCGU-UHFFFAOYSA-N 0.000 claims 1
• MDHBWTLMBOBTGE-UHFFFAOYSA-N 3-(4-fluoro-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.N=1C=2C(F)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 MDHBWTLMBOBTGE-UHFFFAOYSA-N 0.000 claims 1
• IURBHHMYPSFDNX-ZDUSSCGKSA-N 3-(4-fluoro-3-methoxyphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(F)C(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2C[C@H](C)NCC2)=O)=C1 IURBHHMYPSFDNX-ZDUSSCGKSA-N 0.000 claims 1
• GJJPVJQJSOSPQH-UHFFFAOYSA-N 3-(4-fluoro-3-methoxyphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C(F)C(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 GJJPVJQJSOSPQH-UHFFFAOYSA-N 0.000 claims 1
• RHCPDOYPMNDXSO-UHFFFAOYSA-N 3-(4-iodo-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N=1C=2C(I)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 RHCPDOYPMNDXSO-UHFFFAOYSA-N 0.000 claims 1
• ABYDBTIIQXIGAJ-UHFFFAOYSA-N 3-(4-iodo-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.N=1C=2C(I)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 ABYDBTIIQXIGAJ-UHFFFAOYSA-N 0.000 claims 1
• OAMKOGCKTGTNMI-HNNXBMFYSA-N 3-(4-methoxy-3-methylphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=C(C)C(OC)=CC=C1C1=CC2=CC=C(N3C[C@H](C)NCC3)C=C2OC1=O OAMKOGCKTGTNMI-HNNXBMFYSA-N 0.000 claims 1
• ARMZTJDTOFZLOR-UHFFFAOYSA-N 3-(4-methoxy-3-methylphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C(C)C(OC)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O ARMZTJDTOFZLOR-UHFFFAOYSA-N 0.000 claims 1
• JXGCDPGUCPJBMM-CQSZACIVSA-N 3-(4-methoxyphenyl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=CC(OC)=CC=C1C1=CC2=CC=C(N3C[C@@H](C)NCC3)C=C2OC1=O JXGCDPGUCPJBMM-CQSZACIVSA-N 0.000 claims 1
• JXGCDPGUCPJBMM-AWEZNQCLSA-N 3-(4-methoxyphenyl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1=CC(OC)=CC=C1C1=CC2=CC=C(N3C[C@H](C)NCC3)C=C2OC1=O JXGCDPGUCPJBMM-AWEZNQCLSA-N 0.000 claims 1
• WTYKAKKFQYEMEH-UHFFFAOYSA-N 3-(4-methoxyphenyl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC(OC)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O WTYKAKKFQYEMEH-UHFFFAOYSA-N 0.000 claims 1
• SDJWSAGCCQYBIE-UHFFFAOYSA-N 3-(4-methoxypyridin-3-yl)-7-piperazin-1-ylchromen-2-one Chemical compound COC1=CC=NC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O SDJWSAGCCQYBIE-UHFFFAOYSA-N 0.000 claims 1
• HKIVBAJYQVYHEE-UHFFFAOYSA-N 3-(4-methyl-1,3-benzoxazol-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2OC3=CC=CC(C)=C3N=2)C(=O)O2)C2=C1 HKIVBAJYQVYHEE-UHFFFAOYSA-N 0.000 claims 1
• UUUZWVWKHQSTIR-UHFFFAOYSA-N 3-(4-methyl-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N=1C=2C(C)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 UUUZWVWKHQSTIR-UHFFFAOYSA-N 0.000 claims 1
• QCQIUUXIVBFQNY-UHFFFAOYSA-N 3-(4-methyl-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.N=1C=2C(C)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 QCQIUUXIVBFQNY-UHFFFAOYSA-N 0.000 claims 1
• HFZKTRBUMNZFAO-UHFFFAOYSA-N 3-(4-methyl-1,3-thiazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound CC1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 HFZKTRBUMNZFAO-UHFFFAOYSA-N 0.000 claims 1
• ZXOQTYOOCZMGLD-UHFFFAOYSA-N 3-(4-methyl-1h-benzimidazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N=1C=2C(C)=CC=CC=2NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 ZXOQTYOOCZMGLD-UHFFFAOYSA-N 0.000 claims 1
• DVDFMFQMVMBLBL-UHFFFAOYSA-N 3-(4-methyl-1h-pyrazol-5-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=NNC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1C DVDFMFQMVMBLBL-UHFFFAOYSA-N 0.000 claims 1
• BGNLOMKGEIFQHO-UHFFFAOYSA-N 3-(4-methylthiophen-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound CC1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 BGNLOMKGEIFQHO-UHFFFAOYSA-N 0.000 claims 1
• DVZWJEYEPMLGIO-UHFFFAOYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-(4-ethylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 DVZWJEYEPMLGIO-UHFFFAOYSA-N 0.000 claims 1
• UUGBTLYVVQAEFM-UHFFFAOYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 UUGBTLYVVQAEFM-UHFFFAOYSA-N 0.000 claims 1
• JBYMFBJVSYQTSF-UHFFFAOYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound CC=1C=C2C(=C(N1)C)OC(=C2)C=2C(OC1=CC(=CC=C1C2)N2CCN(CC2)C)=O JBYMFBJVSYQTSF-UHFFFAOYSA-N 0.000 claims 1
• GWUCNMHNASONEJ-UHFFFAOYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-(4-propan-2-ylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 GWUCNMHNASONEJ-UHFFFAOYSA-N 0.000 claims 1
• MBRXOOOEUAZZML-UHFFFAOYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-(4-propylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CCC)CCN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 MBRXOOOEUAZZML-UHFFFAOYSA-N 0.000 claims 1
• VTRPOGZVAHXATA-OAHLLOKOSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-[(3r)-3,4-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 VTRPOGZVAHXATA-OAHLLOKOSA-N 0.000 claims 1
• HZNHOVJUYYMPIW-CQSZACIVSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 HZNHOVJUYYMPIW-CQSZACIVSA-N 0.000 claims 1
• VTRPOGZVAHXATA-HNNXBMFYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-[(3s)-3,4-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 VTRPOGZVAHXATA-HNNXBMFYSA-N 0.000 claims 1
• HZNHOVJUYYMPIW-AWEZNQCLSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 HZNHOVJUYYMPIW-AWEZNQCLSA-N 0.000 claims 1
• RSJAQYAPITWDJY-UHFFFAOYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-[4-(2-hydroxyethyl)piperazin-1-yl]chromen-2-one Chemical compound O1C=2C(C)=NC(C)=CC=2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(CCO)CC1 RSJAQYAPITWDJY-UHFFFAOYSA-N 0.000 claims 1
• CTXFUMWOOPMFTC-UHFFFAOYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-[4-(2-methoxyethyl)piperazin-1-yl]chromen-2-one Chemical compound C1CN(CCOC)CCN1C1=CC=C(C=C(C=2OC3=C(C)N=C(C)C=C3C=2)C(=O)O2)C2=C1 CTXFUMWOOPMFTC-UHFFFAOYSA-N 0.000 claims 1
• UQLSYCHINMBUPU-UHFFFAOYSA-N 3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound O1C=2C(C)=NC(C)=CC=2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 UQLSYCHINMBUPU-UHFFFAOYSA-N 0.000 claims 1
• BTIGXTIKCFSUNC-UHFFFAOYSA-N 3-(5-chloropyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=CC(Cl)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O BTIGXTIKCFSUNC-UHFFFAOYSA-N 0.000 claims 1
• BWVUDASJDBDABH-UHFFFAOYSA-N 3-(5-fluoro-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N=1C2=CC(F)=CC=C2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 BWVUDASJDBDABH-UHFFFAOYSA-N 0.000 claims 1
• NJNZIPMSISUYBL-UHFFFAOYSA-N 3-(5-fluoro-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one;hydrochloride Chemical compound Cl.N=1C2=CC(F)=CC=C2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 NJNZIPMSISUYBL-UHFFFAOYSA-N 0.000 claims 1
• FLCJJWWNPABFDV-UHFFFAOYSA-N 3-(5-methylfuro[3,2-b]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2OC3=CC=C(C)N=C3C=2)C(=O)O2)C2=C1 FLCJJWWNPABFDV-UHFFFAOYSA-N 0.000 claims 1
• QBQXKWIEKNZGOB-UHFFFAOYSA-N 3-(5-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=CC=C(C)N3C=2)C(=O)O2)C2=C1 QBQXKWIEKNZGOB-UHFFFAOYSA-N 0.000 claims 1
• ZCYCTORNDBVBLH-UHFFFAOYSA-N 3-(5-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C(C)=CC=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 ZCYCTORNDBVBLH-UHFFFAOYSA-N 0.000 claims 1
• MJMJYADBRFDVLJ-UHFFFAOYSA-N 3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)-7-(4-propylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CCC)CCN1C1=CC=C(C=C(C2=NN3C=CC(C)=CC3=C2)C(=O)O2)C2=C1 MJMJYADBRFDVLJ-UHFFFAOYSA-N 0.000 claims 1
• FAJYHHVPNNUATP-UHFFFAOYSA-N 3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C2C=C(C)C=CN2N=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 FAJYHHVPNNUATP-UHFFFAOYSA-N 0.000 claims 1
• PRMZNKSTTITVTB-UHFFFAOYSA-N 3-(5-phenyl-1,2,4-oxadiazol-3-yl)-7-piperazin-1-ylchromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C(N=1)=NOC=1C1=CC=CC=C1 PRMZNKSTTITVTB-UHFFFAOYSA-N 0.000 claims 1
• YNRLSXKFJJGLPB-UHFFFAOYSA-N 3-(6,8-difluoroimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(F)=CC(F)=CN3C=2)C(=O)O2)C2=C1 YNRLSXKFJJGLPB-UHFFFAOYSA-N 0.000 claims 1
• KHIRGWQVULEIIM-UHFFFAOYSA-N 3-(6,8-difluoroimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(F)=CC(F)=CN3C=2)C(=O)O2)C2=C1 KHIRGWQVULEIIM-UHFFFAOYSA-N 0.000 claims 1
• JQKTUAUDZSULKH-LBPRGKRZSA-N 3-(6,8-difluoroimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(F)=CN3C=2)C(=O)O2)C2=C1 JQKTUAUDZSULKH-LBPRGKRZSA-N 0.000 claims 1
• AVCSUPOCXLZFKK-BETUJISGSA-N 3-(6,8-difluoroimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(F)=CN3C=2)C(=O)O2)C2=C1 AVCSUPOCXLZFKK-BETUJISGSA-N 0.000 claims 1
• GKWQKACIAWHPOM-UHFFFAOYSA-N 3-(6,8-difluoroimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(F)C=C(F)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 GKWQKACIAWHPOM-UHFFFAOYSA-N 0.000 claims 1
• UAKMTPYYVGIUKK-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-5-fluoro-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC(F)=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 UAKMTPYYVGIUKK-UHFFFAOYSA-N 0.000 claims 1
• VPCOTOPGXPUZMT-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1,2,3,6-tetrahydropyridin-4-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1=CCNCC1 VPCOTOPGXPUZMT-UHFFFAOYSA-N 0.000 claims 1
• BKAUMBZGSHMCPB-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-ethyl-4-fluoropiperidin-4-yl)chromen-2-one Chemical compound C1CN(CC)CCC1(F)C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 BKAUMBZGSHMCPB-UHFFFAOYSA-N 0.000 claims 1
• DGAKZQMYBIDSKS-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-ethylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(CC)CCC1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 DGAKZQMYBIDSKS-UHFFFAOYSA-N 0.000 claims 1
• CRKHGKOGQDWBRK-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-ethylpiperidin-4-yl)oxychromen-2-one Chemical compound C1CN(CC)CCC1OC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 CRKHGKOGQDWBRK-UHFFFAOYSA-N 0.000 claims 1
• AOAIUGZWTIYVFL-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)chromen-2-one Chemical compound C1N(C)CCC(C=2C=C3OC(=O)C(C=4N=C5C(C)=NC(C)=CN5C=4)=CC3=CC=2)=C1 AOAIUGZWTIYVFL-UHFFFAOYSA-N 0.000 claims 1
• QXUZSOURGWSBDF-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-methylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(C)CCC1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 QXUZSOURGWSBDF-UHFFFAOYSA-N 0.000 claims 1
• FVFMMLACVCSGHO-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-methylpiperidin-4-yl)oxychromen-2-one Chemical compound C1CN(C)CCC1OC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 FVFMMLACVCSGHO-UHFFFAOYSA-N 0.000 claims 1
• WYBFGGNXONRPFK-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-propan-2-yl-3,6-dihydro-2h-pyridin-4-yl)chromen-2-one Chemical compound C1N(C(C)C)CCC(C=2C=C3OC(=O)C(C=4N=C5C(C)=NC(C)=CN5C=4)=CC3=CC=2)=C1 WYBFGGNXONRPFK-UHFFFAOYSA-N 0.000 claims 1
• HONAKCJZFGKMDJ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-propan-2-ylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCC1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 HONAKCJZFGKMDJ-UHFFFAOYSA-N 0.000 claims 1
• XEDRMGFQMXRWKC-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-propan-2-ylpiperidin-4-yl)oxychromen-2-one Chemical compound C1CN(C(C)C)CCC1OC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 XEDRMGFQMXRWKC-UHFFFAOYSA-N 0.000 claims 1
• YRTXWFOUHNBFPR-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(1-propylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(CCC)CCC1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 YRTXWFOUHNBFPR-UHFFFAOYSA-N 0.000 claims 1
• GAZFJKGBWGJSLH-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(2,2,6,6-tetramethyl-1,3-dihydropyridin-4-yl)chromen-2-one Chemical compound CC=1N=C(C=2N(C=1)C=C(N=2)C=1C(OC2=CC(=CC=C2C=1)C=1CC(NC(C=1)(C)C)(C)C)=O)C GAZFJKGBWGJSLH-UHFFFAOYSA-N 0.000 claims 1
• RJBWASNFZRRYEQ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(2-morpholin-4-ylethoxy)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OCCN1CCOCC1 RJBWASNFZRRYEQ-UHFFFAOYSA-N 0.000 claims 1
• LDDTUQZLRFCKTH-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(2-morpholin-4-ylethyl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCN1CCOCC1 LDDTUQZLRFCKTH-UHFFFAOYSA-N 0.000 claims 1
• CKBFVNLTGHAIFI-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(2-piperazin-1-ylethyl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCN1CCNCC1 CKBFVNLTGHAIFI-UHFFFAOYSA-N 0.000 claims 1
• DNXUBGMZYOXJNU-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(2-piperidin-1-ylethoxy)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OCCN1CCCCC1 DNXUBGMZYOXJNU-UHFFFAOYSA-N 0.000 claims 1
• HUZMOWHGJQUGKM-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(2-pyrrolidin-1-ylethoxy)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OCCN1CCCC1 HUZMOWHGJQUGKM-UHFFFAOYSA-N 0.000 claims 1
• SXPXQPYOJBHFKH-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(3,3,4-trimethylpiperazin-1-yl)chromen-2-one Chemical compound C1C(C)(C)N(C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 SXPXQPYOJBHFKH-UHFFFAOYSA-N 0.000 claims 1
• CZEHAHHSQZAGKD-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(3,3-dimethylpiperazin-1-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNC(C)(C)C1 CZEHAHHSQZAGKD-UHFFFAOYSA-N 0.000 claims 1
• SXYGNOYEGSKVSC-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(3-ethyl-4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)C(CC)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 SXYGNOYEGSKVSC-UHFFFAOYSA-N 0.000 claims 1
• UXKVHFFDMYUWRE-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(3-ethylpiperazin-1-yl)chromen-2-one Chemical compound C1CNC(CC)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 UXKVHFFDMYUWRE-UHFFFAOYSA-N 0.000 claims 1
• VXOYWXPMRUWSBH-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(3-morpholin-4-ylpropyl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCN1CCOCC1 VXOYWXPMRUWSBH-UHFFFAOYSA-N 0.000 claims 1
• PYDKAZWSSSVOQT-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(3-piperazin-1-ylpropyl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCN1CCNCC1 PYDKAZWSSSVOQT-UHFFFAOYSA-N 0.000 claims 1
• IEYWWUSUXVEZMM-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(3-piperidin-1-ylazetidin-1-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(C1)CC1N1CCCCC1 IEYWWUSUXVEZMM-UHFFFAOYSA-N 0.000 claims 1
• PETSCYDXCUXNIW-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-ethyl-3-methylpiperazin-1-yl)chromen-2-one Chemical compound C1C(C)N(CC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 PETSCYDXCUXNIW-UHFFFAOYSA-N 0.000 claims 1
• MUSQHNINIVECCD-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-ethylpiperazin-1-yl)-5-fluorochromen-2-one Chemical compound C1CN(CC)CCN1C1=CC(F)=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 MUSQHNINIVECCD-UHFFFAOYSA-N 0.000 claims 1
• IJXRJMWRSUHNRC-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-ethylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 IJXRJMWRSUHNRC-UHFFFAOYSA-N 0.000 claims 1
• YTOQDGVJFNTOCT-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-hydroxypiperidin-1-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(O)CC1 YTOQDGVJFNTOCT-UHFFFAOYSA-N 0.000 claims 1
• YAJXJBNJJPUPEX-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 YAJXJBNJJPUPEX-UHFFFAOYSA-N 0.000 claims 1
• GGBMOXHXNCDOPL-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 GGBMOXHXNCDOPL-UHFFFAOYSA-N 0.000 claims 1
• CJIZWGJTQNUZQS-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-piperazin-1-ylbutyl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCCN1CCNCC1 CJIZWGJTQNUZQS-UHFFFAOYSA-N 0.000 claims 1
• ZLQCGIKHACCCPE-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-propan-2-ylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 ZLQCGIKHACCCPE-UHFFFAOYSA-N 0.000 claims 1
• YLBYAYCQPIWWBR-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)chromen-2-one Chemical compound C1N(C)CC21CN(C=1C=C3OC(=O)C(C=4N=C5C(C)=NC(C)=CN5C=4)=CC3=CC=1)C2 YLBYAYCQPIWWBR-UHFFFAOYSA-N 0.000 claims 1
• CQZDWAHBVWXGJT-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(imidazol-1-ylmethyl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CN1C=CN=C1 CQZDWAHBVWXGJT-UHFFFAOYSA-N 0.000 claims 1
• LKVYSQMZCOYAAP-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(piperazin-1-ylmethyl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CN1CCNCC1 LKVYSQMZCOYAAP-UHFFFAOYSA-N 0.000 claims 1
• NAYVZKDGUCSHLD-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(piperidin-1-ylmethyl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CN1CCCCC1 NAYVZKDGUCSHLD-UHFFFAOYSA-N 0.000 claims 1
• FKQTVZHLCOOZKW-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(piperidin-4-ylamino)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2NC1CCNCC1 FKQTVZHLCOOZKW-UHFFFAOYSA-N 0.000 claims 1
• GIWAYEDQVVSDLK-XCWJXAQQSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-1-(1-hydroxypropan-2-yl)pyrrolidin-3-yl]oxychromen-2-one Chemical compound C1N(C(CO)C)CC[C@H]1OC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 GIWAYEDQVVSDLK-XCWJXAQQSA-N 0.000 claims 1
• LFABZKCXNHWTKP-GOSISDBHSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-1-(2-hydroxyethyl)pyrrolidin-3-yl]oxychromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCN(CCO)C1 LFABZKCXNHWTKP-GOSISDBHSA-N 0.000 claims 1
• ZQITYDALKODZNR-GOSISDBHSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-1-ethylpyrrolidin-3-yl]oxychromen-2-one Chemical compound C1N(CC)CC[C@H]1OC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 ZQITYDALKODZNR-GOSISDBHSA-N 0.000 claims 1
• HWGAGFSMXQCXJO-QGZVFWFLSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-1-methylpyrrolidin-3-yl]oxychromen-2-one Chemical compound C1N(C)CC[C@H]1OC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 HWGAGFSMXQCXJO-QGZVFWFLSA-N 0.000 claims 1
• RIILKVYVTLMJAO-LJQANCHMSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-1-propan-2-ylpyrrolidin-3-yl]oxychromen-2-one Chemical compound C1N(C(C)C)CC[C@H]1OC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 RIILKVYVTLMJAO-LJQANCHMSA-N 0.000 claims 1
• DVJJKQYCEPQTGT-OAHLLOKOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-3,4-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 DVJJKQYCEPQTGT-OAHLLOKOSA-N 0.000 claims 1
• AWUGZGWYVVYYIP-CYBMUJFWSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 AWUGZGWYVVYYIP-CYBMUJFWSA-N 0.000 claims 1
• PETSCYDXCUXNIW-MRXNPFEDSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-4-ethyl-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N(CC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 PETSCYDXCUXNIW-MRXNPFEDSA-N 0.000 claims 1
• FTPPETYNPDGHAB-MRXNPFEDSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 FTPPETYNPDGHAB-MRXNPFEDSA-N 0.000 claims 1
• DVJJKQYCEPQTGT-HNNXBMFYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3,4-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 DVJJKQYCEPQTGT-HNNXBMFYSA-N 0.000 claims 1
• SXYGNOYEGSKVSC-SFHVURJKSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-ethyl-4-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@@H](CC)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 SXYGNOYEGSKVSC-SFHVURJKSA-N 0.000 claims 1
• UXKVHFFDMYUWRE-KRWDZBQOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-ethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](CC)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 UXKVHFFDMYUWRE-KRWDZBQOSA-N 0.000 claims 1
• AWUGZGWYVVYYIP-ZDUSSCGKSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 AWUGZGWYVVYYIP-ZDUSSCGKSA-N 0.000 claims 1
• NOBPWJXRQUMZJA-HXUWFJFHSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-propan-2-ylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C(C)C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 NOBPWJXRQUMZJA-HXUWFJFHSA-N 0.000 claims 1
• HCUZDGAHEBGNQZ-INIZCTEOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-4-(2-fluoroethyl)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(CCF)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 HCUZDGAHEBGNQZ-INIZCTEOSA-N 0.000 claims 1
• RRRGFROANQHMCZ-INIZCTEOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-4-(2-hydroxyethyl)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(CCO)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 RRRGFROANQHMCZ-INIZCTEOSA-N 0.000 claims 1
• SUFJCMJSOLPZNS-KRWDZBQOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-4-(3-hydroxypropyl)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(CCCO)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 SUFJCMJSOLPZNS-KRWDZBQOSA-N 0.000 claims 1
• PETSCYDXCUXNIW-INIZCTEOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-4-ethyl-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@H](C)N(CC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 PETSCYDXCUXNIW-INIZCTEOSA-N 0.000 claims 1
• OWOAVSPGNKJEKY-HSZRJFAPSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-4-ethyl-3-propan-2-ylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@H](C(C)C)N(CC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 OWOAVSPGNKJEKY-HSZRJFAPSA-N 0.000 claims 1
• UGPWFOYUVZXNDS-JOCHJYFZSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-4-methyl-3-propan-2-ylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@@H](C(C)C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 UGPWFOYUVZXNDS-JOCHJYFZSA-N 0.000 claims 1
• MCLYOEXNMWVWIK-VXKWHMMOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s,4s)-3-hydroxy-4-pyrrolidin-1-ylpyrrolidin-1-yl]chromen-2-one Chemical compound N1([C@@H]2[C@@H](O)CN(C2)C2=CC=C3C=C(C(OC3=C2)=O)C2=CN3C=C(N=C(C)C3=N2)C)CCCC1 MCLYOEXNMWVWIK-VXKWHMMOSA-N 0.000 claims 1
• FKCVGBBOZCWJFG-IYBDPMFKSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s,5r)-3,4,5-trimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 FKCVGBBOZCWJFG-IYBDPMFKSA-N 0.000 claims 1
• OBCVNCNQNGFIHB-OKILXGFUSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 OBCVNCNQNGFIHB-OKILXGFUSA-N 0.000 claims 1
• XSQLPPSRBVRVGN-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(4-methylpiperazin-1-yl)methyl]chromen-2-one Chemical compound C1CN(C)CCN1CC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 XSQLPPSRBVRVGN-UHFFFAOYSA-N 0.000 claims 1
• MCQOJUWAZBSFGK-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(propan-2-ylamino)methyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CNC(C)C)=CN21 MCQOJUWAZBSFGK-UHFFFAOYSA-N 0.000 claims 1
• VOVIEBBFJIXIFR-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[1-(2-hydroxyethyl)-3,6-dihydro-2h-pyridin-4-yl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1=CCN(CCO)CC1 VOVIEBBFJIXIFR-UHFFFAOYSA-N 0.000 claims 1
• RILXBFGWWZIVQM-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[1-(2-hydroxyethyl)piperidin-4-yl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCN(CCO)CC1 RILXBFGWWZIVQM-UHFFFAOYSA-N 0.000 claims 1
• ANFODTBQGMSHOI-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[1-(2-hydroxyethyl)piperidin-4-yl]oxychromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OC1CCN(CCO)CC1 ANFODTBQGMSHOI-UHFFFAOYSA-N 0.000 claims 1
• AEXMMUNGCHCIRE-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[1-(2-methylpropyl)piperidin-4-yl]chromen-2-one Chemical compound C1CN(CC(C)C)CCC1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 AEXMMUNGCHCIRE-UHFFFAOYSA-N 0.000 claims 1
• YXXKAQDLNHEWHL-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[1-(3-fluoropropyl)piperidin-4-yl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCN(CCCF)CC1 YXXKAQDLNHEWHL-UHFFFAOYSA-N 0.000 claims 1
• VZXTZRMMHKUBET-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[1-(oxetan-3-yl)piperidin-4-yl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C(CC1)CCN1C1COC1 VZXTZRMMHKUBET-UHFFFAOYSA-N 0.000 claims 1
• WDDJQPKXGKVTII-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(1-hydroxypropan-2-ylamino)ethyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCNC(CO)C)=CN21 WDDJQPKXGKVTII-UHFFFAOYSA-N 0.000 claims 1
• UJFBQFLMBQNORC-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(2-hydroxyethylamino)ethoxy]chromen-2-one Chemical compound C1=C(OCCNCCO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 UJFBQFLMBQNORC-UHFFFAOYSA-N 0.000 claims 1
• TYCZMYLNISNHOD-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(2-hydroxyethylamino)ethyl]chromen-2-one Chemical compound C1=C(CCNCCO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 TYCZMYLNISNHOD-UHFFFAOYSA-N 0.000 claims 1
• VSPQLHCDDUXTLE-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(2-hydroxypropylamino)ethoxy]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCNCC(O)C)=CN21 VSPQLHCDDUXTLE-UHFFFAOYSA-N 0.000 claims 1
• OBSGBFKJEYFWGM-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(2-methoxyethylamino)ethoxy]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCNCCOC)=CN21 OBSGBFKJEYFWGM-UHFFFAOYSA-N 0.000 claims 1
• YNMPQYPMZQUKNH-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(4-hydroxypiperidin-1-yl)ethoxy]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OCCN1CCC(O)CC1 YNMPQYPMZQUKNH-UHFFFAOYSA-N 0.000 claims 1
• HDRLXBRIEFGFKG-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(ethylamino)ethoxy]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCNCC)=CN21 HDRLXBRIEFGFKG-UHFFFAOYSA-N 0.000 claims 1
• LOOHVGKPRLDENR-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(methylamino)ethyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCNC)=CN21 LOOHVGKPRLDENR-UHFFFAOYSA-N 0.000 claims 1
• YAJFCTSMKQKTEP-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(propan-2-ylamino)ethoxy]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCNC(C)C)=CN21 YAJFCTSMKQKTEP-UHFFFAOYSA-N 0.000 claims 1
• LBXURZLLHITMIC-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-(propan-2-ylamino)ethyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCNC(C)C)=CN21 LBXURZLLHITMIC-UHFFFAOYSA-N 0.000 claims 1
• IYBGTHVEYIYFNJ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[(1-hydroxy-2-methylpropan-2-yl)amino]ethoxy]chromen-2-one Chemical compound C1=C(OCCNC(C)(C)CO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 IYBGTHVEYIYFNJ-UHFFFAOYSA-N 0.000 claims 1
• SQEDGLNOPKQFGG-LJQANCHMSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[(2r)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCN1CCC[C@@H]1CO SQEDGLNOPKQFGG-LJQANCHMSA-N 0.000 claims 1
• IQWKUFYQEWAKGJ-QGZVFWFLSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[(3r)-3-hydroxypyrrolidin-1-yl]ethoxy]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OCCN1CC[C@@H](O)C1 IQWKUFYQEWAKGJ-QGZVFWFLSA-N 0.000 claims 1
• IQWKUFYQEWAKGJ-KRWDZBQOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[(3s)-3-hydroxypyrrolidin-1-yl]ethoxy]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OCCN1CC[C@H](O)C1 IQWKUFYQEWAKGJ-KRWDZBQOSA-N 0.000 claims 1
• NBRYEDSHOQUMEL-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[2-hydroxyethyl(methyl)amino]ethyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCN(CCO)C)=CN21 NBRYEDSHOQUMEL-UHFFFAOYSA-N 0.000 claims 1
• ZMHDNKNGFMIGJF-CQSZACIVSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[[(2r)-1-hydroxypropan-2-yl]amino]ethoxy]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCN[C@@H](CO)C)=CN21 ZMHDNKNGFMIGJF-CQSZACIVSA-N 0.000 claims 1
• ZMHDNKNGFMIGJF-AWEZNQCLSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[[(2s)-1-hydroxypropan-2-yl]amino]ethoxy]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCN[C@H](CO)C)=CN21 ZMHDNKNGFMIGJF-AWEZNQCLSA-N 0.000 claims 1
• KBRNMIPKILFZKQ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[ethyl(2-hydroxyethyl)amino]ethoxy]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCN(CCO)CC)=CN21 KBRNMIPKILFZKQ-UHFFFAOYSA-N 0.000 claims 1
• KGIRDNKIBUGORZ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[2-[ethyl(methyl)amino]ethoxy]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCN(C)CC)=CN21 KGIRDNKIBUGORZ-UHFFFAOYSA-N 0.000 claims 1
• VCCLHOIERORXSL-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(1-hydroxypropan-2-ylamino)propyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCNC(CO)C)=CN21 VCCLHOIERORXSL-UHFFFAOYSA-N 0.000 claims 1
• TXUGBFDIMBODNW-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(2-hydroxyethylamino)propyl]chromen-2-one Chemical compound C1=C(CCCNCCO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 TXUGBFDIMBODNW-UHFFFAOYSA-N 0.000 claims 1
• KAPCVLQVOCLBSO-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(2-methoxyethylamino)propyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCNCCOC)=CN21 KAPCVLQVOCLBSO-UHFFFAOYSA-N 0.000 claims 1
• JBINCGFXUWDWEA-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(2-methylpiperidin-1-yl)azetidin-1-yl]chromen-2-one Chemical compound CC1CCCCN1C1CN(C=2C=C3OC(=O)C(C=4N=C5C(C)=NC(C)=CN5C=4)=CC3=CC=2)C1 JBINCGFXUWDWEA-UHFFFAOYSA-N 0.000 claims 1
• LSMKBHXKLMMYMS-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(4-methylpiperazin-1-yl)propyl]chromen-2-one Chemical compound C1CN(C)CCN1CCCC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 LSMKBHXKLMMYMS-UHFFFAOYSA-N 0.000 claims 1
• ANHYXBRUAMEBRD-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(ethylamino)propyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCNCC)=CN21 ANHYXBRUAMEBRD-UHFFFAOYSA-N 0.000 claims 1
• XKRZWYOBPGDVIH-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(methylamino)propyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCNC)=CN21 XKRZWYOBPGDVIH-UHFFFAOYSA-N 0.000 claims 1
• SGUMHQGGSNPFCR-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(oxolan-2-ylmethylamino)propyl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCNCC1CCCO1 SGUMHQGGSNPFCR-UHFFFAOYSA-N 0.000 claims 1
• ODZBGJCORLOZKO-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(oxolan-3-ylamino)propyl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCNC1CCOC1 ODZBGJCORLOZKO-UHFFFAOYSA-N 0.000 claims 1
• AAPLTHKGIGKSHK-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(propan-2-ylamino)propyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCNC(C)C)=CN21 AAPLTHKGIGKSHK-UHFFFAOYSA-N 0.000 claims 1
• OYXTUAUWIBRBBO-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(pyridin-2-ylmethylamino)propyl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCNCC1=CC=CC=N1 OYXTUAUWIBRBBO-UHFFFAOYSA-N 0.000 claims 1
• WVPQIKFLVDFSES-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(pyridin-4-ylmethylamino)propyl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCNCC1=CC=NC=C1 WVPQIKFLVDFSES-UHFFFAOYSA-N 0.000 claims 1
• FUHAJRJIKOFCLI-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-(thiophen-3-ylmethylamino)propyl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCNCC=1C=CSC=1 FUHAJRJIKOFCLI-UHFFFAOYSA-N 0.000 claims 1
• BAHQDJUQTSQGHJ-HXUWFJFHSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-[(2r)-2-(hydroxymethyl)pyrrolidin-1-yl]propyl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCN1CCC[C@@H]1CO BAHQDJUQTSQGHJ-HXUWFJFHSA-N 0.000 claims 1
• LMEQIOCZIPGQAC-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[3-[2-hydroxyethyl(methyl)amino]propyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCN(CCO)C)=CN21 LMEQIOCZIPGQAC-UHFFFAOYSA-N 0.000 claims 1
• MXNNZPHNBBXQQD-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[4-(1-hydroxypropan-2-ylamino)piperidin-1-yl]chromen-2-one Chemical compound C1CC(NC(CO)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 MXNNZPHNBBXQQD-UHFFFAOYSA-N 0.000 claims 1
• SGJUFJCLVIHLLX-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[4-(2-hydroxy-2-methylpropyl)piperazin-1-yl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(CC(C)(C)O)CC1 SGJUFJCLVIHLLX-UHFFFAOYSA-N 0.000 claims 1
• UVBKOKDNDZKNDD-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[4-(2-hydroxyethyl)piperazin-1-yl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(CCO)CC1 UVBKOKDNDZKNDD-UHFFFAOYSA-N 0.000 claims 1
• HWMFFAHIXJAKKX-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[4-(methylamino)butyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCCNC)=CN21 HWMFFAHIXJAKKX-UHFFFAOYSA-N 0.000 claims 1
• FAZAELHGEUSDDW-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[4-(oxetan-3-yl)piperazin-1-yl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1COC1 FAZAELHGEUSDDW-UHFFFAOYSA-N 0.000 claims 1
• XPRWHWMUOPZGOO-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[4-(propan-2-ylamino)piperidin-1-yl]chromen-2-one Chemical compound C1CC(NC(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 XPRWHWMUOPZGOO-UHFFFAOYSA-N 0.000 claims 1
• UQWZYEIXXZXQPZ-OAQYLSRUSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[4-[(2r)-2-(hydroxymethyl)pyrrolidin-1-yl]butyl]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2CCCCN1CCC[C@@H]1CO UQWZYEIXXZXQPZ-OAQYLSRUSA-N 0.000 claims 1
• ZMFZUTZTDPGREZ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[4-[2-hydroxyethyl(methyl)amino]butyl]chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCCN(CCO)C)=CN21 ZMFZUTZTDPGREZ-UHFFFAOYSA-N 0.000 claims 1
• FGNUJJCJLQXWHG-MRXNPFEDSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[[(2r)-pyrrolidin-2-yl]methoxy]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OC[C@H]1CCCN1 FGNUJJCJLQXWHG-MRXNPFEDSA-N 0.000 claims 1
• WHUBSFFJNYYLEC-GOSISDBHSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[[(3r)-1-(2-hydroxyethyl)pyrrolidin-3-yl]amino]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N[C@@H]1CCN(CCO)C1 WHUBSFFJNYYLEC-GOSISDBHSA-N 0.000 claims 1
• LOHCJXCHELCRSY-GOSISDBHSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[[(3r)-1-ethylpyrrolidin-3-yl]amino]chromen-2-one Chemical compound C1N(CC)CC[C@H]1NC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 LOHCJXCHELCRSY-GOSISDBHSA-N 0.000 claims 1
• IZEFCLCIUBUHCD-QGZVFWFLSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[[(3r)-1-methylpyrrolidin-3-yl]amino]chromen-2-one Chemical compound C1N(C)CC[C@H]1NC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 IZEFCLCIUBUHCD-QGZVFWFLSA-N 0.000 claims 1
• UBPDCWQNIMCJTM-LJQANCHMSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[[(3r)-1-propan-2-ylpyrrolidin-3-yl]amino]chromen-2-one Chemical compound C1N(C(C)C)CC[C@H]1NC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 UBPDCWQNIMCJTM-LJQANCHMSA-N 0.000 claims 1
• VNZRBOQZUIEIFW-MRXNPFEDSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[[(3r)-pyrrolidin-3-yl]amino]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N[C@@H]1CCNC1 VNZRBOQZUIEIFW-MRXNPFEDSA-N 0.000 claims 1
• IZEFCLCIUBUHCD-KRWDZBQOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[[(3s)-1-methylpyrrolidin-3-yl]amino]chromen-2-one Chemical compound C1N(C)CC[C@@H]1NC1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 IZEFCLCIUBUHCD-KRWDZBQOSA-N 0.000 claims 1
• VNZRBOQZUIEIFW-INIZCTEOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[[(3s)-pyrrolidin-3-yl]amino]chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N[C@H]1CCNC1 VNZRBOQZUIEIFW-INIZCTEOSA-N 0.000 claims 1
• GKNQBZVUZVBTCJ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[methyl-(1-methylpyrrolidin-3-yl)amino]chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4C(C)=NC(C)=CN4C=3)C(=O)OC2=CC=1N(C)C1CCN(C)C1 GKNQBZVUZVBTCJ-UHFFFAOYSA-N 0.000 claims 1
• BIBHQWIBROPERY-QGZVFWFLSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[methyl-[(3r)-pyrrolidin-3-yl]amino]chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4C(C)=NC(C)=CN4C=3)C(=O)OC2=CC=1N(C)[C@@H]1CCNC1 BIBHQWIBROPERY-QGZVFWFLSA-N 0.000 claims 1
• GKNQBZVUZVBTCJ-SFHVURJKSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[methyl-[(3s)-1-methylpyrrolidin-3-yl]amino]chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4C(C)=NC(C)=CN4C=3)C(=O)OC2=CC=1N(C)[C@H]1CCN(C)C1 GKNQBZVUZVBTCJ-SFHVURJKSA-N 0.000 claims 1
• BIBHQWIBROPERY-KRWDZBQOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[methyl-[(3s)-pyrrolidin-3-yl]amino]chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4C(C)=NC(C)=CN4C=3)C(=O)OC2=CC=1N(C)[C@H]1CCNC1 BIBHQWIBROPERY-KRWDZBQOSA-N 0.000 claims 1
• NRUOIVVOEKEDEZ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 NRUOIVVOEKEDEZ-UHFFFAOYSA-N 0.000 claims 1
• OPIAGHYYOWVYGX-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-piperidin-4-ylchromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCNCC1 OPIAGHYYOWVYGX-UHFFFAOYSA-N 0.000 claims 1
• RVJDMPBWGRATLW-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-piperidin-4-yloxychromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OC1CCNCC1 RVJDMPBWGRATLW-UHFFFAOYSA-N 0.000 claims 1
• PWCZJOAJXCFVSW-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(C)=CC(C)=CN3C=2)C(=O)O2)C2=C1 PWCZJOAJXCFVSW-UHFFFAOYSA-N 0.000 claims 1
• ORGUMPYLJFAYOG-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=CC(C)=CN3C=2)C(=O)O2)C2=C1 ORGUMPYLJFAYOG-UHFFFAOYSA-N 0.000 claims 1
• NXCUNXBXILARFK-INIZCTEOSA-N 3-(6,8-dimethylimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=CC(C)=CN3C=2)C(=O)O2)C2=C1 NXCUNXBXILARFK-INIZCTEOSA-N 0.000 claims 1
• XMAWNJIVDBXMRL-CALCHBBNSA-N 3-(6,8-dimethylimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=CC(C)=CN3C=2)C(=O)O2)C2=C1 XMAWNJIVDBXMRL-CALCHBBNSA-N 0.000 claims 1
• UUDXQEKUWPRVFJ-UHFFFAOYSA-N 3-(6,8-dimethylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(C)C=C(C)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 UUDXQEKUWPRVFJ-UHFFFAOYSA-N 0.000 claims 1
• VFKVMVWROMCYKU-UHFFFAOYSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-(4-ethylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(Cl)=CN3C=2)C(=O)O2)C2=C1 VFKVMVWROMCYKU-UHFFFAOYSA-N 0.000 claims 1
• RNBOTFIGNSYKJN-UHFFFAOYSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(Cl)=CN3C=2)C(=O)O2)C2=C1 RNBOTFIGNSYKJN-UHFFFAOYSA-N 0.000 claims 1
• RWRSTVJXOLVNTA-UHFFFAOYSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(Cl)=CN3C=2)C(=O)O2)C2=C1 RWRSTVJXOLVNTA-UHFFFAOYSA-N 0.000 claims 1
• DSWBNRBYJOBYQC-IRXDYDNUSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]chromen-2-one Chemical compound ClC=1N=C(C=2N(C=1)C=C(N=2)C=1C(OC2=CC(=CC=C2C=1)N1[C@@H]2CN([C@H](C1)C2)CC)=O)C DSWBNRBYJOBYQC-IRXDYDNUSA-N 0.000 claims 1
• HFTGJCKCGWHZNR-HOTGVXAUSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(1s,4s)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]chromen-2-one Chemical compound C1=C(Cl)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@@H]4C[C@H]3CN4C)=CN21 HFTGJCKCGWHZNR-HOTGVXAUSA-N 0.000 claims 1
• SFTRUUFJOVKGTJ-CYBMUJFWSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-3,4-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(Cl)=CN3C=2)C(=O)O2)C2=C1 SFTRUUFJOVKGTJ-CYBMUJFWSA-N 0.000 claims 1
• KDVOVUUWXVBZID-GFCCVEGCSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(Cl)=CN3C=2)C(=O)O2)C2=C1 KDVOVUUWXVBZID-GFCCVEGCSA-N 0.000 claims 1
• SFTRUUFJOVKGTJ-ZDUSSCGKSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3,4-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(Cl)=CN3C=2)C(=O)O2)C2=C1 SFTRUUFJOVKGTJ-ZDUSSCGKSA-N 0.000 claims 1
• WGQZHBJJGVYQIX-INIZCTEOSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-(dimethylamino)pyrrolidin-1-yl]chromen-2-one Chemical compound C1[C@@H](N(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(Cl)=CN3C=2)C(=O)O2)C2=C1 WGQZHBJJGVYQIX-INIZCTEOSA-N 0.000 claims 1
• KDVOVUUWXVBZID-LBPRGKRZSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(Cl)=CN3C=2)C(=O)O2)C2=C1 KDVOVUUWXVBZID-LBPRGKRZSA-N 0.000 claims 1
• VPKVMAYFXCYDBA-UHFFFAOYSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 VPKVMAYFXCYDBA-UHFFFAOYSA-N 0.000 claims 1
• QJSOMMMDVAEAMV-GASCZTMLSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 QJSOMMMDVAEAMV-GASCZTMLSA-N 0.000 claims 1
• AHRKBEBLVRBVOU-UHFFFAOYSA-N 3-(6-chloro-8-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(C)=CC(Cl)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 AHRKBEBLVRBVOU-UHFFFAOYSA-N 0.000 claims 1
• MAHCZWFICHIJHI-UHFFFAOYSA-N 3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-4-methyl-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C(C)=C(C=3N=C4C=CC(Cl)=CN4C=3)C(=O)OC=2C=C1N1CCNCC1 MAHCZWFICHIJHI-UHFFFAOYSA-N 0.000 claims 1
• WTUSDCDBVCOUCR-UHFFFAOYSA-N 3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 WTUSDCDBVCOUCR-UHFFFAOYSA-N 0.000 claims 1
• AKGBSYQWAIQLRS-UHFFFAOYSA-N 3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 AKGBSYQWAIQLRS-UHFFFAOYSA-N 0.000 claims 1
• LIAXXRPNXJPCKH-UONOGXRCSA-N 3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(2r,5s)-2,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C[C@@H]1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 LIAXXRPNXJPCKH-UONOGXRCSA-N 0.000 claims 1
• KQMGBUQKGPQWFR-OKILXGFUSA-N 3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 KQMGBUQKGPQWFR-OKILXGFUSA-N 0.000 claims 1
• XYSLSDLJEMUAER-UHFFFAOYSA-N 3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-7-[4-(2-hydroxyethyl)piperazin-1-yl]chromen-2-one Chemical compound C1CN(CCO)CCN1C1=CC=C(C=C(C=2N=C3C=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 XYSLSDLJEMUAER-UHFFFAOYSA-N 0.000 claims 1
• WYNCLEUYWLLKQY-UHFFFAOYSA-N 3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(Cl)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 WYNCLEUYWLLKQY-UHFFFAOYSA-N 0.000 claims 1
• AUGRROUULMYISY-UHFFFAOYSA-N 3-(6-chloroimidazo[1,2-a]pyrimidin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3N=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 AUGRROUULMYISY-UHFFFAOYSA-N 0.000 claims 1
• WDNWWMNCIKRJHD-LBPRGKRZSA-N 3-(6-chloroimidazo[1,2-a]pyrimidin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 WDNWWMNCIKRJHD-LBPRGKRZSA-N 0.000 claims 1
• BCRYYGWKOQIYJM-BETUJISGSA-N 3-(6-chloroimidazo[1,2-a]pyrimidin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 BCRYYGWKOQIYJM-BETUJISGSA-N 0.000 claims 1
• VXXPUHARJKGCLT-UHFFFAOYSA-N 3-(6-chloroimidazo[1,2-a]pyrimidin-2-yl)-7-[4-(2-hydroxyethyl)piperazin-1-yl]chromen-2-one Chemical compound C1CN(CCO)CCN1C1=CC=C(C=C(C=2N=C3N=CC(Cl)=CN3C=2)C(=O)O2)C2=C1 VXXPUHARJKGCLT-UHFFFAOYSA-N 0.000 claims 1
• YCLDPMQYUUVHPF-UHFFFAOYSA-N 3-(6-chloroimidazo[1,2-a]pyrimidin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(Cl)C=NC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 YCLDPMQYUUVHPF-UHFFFAOYSA-N 0.000 claims 1
• FWUJDNYDKATCHS-UHFFFAOYSA-N 3-(6-cyclobutyloxypyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C(OC3CCC3)C=CC=2)C(=O)O2)C2=C1 FWUJDNYDKATCHS-UHFFFAOYSA-N 0.000 claims 1
• YMWJFTVBMMFYBR-UHFFFAOYSA-N 3-(6-cyclobutyloxypyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C(N=1)=CC=CC=1OC1CCC1 YMWJFTVBMMFYBR-UHFFFAOYSA-N 0.000 claims 1
• IIFVMYIXRRYFQM-UHFFFAOYSA-N 3-(6-cyclopropyl-8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(F)=CC(=CN3C=2)C2CC2)C(=O)O2)C2=C1 IIFVMYIXRRYFQM-UHFFFAOYSA-N 0.000 claims 1
• HHSAXJAODREWSD-UHFFFAOYSA-N 3-(6-cyclopropyl-8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(F)=CC(=CN3C=2)C2CC2)C(=O)O2)C2=C1 HHSAXJAODREWSD-UHFFFAOYSA-N 0.000 claims 1
• LBCBXAKOTNXBGV-CQSZACIVSA-N 3-(6-cyclopropyl-8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(=CN3C=2)C2CC2)C(=O)O2)C2=C1 LBCBXAKOTNXBGV-CQSZACIVSA-N 0.000 claims 1
• LBCBXAKOTNXBGV-AWEZNQCLSA-N 3-(6-cyclopropyl-8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(=CN3C=2)C2CC2)C(=O)O2)C2=C1 LBCBXAKOTNXBGV-AWEZNQCLSA-N 0.000 claims 1
• FYOBRNHLVGTUNH-GASCZTMLSA-N 3-(6-cyclopropyl-8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(=CN3C=2)C2CC2)C(=O)O2)C2=C1 FYOBRNHLVGTUNH-GASCZTMLSA-N 0.000 claims 1
• JZTXJUUNZVFFPJ-UHFFFAOYSA-N 3-(6-ethoxypyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound CCOC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCN(C)CC2)=O)=N1 JZTXJUUNZVFFPJ-UHFFFAOYSA-N 0.000 claims 1
• KBMUSYDYZUEMLG-UHFFFAOYSA-N 3-(6-fluoro-1h-benzimidazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1C2=CC(F)=CC=C2N=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 KBMUSYDYZUEMLG-UHFFFAOYSA-N 0.000 claims 1
• BSQQDIQVIIJPBM-UHFFFAOYSA-N 3-(6-fluoro-8-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(C)=CC(F)=CN3C=2)C(=O)O2)C2=C1 BSQQDIQVIIJPBM-UHFFFAOYSA-N 0.000 claims 1
• AOPVDHNSWDZXOE-UHFFFAOYSA-N 3-(6-fluoro-8-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=CC(F)=CN3C=2)C(=O)O2)C2=C1 AOPVDHNSWDZXOE-UHFFFAOYSA-N 0.000 claims 1
• BAQCYIXZJCSHGW-UHFFFAOYSA-N 3-(6-fluoro-8-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(C)=CC(F)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 BAQCYIXZJCSHGW-UHFFFAOYSA-N 0.000 claims 1
• NUNFTWMFZLEBNP-UHFFFAOYSA-N 3-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C=CC(F)=CN3C=2)C(=O)O2)C2=C1 NUNFTWMFZLEBNP-UHFFFAOYSA-N 0.000 claims 1
• NISOZQMYYXZGEB-UHFFFAOYSA-N 3-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=CC(F)=CN3C=2)C(=O)O2)C2=C1 NISOZQMYYXZGEB-UHFFFAOYSA-N 0.000 claims 1
• RDYPOSAMNYLOAY-UHFFFAOYSA-N 3-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(F)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 RDYPOSAMNYLOAY-UHFFFAOYSA-N 0.000 claims 1
• FGJNVGAKYVTTBY-UHFFFAOYSA-N 3-(6-fluoroimidazo[1,2-a]pyrimidin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3N=CC(F)=CN3C=2)C(=O)O2)C2=C1 FGJNVGAKYVTTBY-UHFFFAOYSA-N 0.000 claims 1
• JPXNMISSMLDWGT-GFCCVEGCSA-N 3-(6-fluoroimidazo[1,2-a]pyrimidin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC(F)=CN3C=2)C(=O)O2)C2=C1 JPXNMISSMLDWGT-GFCCVEGCSA-N 0.000 claims 1
• JPXNMISSMLDWGT-LBPRGKRZSA-N 3-(6-fluoroimidazo[1,2-a]pyrimidin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC(F)=CN3C=2)C(=O)O2)C2=C1 JPXNMISSMLDWGT-LBPRGKRZSA-N 0.000 claims 1
• WGJOKSYJBVPTTM-UHFFFAOYSA-N 3-(6-fluoroimidazo[1,2-a]pyrimidin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(F)C=NC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 WGJOKSYJBVPTTM-UHFFFAOYSA-N 0.000 claims 1
• GZKBBAMYTHAKMF-UHFFFAOYSA-N 3-(6-fluoropyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound FC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 GZKBBAMYTHAKMF-UHFFFAOYSA-N 0.000 claims 1
• VIJIPHBIUOYUNN-UHFFFAOYSA-N 3-(6-methoxypyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCN(C)CCC2)=O)=N1 VIJIPHBIUOYUNN-UHFFFAOYSA-N 0.000 claims 1
• NRDYSRFZEKLOQQ-UHFFFAOYSA-N 3-(6-methoxypyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCN(C)CC2)=O)=N1 NRDYSRFZEKLOQQ-UHFFFAOYSA-N 0.000 claims 1
• CAUNZKWRXDTONZ-CYBMUJFWSA-N 3-(6-methoxypyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2C[C@@H](C)NCC2)=O)=N1 CAUNZKWRXDTONZ-CYBMUJFWSA-N 0.000 claims 1
• CAUNZKWRXDTONZ-ZDUSSCGKSA-N 3-(6-methoxypyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2C[C@H](C)NCC2)=O)=N1 CAUNZKWRXDTONZ-ZDUSSCGKSA-N 0.000 claims 1
• CGOVROZNPUUNDV-UHFFFAOYSA-N 3-(6-methoxypyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 CGOVROZNPUUNDV-UHFFFAOYSA-N 0.000 claims 1
• UFINMMSUZKPHNF-AWEZNQCLSA-N 3-(6-methyl-8-nitroimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C([N+]([O-])=O)=CC(C)=CN3C=2)C(=O)O2)C2=C1 UFINMMSUZKPHNF-AWEZNQCLSA-N 0.000 claims 1
• PTVNJAZFUDNNOM-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-(1-methylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(C)CCC1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 PTVNJAZFUDNNOM-UHFFFAOYSA-N 0.000 claims 1
• NMGJATUHHOLHLK-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-(1-propylpiperidin-4-yl)chromen-2-one Chemical compound C1CN(CCC)CCC1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 NMGJATUHHOLHLK-UHFFFAOYSA-N 0.000 claims 1
• DNBLCQAFEIWBBL-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 DNBLCQAFEIWBBL-UHFFFAOYSA-N 0.000 claims 1
• BFUMXYITGJMWLF-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-(4-propan-2-ylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 BFUMXYITGJMWLF-UHFFFAOYSA-N 0.000 claims 1
• MJYSOEYQDRGJNR-CYBMUJFWSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 MJYSOEYQDRGJNR-CYBMUJFWSA-N 0.000 claims 1
• RBZVTBWYIKMRHQ-OAHLLOKOSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 RBZVTBWYIKMRHQ-OAHLLOKOSA-N 0.000 claims 1
• MJYSOEYQDRGJNR-ZDUSSCGKSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 MJYSOEYQDRGJNR-ZDUSSCGKSA-N 0.000 claims 1
• QTKZCWKSDLZARG-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-[1-(2-methylpropyl)piperidin-4-yl]chromen-2-one Chemical compound C1CN(CC(C)C)CCC1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 QTKZCWKSDLZARG-UHFFFAOYSA-N 0.000 claims 1
• LQCUXUMOGNHELV-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-[1-(oxetan-3-yl)piperidin-4-yl]chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C(CC1)CCN1C1COC1 LQCUXUMOGNHELV-UHFFFAOYSA-N 0.000 claims 1
• TVMKEVOZIJFATE-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-[4-(oxetan-3-yl)piperazin-1-yl]chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1COC1 TVMKEVOZIJFATE-UHFFFAOYSA-N 0.000 claims 1
• IVWCTWKMIKCZCU-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 IVWCTWKMIKCZCU-UHFFFAOYSA-N 0.000 claims 1
• OWXDCHDWROMLDP-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-piperidin-4-ylchromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCNCC1 OWXDCHDWROMLDP-UHFFFAOYSA-N 0.000 claims 1
• VGVUVFKKTMJTQG-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=CC(C)=CN3C=2)C(=O)O2)C2=C1 VGVUVFKKTMJTQG-UHFFFAOYSA-N 0.000 claims 1
• FZMYYTDMTJQARL-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-propan-2-ylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C=2N=C3C=CC(C)=CN3C=2)C(=O)O2)C2=C1 FZMYYTDMTJQARL-UHFFFAOYSA-N 0.000 claims 1
• AFLFDXHJWQIFGI-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-propylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CCC)CCN1C1=CC=C(C=C(C=2N=C3C=CC(C)=CN3C=2)C(=O)O2)C2=C1 AFLFDXHJWQIFGI-UHFFFAOYSA-N 0.000 claims 1
• GIIGNJGXFVIXGG-OAHLLOKOSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC(C)=CN3C=2)C(=O)O2)C2=C1 GIIGNJGXFVIXGG-OAHLLOKOSA-N 0.000 claims 1
• HFJRDCRDAUGGLL-MRXNPFEDSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 HFJRDCRDAUGGLL-MRXNPFEDSA-N 0.000 claims 1
• LHUOXNKKHKNNOB-PKLMIRHRSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one;hydrochloride Chemical compound Cl.C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 LHUOXNKKHKNNOB-PKLMIRHRSA-N 0.000 claims 1
• XKBWWPQEMVZTQA-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-[methyl(pyridin-3-ylmethyl)amino]chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4C=CC(C)=CN4C=3)C(=O)OC2=CC=1N(C)CC1=CC=CN=C1 XKBWWPQEMVZTQA-UHFFFAOYSA-N 0.000 claims 1
• MEPPREBBXUXVAV-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-[methyl-(1-methylpiperidin-4-yl)amino]chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4C=CC(C)=CN4C=3)C(=O)OC2=CC=1N(C)C1CCN(C)CC1 MEPPREBBXUXVAV-UHFFFAOYSA-N 0.000 claims 1
• NMGPOGZDVSQOCI-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 NMGPOGZDVSQOCI-UHFFFAOYSA-N 0.000 claims 1
• VLBJGCGBXZOTGL-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3N=CC(C)=CN3C=2)C(=O)O2)C2=C1 VLBJGCGBXZOTGL-UHFFFAOYSA-N 0.000 claims 1
• XKOSQDPHZVEHBB-OAHLLOKOSA-N 3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound C=1N2C=C(C)C=NC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 XKOSQDPHZVEHBB-OAHLLOKOSA-N 0.000 claims 1
• GSCSLJSNKJACRM-XFULWGLBSA-N 3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one;hydrochloride Chemical compound Cl.C=1N2C=C(C)C=NC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 GSCSLJSNKJACRM-XFULWGLBSA-N 0.000 claims 1
• BDRJYDRDKMZOEV-AWEZNQCLSA-N 3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC(C)=CN3C=2)C(=O)O2)C2=C1 BDRJYDRDKMZOEV-AWEZNQCLSA-N 0.000 claims 1
• IPROPPNGUBCTAJ-UHFFFAOYSA-N 3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(C)C=NC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 IPROPPNGUBCTAJ-UHFFFAOYSA-N 0.000 claims 1
• XESIHJVDMDEWQV-AWEZNQCLSA-N 3-(6-methylimidazo[1,2-b]pyridazin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC(C)=NN3C=2)C(=O)O2)C2=C1 XESIHJVDMDEWQV-AWEZNQCLSA-N 0.000 claims 1
• ZEARRCHMHYEYLE-UHFFFAOYSA-N 3-(6-methylpyridin-3-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=NC(C)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O ZEARRCHMHYEYLE-UHFFFAOYSA-N 0.000 claims 1
• HVIDUGWNWUPKLQ-UHFFFAOYSA-N 3-(6-methylsulfanylpyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound CSC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 HVIDUGWNWUPKLQ-UHFFFAOYSA-N 0.000 claims 1
• ITTRSYSNRXTXPJ-UHFFFAOYSA-N 3-(7-chloro-1,3-benzothiazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound S1C=2C(Cl)=CC=CC=2N=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 ITTRSYSNRXTXPJ-UHFFFAOYSA-N 0.000 claims 1
• JLSOXPGZFWIJCD-UHFFFAOYSA-N 3-(7-chloro-1,3-benzothiazol-2-yl)-7-piperazin-1-ylchromen-2-one hydrochloride Chemical compound Cl.Clc1cccc2nc(sc12)-c1cc2ccc(cc2oc1=O)N1CCNCC1 JLSOXPGZFWIJCD-UHFFFAOYSA-N 0.000 claims 1
• ZCQJUHMAYWCWID-OKILXGFUSA-N 3-(7-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(Cl)C=CN3C=2)C(=O)O2)C2=C1 ZCQJUHMAYWCWID-OKILXGFUSA-N 0.000 claims 1
• DKKQZSKJCACLON-UHFFFAOYSA-N 3-(7-ethylimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound N1=C2C=C(CC)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCN(C)CC1 DKKQZSKJCACLON-UHFFFAOYSA-N 0.000 claims 1
• JWSILQGFBFEMCT-UHFFFAOYSA-N 3-(7-ethylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound N1=C2C=C(CC)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C)CC1 JWSILQGFBFEMCT-UHFFFAOYSA-N 0.000 claims 1
• JPFYLKOKLSIZAY-UHFFFAOYSA-N 3-(7-ethylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C=C(CC)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 JPFYLKOKLSIZAY-UHFFFAOYSA-N 0.000 claims 1
• JLHPVDADFZNHCL-UHFFFAOYSA-N 3-(7-methoxyimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound N1=C2C=C(OC)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCN(C)CC1 JLHPVDADFZNHCL-UHFFFAOYSA-N 0.000 claims 1
• METKXFHQTOQKOE-UHFFFAOYSA-N 3-(7-methoxyimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound N1=C2C=C(OC)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C)CC1 METKXFHQTOQKOE-UHFFFAOYSA-N 0.000 claims 1
• PJZXFZLXKXPCPX-AWEZNQCLSA-N 3-(7-methoxyimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound N1=C2C=C(OC)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN[C@@H](C)C1 PJZXFZLXKXPCPX-AWEZNQCLSA-N 0.000 claims 1
• BKPCWNOUYCUGEU-UHFFFAOYSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=C(C)C=CN3C=2)C(=O)O2)C2=C1 BKPCWNOUYCUGEU-UHFFFAOYSA-N 0.000 claims 1
• KEVANWPBWBTKFJ-UHFFFAOYSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-(piperidin-4-ylamino)chromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2NC1CCNCC1 KEVANWPBWBTKFJ-UHFFFAOYSA-N 0.000 claims 1
• WVVULBKCRVTLAL-UHFFFAOYSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-[(1-methylpiperidin-4-yl)amino]chromen-2-one Chemical compound C1CN(C)CCC1NC1=CC=C(C=C(C=2N=C3C=C(C)C=CN3C=2)C(=O)O2)C2=C1 WVVULBKCRVTLAL-UHFFFAOYSA-N 0.000 claims 1
• FGIQSNJZVMFREC-OAHLLOKOSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C)C=CN3C=2)C(=O)O2)C2=C1 FGIQSNJZVMFREC-OAHLLOKOSA-N 0.000 claims 1
• RAEDPJKAMXYBSO-MRXNPFEDSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 RAEDPJKAMXYBSO-MRXNPFEDSA-N 0.000 claims 1
• UIROGMJJMUQGOX-PKLMIRHRSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one;hydrochloride Chemical compound Cl.N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 UIROGMJJMUQGOX-PKLMIRHRSA-N 0.000 claims 1
• FGIQSNJZVMFREC-HNNXBMFYSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C)C=CN3C=2)C(=O)O2)C2=C1 FGIQSNJZVMFREC-HNNXBMFYSA-N 0.000 claims 1
• ZUSCYHLHGXAJDE-MRXNPFEDSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-[[(3r)-pyrrolidin-3-yl]amino]chromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N[C@@H]1CCNC1 ZUSCYHLHGXAJDE-MRXNPFEDSA-N 0.000 claims 1
• ZUSCYHLHGXAJDE-INIZCTEOSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-[[(3s)-pyrrolidin-3-yl]amino]chromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N[C@H]1CCNC1 ZUSCYHLHGXAJDE-INIZCTEOSA-N 0.000 claims 1
• QABKZRFGVXEHND-UHFFFAOYSA-N 3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 QABKZRFGVXEHND-UHFFFAOYSA-N 0.000 claims 1
• YKZPAKQESGVWBA-UHFFFAOYSA-N 3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3N=C(C)C=CN3C=2)C(=O)O2)C2=C1 YKZPAKQESGVWBA-UHFFFAOYSA-N 0.000 claims 1
• OEOXTPQGKYSATF-CQSZACIVSA-N 3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3N=C(C)C=CN3C=2)C(=O)O2)C2=C1 OEOXTPQGKYSATF-CQSZACIVSA-N 0.000 claims 1
• ZORHWMALPCTOOR-OAHLLOKOSA-N 3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound N1=C2N=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 ZORHWMALPCTOOR-OAHLLOKOSA-N 0.000 claims 1
• UFQQUSPWNOYNRK-XFULWGLBSA-N 3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one;hydrochloride Chemical compound Cl.N1=C2N=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 UFQQUSPWNOYNRK-XFULWGLBSA-N 0.000 claims 1
• OEOXTPQGKYSATF-AWEZNQCLSA-N 3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=C(C)C=CN3C=2)C(=O)O2)C2=C1 OEOXTPQGKYSATF-AWEZNQCLSA-N 0.000 claims 1
• KABZELXYKHHUKA-UHFFFAOYSA-N 3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2N=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 KABZELXYKHHUKA-UHFFFAOYSA-N 0.000 claims 1
• FCHOIKYXEZVKLC-UHFFFAOYSA-N 3-(8-bromoimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(Br)=CC=CN3C=2)C(=O)O2)C2=C1 FCHOIKYXEZVKLC-UHFFFAOYSA-N 0.000 claims 1
• IFDNUIMAFUHXBZ-UHFFFAOYSA-N 3-(8-chloro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC(C)=CN3C=2)C(=O)O2)C2=C1 IFDNUIMAFUHXBZ-UHFFFAOYSA-N 0.000 claims 1
• SCHVITNQOMNGDF-UHFFFAOYSA-N 3-(8-chloro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC(C)=CN3C=2)C(=O)O2)C2=C1 SCHVITNQOMNGDF-UHFFFAOYSA-N 0.000 claims 1
• VDTUINNSUDYSJY-GASCZTMLSA-N 3-(8-chloro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC(C)=CN3C=2)C(=O)O2)C2=C1 VDTUINNSUDYSJY-GASCZTMLSA-N 0.000 claims 1
• HFTTXUKJXNOKGT-GFCCVEGCSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-5-fluoro-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC(F)=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 HFTTXUKJXNOKGT-GFCCVEGCSA-N 0.000 claims 1
• HFTTXUKJXNOKGT-LBPRGKRZSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-5-fluoro-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC(F)=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 HFTTXUKJXNOKGT-LBPRGKRZSA-N 0.000 claims 1
• YEESOCZYJVOFEP-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-5-fluoro-7-piperazin-1-ylchromen-2-one Chemical compound C=1C=2OC(=O)C(C=3N=C4C(Cl)=CC=CN4C=3)=CC=2C(F)=CC=1N1CCNCC1 YEESOCZYJVOFEP-UHFFFAOYSA-N 0.000 claims 1
• ZSSHUWFOFACFLC-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-(1,4-diazepan-1-yl)chromen-2-one Chemical compound N1=C2C(Cl)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 ZSSHUWFOFACFLC-UHFFFAOYSA-N 0.000 claims 1
• XAEHVXGKBWPGAM-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-(2,5-diazabicyclo[2.2.2]octan-2-yl)chromen-2-one Chemical compound C1C(NC2)CCC2N1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CC=C(Cl)C2=N1 XAEHVXGKBWPGAM-UHFFFAOYSA-N 0.000 claims 1
• IWYANUMLTPRGTQ-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-(3,3-dimethylpiperazin-1-yl)chromen-2-one Chemical compound C1CNC(C)(C)CN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 IWYANUMLTPRGTQ-UHFFFAOYSA-N 0.000 claims 1
• JCYPJUDHQKDVQV-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chromen-2-one Chemical compound C1C(N2)CCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CC=C(Cl)C2=N1 JCYPJUDHQKDVQV-UHFFFAOYSA-N 0.000 claims 1
• IHZXGNFNXBXYPP-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 IHZXGNFNXBXYPP-UHFFFAOYSA-N 0.000 claims 1
• RIXLXUGVNHNYHR-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-(4-propylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CCC)CCN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 RIXLXUGVNHNYHR-UHFFFAOYSA-N 0.000 claims 1
• GFAJZGVELMVMSK-CQSZACIVSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-3,4-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 GFAJZGVELMVMSK-CQSZACIVSA-N 0.000 claims 1
• HRFCABDMLKTYEX-CYBMUJFWSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 HRFCABDMLKTYEX-CYBMUJFWSA-N 0.000 claims 1
• MBFCWDLRXQPKKA-GASCZTMLSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3r,5s)-3,4,5-trimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 MBFCWDLRXQPKKA-GASCZTMLSA-N 0.000 claims 1
• GFAJZGVELMVMSK-AWEZNQCLSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3,4-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 GFAJZGVELMVMSK-AWEZNQCLSA-N 0.000 claims 1
• POHOUXQRAMWFNI-INIZCTEOSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-(dimethylamino)pyrrolidin-1-yl]chromen-2-one Chemical compound C1[C@@H](N(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 POHOUXQRAMWFNI-INIZCTEOSA-N 0.000 claims 1
• HRFCABDMLKTYEX-ZDUSSCGKSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 HRFCABDMLKTYEX-ZDUSSCGKSA-N 0.000 claims 1
• MXMCVFLYQKYUQP-BETUJISGSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-5-fluorochromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC(F)=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 MXMCVFLYQKYUQP-BETUJISGSA-N 0.000 claims 1
• UQIGLMVUHAGZKG-OKILXGFUSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 UQIGLMVUHAGZKG-OKILXGFUSA-N 0.000 claims 1
• GHQGPRYITXEIIX-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-[4-(2-hydroxyethyl)piperazin-1-yl]chromen-2-one Chemical compound C1CN(CCO)CCN1C1=CC=C(C=C(C=2N=C3C(Cl)=CC=CN3C=2)C(=O)O2)C2=C1 GHQGPRYITXEIIX-UHFFFAOYSA-N 0.000 claims 1
• BBYDDLLURWNMSH-UHFFFAOYSA-N 3-(8-chloroimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(Cl)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 BBYDDLLURWNMSH-UHFFFAOYSA-N 0.000 claims 1
• AQHOQCMAOIZRJG-UHFFFAOYSA-N 3-(8-cyclopropylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(C4CC4)=CC=CN3C=2)C(=O)O2)C2=C1 AQHOQCMAOIZRJG-UHFFFAOYSA-N 0.000 claims 1
• ZNMQCFDXWAVARH-UHFFFAOYSA-N 3-(8-ethyl-6-methylimidazo[1,2-a]pyrazin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound N1=C2C(CC)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C)CC1 ZNMQCFDXWAVARH-UHFFFAOYSA-N 0.000 claims 1
• MGYPCZABJAMZFB-UHFFFAOYSA-N 3-(8-ethyl-6-methylimidazo[1,2-a]pyrazin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(CC)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 MGYPCZABJAMZFB-UHFFFAOYSA-N 0.000 claims 1
• DIZLWBINPNKMBH-UHFFFAOYSA-N 3-(8-ethyl-6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound N1=C2C(CC)=CC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCN(C)CC1 DIZLWBINPNKMBH-UHFFFAOYSA-N 0.000 claims 1
• HLGWNKRCQKLNTD-UHFFFAOYSA-N 3-(8-ethyl-6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound N1=C2C(CC)=CC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C)CC1 HLGWNKRCQKLNTD-UHFFFAOYSA-N 0.000 claims 1
• PHVKFUMUPZWGMJ-UHFFFAOYSA-N 3-(8-ethyl-6-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(CC)=CC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 PHVKFUMUPZWGMJ-UHFFFAOYSA-N 0.000 claims 1
• LQRXISJNMXQCGQ-UHFFFAOYSA-N 3-(8-ethylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound N1=C2C(CC)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C)CC1 LQRXISJNMXQCGQ-UHFFFAOYSA-N 0.000 claims 1
• RKKWLFMCRBFJSO-UHFFFAOYSA-N 3-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C3C(F)=C2)C(=O)O2)C2=C1 RKKWLFMCRBFJSO-UHFFFAOYSA-N 0.000 claims 1
• ALDOFYOUFVBMMX-ZDUSSCGKSA-N 3-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=C3C(F)=C2)C(=O)O2)C2=C1 ALDOFYOUFVBMMX-ZDUSSCGKSA-N 0.000 claims 1
• PVBIPSDEOPUADX-UHFFFAOYSA-N 3-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7-[3-(methylamino)propyl]chromen-2-one Chemical compound C1=C(F)C2=NC(C)=CN2C=C1C1=CC2=CC=C(CCCNC)C=C2OC1=O PVBIPSDEOPUADX-UHFFFAOYSA-N 0.000 claims 1
• RJCMIBUBMSQWOZ-UHFFFAOYSA-N 3-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=C(F)C2=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 RJCMIBUBMSQWOZ-UHFFFAOYSA-N 0.000 claims 1
• LPFOEWDYGZDOQZ-UHFFFAOYSA-N 3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(F)=CC(C)=CN3C=2)C(=O)O2)C2=C1 LPFOEWDYGZDOQZ-UHFFFAOYSA-N 0.000 claims 1
• XJBBWUXEAGXIHC-UHFFFAOYSA-N 3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(F)=CC(C)=CN3C=2)C(=O)O2)C2=C1 XJBBWUXEAGXIHC-UHFFFAOYSA-N 0.000 claims 1
• WZARTVZUNUJNLR-UHFFFAOYSA-N 3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-(8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl)chromen-2-one Chemical compound C1=C(C)C=C(F)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3CC4CCC(C3)N4C)=CN21 WZARTVZUNUJNLR-UHFFFAOYSA-N 0.000 claims 1
• ZGGNHGRAGWEDFT-CQSZACIVSA-N 3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(C)=CN3C=2)C(=O)O2)C2=C1 ZGGNHGRAGWEDFT-CQSZACIVSA-N 0.000 claims 1
• ZGGNHGRAGWEDFT-AWEZNQCLSA-N 3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(C)=CN3C=2)C(=O)O2)C2=C1 ZGGNHGRAGWEDFT-AWEZNQCLSA-N 0.000 claims 1
• CPUROOPGVHBYBO-OAHLLOKOSA-N 3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-[[(3r)-pyrrolidin-3-yl]amino]chromen-2-one Chemical compound C=1N2C=C(C)C=C(F)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N[C@@H]1CCNC1 CPUROOPGVHBYBO-OAHLLOKOSA-N 0.000 claims 1
• CPUROOPGVHBYBO-HNNXBMFYSA-N 3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-[[(3s)-pyrrolidin-3-yl]amino]chromen-2-one Chemical compound C=1N2C=C(C)C=C(F)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N[C@H]1CCNC1 CPUROOPGVHBYBO-HNNXBMFYSA-N 0.000 claims 1
• UOVLNYJLYAECJF-UHFFFAOYSA-N 3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(C)C=C(F)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 UOVLNYJLYAECJF-UHFFFAOYSA-N 0.000 claims 1
• PDDAZOUIEYDWEJ-UHFFFAOYSA-N 3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(F)=CC=CN3C=2)C(=O)O2)C2=C1 PDDAZOUIEYDWEJ-UHFFFAOYSA-N 0.000 claims 1
• NQQTXYZYWKCJAP-UHFFFAOYSA-N 3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(F)=CC=CN3C=2)C(=O)O2)C2=C1 NQQTXYZYWKCJAP-UHFFFAOYSA-N 0.000 claims 1
• LEQSMKOPNPLMHR-CYBMUJFWSA-N 3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC=CN3C=2)C(=O)O2)C2=C1 LEQSMKOPNPLMHR-CYBMUJFWSA-N 0.000 claims 1
• LEQSMKOPNPLMHR-ZDUSSCGKSA-N 3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC=CN3C=2)C(=O)O2)C2=C1 LEQSMKOPNPLMHR-ZDUSSCGKSA-N 0.000 claims 1
• PSPWJRNTCVXVCV-UHFFFAOYSA-N 3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(F)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 PSPWJRNTCVXVCV-UHFFFAOYSA-N 0.000 claims 1
• MFKLDXXGMIGMCN-UHFFFAOYSA-N 3-(8-methoxyimidazo[1,2-a]pyridin-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound N1=C2C(OC)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCN(C)CC1 MFKLDXXGMIGMCN-UHFFFAOYSA-N 0.000 claims 1
• XLSNOVSVAIAMNI-UHFFFAOYSA-N 3-(8-methoxyimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound N1=C2C(OC)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C)CC1 XLSNOVSVAIAMNI-UHFFFAOYSA-N 0.000 claims 1
• DCVULPPUKSAYFX-UHFFFAOYSA-N 3-(8-methoxyimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(OC)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 DCVULPPUKSAYFX-UHFFFAOYSA-N 0.000 claims 1
• NJMJFYVJWVJKGC-UHFFFAOYSA-N 3-(8-methylimidazo[1,2-a]pyrazin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC=CN3C=2)C(=O)O2)C2=C1 NJMJFYVJWVJKGC-UHFFFAOYSA-N 0.000 claims 1
• QOASCNBNYSOTQT-CYBMUJFWSA-N 3-(8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC=CN3C=2)C(=O)O2)C2=C1 QOASCNBNYSOTQT-CYBMUJFWSA-N 0.000 claims 1
• SKPWFVFTFMEIQC-OAHLLOKOSA-N 3-(8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound N1=C2C(C)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2O[C@@H]1CCNC1 SKPWFVFTFMEIQC-OAHLLOKOSA-N 0.000 claims 1
• QOASCNBNYSOTQT-ZDUSSCGKSA-N 3-(8-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC=CN3C=2)C(=O)O2)C2=C1 QOASCNBNYSOTQT-ZDUSSCGKSA-N 0.000 claims 1
• SZSVMEBWIQHFGY-UHFFFAOYSA-N 3-(8-methylimidazo[1,2-a]pyrazin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(C)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 SZSVMEBWIQHFGY-UHFFFAOYSA-N 0.000 claims 1
• MEINPOUTDANRHO-UHFFFAOYSA-N 3-(8-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 MEINPOUTDANRHO-UHFFFAOYSA-N 0.000 claims 1
• NJKJWNHYIIFIEM-UHFFFAOYSA-N 3-(8-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-propylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CCC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 NJKJWNHYIIFIEM-UHFFFAOYSA-N 0.000 claims 1
• PNCGOCKIBALJSK-OAHLLOKOSA-N 3-(8-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 PNCGOCKIBALJSK-OAHLLOKOSA-N 0.000 claims 1
• PNCGOCKIBALJSK-HNNXBMFYSA-N 3-(8-methylimidazo[1,2-a]pyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 PNCGOCKIBALJSK-HNNXBMFYSA-N 0.000 claims 1
• JTAGBCNIGQFXAE-UHFFFAOYSA-N 3-(8-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(C)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 JTAGBCNIGQFXAE-UHFFFAOYSA-N 0.000 claims 1
• CSMGNASPFXOGFX-UHFFFAOYSA-N 3-(8-methylsulfanylimidazo[1,2-a]pyrazin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C(SC)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 CSMGNASPFXOGFX-UHFFFAOYSA-N 0.000 claims 1
• LDJJCVYQSSCQSX-UHFFFAOYSA-N 3-([1,3]oxazolo[4,5-b]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3OC4=CC=CN=C4N=3)C(=O)OC=2C=C1N1CCNCC1 LDJJCVYQSSCQSX-UHFFFAOYSA-N 0.000 claims 1
• KGOLZGAQRKGLFK-UHFFFAOYSA-N 3-([1,3]oxazolo[4,5-b]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one hydrochloride Chemical compound Cl.O=c1oc2cc(ccc2cc1-c1nc2ncccc2o1)N1CCNCC1 KGOLZGAQRKGLFK-UHFFFAOYSA-N 0.000 claims 1
• KQYMGCBUOWVPEB-UHFFFAOYSA-N 3-[(3-methylpyridin-2-yl)amino]-7-piperazin-1-ylchromen-2-one Chemical compound CC1=CC=CN=C1NC1=CC2=CC=C(N3CCNCC3)C=C2OC1=O KQYMGCBUOWVPEB-UHFFFAOYSA-N 0.000 claims 1
• DXJPYOJFVWRWAP-UHFFFAOYSA-N 3-[(4-methylpyridin-2-yl)amino]-7-piperazin-1-ylchromen-2-one Chemical compound CC1=CC=NC(NC=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 DXJPYOJFVWRWAP-UHFFFAOYSA-N 0.000 claims 1
• JBNKZZTXURGCSH-UHFFFAOYSA-N 3-[(5-chloropyridin-2-yl)amino]-7-piperazin-1-ylchromen-2-one Chemical compound N1=CC(Cl)=CC=C1NC1=CC2=CC=C(N3CCNCC3)C=C2OC1=O JBNKZZTXURGCSH-UHFFFAOYSA-N 0.000 claims 1
• QODYXGDCCYXINR-UHFFFAOYSA-N 3-[(5-methylpyridin-2-yl)amino]-7-piperazin-1-ylchromen-2-one Chemical compound N1=CC(C)=CC=C1NC1=CC2=CC=C(N3CCNCC3)C=C2OC1=O QODYXGDCCYXINR-UHFFFAOYSA-N 0.000 claims 1
• VOYHHSRPXAMSNN-UHFFFAOYSA-N 3-[(6-methylpyridin-2-yl)amino]-7-piperazin-1-ylchromen-2-one Chemical compound CC1=CC=CC(NC=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 VOYHHSRPXAMSNN-UHFFFAOYSA-N 0.000 claims 1
• MZNWAGNIXCQURM-UHFFFAOYSA-N 3-[2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-7-(1,2,3,6-tetrahydropyridin-4-yl)chromen-2-one Chemical compound CC=1N=C2C=CC(C=3C(OC4=CC(=CC=C4C=3)C=3CCNCC=3)=O)=NN2C=1C1=CCNCC1 MZNWAGNIXCQURM-UHFFFAOYSA-N 0.000 claims 1
• FBAUIMCNYYDZTO-AWEZNQCLSA-N 3-[6-(dimethylamino)pyridin-3-yl]-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=NC(=CC=2)N(C)C)C(=O)O2)C2=C1 FBAUIMCNYYDZTO-AWEZNQCLSA-N 0.000 claims 1
• NVCGERJWDHUEBC-UHFFFAOYSA-N 3-[6-(dimethylamino)pyridin-3-yl]-7-piperazin-1-ylchromen-2-one Chemical compound C1=NC(N(C)C)=CC=C1C1=CC2=CC=C(N3CCNCC3)C=C2OC1=O NVCGERJWDHUEBC-UHFFFAOYSA-N 0.000 claims 1
• QIPUQUJCPKEFFY-GASCZTMLSA-N 3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]-7-[(3s,5r)-3,4,5-trimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 QIPUQUJCPKEFFY-GASCZTMLSA-N 0.000 claims 1
• JEDDSKPYBCDCOM-GFCCVEGCSA-N 3-[methyl-[(3R)-1-methylpyrrolidin-3-yl]amino]chromen-2-one Chemical compound CN([C@H]1CN(CC1)C)C=1C(OC2=CC=CC=C2C1)=O JEDDSKPYBCDCOM-GFCCVEGCSA-N 0.000 claims 1
• GMVLTWHDMNYVHA-UHFFFAOYSA-N 3-anilino-7-piperazin-1-ylchromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1NC1=CC=CC=C1 GMVLTWHDMNYVHA-UHFFFAOYSA-N 0.000 claims 1
• RSGAFRJYEPKWPN-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrazin-2-yl-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C=NC=CN3C=2)C(=O)O2)C2=C1 RSGAFRJYEPKWPN-UHFFFAOYSA-N 0.000 claims 1
• KLVTWNJRDMNMMZ-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrazin-2-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=NC=CN3C=2)C(=O)O2)C2=C1 KLVTWNJRDMNMMZ-UHFFFAOYSA-N 0.000 claims 1
• ROFRAKIBSAFCKG-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrazin-2-yl-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4C=NC=CN4C=3)C(=O)OC=2C=C1N1CCNCC1 ROFRAKIBSAFCKG-UHFFFAOYSA-N 0.000 claims 1
• HCNYHFMAWYWBMC-UHFFFAOYSA-N 3-imidazo[1,2-a]pyridin-2-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=CC=CN3C=2)C(=O)O2)C2=C1 HCNYHFMAWYWBMC-UHFFFAOYSA-N 0.000 claims 1
• UFPCACZWKDENSF-IYBDPMFKSA-N 3-imidazo[1,2-a]pyridin-2-yl-7-[(3r,5s)-3,4,5-trimethylpiperazin-1-yl]chromen-2-one Chemical compound C1[C@@H](C)N(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC=CN3C=2)C(=O)O2)C2=C1 UFPCACZWKDENSF-IYBDPMFKSA-N 0.000 claims 1
• ABKUPOMNBCNVRC-UHFFFAOYSA-N 3-imidazo[1,2-a]pyridin-2-yl-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4C=CC=CN4C=3)C(=O)OC=2C=C1N1CCNCC1 ABKUPOMNBCNVRC-UHFFFAOYSA-N 0.000 claims 1
• MWEISZIMBOZIBQ-UHFFFAOYSA-N 3-imidazo[1,2-a]pyridin-6-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=CN3C=CN=C3C=C2)C(=O)O2)C2=C1 MWEISZIMBOZIBQ-UHFFFAOYSA-N 0.000 claims 1
• IKWKXYVCXYTWCJ-AWEZNQCLSA-N 3-imidazo[1,2-a]pyridin-6-yl-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=CN=C3C=C2)C(=O)O2)C2=C1 IKWKXYVCXYTWCJ-AWEZNQCLSA-N 0.000 claims 1
• DFEJKWYSRHBWJT-UHFFFAOYSA-N 3-imidazo[1,2-a]pyridin-6-yl-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C3=CN4C=CN=C4C=C3)C(=O)OC=2C=C1N1CCNCC1 DFEJKWYSRHBWJT-UHFFFAOYSA-N 0.000 claims 1
• BXIMLMQKTLNHCV-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 BXIMLMQKTLNHCV-UHFFFAOYSA-N 0.000 claims 1
• CUPKFBDNXZRTFL-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 CUPKFBDNXZRTFL-UHFFFAOYSA-N 0.000 claims 1
• BXPPWFDTPSOARZ-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-(4-propylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(CCC)CCN1C1=CC=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 BXPPWFDTPSOARZ-UHFFFAOYSA-N 0.000 claims 1
• QDZNUKMJAZZVEU-CYBMUJFWSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 QDZNUKMJAZZVEU-CYBMUJFWSA-N 0.000 claims 1
• DAIJTJOVUQQKCH-CQSZACIVSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4N=CC=CN4C=3)C(=O)OC=2C=C1O[C@@H]1CCNC1 DAIJTJOVUQQKCH-CQSZACIVSA-N 0.000 claims 1
• HVYQOYKDJQPRRA-PFEQFJNWSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one;hydrochloride Chemical compound Cl.C1=CC=2C=C(C=3N=C4N=CC=CN4C=3)C(=O)OC=2C=C1O[C@@H]1CCNC1 HVYQOYKDJQPRRA-PFEQFJNWSA-N 0.000 claims 1
• QDZNUKMJAZZVEU-ZDUSSCGKSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 QDZNUKMJAZZVEU-ZDUSSCGKSA-N 0.000 claims 1
• LYRQVVCPZJYIJC-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-[methyl-(1-methylpyrrolidin-3-yl)amino]chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4N=CC=CN4C=3)C(=O)OC2=CC=1N(C)C1CCN(C)C1 LYRQVVCPZJYIJC-UHFFFAOYSA-N 0.000 claims 1
• IRJHOHTZAKXYFH-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4N=CC=CN4C=3)C(=O)OC=2C=C1N1CCNCC1 IRJHOHTZAKXYFH-UHFFFAOYSA-N 0.000 claims 1
• KSYWUCLIRPSDNW-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-piperidin-4-yloxychromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4N=CC=CN4C=3)C(=O)OC=2C=C1OC1CCNCC1 KSYWUCLIRPSDNW-UHFFFAOYSA-N 0.000 claims 1
• IKXLGWPVPQWXLS-UHFFFAOYSA-N 3-imidazo[1,2-a]pyrimidin-2-yl-7-piperidin-4-yloxychromen-2-one hydrochloride Chemical compound Cl.O=c1oc2cc(OC3CCNCC3)ccc2cc1-c1cn2cccnc2n1 IKXLGWPVPQWXLS-UHFFFAOYSA-N 0.000 claims 1
• VPMIEFGOECJMMP-UHFFFAOYSA-N 3-imidazo[1,2-b]pyridazin-2-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=CC=NN3C=2)C(=O)O2)C2=C1 VPMIEFGOECJMMP-UHFFFAOYSA-N 0.000 claims 1
• JEXHOIGATWERIS-UHFFFAOYSA-N 3-imidazo[1,2-c]pyrimidin-2-yl-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C=CN=CN3C=2)C(=O)O2)C2=C1 JEXHOIGATWERIS-UHFFFAOYSA-N 0.000 claims 1
• MLHLUIRMZWOQGO-UHFFFAOYSA-N 3-imidazo[1,2-c]pyrimidin-2-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=CN=CN3C=2)C(=O)O2)C2=C1 MLHLUIRMZWOQGO-UHFFFAOYSA-N 0.000 claims 1
• BMDNFAZNHKFPIN-UHFFFAOYSA-N 3-imidazo[2,1-b][1,3]thiazol-6-yl-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 BMDNFAZNHKFPIN-UHFFFAOYSA-N 0.000 claims 1
• LBIHGHSBAGVAGO-UHFFFAOYSA-N 3-imidazo[2,1-b][1,3]thiazol-6-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 LBIHGHSBAGVAGO-UHFFFAOYSA-N 0.000 claims 1
• FIMXDQUAHGZCCZ-GFCCVEGCSA-N 3-imidazo[2,1-b][1,3]thiazol-6-yl-7-[(3r)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 FIMXDQUAHGZCCZ-GFCCVEGCSA-N 0.000 claims 1
• YQJMJFJYPHXRKN-CYBMUJFWSA-N 3-imidazo[2,1-b][1,3]thiazol-6-yl-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4SC=CN4C=3)C(=O)OC=2C=C1O[C@@H]1CCNC1 YQJMJFJYPHXRKN-CYBMUJFWSA-N 0.000 claims 1
• VZDASWMBPYLACI-BTQNPOSSSA-N 3-imidazo[2,1-b][1,3]thiazol-6-yl-7-[(3r)-pyrrolidin-3-yl]oxychromen-2-one;hydrochloride Chemical compound Cl.C1=CC=2C=C(C=3N=C4SC=CN4C=3)C(=O)OC=2C=C1O[C@@H]1CCNC1 VZDASWMBPYLACI-BTQNPOSSSA-N 0.000 claims 1
• FIMXDQUAHGZCCZ-LBPRGKRZSA-N 3-imidazo[2,1-b][1,3]thiazol-6-yl-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 FIMXDQUAHGZCCZ-LBPRGKRZSA-N 0.000 claims 1
• HEBGCWJYZGFNKB-UHFFFAOYSA-N 3-imidazo[2,1-b][1,3]thiazol-6-yl-7-[(propan-2-ylamino)methyl]chromen-2-one Chemical compound O=C1OC2=CC(CNC(C)C)=CC=C2C=C1C1=CN(C=CS2)C2=N1 HEBGCWJYZGFNKB-UHFFFAOYSA-N 0.000 claims 1
• JKRWYBDUHGUPFL-UHFFFAOYSA-N 3-imidazo[2,1-b][1,3]thiazol-6-yl-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4SC=CN4C=3)C(=O)OC=2C=C1N1CCNCC1 JKRWYBDUHGUPFL-UHFFFAOYSA-N 0.000 claims 1
• JAKNUJNWJOGUSJ-HNNXBMFYSA-N 3-indolizin-2-yl-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=CC=CC3=C2)C(=O)O2)C2=C1 JAKNUJNWJOGUSJ-HNNXBMFYSA-N 0.000 claims 1
• PMDPNCLJKSSMMW-UHFFFAOYSA-N 3-indolizin-2-yl-7-piperazin-1-ylchromen-2-one Chemical compound C1=CC=2C=C(C3=CN4C=CC=CC4=C3)C(=O)OC=2C=C1N1CCNCC1 PMDPNCLJKSSMMW-UHFFFAOYSA-N 0.000 claims 1
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• IBOSEBPUDDUZJZ-UHFFFAOYSA-N 5-fluoro-3-(4-fluoro-1,3-benzoxazol-2-yl)-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC(F)=C(C=C(C=2OC3=CC=CC(F)=C3N=2)C(=O)O2)C2=C1 IBOSEBPUDDUZJZ-UHFFFAOYSA-N 0.000 claims 1
• QRBUGZNVIUYVHI-UHFFFAOYSA-N 5-fluoro-3-(4-fluoro-1,3-benzoxazol-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC(F)=C(C=C(C=2OC3=CC=CC(F)=C3N=2)C(=O)O2)C2=C1 QRBUGZNVIUYVHI-UHFFFAOYSA-N 0.000 claims 1
• RCWDNKNUWRPAGO-UHFFFAOYSA-N 5-fluoro-3-(4-fluoro-1,3-benzoxazol-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N=1C=2C(F)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=C(F)C=C2N1CCNCC1 RCWDNKNUWRPAGO-UHFFFAOYSA-N 0.000 claims 1
• RCABMTOOQVTJFH-LBPRGKRZSA-N 5-fluoro-3-(6-methoxypyridin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC(F)=C3C=2)N2C[C@H](C)NCC2)=O)=N1 RCABMTOOQVTJFH-LBPRGKRZSA-N 0.000 claims 1
• DBWMHFCQNRFJGS-UHFFFAOYSA-N 5-fluoro-3-(6-methoxypyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC(F)=C3C=2)N2CCNCC2)=O)=N1 DBWMHFCQNRFJGS-UHFFFAOYSA-N 0.000 claims 1
• AHAWUASQIRBSIF-UHFFFAOYSA-N 5-fluoro-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC(F)=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 AHAWUASQIRBSIF-UHFFFAOYSA-N 0.000 claims 1
• XFGIKJWOQRBTHY-LBPRGKRZSA-N 5-fluoro-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-methylpiperazin-1-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC(F)=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 XFGIKJWOQRBTHY-LBPRGKRZSA-N 0.000 claims 1
• AQWWRZVFOHVWCD-UHFFFAOYSA-N 5-fluoro-3-(7-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=C(F)C=C2N1CCNCC1 AQWWRZVFOHVWCD-UHFFFAOYSA-N 0.000 claims 1
• OUCKMSFPEKRBEG-UHFFFAOYSA-N 5-fluoro-3-(8-methylimidazo[1,2-a]pyridin-2-yl)-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC(F)=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 OUCKMSFPEKRBEG-UHFFFAOYSA-N 0.000 claims 1
• AYPJHHRTAUJGIJ-UHFFFAOYSA-N 5-fluoro-3-imidazo[1,2-a]pyridin-2-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC(F)=C(C=C(C=2N=C3C=CC=CN3C=2)C(=O)O2)C2=C1 AYPJHHRTAUJGIJ-UHFFFAOYSA-N 0.000 claims 1
• PLCFKSZNYSDGCP-UHFFFAOYSA-N 5-fluoro-3-imidazo[1,2-a]pyrimidin-2-yl-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC(F)=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 PLCFKSZNYSDGCP-UHFFFAOYSA-N 0.000 claims 1
• XSHRFYBDFCSADG-UHFFFAOYSA-N 5-fluoro-3-imidazo[1,2-a]pyrimidin-2-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound FC1=C2C=C(C(OC2=CC(=C1)N1CCN(CC1)C)=O)C=1N=C2N(C=CC=N2)C=1 XSHRFYBDFCSADG-UHFFFAOYSA-N 0.000 claims 1
• HIOYHLOUIFJPFH-UHFFFAOYSA-N 5-fluoro-3-imidazo[1,2-a]pyrimidin-2-yl-7-piperazin-1-ylchromen-2-one Chemical compound C=1C=2OC(=O)C(C=3N=C4N=CC=CN4C=3)=CC=2C(F)=CC=1N1CCNCC1 HIOYHLOUIFJPFH-UHFFFAOYSA-N 0.000 claims 1
• SHWYBOWRIZXREW-UHFFFAOYSA-N 5-fluoro-3-imidazo[2,1-b][1,3]thiazol-6-yl-7-(4-methyl-1,4-diazepan-1-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC(F)=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 SHWYBOWRIZXREW-UHFFFAOYSA-N 0.000 claims 1
• TWSPACMKLRSRLX-UHFFFAOYSA-N 5-fluoro-3-imidazo[2,1-b][1,3]thiazol-6-yl-7-(4-methylpiperazin-1-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC(F)=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 TWSPACMKLRSRLX-UHFFFAOYSA-N 0.000 claims 1
• AQOISJMWQCXHLU-UHFFFAOYSA-N 5-fluoro-3-imidazo[2,1-b][1,3]thiazol-6-yl-7-piperazin-1-ylchromen-2-one Chemical compound C=1C=2OC(=O)C(C=3N=C4SC=CN4C=3)=CC=2C(F)=CC=1N1CCNCC1 AQOISJMWQCXHLU-UHFFFAOYSA-N 0.000 claims 1
• FYDYOOYAXQGKBI-UHFFFAOYSA-N 5-fluoro-7-(4-methyl-1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC(F)=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 FYDYOOYAXQGKBI-UHFFFAOYSA-N 0.000 claims 1
• POZMOKLHVKEKNR-UHFFFAOYSA-N 5-fluoro-7-(hydroxymethyl)-3-imidazo[2,1-b][1,3]thiazol-6-ylchromen-2-one Chemical compound O=C1OC2=CC(CO)=CC(F)=C2C=C1C1=CN(C=CS2)C2=N1 POZMOKLHVKEKNR-UHFFFAOYSA-N 0.000 claims 1
• BQYUDMIAFHXZLD-UHFFFAOYSA-N 5-fluoro-7-piperazin-1-yl-3-[4-(trifluoromethyl)-1,3-benzoxazol-2-yl]chromen-2-one Chemical compound C=1C=2OC(=O)C(C=3OC4=CC=CC(=C4N=3)C(F)(F)F)=CC=2C(F)=CC=1N1CCNCC1 BQYUDMIAFHXZLD-UHFFFAOYSA-N 0.000 claims 1
• PCJASSBELPWANK-UHFFFAOYSA-N 5-fluoro-7-piperazin-1-yl-3-pyridin-2-ylchromen-2-one Chemical compound C=1C=2C(F)=CC(N3CCNCC3)=CC=2OC(=O)C=1C1=CC=CC=N1 PCJASSBELPWANK-UHFFFAOYSA-N 0.000 claims 1
• DOQUXGSANARWAR-UHFFFAOYSA-N 6-fluoro-3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC(F)=C2N1CCNCC1 DOQUXGSANARWAR-UHFFFAOYSA-N 0.000 claims 1
• WSSKQTGMKAFWGQ-UHFFFAOYSA-N 7-(1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl)-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1C2CCCNC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN(C=C(C)C=C2)C2=N1 WSSKQTGMKAFWGQ-UHFFFAOYSA-N 0.000 claims 1
• FKIOFNLGOQXLSV-UHFFFAOYSA-N 7-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN2CCCCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=C1 FKIOFNLGOQXLSV-UHFFFAOYSA-N 0.000 claims 1
• SXJYGCZLBLPADV-UHFFFAOYSA-N 7-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN2CCCCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=CC2=C1 SXJYGCZLBLPADV-UHFFFAOYSA-N 0.000 claims 1
• DOWINELKSIWLGU-UHFFFAOYSA-N 7-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN2CCCCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=N1 DOWINELKSIWLGU-UHFFFAOYSA-N 0.000 claims 1
• JJLHULUCZCONDB-UHFFFAOYSA-N 7-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN2CCCCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=CC2=N1 JJLHULUCZCONDB-UHFFFAOYSA-N 0.000 claims 1
• FGQWQIBKIKFRPB-UHFFFAOYSA-N 7-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN2CCCCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN(C=C(C)C=C2F)C2=N1 FGQWQIBKIKFRPB-UHFFFAOYSA-N 0.000 claims 1
• PETXHXCTCYQAAO-UHFFFAOYSA-N 7-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN2CCCCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CC=C(F)C2=N1 PETXHXCTCYQAAO-UHFFFAOYSA-N 0.000 claims 1
• PYMOQGUCRCTBSA-UHFFFAOYSA-N 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN2CCC1CC2 PYMOQGUCRCTBSA-UHFFFAOYSA-N 0.000 claims 1
• IJVVOJJKRCHGSE-UHFFFAOYSA-N 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=C(F)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN2CCC1CC2 IJVVOJJKRCHGSE-UHFFFAOYSA-N 0.000 claims 1
• RMOVNUUWQXDSHD-UHFFFAOYSA-N 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C(F)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN2CCC1CC2 RMOVNUUWQXDSHD-UHFFFAOYSA-N 0.000 claims 1
• YMAFZOIMXUCJIP-UHFFFAOYSA-N 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(8-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN2CCC1CC2 YMAFZOIMXUCJIP-UHFFFAOYSA-N 0.000 claims 1
• OKMHCUCSMRWLAJ-UHFFFAOYSA-N 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4N=CC=CN4C=3)C(=O)OC=2C=C1N1CCN2CCC1CC2 OKMHCUCSMRWLAJ-UHFFFAOYSA-N 0.000 claims 1
• CHCLTSKQNDGBKV-UHFFFAOYSA-N 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-imidazo[2,1-b][1,3]thiazol-6-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4SC=CN4C=3)C(=O)OC=2C=C1N1CCN2CCC1CC2 CHCLTSKQNDGBKV-UHFFFAOYSA-N 0.000 claims 1
• CKNBMUUWDDATKL-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 CKNBMUUWDDATKL-UHFFFAOYSA-N 0.000 claims 1
• OGGWXCPMOWTVMT-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 OGGWXCPMOWTVMT-UHFFFAOYSA-N 0.000 claims 1
• ZVEUTTMEESWKEO-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(2-ethylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound N1=C2SC(CC)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 ZVEUTTMEESWKEO-UHFFFAOYSA-N 0.000 claims 1
• VHWXLNMCGBOKSO-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(2-methyl-1,3-benzothiazol-6-yl)chromen-2-one Chemical compound C1=C2SC(C)=NC2=CC=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 VHWXLNMCGBOKSO-UHFFFAOYSA-N 0.000 claims 1
• QNCCHKQOEAMRJU-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1=CC2=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 QNCCHKQOEAMRJU-UHFFFAOYSA-N 0.000 claims 1
• RBCWSVIXAIBKLE-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(2-methylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)chromen-2-one Chemical compound N1=C2SC(C)=NN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 RBCWSVIXAIBKLE-UHFFFAOYSA-N 0.000 claims 1
• NTTSAAXHIJZWHD-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound N1=C2SC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 NTTSAAXHIJZWHD-UHFFFAOYSA-N 0.000 claims 1
• CEQJMTHUOCPQJU-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(3,5-dimethoxyphenyl)chromen-2-one Chemical compound COC1=CC(OC)=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCCC2)=O)=C1 CEQJMTHUOCPQJU-UHFFFAOYSA-N 0.000 claims 1
• STKQIZUVUQWZQY-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 STKQIZUVUQWZQY-UHFFFAOYSA-N 0.000 claims 1
• PZIKZQSXUROQSB-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(4-methyl-1,3-thiazol-2-yl)chromen-2-one Chemical compound CC1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCCC2)=O)=N1 PZIKZQSXUROQSB-UHFFFAOYSA-N 0.000 claims 1
• APWUHQOWASXXAE-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)chromen-2-one Chemical compound C1=C2C=C(C)C=CN2N=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 APWUHQOWASXXAE-UHFFFAOYSA-N 0.000 claims 1
• NYXBKNXCJWHUIT-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-5-fluorochromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=C(F)C=C2N1CCCNCC1 NYXBKNXCJWHUIT-UHFFFAOYSA-N 0.000 claims 1
• GGJYNLWIMBZGDL-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 GGJYNLWIMBZGDL-UHFFFAOYSA-N 0.000 claims 1
• SDYKCRAODNZDLP-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 SDYKCRAODNZDLP-UHFFFAOYSA-N 0.000 claims 1
• QPUHLPSTYAJUFM-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1(CCNCCC1)C1=CC=C2C=C(C(OC2=C1)=O)C=1N=C2N(C=C(C=C2)C)C=1 QPUHLPSTYAJUFM-UHFFFAOYSA-N 0.000 claims 1
• NGARQVHCCCQFOW-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=NC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 NGARQVHCCCQFOW-UHFFFAOYSA-N 0.000 claims 1
• DAOSQSQZYPZRHP-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-b]pyridazin-2-yl)chromen-2-one Chemical compound C=1N2N=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 DAOSQSQZYPZRHP-UHFFFAOYSA-N 0.000 claims 1
• KYGADKMTQDGMPV-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 KYGADKMTQDGMPV-UHFFFAOYSA-N 0.000 claims 1
• BISHICSZROSJGP-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound N1=C2N=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 BISHICSZROSJGP-UHFFFAOYSA-N 0.000 claims 1
• JIAFJVYWIBBFOL-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=C(F)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 JIAFJVYWIBBFOL-UHFFFAOYSA-N 0.000 claims 1
• YLARYERZBBVTND-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C(F)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 YLARYERZBBVTND-UHFFFAOYSA-N 0.000 claims 1
• FISSHYUVPGSRRX-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(8-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 FISSHYUVPGSRRX-UHFFFAOYSA-N 0.000 claims 1
• QUFTZIFJNSHTJK-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-(8-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 QUFTZIFJNSHTJK-UHFFFAOYSA-N 0.000 claims 1
• KMAKWRCLQKSPOP-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one Chemical compound FC(F)(F)C1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCCC2)=O)=N1 KMAKWRCLQKSPOP-UHFFFAOYSA-N 0.000 claims 1
• GPYKVOKSYFXWEZ-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-[6-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyrazin-2-yl]chromen-2-one Chemical compound N1=C2C(C(F)(F)F)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 GPYKVOKSYFXWEZ-UHFFFAOYSA-N 0.000 claims 1
• SCLJZYDRKPGLSE-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound N1=C2C=C(C(F)(F)F)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCNCC1 SCLJZYDRKPGLSE-UHFFFAOYSA-N 0.000 claims 1
• HYJZRYMRZQJLEV-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-imidazo[1,2-a]pyrazin-2-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4C=NC=CN4C=3)C(=O)OC=2C=C1N1CCCNCC1 HYJZRYMRZQJLEV-UHFFFAOYSA-N 0.000 claims 1
• LSRLGSKFYQEUPA-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4N=CC=CN4C=3)C(=O)OC=2C=C1N1CCCNCC1 LSRLGSKFYQEUPA-UHFFFAOYSA-N 0.000 claims 1
• YBFFXOXBGCHAGI-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one hydrochloride Chemical compound Cl.O=c1oc2cc(ccc2cc1-c1cn2cccnc2n1)N1CCCNCC1 YBFFXOXBGCHAGI-UHFFFAOYSA-N 0.000 claims 1
• CUBLNWDSHNJOQM-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-imidazo[2,1-b][1,3]thiazol-6-ylchromen-2-one Chemical compound C1=CC=2C=C(C=3N=C4SC=CN4C=3)C(=O)OC=2C=C1N1CCCNCC1 CUBLNWDSHNJOQM-UHFFFAOYSA-N 0.000 claims 1
• RZAHYASXYRDOHC-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1=CC=2C=C(C3=NN4C=CC=CC4=C3)C(=O)OC=2C=C1N1CCCNCC1 RZAHYASXYRDOHC-UHFFFAOYSA-N 0.000 claims 1
• BXTHBYSKFSMCCX-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-5-fluoro-3-(4-fluoro-1,3-benzoxazol-2-yl)chromen-2-one Chemical compound N=1C=2C(F)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=C(F)C=C2N1CCCNCC1 BXTHBYSKFSMCCX-UHFFFAOYSA-N 0.000 claims 1
• PLXPLHMWRZWRTK-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-5-fluoro-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=C(F)C=C2N1CCCNCC1 PLXPLHMWRZWRTK-UHFFFAOYSA-N 0.000 claims 1
• APZCIJAXGVHVII-UHFFFAOYSA-N 7-(1,4-diazepan-1-yl)-5-fluoro-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one Chemical compound C=1C=2OC(=O)C(C=3N=C4N=CC=CN4C=3)=CC=2C(F)=CC=1N1CCCNCC1 APZCIJAXGVHVII-UHFFFAOYSA-N 0.000 claims 1
• HJVROBNWRKGOOA-UHFFFAOYSA-N 7-(1-cyclobutylpiperidin-4-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C(CC1)CCN1C1CCC1 HJVROBNWRKGOOA-UHFFFAOYSA-N 0.000 claims 1
• STNQNEGPPMHEHK-UHFFFAOYSA-N 7-(1-cyclobutylpiperidin-4-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C(CC1)CCN1C1CCC1 STNQNEGPPMHEHK-UHFFFAOYSA-N 0.000 claims 1
• VCWDUWZUIAFEKO-UHFFFAOYSA-N 7-(1-cyclopropylpiperidin-4-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C(CC1)CCN1C1CC1 VCWDUWZUIAFEKO-UHFFFAOYSA-N 0.000 claims 1
• CCUNBUSFIGPUIO-UHFFFAOYSA-N 7-(1-ethylpiperidin-4-yl)-3-(2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1CN(CC)CCC1C1=CC=C(C=C(C2=CN3C=C(C)N=C3C=C2)C(=O)O2)C2=C1 CCUNBUSFIGPUIO-UHFFFAOYSA-N 0.000 claims 1
• YEHAQVIUWXPJMZ-UHFFFAOYSA-N 7-(1-ethylpiperidin-4-yl)-3-(2-methylimidazo[1,2-a]pyrimidin-6-yl)chromen-2-one Chemical compound C1CN(CC)CCC1C1=CC=C(C=C(C2=CN3C=C(C)N=C3N=C2)C(=O)O2)C2=C1 YEHAQVIUWXPJMZ-UHFFFAOYSA-N 0.000 claims 1
• YKDDXQRKAJXERG-UHFFFAOYSA-N 7-(1-ethylpiperidin-4-yl)-3-(2-methylindazol-5-yl)chromen-2-one Chemical compound C1CN(CC)CCC1C1=CC=C(C=C(C2=CC3=CN(C)N=C3C=C2)C(=O)O2)C2=C1 YKDDXQRKAJXERG-UHFFFAOYSA-N 0.000 claims 1
• OQTHFDNWQQQNMM-UHFFFAOYSA-N 7-(1-ethylpiperidin-4-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN(CC)CCC1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 OQTHFDNWQQQNMM-UHFFFAOYSA-N 0.000 claims 1
• YDHKJAGYLRDCNH-UHFFFAOYSA-N 7-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C(CN2)CC2C1 YDHKJAGYLRDCNH-UHFFFAOYSA-N 0.000 claims 1
• RMNALNNBARYUEL-UHFFFAOYSA-N 7-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C(CN2)CC2C1 RMNALNNBARYUEL-UHFFFAOYSA-N 0.000 claims 1
• ZOAQMYRKJJHCOH-UHFFFAOYSA-N 7-(2,5-diazabicyclo[2.2.2]octan-2-yl)-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1C(NC2)CCC2N1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CC(C)=CC2=N1 ZOAQMYRKJJHCOH-UHFFFAOYSA-N 0.000 claims 1
• GYNPRJBODQADNY-UHFFFAOYSA-N 7-(2,5-diazabicyclo[2.2.2]octan-2-yl)-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1C(NC2)CCC2N1C(C=C1OC2=O)=CC=C1C=C2C1=CN(C=C(C)C=C2F)C2=N1 GYNPRJBODQADNY-UHFFFAOYSA-N 0.000 claims 1
• CARQXEOGKYNJPX-UHFFFAOYSA-N 7-(2,5-diazabicyclo[2.2.2]octan-2-yl)-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1C(NC2)CCC2N1C1=CC(OC(C(=C2)C3=NN4C=CC=CC4=C3)=O)=C2C=C1 CARQXEOGKYNJPX-UHFFFAOYSA-N 0.000 claims 1
• KJISIIZOCLMFNX-UHFFFAOYSA-N 7-(2,6-diazaspiro[3.3]heptan-2-yl)-3-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1=C(F)C2=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(C1)CC21CNC2 KJISIIZOCLMFNX-UHFFFAOYSA-N 0.000 claims 1
• NVQHPAINPVECJQ-UHFFFAOYSA-N 7-(2,7-diazaspiro[3.5]nonan-7-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCC21CNC2 NVQHPAINPVECJQ-UHFFFAOYSA-N 0.000 claims 1
• UWOYOCYEGIAMTF-UHFFFAOYSA-N 7-(2-methylimidazo[1,2-a]pyridin-6-yl)-3-piperazin-1-ylchromen-2-one Chemical compound C1=CC2=NC(C)=CN2C=C1C(C=C1OC2=O)=CC=C1C=C2N1CCNCC1 UWOYOCYEGIAMTF-UHFFFAOYSA-N 0.000 claims 1
• SRVMZOGDLNVLAQ-UHFFFAOYSA-N 7-(3,3-dimethylpiperazin-1-yl)-3-(4-methyl-1,3-thiazol-2-yl)chromen-2-one Chemical compound CC1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2CC(C)(C)NCC2)=O)=N1 SRVMZOGDLNVLAQ-UHFFFAOYSA-N 0.000 claims 1
• BPYAAZRZNWVMLS-UHFFFAOYSA-N 7-(3,3-dimethylpiperazin-1-yl)-3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)chromen-2-one Chemical compound C1=C2C=C(C)C=CN2N=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNC(C)(C)C1 BPYAAZRZNWVMLS-UHFFFAOYSA-N 0.000 claims 1
• KGEASGJJDRZUDA-UHFFFAOYSA-N 7-(3,3-dimethylpiperazin-1-yl)-3-(6-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CNC(C)(C)CN1C1=CC=C(C=C(C=2N=C3C=CC(F)=CN3C=2)C(=O)O2)C2=C1 KGEASGJJDRZUDA-UHFFFAOYSA-N 0.000 claims 1
• MXVFMZCAFGQVRH-UHFFFAOYSA-N 7-(3,3-dimethylpiperazin-1-yl)-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNC(C)(C)C1 MXVFMZCAFGQVRH-UHFFFAOYSA-N 0.000 claims 1
• OHKDLVHBOJSEIL-UHFFFAOYSA-N 7-(3,3-dimethylpiperazin-1-yl)-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNC(C)(C)C1 OHKDLVHBOJSEIL-UHFFFAOYSA-N 0.000 claims 1
• XOVNXUPHFNRQAN-UHFFFAOYSA-N 7-(3,3-dimethylpiperazin-1-yl)-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CNC(C)(C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC=CN3C=2)C(=O)O2)C2=C1 XOVNXUPHFNRQAN-UHFFFAOYSA-N 0.000 claims 1
• LKIUFNNLSUAHKV-UHFFFAOYSA-N 7-(3,3-dimethylpiperazin-1-yl)-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1CNC(C)(C)CN1C1=CC=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 LKIUFNNLSUAHKV-UHFFFAOYSA-N 0.000 claims 1
• JGENPIBHFXOGAY-UHFFFAOYSA-N 7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1C(N2)CCC2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CC=C(F)C2=N1 JGENPIBHFXOGAY-UHFFFAOYSA-N 0.000 claims 1
• AIOXIZKCGXTKNL-UHFFFAOYSA-N 7-(3-aminopropyl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(CCCN)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 AIOXIZKCGXTKNL-UHFFFAOYSA-N 0.000 claims 1
• JNOIAIFCEVJUFH-UHFFFAOYSA-N 7-(4-amino-4-methylpiperidin-1-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(C)(N)CC1 JNOIAIFCEVJUFH-UHFFFAOYSA-N 0.000 claims 1
• RHSHJFCXVCPVGL-UHFFFAOYSA-N 7-(4-aminopiperidin-1-yl)-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(N)CC1 RHSHJFCXVCPVGL-UHFFFAOYSA-N 0.000 claims 1
• FOSDVKSSRNAQHY-UHFFFAOYSA-N 7-(4-aminopiperidin-1-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(N)CC1 FOSDVKSSRNAQHY-UHFFFAOYSA-N 0.000 claims 1
• OQARYQNENBPVSJ-UHFFFAOYSA-N 7-(4-aminopiperidin-1-yl)-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(N)CC1 OQARYQNENBPVSJ-UHFFFAOYSA-N 0.000 claims 1
• YDZKOQVQTXJMOO-UHFFFAOYSA-N 7-(4-cyclobutylpiperazin-1-yl)-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1CCC1 YDZKOQVQTXJMOO-UHFFFAOYSA-N 0.000 claims 1
• QIZPOMCHMNACTR-UHFFFAOYSA-N 7-(4-cyclobutylpiperazin-1-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1CCC1 QIZPOMCHMNACTR-UHFFFAOYSA-N 0.000 claims 1
• XZODKDKXDFZRHN-UHFFFAOYSA-N 7-(4-cyclobutylpiperazin-1-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1CCC1 XZODKDKXDFZRHN-UHFFFAOYSA-N 0.000 claims 1
• SBVMJZRDEJCYGW-UHFFFAOYSA-N 7-(4-cyclopropylpiperazin-1-yl)-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1CC1 SBVMJZRDEJCYGW-UHFFFAOYSA-N 0.000 claims 1
• KORNPXXACAZKFB-UHFFFAOYSA-N 7-(4-cyclopropylpiperazin-1-yl)-3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)chromen-2-one Chemical compound O1C=2C(C)=NC(C)=CC=2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1CC1 KORNPXXACAZKFB-UHFFFAOYSA-N 0.000 claims 1
• XJGRLKYNVDIPKU-UHFFFAOYSA-N 7-(4-cyclopropylpiperazin-1-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1CC1 XJGRLKYNVDIPKU-UHFFFAOYSA-N 0.000 claims 1
• CWANRZNUYUVBDD-UHFFFAOYSA-N 7-(4-cyclopropylpiperazin-1-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1C1CC1 CWANRZNUYUVBDD-UHFFFAOYSA-N 0.000 claims 1
• VNDMKZQQYNPVKH-UHFFFAOYSA-N 7-(4-ethyl-1,4-diazepan-1-yl)-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN(CC)CCCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 VNDMKZQQYNPVKH-UHFFFAOYSA-N 0.000 claims 1
• OBRBJHURMGXNGW-UHFFFAOYSA-N 7-(4-ethyl-1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN(CC)CCCN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 OBRBJHURMGXNGW-UHFFFAOYSA-N 0.000 claims 1
• YZTOQLLYOQDUJS-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3SC(C)=CN3C=2)C(=O)O2)C2=C1 YZTOQLLYOQDUJS-UHFFFAOYSA-N 0.000 claims 1
• VMFNKUJJJBQLOQ-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3SC=C(C)N3C=2)C(=O)O2)C2=C1 VMFNKUJJJBQLOQ-UHFFFAOYSA-N 0.000 claims 1
• DMARLVUZMLNQPS-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 DMARLVUZMLNQPS-UHFFFAOYSA-N 0.000 claims 1
• AWGBRQCNSZKGIL-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C2=NN3C=CC(C)=CC3=C2)C(=O)O2)C2=C1 AWGBRQCNSZKGIL-UHFFFAOYSA-N 0.000 claims 1
• APLMDOMYIQPZBX-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-(6-methoxypyridin-2-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C(OC)C=CC=2)C(=O)O2)C2=C1 APLMDOMYIQPZBX-UHFFFAOYSA-N 0.000 claims 1
• LKTYKMAENNNFEP-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 LKTYKMAENNNFEP-UHFFFAOYSA-N 0.000 claims 1
• HAOFKAFMTMORGA-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3C=CC(C)=CN3C=2)C(=O)O2)C2=C1 HAOFKAFMTMORGA-UHFFFAOYSA-N 0.000 claims 1
• YCPLWESAQGHDRT-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-(8-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 YCPLWESAQGHDRT-UHFFFAOYSA-N 0.000 claims 1
• GBBUFBBSMXOSCO-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 GBBUFBBSMXOSCO-UHFFFAOYSA-N 0.000 claims 1
• VXCSUHPTTRITGQ-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-imidazo[2,1-b][1,3]thiazol-6-ylchromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 VXCSUHPTTRITGQ-UHFFFAOYSA-N 0.000 claims 1
• PPSCSRDIGYRPKI-UHFFFAOYSA-N 7-(4-ethylpiperazin-1-yl)-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1CN(CC)CCN1C1=CC=C(C=C(C2=NN3C=CC=CC3=C2)C(=O)O2)C2=C1 PPSCSRDIGYRPKI-UHFFFAOYSA-N 0.000 claims 1
• FPJLBOKQUWWYSA-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C2=CN3C=CN=C(C)C3=C2)C(=O)O2)C2=C1 FPJLBOKQUWWYSA-UHFFFAOYSA-N 0.000 claims 1
• OVBPUVSTJCJBLP-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(2-methyl-1-pyridin-2-ylimidazol-4-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C(C)N(C=2)C=2N=CC=CC=2)C(=O)O2)C2=C1 OVBPUVSTJCJBLP-UHFFFAOYSA-N 0.000 claims 1
• VFFYTERDHYVELL-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C3C=C2)C(=O)O2)C2=C1 VFFYTERDHYVELL-UHFFFAOYSA-N 0.000 claims 1
• YYCIKAANRUZJIW-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(2-methylimidazo[1,2-a]pyrimidin-6-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C3N=C2)C(=O)O2)C2=C1 YYCIKAANRUZJIW-UHFFFAOYSA-N 0.000 claims 1
• JQWIPIFRCRVQGM-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(2-methylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3SC(C)=NN3C=2)C(=O)O2)C2=C1 JQWIPIFRCRVQGM-UHFFFAOYSA-N 0.000 claims 1
• BFONMDKYQOBVTH-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3SC(C)=CN3C=2)C(=O)O2)C2=C1 BFONMDKYQOBVTH-UHFFFAOYSA-N 0.000 claims 1
• JSZGQPHKSQZGOG-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3SC=C(C)N3C=2)C(=O)O2)C2=C1 JSZGQPHKSQZGOG-UHFFFAOYSA-N 0.000 claims 1
• RQFORZIHZHMUOR-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 RQFORZIHZHMUOR-UHFFFAOYSA-N 0.000 claims 1
• VNWANZICEVKALV-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(4-methyl-1,3-thiazol-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2SC=C(C)N=2)C(=O)O2)C2=C1 VNWANZICEVKALV-UHFFFAOYSA-N 0.000 claims 1
• VSBYCLFKDWMXKD-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C2=NN3C=CC(C)=CC3=C2)C(=O)O2)C2=C1 VSBYCLFKDWMXKD-UHFFFAOYSA-N 0.000 claims 1
• BDHRZOTZACSONU-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 BDHRZOTZACSONU-UHFFFAOYSA-N 0.000 claims 1
• AXIOHGIZZOBHIM-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C=CC(C)=CN3C=2)C(=O)O2)C2=C1 AXIOHGIZZOBHIM-UHFFFAOYSA-N 0.000 claims 1
• XPTXQCIBLKKIDB-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3N=CC(C)=CN3C=2)C(=O)O2)C2=C1 XPTXQCIBLKKIDB-UHFFFAOYSA-N 0.000 claims 1
• NWWDRWXZEGPBAK-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C=C(C)C=CN3C=2)C(=O)O2)C2=C1 NWWDRWXZEGPBAK-UHFFFAOYSA-N 0.000 claims 1
• OOKQBFQJAQCUHU-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3N=C(C)C=CN3C=2)C(=O)O2)C2=C1 OOKQBFQJAQCUHU-UHFFFAOYSA-N 0.000 claims 1
• ALFNXFHJQWAVQK-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(8-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(C)=NC=CN3C=2)C(=O)O2)C2=C1 ALFNXFHJQWAVQK-UHFFFAOYSA-N 0.000 claims 1
• YQQLQWQNRILVSD-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(8-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 YQQLQWQNRILVSD-UHFFFAOYSA-N 0.000 claims 1
• IKBPUOVCHMHCAQ-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-(8-methylsulfanylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(SC)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCCN(C)CC1 IKBPUOVCHMHCAQ-UHFFFAOYSA-N 0.000 claims 1
• DDLQNFSAEKWQMZ-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 DDLQNFSAEKWQMZ-UHFFFAOYSA-N 0.000 claims 1
• IBPTVWRXGLAQCL-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-[8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C=2N=C3C(=CC=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 IBPTVWRXGLAQCL-UHFFFAOYSA-N 0.000 claims 1
• DVHLZQRBHDXEOD-UHFFFAOYSA-N 7-(4-methyl-1,4-diazepan-1-yl)-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1CN(C)CCCN1C1=CC=C(C=C(C2=NN3C=CC=CC3=C2)C(=O)O2)C2=C1 DVHLZQRBHDXEOD-UHFFFAOYSA-N 0.000 claims 1
• QIZDEBSPKLMGMW-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(1-methylpyrazol-3-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=NN(C)C=C2)C(=O)O2)C2=C1 QIZDEBSPKLMGMW-UHFFFAOYSA-N 0.000 claims 1
• CXKAHXJSKNNMFO-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=CN3C=CN=C(C)C3=C2)C(=O)O2)C2=C1 CXKAHXJSKNNMFO-UHFFFAOYSA-N 0.000 claims 1
• GNXLCMTXKBYQHE-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(1-phenylpyrazol-3-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=NN(C=C2)C=2C=CC=CC=2)C(=O)O2)C2=C1 GNXLCMTXKBYQHE-UHFFFAOYSA-N 0.000 claims 1
• MKMKCDHWRHIHBU-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(2-methylpyrimidin-4-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C(C)N=CC=2)C(=O)O2)C2=C1 MKMKCDHWRHIHBU-UHFFFAOYSA-N 0.000 claims 1
• OPYLDWHCJSZZFG-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 OPYLDWHCJSZZFG-UHFFFAOYSA-N 0.000 claims 1
• VEKLYLMRJRSMSR-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(4-phenyl-1,3-thiazol-2-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2SC=C(N=2)C=2C=CC=CC=2)C(=O)O2)C2=C1 VEKLYLMRJRSMSR-UHFFFAOYSA-N 0.000 claims 1
• ODWDRMBJEWXXTO-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=NN3C=CC(C)=CC3=C2)C(=O)O2)C2=C1 ODWDRMBJEWXXTO-UHFFFAOYSA-N 0.000 claims 1
• GBDKURDGOYFUTF-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(6-methylpyridin-3-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2C=NC(C)=CC=2)C(=O)O2)C2=C1 GBDKURDGOYFUTF-UHFFFAOYSA-N 0.000 claims 1
• HCYIBLJENAJNNN-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-(8-methylsulfanylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(SC)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C)CC1 HCYIBLJENAJNNN-UHFFFAOYSA-N 0.000 claims 1
• VYBVJRYHRKNMAE-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-([1,3]oxazolo[4,5-b]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2OC3=CC=CN=C3N=2)C(=O)O2)C2=C1 VYBVJRYHRKNMAE-UHFFFAOYSA-N 0.000 claims 1
• HTCYLQUFXLUYCR-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-[2-(trifluoromethyl)pyridin-3-yl]chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2C(=NC=CC=2)C(F)(F)F)C(=O)O2)C2=C1 HTCYLQUFXLUYCR-UHFFFAOYSA-N 0.000 claims 1
• MVKDLIZETRJIDX-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-[3-(trifluoromethyl)phenyl]chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2C=C(C=CC=2)C(F)(F)F)C(=O)O2)C2=C1 MVKDLIZETRJIDX-UHFFFAOYSA-N 0.000 claims 1
• HHQGBHVJEOFIEN-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2SC=C(N=2)C(F)(F)F)C(=O)O2)C2=C1 HHQGBHVJEOFIEN-UHFFFAOYSA-N 0.000 claims 1
• ZTVWTBAQEHZPTJ-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1CN(C)CCN1C1=CC=C(C=C(C=2SC=C(N=2)C(F)(F)F)C(=O)O2)C2=C1 ZTVWTBAQEHZPTJ-UHFFFAOYSA-N 0.000 claims 1
• PWDVIXJKKBSQLA-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 PWDVIXJKKBSQLA-UHFFFAOYSA-N 0.000 claims 1
• SZFDURCEXGFOTI-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-[8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C=2N=C3C(=CC=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 SZFDURCEXGFOTI-UHFFFAOYSA-N 0.000 claims 1
• PDPCDSPPRDRSME-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=NN3C=CC=CC3=C2)C(=O)O2)C2=C1 PDPCDSPPRDRSME-UHFFFAOYSA-N 0.000 claims 1
• DAUNOTJTOYQGCL-UHFFFAOYSA-N 7-(4-methylpiperazin-1-yl)-3-thiophen-3-ylchromen-2-one Chemical compound C1CN(C)CCN1C1=CC=C(C=C(C2=CSC=C2)C(=O)O2)C2=C1 DAUNOTJTOYQGCL-UHFFFAOYSA-N 0.000 claims 1
• JFMPAUAHFCDAMD-UHFFFAOYSA-N 7-(4-propan-2-ylpiperazin-1-yl)-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1CN(C(C)C)CCN1C1=CC=C(C=C(C2=NN3C=CC=CC3=C2)C(=O)O2)C2=C1 JFMPAUAHFCDAMD-UHFFFAOYSA-N 0.000 claims 1
• SJGAPUAWQUBCRU-UHFFFAOYSA-N 7-(4-propylpiperazin-1-yl)-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1CN(CCC)CCN1C1=CC=C(C=C(C2=NN3C=CC=CC3=C2)C(=O)O2)C2=C1 SJGAPUAWQUBCRU-UHFFFAOYSA-N 0.000 claims 1
• KBXWTNXEDMYCPE-UHFFFAOYSA-N 7-(4-tert-butylpiperazin-1-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C(C)(C)C)CC1 KBXWTNXEDMYCPE-UHFFFAOYSA-N 0.000 claims 1
• UJTKLRLURGSSAT-UHFFFAOYSA-N 7-(5,8-diazaspiro[3.5]nonan-8-yl)-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(C1)CCNC21CCC2 UJTKLRLURGSSAT-UHFFFAOYSA-N 0.000 claims 1
• VTFIWEUCYPZMNL-UHFFFAOYSA-N 7-(5,8-diazaspiro[3.5]nonan-8-yl)-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=C(F)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N(C1)CCNC21CCC2 VTFIWEUCYPZMNL-UHFFFAOYSA-N 0.000 claims 1
• MJJQMGXNAZWNEI-UHFFFAOYSA-N 7-(6,9-diazaspiro[4.5]decan-9-yl)-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C=C(C)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(C1)CCNC21CCCC2 MJJQMGXNAZWNEI-UHFFFAOYSA-N 0.000 claims 1
• QLJQCTMDYUHPPF-UHFFFAOYSA-N 7-(6,9-diazaspiro[4.5]decan-9-yl)-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=C(F)C2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2N(C1)CCNC21CCCC2 QLJQCTMDYUHPPF-UHFFFAOYSA-N 0.000 claims 1
• NDAPBVHOHXBLRZ-UHFFFAOYSA-N 7-(6-amino-2-azaspiro[3.3]heptan-2-yl)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(C1)CC21CC(N)C2 NDAPBVHOHXBLRZ-UHFFFAOYSA-N 0.000 claims 1
• ARQNHBOFYJFIQZ-UHFFFAOYSA-N 7-(azetidin-3-ylamino)-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2NC1CNC1 ARQNHBOFYJFIQZ-UHFFFAOYSA-N 0.000 claims 1
• JIRFSRRNLCZBMW-UHFFFAOYSA-N 7-[(1-benzylpyrrolidin-3-yl)-methylamino]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4C(C)=NC(C)=CN4C=3)C(=O)OC2=CC=1N(C)C(C1)CCN1CC1=CC=CC=C1 JIRFSRRNLCZBMW-UHFFFAOYSA-N 0.000 claims 1
• LJYBJJSUFWWWJI-UHFFFAOYSA-N 7-[(1-benzylpyrrolidin-3-yl)-methylamino]-3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound C=1C=C2C=C(C=3N=C4N=C(C)C=CN4C=3)C(=O)OC2=CC=1N(C)C(C1)CCN1CC1=CC=CC=C1 LJYBJJSUFWWWJI-UHFFFAOYSA-N 0.000 claims 1
• UADPLSXOAINJKH-UHFFFAOYSA-N 7-[(1-hydroxypropan-2-ylamino)methyl]-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1=C(C)C=CC2=NC(C3=CC4=CC=C(C=C4OC3=O)CNC(CO)C)=CN21 UADPLSXOAINJKH-UHFFFAOYSA-N 0.000 claims 1
• UPRDHFPQEHFNGZ-KDURUIRLSA-N 7-[(1R,5S)-8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl]-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound CN1[C@H]2CN(C[C@@H]1CC2)C1=CC=C2C=C(C(OC2=C1)=O)C=1N=C2N(C=CC(=C2)C)C=1 UPRDHFPQEHFNGZ-KDURUIRLSA-N 0.000 claims 1
• QOUOKELQWNQUNF-ZFWWWQNUSA-N 7-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-(3,4-dimethoxyphenyl)-5-fluorochromen-2-one Chemical compound [C@@H]12N(C[C@@H](NC1)C2)C2=CC(=C1C=C(C(OC1=C2)=O)C2=CC(=C(C=C2)OC)OC)F QOUOKELQWNQUNF-ZFWWWQNUSA-N 0.000 claims 1
• IJZJGKWRSNADHR-HOCLYGCPSA-N 7-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound [C@@H]12N(C[C@@H](NC1)C2)C2=CC=C1C=C(C(OC1=C2)=O)C=2N=C1N(C=C(N=C1)C)C2 IJZJGKWRSNADHR-HOCLYGCPSA-N 0.000 claims 1
• ZBENNNYWVRFATP-RDJZCZTQSA-N 7-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound [C@@H]12N(C[C@@H](NC1)C2)C2=CC=C1C=C(C(OC1=C2)=O)C=2N=C1N(C=C(C=C1)C)C2 ZBENNNYWVRFATP-RDJZCZTQSA-N 0.000 claims 1
• NHYPFTPNJWWMNQ-JQWIXIFHSA-N 7-[(1s,4s)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one Chemical compound FC(F)(F)C1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2[C@H]3C[C@H](NC3)C2)=O)=N1 NHYPFTPNJWWMNQ-JQWIXIFHSA-N 0.000 claims 1
• SLPAGAPOVPTRLD-ZFWWWQNUSA-N 7-[(1s,4s)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one Chemical compound C1=CC=NC2=NC(C3=CC=4C=CC(=CC=4OC3=O)N3[C@H]4C[C@H](NC4)C3)=CN21 SLPAGAPOVPTRLD-ZFWWWQNUSA-N 0.000 claims 1
• RZPZGZNQKGOTHG-SLHAJLBXSA-N 7-[(1s,4s)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one;hydrochloride Chemical compound Cl.C1=CC=NC2=NC(C3=CC=4C=CC(=CC=4OC3=O)N3[C@H]4C[C@H](NC4)C3)=CN21 RZPZGZNQKGOTHG-SLHAJLBXSA-N 0.000 claims 1
• SXDOIMMLEGXICK-JKSUJKDBSA-N 7-[(2r,5s)-2,5-dimethylpiperazin-1-yl]-3-(8-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C[C@@H]1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 SXDOIMMLEGXICK-JKSUJKDBSA-N 0.000 claims 1
• BQHYONNGZBTZCI-UONOGXRCSA-N 7-[(2r,5s)-2,5-dimethylpiperazin-1-yl]-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C[C@@H]1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 BQHYONNGZBTZCI-UONOGXRCSA-N 0.000 claims 1
• INHLXAHCBWPECJ-YPMHNXCESA-N 7-[(2s,5r)-2,5-dimethylpiperazin-1-yl]-3-(4-methyl-1,3-thiazol-2-yl)chromen-2-one Chemical compound C[C@H]1CN[C@H](C)CN1C1=CC=C(C=C(C=2SC=C(C)N=2)C(=O)O2)C2=C1 INHLXAHCBWPECJ-YPMHNXCESA-N 0.000 claims 1
• SNSFKKZCZRLUJP-UHFFFAOYSA-N 7-[(3-hydroxypyrrolidin-1-yl)methyl]-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2CN1CCC(O)C1 SNSFKKZCZRLUJP-UHFFFAOYSA-N 0.000 claims 1
• CESPEISJIISOTR-OAHLLOKOSA-N 7-[(3R)-3,4-dimethylpiperazin-1-yl]-3-(2-methylimidazo[1,2-a]pyrimidin-6-yl)chromen-2-one Chemical compound C[C@@H]1CN(CCN1C)C1=CC=C2C=C(C(OC2=C1)=O)C=1C=NC=2N(C=1)C=C(N=2)C CESPEISJIISOTR-OAHLLOKOSA-N 0.000 claims 1
• JZQWUKQXNFNWLI-GASCZTMLSA-N 7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C[C@@H]1CN(C[C@@H](N1)C)C1=CC=C2C=C(C(OC2=C1)=O)C=1N=C2N(C=C(C=C2F)C)C=1 JZQWUKQXNFNWLI-GASCZTMLSA-N 0.000 claims 1
• LKJQRKHRHBLTBC-IBGZPJMESA-N 7-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-3-(2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound CN([C@@H]1CN(CC1)C1=CC=C2C=C(C(OC2=C1)=O)C=1C=CC=2N(C=1)C=C(N=2)C)C LKJQRKHRHBLTBC-IBGZPJMESA-N 0.000 claims 1
• QMVXWTYGGHBGER-OXJNMPFZSA-N 7-[(3aS,6aS)-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[2,3-c]pyrrol-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound CC=1N=C(C=2N(C=1)C=C(N=2)C=1C(OC2=CC(=CC=C2C=1)N1[C@H]2[C@@H](CC1)CNC2)=O)C QMVXWTYGGHBGER-OXJNMPFZSA-N 0.000 claims 1
• YLPYQMZVJVMPPE-LAUBAEHRSA-N 7-[(3aS,6aS)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound CC=1N=C(C=2N(C=1)C=C(N=2)C=1C(OC2=CC(=CC=C2C=1)N1[C@H]2[C@@H](CC1)CN(C2)C)=O)C YLPYQMZVJVMPPE-LAUBAEHRSA-N 0.000 claims 1
• UDNFWOTUWJTLNO-JPYJTQIMSA-N 7-[(3ar,6ar)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(=O)OC1=C2)=CC1=CC=C2N1C[C@H]2CCN(C)[C@H]2C1 UDNFWOTUWJTLNO-JPYJTQIMSA-N 0.000 claims 1
• YUMBGLAOOAUSOU-UTKZUKDTSA-N 7-[(3ar,6ar)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@H]4CCN([C@H]4C3)C)=CN21 YUMBGLAOOAUSOU-UTKZUKDTSA-N 0.000 claims 1
• FYQHLVBQNGWUFT-IYBDPMFKSA-N 7-[(3ar,6as)-2,3,3a,4,6,6a-hexahydro-1h-pyrrolo[3,4-c]pyrrol-5-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H]2CNC[C@H]2C1 FYQHLVBQNGWUFT-IYBDPMFKSA-N 0.000 claims 1
• PXQUFLVCKRPSGA-KDURUIRLSA-N 7-[(3ar,6as)-2-ethyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@@H]4CN(C[C@@H]4C3)CC)=CN21 PXQUFLVCKRPSGA-KDURUIRLSA-N 0.000 claims 1
• LJAWFJSQTCGJQU-BGYRXZFFSA-N 7-[(3ar,6as)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(=O)OC1=C2)=CC1=CC=C2N1C[C@@H]2CN(C)C[C@@H]2C1 LJAWFJSQTCGJQU-BGYRXZFFSA-N 0.000 claims 1
• XKFZPKDBZOGPBP-HDICACEKSA-N 7-[(3ar,6as)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@@H]4CN(C[C@@H]4C3)C)=CN21 XKFZPKDBZOGPBP-HDICACEKSA-N 0.000 claims 1
• SZTOJJHZIDWOSC-CALCHBBNSA-N 7-[(3as,6ar)-2,3,3a,4,6,6a-hexahydro-1h-pyrrolo[3,4-c]pyrrol-5-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H]2CNC[C@H]2C1 SZTOJJHZIDWOSC-CALCHBBNSA-N 0.000 claims 1
• LXKZMBCRZCEMLA-KDURUIRLSA-N 7-[(3as,6ar)-2-(2-hydroxyethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H]2CN(CCO)C[C@H]2C1 LXKZMBCRZCEMLA-KDURUIRLSA-N 0.000 claims 1
• UDNFWOTUWJTLNO-FDDCHVKYSA-N 7-[(3as,6as)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(=O)OC1=C2)=CC1=CC=C2N1C[C@@H]2CCN(C)[C@@H]2C1 UDNFWOTUWJTLNO-FDDCHVKYSA-N 0.000 claims 1
• YUMBGLAOOAUSOU-LAUBAEHRSA-N 7-[(3as,6as)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@@H]4CCN([C@@H]4C3)C)=CN21 YUMBGLAOOAUSOU-LAUBAEHRSA-N 0.000 claims 1
• GNGVJTMNZZEEMJ-MRXNPFEDSA-N 7-[(3r)-3,4-dimethylpiperazin-1-yl]-3-(2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=C3C=C2)C(=O)O2)C2=C1 GNGVJTMNZZEEMJ-MRXNPFEDSA-N 0.000 claims 1
• NFXWFLCKFXMKIC-OAHLLOKOSA-N 7-[(3r)-3,4-dimethylpiperazin-1-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 NFXWFLCKFXMKIC-OAHLLOKOSA-N 0.000 claims 1
• UQHNUAZOORZNOU-OAHLLOKOSA-N 7-[(3r)-3,4-dimethylpiperazin-1-yl]-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(C)=CN3C=2)C(=O)O2)C2=C1 UQHNUAZOORZNOU-OAHLLOKOSA-N 0.000 claims 1
• LKCWJYDOJHVSRH-OAHLLOKOSA-N 7-[(3r)-3,4-dimethylpiperazin-1-yl]-3-(8-methoxy-6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(OC)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(C)[C@H](C)C1 LKCWJYDOJHVSRH-OAHLLOKOSA-N 0.000 claims 1
• WKOKBHAUYFFACL-OAHLLOKOSA-N 7-[(3r)-3-(aminomethyl)pyrrolidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CC[C@H](CN)C1 WKOKBHAUYFFACL-OAHLLOKOSA-N 0.000 claims 1
• FKPURNRXSHBFDM-HXUWFJFHSA-N 7-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1[C@H](N(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 FKPURNRXSHBFDM-HXUWFJFHSA-N 0.000 claims 1
• ZZNBUOGAUBYQDE-LJQANCHMSA-N 7-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1[C@H](N(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 ZZNBUOGAUBYQDE-LJQANCHMSA-N 0.000 claims 1
• CLESMTCZJDWAJT-GOSISDBHSA-N 7-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@H](N(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 CLESMTCZJDWAJT-GOSISDBHSA-N 0.000 claims 1
• VBHRNAXFLDMIMI-QGZVFWFLSA-N 7-[(3r)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@@H](CN(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 VBHRNAXFLDMIMI-QGZVFWFLSA-N 0.000 claims 1
• BUMJFTFHKJYODF-CQSZACIVSA-N 7-[(3r)-3-methylpiperazin-1-yl]-3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C2=CN3C=CN=C(C)C3=C2)C(=O)O2)C2=C1 BUMJFTFHKJYODF-CQSZACIVSA-N 0.000 claims 1
• QIAQAXIINKAEDE-CQSZACIVSA-N 7-[(3r)-3-methylpiperazin-1-yl]-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 QIAQAXIINKAEDE-CQSZACIVSA-N 0.000 claims 1
• FUEDMEPMIYMTAX-LLVKDONJSA-N 7-[(3r)-3-methylpiperazin-1-yl]-3-(4-methyl-1,3-thiazol-2-yl)chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2SC=C(C)N=2)C(=O)O2)C2=C1 FUEDMEPMIYMTAX-LLVKDONJSA-N 0.000 claims 1
• BXPMKNFBZJPDFW-OAHLLOKOSA-N 7-[(3r)-3-methylpiperazin-1-yl]-3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C2=NN3C=CC(C)=CC3=C2)C(=O)O2)C2=C1 BXPMKNFBZJPDFW-OAHLLOKOSA-N 0.000 claims 1
• OJCCOGPRYSDGIN-SNVBAGLBSA-N 7-[(3r)-3-methylpiperazin-1-yl]-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2SC=C(N=2)C(F)(F)F)C(=O)O2)C2=C1 OJCCOGPRYSDGIN-SNVBAGLBSA-N 0.000 claims 1
• HNSHDWIBXZZKAU-CYBMUJFWSA-N 7-[(3r)-3-methylpiperazin-1-yl]-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1CN[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 HNSHDWIBXZZKAU-CYBMUJFWSA-N 0.000 claims 1
• BCGJFNHIOWPOKH-FGZHOGPDSA-N 7-[(3r,4r)-3-(dimethylamino)-4-hydroxypyrrolidin-1-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1[C@@H](O)[C@H](N(C)C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 BCGJFNHIOWPOKH-FGZHOGPDSA-N 0.000 claims 1
• WKUWNFXMMGNCNE-GASCZTMLSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-2-oxo-n-phenylchromene-3-carboxamide Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C(=O)NC=2C=CC=CC=2)C(=O)O2)C2=C1 WKUWNFXMMGNCNE-GASCZTMLSA-N 0.000 claims 1
• DJGXAZOLZLHBOG-GASCZTMLSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 DJGXAZOLZLHBOG-GASCZTMLSA-N 0.000 claims 1
• DDXBTMDWASWEFT-CALCHBBNSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(1-phenylimidazol-4-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=CN(C=2)C=2C=CC=CC=2)C(=O)O2)C2=C1 DDXBTMDWASWEFT-CALCHBBNSA-N 0.000 claims 1
• ZAHWUCLPWJJHHC-BETUJISGSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(4-fluoro-1,3-benzoxazol-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=CC=CC(F)=C3N=2)C(=O)O2)C2=C1 ZAHWUCLPWJJHHC-BETUJISGSA-N 0.000 claims 1
• RXQJLYWXACYOJS-IYBDPMFKSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(4-methoxy-3-methylphenyl)chromen-2-one Chemical compound C1=C(C)C(OC)=CC=C1C1=CC2=CC=C(N3C[C@@H](C)N[C@@H](C)C3)C=C2OC1=O RXQJLYWXACYOJS-IYBDPMFKSA-N 0.000 claims 1
• ZFQPWOULGDMHBO-GASCZTMLSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(4-methyl-1,3-benzoxazol-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=CC=CC(C)=C3N=2)C(=O)O2)C2=C1 ZFQPWOULGDMHBO-GASCZTMLSA-N 0.000 claims 1
• QDDJBOVUFDSONW-OKILXGFUSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(6-methoxypyridin-2-yl)chromen-2-one Chemical compound COC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2C[C@@H](C)N[C@@H](C)C2)=O)=N1 QDDJBOVUFDSONW-OKILXGFUSA-N 0.000 claims 1
• OIRGRNOOQFBRAU-GASCZTMLSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC(C)=CN3C=2)C(=O)O2)C2=C1 OIRGRNOOQFBRAU-GASCZTMLSA-N 0.000 claims 1
• NSMJYJHVAIQGMD-IYBDPMFKSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(7-ethylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C=C(CC)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H](C)N[C@H](C)C1 NSMJYJHVAIQGMD-IYBDPMFKSA-N 0.000 claims 1
• OOLDDNUVASFMDT-CALCHBBNSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(8-ethyl-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C(CC)=CC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H](C)N[C@H](C)C1 OOLDDNUVASFMDT-CALCHBBNSA-N 0.000 claims 1
• RVTNNMSAKXXYCB-OKILXGFUSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC=CN3C=2)C(=O)O2)C2=C1 RVTNNMSAKXXYCB-OKILXGFUSA-N 0.000 claims 1
• QWCMTJZFDDCDQH-GASCZTMLSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(8-methoxyimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C(OC)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H](C)N[C@H](C)C1 QWCMTJZFDDCDQH-GASCZTMLSA-N 0.000 claims 1
• XXCGYSAFCHWWSI-IYBDPMFKSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-(8-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=CC=CN3C=2)C(=O)O2)C2=C1 XXCGYSAFCHWWSI-IYBDPMFKSA-N 0.000 claims 1
• YHYPIKUZSJOCDT-PHIMTYICSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2SC=C(N=2)C(F)(F)F)C(=O)O2)C2=C1 YHYPIKUZSJOCDT-PHIMTYICSA-N 0.000 claims 1
• HTTZWDARAQHBMV-OKILXGFUSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 HTTZWDARAQHBMV-OKILXGFUSA-N 0.000 claims 1
• RPNCAUKGJVOPFA-OKILXGFUSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-[8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(=CC=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 RPNCAUKGJVOPFA-OKILXGFUSA-N 0.000 claims 1
• VIJCSBAIULQYFE-GASCZTMLSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-imidazo[1,2-a]pyridin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC=CN3C=2)C(=O)O2)C2=C1 VIJCSBAIULQYFE-GASCZTMLSA-N 0.000 claims 1
• BSGMUQDAVHDGCL-OKILXGFUSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 BSGMUQDAVHDGCL-OKILXGFUSA-N 0.000 claims 1
• FEAPUZSHHPJWMS-GASCZTMLSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C2=NN3C=CC=CC3=C2)C(=O)O2)C2=C1 FEAPUZSHHPJWMS-GASCZTMLSA-N 0.000 claims 1
• WCRBRNRUBHSFCM-BETUJISGSA-N 7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-3-thiophen-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2SC=CC=2)C(=O)O2)C2=C1 WCRBRNRUBHSFCM-BETUJISGSA-N 0.000 claims 1
• HDXTYAXXSXBZJZ-CALCHBBNSA-N 7-[(3r,5s)-4-ethyl-3,5-dimethylpiperazin-1-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N(CC)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 HDXTYAXXSXBZJZ-CALCHBBNSA-N 0.000 claims 1
• HSMDUPVUUOMEQS-AWEZNQCLSA-N 7-[(3s)-3,4-dimethylpiperazin-1-yl]-3-(2-methyl-1,3-benzothiazol-6-yl)chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC=C(C=C(C=2C=C3SC(C)=NC3=CC=2)C(=O)O2)C2=C1 HSMDUPVUUOMEQS-AWEZNQCLSA-N 0.000 claims 1
• OGQCEDNNIMVIDH-INIZCTEOSA-N 7-[(3s)-3,4-dimethylpiperazin-1-yl]-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C)C=CN3C=2)C(=O)O2)C2=C1 OGQCEDNNIMVIDH-INIZCTEOSA-N 0.000 claims 1
• UQHNUAZOORZNOU-HNNXBMFYSA-N 7-[(3s)-3,4-dimethylpiperazin-1-yl]-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC(C)=CN3C=2)C(=O)O2)C2=C1 UQHNUAZOORZNOU-HNNXBMFYSA-N 0.000 claims 1
• TTXPWMBSQLQKER-AWEZNQCLSA-N 7-[(3s)-3,4-dimethylpiperazin-1-yl]-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(F)=CC=CN3C=2)C(=O)O2)C2=C1 TTXPWMBSQLQKER-AWEZNQCLSA-N 0.000 claims 1
• QEDWELKSJXTXOT-AWEZNQCLSA-N 7-[(3s)-3,4-dimethylpiperazin-1-yl]-5-fluoro-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN(C)[C@@H](C)CN1C1=CC(F)=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 QEDWELKSJXTXOT-AWEZNQCLSA-N 0.000 claims 1
• WKOKBHAUYFFACL-HNNXBMFYSA-N 7-[(3s)-3-(aminomethyl)pyrrolidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CC[C@@H](CN)C1 WKOKBHAUYFFACL-HNNXBMFYSA-N 0.000 claims 1
• FKPURNRXSHBFDM-FQEVSTJZSA-N 7-[(3s)-3-(dimethylamino)pyrrolidin-1-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1[C@@H](N(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 FKPURNRXSHBFDM-FQEVSTJZSA-N 0.000 claims 1
• ZZNBUOGAUBYQDE-IBGZPJMESA-N 7-[(3s)-3-(dimethylamino)pyrrolidin-1-yl]-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1[C@@H](N(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 ZZNBUOGAUBYQDE-IBGZPJMESA-N 0.000 claims 1
• CLESMTCZJDWAJT-SFHVURJKSA-N 7-[(3s)-3-(dimethylamino)pyrrolidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@@H](N(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 CLESMTCZJDWAJT-SFHVURJKSA-N 0.000 claims 1
• VBHRNAXFLDMIMI-KRWDZBQOSA-N 7-[(3s)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@H](CN(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 VBHRNAXFLDMIMI-KRWDZBQOSA-N 0.000 claims 1
• BUMJFTFHKJYODF-AWEZNQCLSA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=CN=C(C)C3=C2)C(=O)O2)C2=C1 BUMJFTFHKJYODF-AWEZNQCLSA-N 0.000 claims 1
• QIAQAXIINKAEDE-AWEZNQCLSA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 QIAQAXIINKAEDE-AWEZNQCLSA-N 0.000 claims 1
• FUEDMEPMIYMTAX-NSHDSACASA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-(4-methyl-1,3-thiazol-2-yl)chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2SC=C(C)N=2)C(=O)O2)C2=C1 FUEDMEPMIYMTAX-NSHDSACASA-N 0.000 claims 1
• HKPNTUGVJGMLPD-ZDUSSCGKSA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=C(C=CC=2)C(F)(F)F)C(=O)O2)C2=C1 HKPNTUGVJGMLPD-ZDUSSCGKSA-N 0.000 claims 1
• OJCCOGPRYSDGIN-JTQLQIEISA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2SC=C(N=2)C(F)(F)F)C(=O)O2)C2=C1 OJCCOGPRYSDGIN-JTQLQIEISA-N 0.000 claims 1
• HNSHDWIBXZZKAU-ZDUSSCGKSA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 HNSHDWIBXZZKAU-ZDUSSCGKSA-N 0.000 claims 1
• NNZJHOAMBYZPJK-ZDUSSCGKSA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-pyridin-2-ylchromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2N=CC=CC=2)C(=O)O2)C2=C1 NNZJHOAMBYZPJK-ZDUSSCGKSA-N 0.000 claims 1
• ZIZZTOWHTRIEFQ-ZDUSSCGKSA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-pyridin-4-ylchromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2C=CN=CC=2)C(=O)O2)C2=C1 ZIZZTOWHTRIEFQ-ZDUSSCGKSA-N 0.000 claims 1
• IWJOTCVMUOZAGB-ZDUSSCGKSA-N 7-[(3s)-3-methylpiperazin-1-yl]-3-thieno[3,2-c]pyridin-2-ylchromen-2-one Chemical compound C1CN[C@@H](C)CN1C1=CC=C(C=C(C=2SC3=CC=NC=C3C=2)C(=O)O2)C2=C1 IWJOTCVMUOZAGB-ZDUSSCGKSA-N 0.000 claims 1
• RHNKBLAJOXLQSM-HNNXBMFYSA-N 7-[(3s)-4-ethyl-3-methylpiperazin-1-yl]-3-(2-methyl-1,3-benzothiazol-6-yl)chromen-2-one Chemical compound C1[C@H](C)N(CC)CCN1C1=CC=C(C=C(C=2C=C3SC(C)=NC3=CC=2)C(=O)O2)C2=C1 RHNKBLAJOXLQSM-HNNXBMFYSA-N 0.000 claims 1
• ZRRDOWBQDYICPB-INIZCTEOSA-N 7-[(3s)-4-ethyl-3-methylpiperazin-1-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@H](C)N(CC)CCN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 ZRRDOWBQDYICPB-INIZCTEOSA-N 0.000 claims 1
• APRVLQIYZTVDPW-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=CN=C(C)C3=C2)C(=O)O2)C2=C1 APRVLQIYZTVDPW-GASCZTMLSA-N 0.000 claims 1
• SXXUXPLJZWKWFC-IYBDPMFKSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(1-pyridin-2-ylimidazol-4-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=CN(C=2)C=2N=CC=CC=2)C(=O)O2)C2=C1 SXXUXPLJZWKWFC-IYBDPMFKSA-N 0.000 claims 1
• PEAPWGRHPWDFKB-OKILXGFUSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(2-ethylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound N1=C2SC(CC)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H](C)N[C@H](C)C1 PEAPWGRHPWDFKB-OKILXGFUSA-N 0.000 claims 1
• DYIRCOMBHYAAPT-TXEJJXNPSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(2-methylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3SC(C)=NN3C=2)C(=O)O2)C2=C1 DYIRCOMBHYAAPT-TXEJJXNPSA-N 0.000 claims 1
• QOGWHFGUWOMXAZ-BETUJISGSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3SC(C)=CN3C=2)C(=O)O2)C2=C1 QOGWHFGUWOMXAZ-BETUJISGSA-N 0.000 claims 1
• GQLOMUMYPIQWLC-IYBDPMFKSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(2-methylpyrrolo[1,2-b]pyridazin-6-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C2=CN3N=C(C)C=CC3=C2)C(=O)O2)C2=C1 GQLOMUMYPIQWLC-IYBDPMFKSA-N 0.000 claims 1
• YLYHQDYEHHDAOR-BETUJISGSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3SC=C(C)N3C=2)C(=O)O2)C2=C1 YLYHQDYEHHDAOR-BETUJISGSA-N 0.000 claims 1
• GYZDCWWQOIGIEG-IYBDPMFKSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 GYZDCWWQOIGIEG-IYBDPMFKSA-N 0.000 claims 1
• IWYNCVCSUUGAFA-TXEJJXNPSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(4-methyl-1,3-thiazol-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2SC=C(C)N=2)C(=O)O2)C2=C1 IWYNCVCSUUGAFA-TXEJJXNPSA-N 0.000 claims 1
• VHERVRDSZJOLKY-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(5-methylfuro[3,2-b]pyridin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2OC3=CC=C(C)N=C3C=2)C(=O)O2)C2=C1 VHERVRDSZJOLKY-GASCZTMLSA-N 0.000 claims 1
• MHWBJXZVZDWWQK-IYBDPMFKSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(5-methylpyrazolo[1,5-a]pyridin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C2=NN3C=CC(C)=CC3=C2)C(=O)O2)C2=C1 MHWBJXZVZDWWQK-IYBDPMFKSA-N 0.000 claims 1
• YZHLOMVBSGCXMU-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(6-fluoro-8-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=CC(F)=CN3C=2)C(=O)O2)C2=C1 YZHLOMVBSGCXMU-GASCZTMLSA-N 0.000 claims 1
• CTQBZGOEZDSKSF-BETUJISGSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(6-fluoroimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=CC(F)=CN3C=2)C(=O)O2)C2=C1 CTQBZGOEZDSKSF-BETUJISGSA-N 0.000 claims 1
• RYCOAJMFSYQAQC-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(6-methyl-8-nitroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C([N+]([O-])=O)=CC(C)=CN3C=2)C(=O)O2)C2=C1 RYCOAJMFSYQAQC-GASCZTMLSA-N 0.000 claims 1
• INFBOMZBTFNHFY-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=NC(C)=CN3C=2)C(=O)O2)C2=C1 INFBOMZBTFNHFY-GASCZTMLSA-N 0.000 claims 1
• GJSLIQHXFMYURR-IYBDPMFKSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC(C)=CN3C=2)C(=O)O2)C2=C1 GJSLIQHXFMYURR-IYBDPMFKSA-N 0.000 claims 1
• HGBGOMDXSWONBI-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(6-methylimidazo[1,2-b]pyridazin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC(C)=NN3C=2)C(=O)O2)C2=C1 HGBGOMDXSWONBI-GASCZTMLSA-N 0.000 claims 1
• ZQOXODRBBDISQD-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(7-methoxyimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C=C(OC)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H](C)N[C@H](C)C1 ZQOXODRBBDISQD-GASCZTMLSA-N 0.000 claims 1
• RLGDWMLIOIDCDP-IYBDPMFKSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=C(C)C=CN3C=2)C(=O)O2)C2=C1 RLGDWMLIOIDCDP-IYBDPMFKSA-N 0.000 claims 1
• SMKNFDMREWHIAF-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3N=C(C)C=CN3C=2)C(=O)O2)C2=C1 SMKNFDMREWHIAF-GASCZTMLSA-N 0.000 claims 1
• IYWNAQQTEKLRQS-OKILXGFUSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(8-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC=CN3C=2)C(=O)O2)C2=C1 IYWNAQQTEKLRQS-OKILXGFUSA-N 0.000 claims 1
• DVQOCBQTWRIEBL-OKILXGFUSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-(8-methylsulfanylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(SC)=NC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1C[C@H](C)N[C@H](C)C1 DVQOCBQTWRIEBL-OKILXGFUSA-N 0.000 claims 1
• ANSLPJYVJCHLLL-OKILXGFUSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-imidazo[1,2-a]pyrazin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=NC=CN3C=2)C(=O)O2)C2=C1 ANSLPJYVJCHLLL-OKILXGFUSA-N 0.000 claims 1
• NAYQDXUGNFQTSS-OKILXGFUSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-imidazo[1,2-c]pyrimidin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CN=CN3C=2)C(=O)O2)C2=C1 NAYQDXUGNFQTSS-OKILXGFUSA-N 0.000 claims 1
• NCEQGCUHZBQJKN-BETUJISGSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-imidazo[2,1-b][1,3]thiazol-6-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 NCEQGCUHZBQJKN-BETUJISGSA-N 0.000 claims 1
• PDRCQAUOAWNATE-IYBDPMFKSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-indolizin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=CC=CC3=C2)C(=O)O2)C2=C1 PDRCQAUOAWNATE-IYBDPMFKSA-N 0.000 claims 1
• KVVVDIGKGMYJJH-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-pyrrolo[1,2-a]pyrimidin-7-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C2=CN3C=CC=NC3=C2)C(=O)O2)C2=C1 KVVVDIGKGMYJJH-GASCZTMLSA-N 0.000 claims 1
• OWXQLYDFPFRLNW-GASCZTMLSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-quinoxalin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2N=C3C=CC=CC3=NC=2)C(=O)O2)C2=C1 OWXQLYDFPFRLNW-GASCZTMLSA-N 0.000 claims 1
• VIWCMTYDRYDFKC-OKILXGFUSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-3-thieno[3,2-c]pyridin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC=C(C=C(C=2SC3=CC=NC=C3C=2)C(=O)O2)C2=C1 VIWCMTYDRYDFKC-OKILXGFUSA-N 0.000 claims 1
• TZCCHOWKZMIKGK-TXEJJXNPSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-5-fluoro-3-(4-fluoro-1,3-benzoxazol-2-yl)chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC(F)=C(C=C(C=2OC3=CC=CC(F)=C3N=2)C(=O)O2)C2=C1 TZCCHOWKZMIKGK-TXEJJXNPSA-N 0.000 claims 1
• QTHBFUIHILMZKD-BETUJISGSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-5-fluoro-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC(F)=C(C=C(C=2N=C3C=C(C=CN3C=2)C(F)(F)F)C(=O)O2)C2=C1 QTHBFUIHILMZKD-BETUJISGSA-N 0.000 claims 1
• WVGHRYGWTAPWDH-BETUJISGSA-N 7-[(3s,5r)-3,5-dimethylpiperazin-1-yl]-5-fluoro-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=CC(F)=C(C=C(C=2N=C3N=CC=CN3C=2)C(=O)O2)C2=C1 WVGHRYGWTAPWDH-BETUJISGSA-N 0.000 claims 1
• OUOPXEROWTXYCR-UHFFFAOYSA-N 7-[(4-hydroxypiperidin-1-yl)methyl]-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2)=O)=CC1=CC=C2CN1CCC(O)CC1 OUOPXEROWTXYCR-UHFFFAOYSA-N 0.000 claims 1
• NPIAWJSKUJESAE-UHFFFAOYSA-N 7-[(4-hydroxypiperidin-1-yl)methyl]-3-imidazo[2,1-b][1,3]thiazol-6-ylchromen-2-one Chemical compound C1CC(O)CCN1CC1=CC=C(C=C(C=2N=C3SC=CN3C=2)C(=O)O2)C2=C1 NPIAWJSKUJESAE-UHFFFAOYSA-N 0.000 claims 1
• PPJXGKYPVUWVBJ-APWZRJJASA-N 7-[(4ar,7ar)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C([C@@H]1C2)CCN[C@H]1CN2C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=CC2=N1 PPJXGKYPVUWVBJ-APWZRJJASA-N 0.000 claims 1
• VJWQPHHSDFLEJF-XXBNENTESA-N 7-[(4ar,7ar)-1-ethyl-3,4,4a,5,7,7a-hexahydro-2h-pyrrolo[3,4-b]pyridin-6-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@H]4CCCN([C@H]4C3)CC)=CN21 VJWQPHHSDFLEJF-XXBNENTESA-N 0.000 claims 1
• TUJVMUVNOXASGN-FXAWDEMLSA-N 7-[(4as,7as)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C([C@H]1C2)CCN[C@@H]1CN2C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=N1 TUJVMUVNOXASGN-FXAWDEMLSA-N 0.000 claims 1
• VJWQPHHSDFLEJF-WMZHIEFXSA-N 7-[(4as,7as)-1-ethyl-3,4,4a,5,7,7a-hexahydro-2h-pyrrolo[3,4-b]pyridin-6-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@@H]4CCCN([C@@H]4C3)CC)=CN21 VJWQPHHSDFLEJF-WMZHIEFXSA-N 0.000 claims 1
• SBIQSXJVVHYVRK-PGRDOPGGSA-N 7-[(4as,7as)-1-methyl-3,4,4a,5,7,7a-hexahydro-2h-pyrrolo[3,4-b]pyridin-6-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)N3C[C@@H]4CCCN([C@@H]4C3)C)=CN21 SBIQSXJVVHYVRK-PGRDOPGGSA-N 0.000 claims 1
• HEPCEFMLQAKJDK-LEWJYISDSA-N 7-[(7r,8as)-7-hydroxy-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN2C[C@H](O)C[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=C1 HEPCEFMLQAKJDK-LEWJYISDSA-N 0.000 claims 1
• HGWSUMCRSKTVAC-RBUKOAKNSA-N 7-[(7r,8as)-7-hydroxy-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN2C[C@H](O)C[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=N1 HGWSUMCRSKTVAC-RBUKOAKNSA-N 0.000 claims 1
• PHNGWWXQFSLTKH-SFHVURJKSA-N 7-[(8aS)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-3-(5-methylfuro[3,2-b]pyridin-2-yl)chromen-2-one Chemical compound C1[C@H]2N(CCN1C1=CC=C3C=C(C(OC3=C1)=O)C1=CC3=NC(=CC=C3O1)C)CCC2 PHNGWWXQFSLTKH-SFHVURJKSA-N 0.000 claims 1
• OJCVEIWREFIENF-SFHVURJKSA-N 7-[(8aS)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1[C@H]2N(CCN1C1=CC=C3C=C(C(OC3=C1)=O)C=1N=C3N(C=C(N=C3)C)C=1)CCC2 OJCVEIWREFIENF-SFHVURJKSA-N 0.000 claims 1
• RYQCOYWPBQOYNB-IBGZPJMESA-N 7-[(8aS)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1[C@H]2N(CCN1C1=CC=C3C=C(C(OC3=C1)=O)C=1N=C3N(C=CC(=C3)C)C=1)CCC2 RYQCOYWPBQOYNB-IBGZPJMESA-N 0.000 claims 1
• MLRPNAWEYKVYNY-OAQYLSRUSA-N 7-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN2CCC[C@@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=C1 MLRPNAWEYKVYNY-OAQYLSRUSA-N 0.000 claims 1
• RLHSGFWFCWCZSS-HXUWFJFHSA-N 7-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN2CCC[C@@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CN=C(C)C2=C1 RLHSGFWFCWCZSS-HXUWFJFHSA-N 0.000 claims 1
• PHNGWWXQFSLTKH-GOSISDBHSA-N 7-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(5-methylfuro[3,2-b]pyridin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CC2=NC(C)=CC=C2O1 PHNGWWXQFSLTKH-GOSISDBHSA-N 0.000 claims 1
• TWOSXUJYJHNHEN-LJQANCHMSA-N 7-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=N1 TWOSXUJYJHNHEN-LJQANCHMSA-N 0.000 claims 1
• KLTNJDGGUUQOLF-QGZVFWFLSA-N 7-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(Cl)N=C(C)C2=N1 KLTNJDGGUUQOLF-QGZVFWFLSA-N 0.000 claims 1
• OJCVEIWREFIENF-GOSISDBHSA-N 7-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=CC2=N1 OJCVEIWREFIENF-GOSISDBHSA-N 0.000 claims 1
• AXOKGHLIFRZYLY-GOSISDBHSA-N 7-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN(C=C(C)C=C2F)C2=N1 AXOKGHLIFRZYLY-GOSISDBHSA-N 0.000 claims 1
• RLGZODNSKMJBPM-QGZVFWFLSA-N 7-[(8ar)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CC=C(F)C2=N1 RLGZODNSKMJBPM-QGZVFWFLSA-N 0.000 claims 1
• MLRPNAWEYKVYNY-NRFANRHFSA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=C1 MLRPNAWEYKVYNY-NRFANRHFSA-N 0.000 claims 1
• RLHSGFWFCWCZSS-FQEVSTJZSA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(1-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CN=C(C)C2=C1 RLHSGFWFCWCZSS-FQEVSTJZSA-N 0.000 claims 1
• WWSFNIMLXGMXIR-FQEVSTJZSA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C2C=C1 WWSFNIMLXGMXIR-FQEVSTJZSA-N 0.000 claims 1
• MNCRBQGXKLYURN-IBGZPJMESA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(2-methylimidazo[1,2-a]pyrimidin-6-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C2N=C1 MNCRBQGXKLYURN-IBGZPJMESA-N 0.000 claims 1
• MZBCWBPFDPIASQ-FQEVSTJZSA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CC(C=C(N=C2C)C)=C2O1 MZBCWBPFDPIASQ-FQEVSTJZSA-N 0.000 claims 1
• TWOSXUJYJHNHEN-IBGZPJMESA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C(C)C2=N1 TWOSXUJYJHNHEN-IBGZPJMESA-N 0.000 claims 1
• KLTNJDGGUUQOLF-KRWDZBQOSA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(6-chloro-8-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(Cl)N=C(C)C2=N1 KLTNJDGGUUQOLF-KRWDZBQOSA-N 0.000 claims 1
• MWNKNIDRCMAMNW-IBGZPJMESA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=C(C)N=C2C(F)=C1 MWNKNIDRCMAMNW-IBGZPJMESA-N 0.000 claims 1
• AXOKGHLIFRZYLY-SFHVURJKSA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN(C=C(C)C=C2F)C2=N1 AXOKGHLIFRZYLY-SFHVURJKSA-N 0.000 claims 1
• RLGZODNSKMJBPM-KRWDZBQOSA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-(8-fluoroimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C(C=C1OC2=O)=CC=C1C=C2C1=CN2C=CC=C(F)C2=N1 RLGZODNSKMJBPM-KRWDZBQOSA-N 0.000 claims 1
• SUPZLVKDTMQLML-IBGZPJMESA-N 7-[(8as)-3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl]-3-imidazo[1,2-a]pyridin-6-ylchromen-2-one Chemical compound C1CN2CCC[C@H]2CN1C1=CC(OC(C(=C2)C3=CN4C=CN=C4C=C3)=O)=C2C=C1 SUPZLVKDTMQLML-IBGZPJMESA-N 0.000 claims 1
• PCEMOGJOUFMLES-UHFFFAOYSA-N 7-[(dimethylamino)methyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CN(C)C)=CN21 PCEMOGJOUFMLES-UHFFFAOYSA-N 0.000 claims 1
• QYVVKAIVXDYCPM-UHFFFAOYSA-N 7-[(dimethylamino)methyl]-3-imidazo[2,1-b][1,3]thiazol-6-ylchromen-2-one Chemical compound O=C1OC2=CC(CN(C)C)=CC=C2C=C1C1=CN(C=CS2)C2=N1 QYVVKAIVXDYCPM-UHFFFAOYSA-N 0.000 claims 1
• RPGLURVRDKSNJT-UHFFFAOYSA-N 7-[(propan-2-ylamino)methyl]-3-[4-(trifluoromethyl)-1,3-benzothiazol-2-yl]chromen-2-one Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)CNC(C)C)=NC2=C1C(F)(F)F RPGLURVRDKSNJT-UHFFFAOYSA-N 0.000 claims 1
• PXJNRXGRFGPSIF-UHFFFAOYSA-N 7-[1-(1,3-dihydroxypropan-2-yl)piperidin-4-yl]oxy-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2OC1CCN(C(CO)CO)CC1 PXJNRXGRFGPSIF-UHFFFAOYSA-N 0.000 claims 1
• GEEGXMGCWUHRTP-UHFFFAOYSA-N 7-[1-(2-hydroxyethyl)piperidin-4-yl]-3-(2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1=CC2=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCN(CCO)CC1 GEEGXMGCWUHRTP-UHFFFAOYSA-N 0.000 claims 1
• AGZOJKPHLYKVFW-UHFFFAOYSA-N 7-[1-(2-hydroxyethyl)piperidin-4-yl]-3-(2-methylindazol-5-yl)chromen-2-one Chemical compound C1=CC2=NN(C)C=C2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCN(CCO)CC1 AGZOJKPHLYKVFW-UHFFFAOYSA-N 0.000 claims 1
• JWGASHFFBRWGGO-UHFFFAOYSA-N 7-[1-(2-hydroxyethyl)piperidin-4-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCN(CCO)CC1 JWGASHFFBRWGGO-UHFFFAOYSA-N 0.000 claims 1
• PSYYUWLZOAFUSF-UHFFFAOYSA-N 7-[1-(3-fluoropropyl)piperidin-4-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2C1CCN(CCCF)CC1 PSYYUWLZOAFUSF-UHFFFAOYSA-N 0.000 claims 1
• USOVPSLXPLTXAL-UHFFFAOYSA-N 7-[2-(1,3-dihydroxypropan-2-ylamino)ethyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(CCNC(CO)CO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 USOVPSLXPLTXAL-UHFFFAOYSA-N 0.000 claims 1
• NZAYDEORQLJGEQ-UHFFFAOYSA-N 7-[2-(diethylamino)ethoxy]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCN(CC)CC)=CN21 NZAYDEORQLJGEQ-UHFFFAOYSA-N 0.000 claims 1
• AVENWKVVKCOILT-UHFFFAOYSA-N 7-[2-(diethylamino)ethyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCN(CC)CC)=CN21 AVENWKVVKCOILT-UHFFFAOYSA-N 0.000 claims 1
• XMEFAIHOJNPYGV-UHFFFAOYSA-N 7-[2-(dimethylamino)ethoxy]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)OCCN(C)C)=CN21 XMEFAIHOJNPYGV-UHFFFAOYSA-N 0.000 claims 1
• WWCYIJHSBLDZND-UHFFFAOYSA-N 7-[2-(dimethylamino)ethyl-methylamino]-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1=C(C)C=CC2=NC(C3=CC4=CC=C(C=C4OC3=O)N(C)CCN(C)C)=CN21 WWCYIJHSBLDZND-UHFFFAOYSA-N 0.000 claims 1
• AELGPDSDTDCYOO-UHFFFAOYSA-N 7-[2-(dimethylamino)ethyl-methylamino]-3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound C1=CC(C)=NC2=NC(C3=CC4=CC=C(C=C4OC3=O)N(C)CCN(C)C)=CN21 AELGPDSDTDCYOO-UHFFFAOYSA-N 0.000 claims 1
• HAHXGJKQSRHPHA-UHFFFAOYSA-N 7-[2-(dimethylamino)ethyl-methylamino]-3-imidazo[1,2-a]pyrimidin-2-ylchromen-2-one Chemical compound C1=CC=NC2=NC(C3=CC4=CC=C(C=C4OC3=O)N(C)CCN(C)C)=CN21 HAHXGJKQSRHPHA-UHFFFAOYSA-N 0.000 claims 1
• NFWVPXGOGUNPLB-UHFFFAOYSA-N 7-[2-(dimethylamino)ethyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCN(C)C)=CN21 NFWVPXGOGUNPLB-UHFFFAOYSA-N 0.000 claims 1
• YLLRJHDHPNXSOC-UHFFFAOYSA-N 7-[2-(dimethylamino)ethylamino]-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1=CC(C)=CC2=NC(C3=CC4=CC=C(C=C4OC3=O)NCCN(C)C)=CN21 YLLRJHDHPNXSOC-UHFFFAOYSA-N 0.000 claims 1
• RHLBDJQYSKXQNP-UHFFFAOYSA-N 7-[2-[bis(2-hydroxyethyl)amino]ethoxy]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(OCCN(CCO)CCO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 RHLBDJQYSKXQNP-UHFFFAOYSA-N 0.000 claims 1
• VHMHYZHUECCWCL-UHFFFAOYSA-N 7-[2-[bis(2-hydroxyethyl)amino]ethyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(CCN(CCO)CCO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 VHMHYZHUECCWCL-UHFFFAOYSA-N 0.000 claims 1
• IASQNQUAYMAXML-UHFFFAOYSA-N 7-[3-(1,3-dihydroxypropan-2-ylamino)propyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(CCCNC(CO)CO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 IASQNQUAYMAXML-UHFFFAOYSA-N 0.000 claims 1
• HAZUTZVWNWGJNA-UHFFFAOYSA-N 7-[3-(aminomethyl)azetidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CC(CN)C1 HAZUTZVWNWGJNA-UHFFFAOYSA-N 0.000 claims 1
• VFULFEGIPSOOFU-UHFFFAOYSA-N 7-[3-(diethylamino)azetidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1C(N(CC)CC)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 VFULFEGIPSOOFU-UHFFFAOYSA-N 0.000 claims 1
• HRBWMBWXWXRIPE-UHFFFAOYSA-N 7-[3-(diethylamino)propyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCN(CC)CC)=CN21 HRBWMBWXWXRIPE-UHFFFAOYSA-N 0.000 claims 1
• PEJNNNDNCBLGIN-UHFFFAOYSA-N 7-[3-(diethylamino)pyrrolidin-1-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1C(N(CC)CC)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 PEJNNNDNCBLGIN-UHFFFAOYSA-N 0.000 claims 1
• NIVDEUHQXBDPPE-UHFFFAOYSA-N 7-[3-(dimethylamino)azetidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1C(N(C)C)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 NIVDEUHQXBDPPE-UHFFFAOYSA-N 0.000 claims 1
• GGSFEKXSDQSIKS-UHFFFAOYSA-N 7-[3-(dimethylamino)piperidin-1-yl]-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1C(N(C)C)CCCN1C1=CC=C(C=C(C=2N=C3C=CC(C)=CN3C=2)C(=O)O2)C2=C1 GGSFEKXSDQSIKS-UHFFFAOYSA-N 0.000 claims 1
• UOWTVCCNLHCYJF-UHFFFAOYSA-N 7-[3-(dimethylamino)propyl]-3-(2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1=CC2=NC(C)=CN2C=C1C1=CC2=CC=C(CCCN(C)C)C=C2OC1=O UOWTVCCNLHCYJF-UHFFFAOYSA-N 0.000 claims 1
• COFIIYKFLIVAEI-UHFFFAOYSA-N 7-[3-(dimethylamino)propyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCN(C)C)=CN21 COFIIYKFLIVAEI-UHFFFAOYSA-N 0.000 claims 1
• URLABCDITRLUAL-UHFFFAOYSA-N 7-[3-(dimethylamino)propyl]-3-(8-ethyl-2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1=C(CCCN(C)C)C=C2OC(=O)C(C=3C=C(C4=NC(C)=CN4C=3)CC)=CC2=C1 URLABCDITRLUAL-UHFFFAOYSA-N 0.000 claims 1
• XFQYKVXKNVRPGG-UHFFFAOYSA-N 7-[3-(dimethylamino)propyl]-3-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)chromen-2-one Chemical compound C1=C(F)C2=NC(C)=CN2C=C1C1=CC2=CC=C(CCCN(C)C)C=C2OC1=O XFQYKVXKNVRPGG-UHFFFAOYSA-N 0.000 claims 1
• WUVQIVAKVOGLNW-UHFFFAOYSA-N 7-[3-(dimethylamino)propylamino]-3-(7-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1=CC(C)=CC2=NC(C3=CC4=CC=C(C=C4OC3=O)NCCCN(C)C)=CN21 WUVQIVAKVOGLNW-UHFFFAOYSA-N 0.000 claims 1
• VKDPWXNAJNUJDI-UHFFFAOYSA-N 7-[3-(dimethylamino)pyrrolidin-1-yl]-3-(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)chromen-2-one Chemical compound C1C(N(C)C)CCN1C1=CC=C(C=C(C=2N=C3SC(C)=CN3C=2)C(=O)O2)C2=C1 VKDPWXNAJNUJDI-UHFFFAOYSA-N 0.000 claims 1
• JPJOTNLUDFAZPN-UHFFFAOYSA-N 7-[3-[bis(2-hydroxyethyl)amino]propyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(CCCN(CCO)CCO)C=C2OC(=O)C(C3=CN4C=C(N=C(C)C4=N3)C)=CC2=C1 JPJOTNLUDFAZPN-UHFFFAOYSA-N 0.000 claims 1
• VFFDKLYYLXIDCR-UHFFFAOYSA-N 7-[4-(1,3-dihydroxypropan-2-ylamino)piperidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(NC(CO)CO)CC1 VFFDKLYYLXIDCR-UHFFFAOYSA-N 0.000 claims 1
• DEAYQYKNZFPFPP-UHFFFAOYSA-N 7-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(CCO)CC1 DEAYQYKNZFPFPP-UHFFFAOYSA-N 0.000 claims 1
• QJGHNNORWNFSDT-UHFFFAOYSA-N 7-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(6-methylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(CCO)CC1 QJGHNNORWNFSDT-UHFFFAOYSA-N 0.000 claims 1
• OPGPLBCGVZEIAC-UHFFFAOYSA-N 7-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(8-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCN(CCO)CC1 OPGPLBCGVZEIAC-UHFFFAOYSA-N 0.000 claims 1
• QICMKMOYBAHDHB-UHFFFAOYSA-N 7-[4-(2-hydroxyethyl)piperazin-1-yl]-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1CN(CCO)CCN1C1=CC=C(C=C(C2=NN3C=CC=CC3=C2)C(=O)O2)C2=C1 QICMKMOYBAHDHB-UHFFFAOYSA-N 0.000 claims 1
• CUBXZRJBBYUPDI-UHFFFAOYSA-N 7-[4-(aminomethyl)piperidin-1-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(CN)CC1 CUBXZRJBBYUPDI-UHFFFAOYSA-N 0.000 claims 1
• MWZPQDBCJQVEHR-UHFFFAOYSA-N 7-[4-(cyclobutylamino)piperidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCC1NC1CCC1 MWZPQDBCJQVEHR-UHFFFAOYSA-N 0.000 claims 1
• VLZJWUVJTNYCMP-UHFFFAOYSA-N 7-[4-(cyclopropylmethyl)piperazin-1-yl]-3-(5,7-dimethylfuro[2,3-c]pyridin-2-yl)chromen-2-one Chemical compound O1C=2C(C)=NC(C)=CC=2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N(CC1)CCN1CC1CC1 VLZJWUVJTNYCMP-UHFFFAOYSA-N 0.000 claims 1
• KGYWGALJSRTRJO-UHFFFAOYSA-N 7-[4-(diethylamino)butyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCCN(CC)CC)=CN21 KGYWGALJSRTRJO-UHFFFAOYSA-N 0.000 claims 1
• HWPUZWKNWRONEO-UHFFFAOYSA-N 7-[4-(diethylamino)piperidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CC(N(CC)CC)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 HWPUZWKNWRONEO-UHFFFAOYSA-N 0.000 claims 1
• WXGHCHANJJNGCB-UHFFFAOYSA-N 7-[4-(dimethylamino)butyl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1=C(C)N=C(C)C2=NC(C3=CC4=CC=C(C=C4OC3=O)CCCCN(C)C)=CN21 WXGHCHANJJNGCB-UHFFFAOYSA-N 0.000 claims 1
• GRBGUZSWOBMJFR-UHFFFAOYSA-N 7-[4-(dimethylamino)piperidin-1-yl]-3-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CC(N(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=C(C)C3=C2)C(=O)O2)C2=C1 GRBGUZSWOBMJFR-UHFFFAOYSA-N 0.000 claims 1
• ZBLOICKJOHYDKD-UHFFFAOYSA-N 7-[4-(dimethylamino)piperidin-1-yl]-3-(3-methylpyrrolo[1,2-a]pyrazin-7-yl)chromen-2-one Chemical compound C1CC(N(C)C)CCN1C1=CC=C(C=C(C2=CN3C=C(C)N=CC3=C2)C(=O)O2)C2=C1 ZBLOICKJOHYDKD-UHFFFAOYSA-N 0.000 claims 1
• DTPDNZIBLYXMFI-UHFFFAOYSA-N 7-[4-(dimethylamino)piperidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound C1CC(N(C)C)CCN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 DTPDNZIBLYXMFI-UHFFFAOYSA-N 0.000 claims 1
• UGHBFYZZPCYPLA-UHFFFAOYSA-N 7-[4-[bis(2-hydroxyethyl)amino]piperidin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound N1=C2C(C)=NC(C)=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCC(N(CCO)CCO)CC1 UGHBFYZZPCYPLA-UHFFFAOYSA-N 0.000 claims 1
• DAVKIWWMZRKFAU-UHFFFAOYSA-N 7-[[2-hydroxyethyl(methyl)amino]methyl]-3-(6-methylimidazo[1,2-a]pyridin-2-yl)chromen-2-one Chemical compound C1=C(C)C=CC2=NC(C3=CC4=CC=C(C=C4OC3=O)CN(CCO)C)=CN21 DAVKIWWMZRKFAU-UHFFFAOYSA-N 0.000 claims 1
• DVYZGHIAVXKVCI-UHFFFAOYSA-N 7-[[2-hydroxyethyl(methyl)amino]methyl]-3-imidazo[2,1-b][1,3]thiazol-6-ylchromen-2-one Chemical compound O=C1OC2=CC(CN(CCO)C)=CC=C2C=C1C1=CN(C=CS2)C2=N1 DVYZGHIAVXKVCI-UHFFFAOYSA-N 0.000 claims 1
• ZNUYBOBDSZKGKO-UHFFFAOYSA-N 7-piperazin-1-yl-3-(1h-pyrazol-5-yl)chromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C1=CC=NN1 ZNUYBOBDSZKGKO-UHFFFAOYSA-N 0.000 claims 1
• HTOJPYOYTRRASJ-UHFFFAOYSA-N 7-piperazin-1-yl-3-(2-propan-2-ylpyrimidin-4-yl)chromen-2-one Chemical compound CC(C)C1=NC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 HTOJPYOYTRRASJ-UHFFFAOYSA-N 0.000 claims 1
• DAFHHTGXOSDBKA-UHFFFAOYSA-N 7-piperazin-1-yl-3-(2-propan-2-ylpyrimidin-4-yl)chromen-2-one;hydrochloride Chemical compound Cl.CC(C)C1=NC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 DAFHHTGXOSDBKA-UHFFFAOYSA-N 0.000 claims 1
• UZSVDLWPRGADLW-UHFFFAOYSA-N 7-piperazin-1-yl-3-(6-propan-2-yloxypyridin-2-yl)chromen-2-one Chemical compound CC(C)OC1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 UZSVDLWPRGADLW-UHFFFAOYSA-N 0.000 claims 1
• PJKQTAGXJNPUOQ-UHFFFAOYSA-N 7-piperazin-1-yl-3-(6-pyrrolidin-1-ylpyridin-2-yl)chromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C(N=1)=CC=CC=1N1CCCC1 PJKQTAGXJNPUOQ-UHFFFAOYSA-N 0.000 claims 1
• OYGPYNAJYUTMFW-UHFFFAOYSA-N 7-piperazin-1-yl-3-(7h-purin-8-yl)chromen-2-one Chemical compound C1=CC=2C=C(C=3NC4=CN=CN=C4N=3)C(=O)OC=2C=C1N1CCNCC1 OYGPYNAJYUTMFW-UHFFFAOYSA-N 0.000 claims 1
• RTRGCMDZKZQTCP-UHFFFAOYSA-N 7-piperazin-1-yl-3-(pyridin-2-ylamino)chromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1NC1=CC=CC=N1 RTRGCMDZKZQTCP-UHFFFAOYSA-N 0.000 claims 1
• LHQYFBYOXDIWHY-UHFFFAOYSA-N 7-piperazin-1-yl-3-(pyridin-3-ylamino)chromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1NC1=CC=CN=C1 LHQYFBYOXDIWHY-UHFFFAOYSA-N 0.000 claims 1
• SBNDCNJXWAQGQF-UHFFFAOYSA-N 7-piperazin-1-yl-3-(pyrimidin-2-ylamino)chromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1NC1=NC=CC=N1 SBNDCNJXWAQGQF-UHFFFAOYSA-N 0.000 claims 1
• JIGCBLMHHOJLLB-UHFFFAOYSA-N 7-piperazin-1-yl-3-[4-(trifluoromethyl)-1,3-benzoxazol-2-yl]chromen-2-one Chemical compound N=1C=2C(C(F)(F)F)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 JIGCBLMHHOJLLB-UHFFFAOYSA-N 0.000 claims 1
• ILBQSPJUVDYMFL-UHFFFAOYSA-N 7-piperazin-1-yl-3-[4-(trifluoromethyl)-1,3-benzoxazol-2-yl]chromen-2-one;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.N=1C=2C(C(F)(F)F)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 ILBQSPJUVDYMFL-UHFFFAOYSA-N 0.000 claims 1
• OFIHUQSACCYDKS-UHFFFAOYSA-N 7-piperazin-1-yl-3-[4-(trifluoromethyl)-1,3-benzoxazol-2-yl]chromen-2-one;hydrochloride Chemical compound Cl.N=1C=2C(C(F)(F)F)=CC=CC=2OC=1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 OFIHUQSACCYDKS-UHFFFAOYSA-N 0.000 claims 1
• MGIUQMUNXFBXPL-UHFFFAOYSA-N 7-piperazin-1-yl-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one Chemical compound FC(F)(F)C1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 MGIUQMUNXFBXPL-UHFFFAOYSA-N 0.000 claims 1
• ZXHREQGDDROBQO-UHFFFAOYSA-N 7-piperazin-1-yl-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.FC(F)(F)C1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 ZXHREQGDDROBQO-UHFFFAOYSA-N 0.000 claims 1
• GZXLSBQIGZEGGF-UHFFFAOYSA-N 7-piperazin-1-yl-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]chromen-2-one;hydrochloride Chemical compound Cl.FC(F)(F)C1=CSC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 GZXLSBQIGZEGGF-UHFFFAOYSA-N 0.000 claims 1
• WNZRSYJWSKBVDG-UHFFFAOYSA-N 7-piperazin-1-yl-3-[4-(trifluoromethyl)pyridin-2-yl]chromen-2-one Chemical compound FC(F)(F)C1=CC=NC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=C1 WNZRSYJWSKBVDG-UHFFFAOYSA-N 0.000 claims 1
• GBONWOIESRMJAU-UHFFFAOYSA-N 7-piperazin-1-yl-3-[6-(trifluoromethyl)pyridin-2-yl]chromen-2-one Chemical compound FC(F)(F)C1=CC=CC(C=2C(OC3=CC(=CC=C3C=2)N2CCNCC2)=O)=N1 GBONWOIESRMJAU-UHFFFAOYSA-N 0.000 claims 1
• GAPAXUMTXMDXDK-UHFFFAOYSA-N 7-piperazin-1-yl-3-[7-(trifluoromethyl)-1,3-benzoxazol-2-yl]chromen-2-one Chemical compound O1C=2C(C(F)(F)F)=CC=CC=2N=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 GAPAXUMTXMDXDK-UHFFFAOYSA-N 0.000 claims 1
• FQAOPEBNZHWILG-UHFFFAOYSA-N 7-piperazin-1-yl-3-[7-(trifluoromethyl)-1,3-benzoxazol-2-yl]chromen-2-one;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.O1C=2C(C(F)(F)F)=CC=CC=2N=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 FQAOPEBNZHWILG-UHFFFAOYSA-N 0.000 claims 1
• FFRSWMXMBLIWRL-UHFFFAOYSA-N 7-piperazin-1-yl-3-[7-(trifluoromethyl)-1,3-benzoxazol-2-yl]chromen-2-one;hydrochloride Chemical compound Cl.O1C=2C(C(F)(F)F)=CC=CC=2N=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 FFRSWMXMBLIWRL-UHFFFAOYSA-N 0.000 claims 1
• SRDOTLIRANAIPV-UHFFFAOYSA-N 7-piperazin-1-yl-3-[7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound N1=C2C=C(C(F)(F)F)C=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 SRDOTLIRANAIPV-UHFFFAOYSA-N 0.000 claims 1
• IDUBEMSXZQSWCI-UHFFFAOYSA-N 7-piperazin-1-yl-3-[8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]chromen-2-one Chemical compound N1=C2C(C(F)(F)F)=CC=CN2C=C1C(C(OC1=C2)=O)=CC1=CC=C2N1CCNCC1 IDUBEMSXZQSWCI-UHFFFAOYSA-N 0.000 claims 1
• AJDPGLKDVMKPDG-UHFFFAOYSA-N 7-piperazin-1-yl-3-pyrazolo[1,5-a]pyridin-2-ylchromen-2-one Chemical compound C1=CC=2C=C(C3=NN4C=CC=CC4=C3)C(=O)OC=2C=C1N1CCNCC1 AJDPGLKDVMKPDG-UHFFFAOYSA-N 0.000 claims 1
• IETQHSYGCTXLGQ-UHFFFAOYSA-N 7-piperazin-1-yl-3-pyridin-3-ylchromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C1=CC=CN=C1 IETQHSYGCTXLGQ-UHFFFAOYSA-N 0.000 claims 1
• YCSNFWCZDBPILB-UHFFFAOYSA-N 7-piperazin-1-yl-3-pyridin-4-ylchromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C1=CC=NC=C1 YCSNFWCZDBPILB-UHFFFAOYSA-N 0.000 claims 1
• FZIDHSABWKVIQJ-UHFFFAOYSA-N 7-piperazin-1-yl-3-pyrrolo[1,2-a]pyrimidin-7-ylchromen-2-one Chemical compound C1=CC=2C=C(C3=CN4C=CC=NC4=C3)C(=O)OC=2C=C1N1CCNCC1 FZIDHSABWKVIQJ-UHFFFAOYSA-N 0.000 claims 1
• HITKLPSINHGWSH-UHFFFAOYSA-N 7-piperazin-1-yl-3-thiophen-2-ylchromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C1=CC=CS1 HITKLPSINHGWSH-UHFFFAOYSA-N 0.000 claims 1
• BBAQIVGIYCBGHG-UHFFFAOYSA-N 7-piperazin-1-yl-3-thiophen-3-ylchromen-2-one Chemical compound O=C1OC=2C=C(N3CCNCC3)C=CC=2C=C1C=1C=CSC=1 BBAQIVGIYCBGHG-UHFFFAOYSA-N 0.000 claims 1
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
• UHVBKTJIYHJGDQ-UHFFFAOYSA-N 8-fluoro-3-(6-methylimidazo[1,2-a]pyridin-2-yl)-7-piperazin-1-ylchromen-2-one Chemical compound C=1N2C=C(C)C=CC2=NC=1C(C(OC1=C2F)=O)=CC1=CC=C2N1CCNCC1 UHVBKTJIYHJGDQ-UHFFFAOYSA-N 0.000 claims 1
• GEMQVMXPZMKEEH-UHFFFAOYSA-N 8-fluoro-7-piperazin-1-yl-3-pyridin-2-ylchromen-2-one Chemical compound O=C1OC=2C(F)=C(N3CCNCC3)C=CC=2C=C1C1=CC=CC=N1 GEMQVMXPZMKEEH-UHFFFAOYSA-N 0.000 claims 1
• 101000617738 Homo sapiens Survival motor neuron protein Proteins 0.000 claims 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
• 101150015954 SMN2 gene Proteins 0.000 claims 1
• 102100021947 Survival motor neuron protein Human genes 0.000 claims 1
• DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
• QIHJPVCQKILNPD-UHFFFAOYSA-N [3-(1,3-benzothiazol-2-yl)-2-oxochromen-7-yl] piperazine-1-carboxylate Chemical compound C=1C=C2C=C(C=3SC4=CC=CC=C4N=3)C(=O)OC2=CC=1OC(=O)N1CCNCC1 QIHJPVCQKILNPD-UHFFFAOYSA-N 0.000 claims 1
• AYLAXIFNOJDDAB-UHFFFAOYSA-N [3-(4-chloro-1,3-benzothiazol-2-yl)-2-oxochromen-7-yl] piperazine-1-carboxylate Chemical compound N=1C=2C(Cl)=CC=CC=2SC=1C(C(OC1=C2)=O)=CC1=CC=C2OC(=O)N1CCNCC1 AYLAXIFNOJDDAB-UHFFFAOYSA-N 0.000 claims 1
• FFTLUHVDHXLUCV-PFEQFJNWSA-N acetic acid;2-[7-[(3r)-3,4-dimethylpiperazin-1-yl]-2-oxochromen-3-yl]-6-methyl-7h-imidazo[1,2-a]pyrazin-8-one Chemical compound CC(O)=O.C1CN(C)[C@H](C)CN1C1=CC=C(C=C(C=2N=C3C(=O)NC(C)=CN3C=2)C(=O)O2)C2=C1 FFTLUHVDHXLUCV-PFEQFJNWSA-N 0.000 claims 1
• YUWYQLUDHYOZOQ-FERBBOLQSA-N acetic acid;3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-[(3s)-3-ethyl-4-methylpiperazin-1-yl]chromen-2-one Chemical compound CC(O)=O.C1CN(C)[C@@H](CC)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 YUWYQLUDHYOZOQ-FERBBOLQSA-N 0.000 claims 1
• IBJVZAZEJYSWJT-UHFFFAOYSA-N acetic acid;7-[(1-benzylpyrrolidin-3-yl)-methylamino]-3-(7-methylimidazo[1,2-a]pyrimidin-2-yl)chromen-2-one Chemical compound CC(O)=O.C=1C=C2C=C(C=3N=C4N=C(C)C=CN4C=3)C(=O)OC2=CC=1N(C)C(C1)CCN1CC1=CC=CC=C1 IBJVZAZEJYSWJT-UHFFFAOYSA-N 0.000 claims 1
• JFKTXUNWNDQPGQ-FYZYNONXSA-N acetic acid;7-[(3s)-3,4-diethylpiperazin-1-yl]-3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)chromen-2-one Chemical compound CC(O)=O.C1CN(CC)[C@@H](CC)CN1C1=CC=C(C=C(C=2N=C3C(C)=NC(C)=CN3C=2)C(=O)O2)C2=C1 JFKTXUNWNDQPGQ-FYZYNONXSA-N 0.000 claims 1
• ZWNOOCIOLNJOGE-RSAXXLAASA-N acetic acid;7-[(3s)-4-ethyl-3-methylpiperazin-1-yl]-3-(2-methyl-1,3-benzothiazol-6-yl)chromen-2-one Chemical compound CC(O)=O.C1[C@H](C)N(CC)CCN1C1=CC=C(C=C(C=2C=C3SC(C)=NC3=CC=2)C(=O)O2)C2=C1 ZWNOOCIOLNJOGE-RSAXXLAASA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 1
• 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
• 125000005100 aryl amino carbonyl group Chemical group 0.000 claims 1
• 125000001769 aryl amino group Chemical group 0.000 claims 1
• 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
• 150000001805 chlorine compounds Chemical group 0.000 claims 1
• 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
• 125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 1
• 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000004043 oxo group Chemical group O=* 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1