JP2014506929A5

JP2014506929A5 -

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Publication number: JP2014506929A5
Authority: JP; Japan
Prior art keywords: pyrimido; amino; imidazo; pyrimidin; phenyl
Prior art date: 2012-02-27
Legal status : Granted

Application number

JP2013556755A

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English (en)

Japanese (ja)

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JP2014506929A (ja

JP5886326B2 (ja

Filing date

2012-02-27

Publication date

2015-04-16

2012-02-27 Application filed filed Critical

2012-02-27 Priority claimed from PCT/US2012/026685 external-priority patent/WO2012161812A1/en

2014-03-20 Publication of JP2014506929A publication Critical patent/JP2014506929A/ja

2015-04-16 Publication of JP2014506929A5 publication Critical patent/JP2014506929A5/ja

2016-03-16 Application granted granted Critical

2016-03-16 Publication of JP5886326B2 publication Critical patent/JP5886326B2/ja

Status Expired - Fee Related legal-status Critical Current

2032-02-27 Anticipated expiration legal-status Critical

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-1 heteroaryl Aryl Chemical group 0.000 claims 62
125000000592 heterocycloalkyl group Chemical group 0.000 claims 37
125000003118 aryl group Chemical group 0.000 claims 35
125000001072 heteroaryl group Chemical group 0.000 claims 34
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 33
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 32
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 31
125000005843 halogen group Chemical group 0.000 claims 30
125000000217 alkyl group Chemical group 0.000 claims 26
125000001424 substituent group Chemical group 0.000 claims 25
125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 20
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 20
150000001875 compounds Chemical class 0.000 claims 19
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 18
229910052799 carbon Inorganic materials 0.000 claims 18
229910052739 hydrogen Inorganic materials 0.000 claims 14
125000004043 oxo group Chemical group O=* 0.000 claims 11
BDTRIDKONHOQQN-UHFFFAOYSA-N 4h-pyrimidin-5-one Chemical compound O=C1CN=CN=C1 BDTRIDKONHOQQN-UHFFFAOYSA-N 0.000 claims 10
125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 8
125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 8
125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 7
125000000753 cycloalkyl group Chemical group 0.000 claims 7
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 6
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 5
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 5
125000001624 naphthyl group Chemical group 0.000 claims 5
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 5
229910052736 halogen Inorganic materials 0.000 claims 4
150000002367 halogens Chemical class 0.000 claims 4
125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 4
229910052757 nitrogen Inorganic materials 0.000 claims 4
125000000623 heterocyclic group Chemical group 0.000 claims 3
229910052717 sulfur Inorganic materials 0.000 claims 3
HYVBUDMPUNEJHM-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(2-fluoroethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(NCCF)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl HYVBUDMPUNEJHM-UHFFFAOYSA-N 0.000 claims 2
NNQKGOSIJAERJY-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(cyclopropylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CC(CC4=CC=3)NC3CC3)N=C2N2C=CN=C21 NNQKGOSIJAERJY-UHFFFAOYSA-N 0.000 claims 2
QXZZUBFQRVTJCD-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(diethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(CC)CC)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl QXZZUBFQRVTJCD-UHFFFAOYSA-N 0.000 claims 2
VEYHNBOUKBIXHN-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(propylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(NCCC)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl VEYHNBOUKBIXHN-UHFFFAOYSA-N 0.000 claims 2
LAMLNRBJGRMUNN-KKFHFHRHSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-[(3S)-3-fluoropyrrolidin-1-yl]-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@@H](F)CCN1C1CC2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5F)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C1 LAMLNRBJGRMUNN-KKFHFHRHSA-N 0.000 claims 2
FAPREGZSIDHQBT-UHFFFAOYSA-N C1=NC=C2C(=O)NC3=NC=CN3C2=N1 Chemical compound C1=NC=C2C(=O)NC3=NC=CN3C2=N1 FAPREGZSIDHQBT-UHFFFAOYSA-N 0.000 claims 2
125000003545 alkoxy group Chemical group 0.000 claims 2
125000004093 cyano group Chemical group *C#N 0.000 claims 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
150000003839 salts Chemical class 0.000 claims 2
125000000169 tricyclic heterocycle group Chemical group 0.000 claims 2
MXNPKUQHTFLYOQ-UHFFFAOYSA-N 1-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-N,N-diethylpiperidine-3-carboxamide Chemical compound C1C(C(=O)N(CC)CC)CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 MXNPKUQHTFLYOQ-UHFFFAOYSA-N 0.000 claims 1
WSKYCBFAXMTTQI-UHFFFAOYSA-N 1-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-N-methylmethanesulfonamide Chemical compound C1=CC(CS(=O)(=O)NC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 WSKYCBFAXMTTQI-UHFFFAOYSA-N 0.000 claims 1
125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims 1
WSTMFUSTYZOYDL-UHFFFAOYSA-N 12-(1,2,3-benzothiadiazol-5-ylamino)-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4N=NSC4=CC=3)N=C2N2C=CN=C21 WSTMFUSTYZOYDL-UHFFFAOYSA-N 0.000 claims 1
CFYZZUMUBPACPF-UHFFFAOYSA-N 12-(1,3-benzothiazol-6-ylamino)-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4SC=NC4=CC=3)N=C2N2C=CN=C21 CFYZZUMUBPACPF-UHFFFAOYSA-N 0.000 claims 1
AOFIYKYYKPEQEY-UHFFFAOYSA-N 12-(4-aminoanilino)-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 AOFIYKYYKPEQEY-UHFFFAOYSA-N 0.000 claims 1
LPWIXQTVUKDQPE-UHFFFAOYSA-N 12-(4-bromoanilino)-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(Br)=CC=3)N=C2N2C=CN=C21 LPWIXQTVUKDQPE-UHFFFAOYSA-N 0.000 claims 1
XBXHHAXUUZSAER-UHFFFAOYSA-N 12-(4-cyclohexylanilino)-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3CCCCC3)N=C2N2C=CN=C21 XBXHHAXUUZSAER-UHFFFAOYSA-N 0.000 claims 1
ZQLRREONZSVIQO-UHFFFAOYSA-N 12-[(1-acetyl-2,3-dihydroindol-6-yl)amino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2N(C(=O)C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl ZQLRREONZSVIQO-UHFFFAOYSA-N 0.000 claims 1
XQCSSURHRLCVFQ-UHFFFAOYSA-N 12-[(2-acetyl-3,4-dihydro-1H-isoquinolin-6-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2CN(C(=O)C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl XQCSSURHRLCVFQ-UHFFFAOYSA-N 0.000 claims 1
ZOERDVHQLNAKHE-UHFFFAOYSA-N 12-[(2-acetyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CN(C(=O)C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl ZOERDVHQLNAKHE-UHFFFAOYSA-N 0.000 claims 1
UEQZOEVKMMEQFQ-UHFFFAOYSA-N 12-[(2-acetyl-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl UEQZOEVKMMEQFQ-UHFFFAOYSA-N 0.000 claims 1
WYUGYFWIJUABRJ-UHFFFAOYSA-N 12-[(2-acetylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2,6-dichloro-4-fluorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=C(F)C=C1Cl WYUGYFWIJUABRJ-UHFFFAOYSA-N 0.000 claims 1
GKAIUFLVMQMDHO-UHFFFAOYSA-N 12-[(2-acetylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GKAIUFLVMQMDHO-UHFFFAOYSA-N 0.000 claims 1
CWGJVAOSKXUZTO-UHFFFAOYSA-N 12-[(2-acetylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2-chloro-6-fluorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl CWGJVAOSKXUZTO-UHFFFAOYSA-N 0.000 claims 1
WJRROINZDMTREW-UHFFFAOYSA-N 12-[(2-acetylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl WJRROINZDMTREW-UHFFFAOYSA-N 0.000 claims 1
IDVBIPAGPCIDPV-UHFFFAOYSA-N 12-[(2-cyclopropylsulfonylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)S(=O)(=O)C4CC4)=CC=3)N=C2N2C=CN=C21 IDVBIPAGPCIDPV-UHFFFAOYSA-N 0.000 claims 1
LDPUHXKJRAXDON-UHFFFAOYSA-N 12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-propan-2-yl-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound N=1C=C2C(=O)N(C(C)C)C3=NC=CN3C2=NC=1NC(C=1)=CC=C2C=1CN(C)CC21CC1 LDPUHXKJRAXDON-UHFFFAOYSA-N 0.000 claims 1
PLQFKOCDZHKHRX-UHFFFAOYSA-N 12-[3-chloro-4-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C(=C1)C(F)(F)F)=C(Cl)C=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 PLQFKOCDZHKHRX-UHFFFAOYSA-N 0.000 claims 1
OXBXLTUEEZXRSD-UHFFFAOYSA-N 12-[3-chloro-4-(4-methylpiperazin-1-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C(=C1)Cl)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 OXBXLTUEEZXRSD-UHFFFAOYSA-N 0.000 claims 1
QVYKKSXEJXHNGJ-UHFFFAOYSA-N 12-[3-chloro-4-(4-methylpiperazin-1-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C(=C1)Cl)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 QVYKKSXEJXHNGJ-UHFFFAOYSA-N 0.000 claims 1
PWNBRPDHBMSFSF-UHFFFAOYSA-N 12-[4-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4CCCCN4CC3)N=C2N2C=CN=C21 PWNBRPDHBMSFSF-UHFFFAOYSA-N 0.000 claims 1
KFZPTHFHLAAPLY-UHFFFAOYSA-N 12-[4-(1,4-diazepan-1-yl)-3-methylanilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCCC2)C(C)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl KFZPTHFHLAAPLY-UHFFFAOYSA-N 0.000 claims 1
SARRXSLLADDAOE-UHFFFAOYSA-N 12-[4-(2,7-diazaspiro[3.4]octan-2-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4(C3)CNCC4)N=C2N2C=CN=C21 SARRXSLLADDAOE-UHFFFAOYSA-N 0.000 claims 1
KWDCBYJISYZLLU-UHFFFAOYSA-N 12-[4-(2,7-diazaspiro[3.5]nonan-2-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4(C3)CCNCC4)N=C2N2C=CN=C21 KWDCBYJISYZLLU-UHFFFAOYSA-N 0.000 claims 1
PMWSRMFYNLXUOL-UHFFFAOYSA-N 12-[4-(2,7-diazaspiro[3.5]nonan-7-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC4(CNC4)CC3)N=C2N2C=CN=C21 PMWSRMFYNLXUOL-UHFFFAOYSA-N 0.000 claims 1
CQQNPOAQLYKSME-UHFFFAOYSA-N 12-[4-(2-acetyl-2,7-diazaspiro[3.5]nonan-7-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1N(C(=O)C)CC21CCN(C=1C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=1)CC2 CQQNPOAQLYKSME-UHFFFAOYSA-N 0.000 claims 1
ZJEYDTIPPFWMNI-UHFFFAOYSA-N 12-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4CCCN4CC3)N=C2N2C=CN=C21 ZJEYDTIPPFWMNI-UHFFFAOYSA-N 0.000 claims 1
CAFTYPPLMPBFKG-UHFFFAOYSA-N 12-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4CCCN4CC3)N=C2N2C=CN=C21 CAFTYPPLMPBFKG-UHFFFAOYSA-N 0.000 claims 1
TWJWRKWSQONEGU-UHFFFAOYSA-N 12-[4-(4-acetylpiperazin-1-yl)anilino]-7-(2-chloro-6-fluorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 TWJWRKWSQONEGU-UHFFFAOYSA-N 0.000 claims 1
BQXGAXHVZLYFLW-UHFFFAOYSA-N 12-[4-(4-acetylpiperazin-1-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 BQXGAXHVZLYFLW-UHFFFAOYSA-N 0.000 claims 1
RAOFCVHAVATOES-UHFFFAOYSA-N 12-[4-(4-methylpiperazin-1-yl)anilino]-7-[2-(trifluoromethoxy)phenyl]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)OC(F)(F)F)C3=NC=CN3C2=N1 RAOFCVHAVATOES-UHFFFAOYSA-N 0.000 claims 1
ABVBVZIBDDRXHB-UHFFFAOYSA-N 12-[4-(4-methylpiperazin-1-yl)anilino]-7-[2-(trifluoromethyl)phenyl]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)C(F)(F)F)C3=NC=CN3C2=N1 ABVBVZIBDDRXHB-UHFFFAOYSA-N 0.000 claims 1
DVCFSMPQEKMGAH-UHFFFAOYSA-N 12-[4-(4-methylpiperazin-1-yl)anilino]-7-phenyl-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C=CC=CC=3)C3=NC=CN3C2=N1 DVCFSMPQEKMGAH-UHFFFAOYSA-N 0.000 claims 1
GSNIAXMXBBAXNE-UHFFFAOYSA-N 12-[4-[(1-acetylpiperidin-4-yl)amino]anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(=O)C)CCC1NC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 GSNIAXMXBBAXNE-UHFFFAOYSA-N 0.000 claims 1
VJRKBAPOWFAEMZ-NVXWUHKLSA-N 12-[4-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C([C@@]1(NC[C@@]2([H])C1)[H])N2C(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl VJRKBAPOWFAEMZ-NVXWUHKLSA-N 0.000 claims 1
VJRKBAPOWFAEMZ-RDJZCZTQSA-N 12-[4-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C([C@]1(NC[C@]2([H])C1)[H])N2C(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl VJRKBAPOWFAEMZ-RDJZCZTQSA-N 0.000 claims 1
KVIAXHIZFPEROL-ZHRRBRCNSA-N 12-[4-[(3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C([C@@H]1CN(C[C@@H]11)C)CN1C(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl KVIAXHIZFPEROL-ZHRRBRCNSA-N 0.000 claims 1
CAFTYPPLMPBFKG-HXUWFJFHSA-N 12-[4-[(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3C[C@H]4CCCN4CC3)N=C2N2C=CN=C21 CAFTYPPLMPBFKG-HXUWFJFHSA-N 0.000 claims 1
CAFTYPPLMPBFKG-FQEVSTJZSA-N 12-[4-[(8aS)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3C[C@@H]4CCCN4CC3)N=C2N2C=CN=C21 CAFTYPPLMPBFKG-FQEVSTJZSA-N 0.000 claims 1
BESVCKOFTCVZIZ-QFIPXVFZSA-N 12-[4-[[(3R)-1-azabicyclo[2.2.2]octan-3-yl]amino]anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(N[C@@H]4C5CCN(CC5)C4)=CC=3)N=C2N2C=CN=C21 BESVCKOFTCVZIZ-QFIPXVFZSA-N 0.000 claims 1
ZFECWWBXIJRTEA-UHFFFAOYSA-N 12-[4-[bis(2-methoxyethyl)amino]anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(CCOC)CCOC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ZFECWWBXIJRTEA-UHFFFAOYSA-N 0.000 claims 1
MHOWYCRQHGHKCI-UHFFFAOYSA-N 12-[[2-(cyclopropanecarbonyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-7-(2,6-dichloro-4-fluorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC(F)=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)C(=O)C4CC4)=CC=3)N=C2N2C=CN=C21 MHOWYCRQHGHKCI-UHFFFAOYSA-N 0.000 claims 1
UOLZCRZBSIDSIC-UHFFFAOYSA-N 12-[[2-(cyclopropanecarbonyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)C(=O)C4CC4)=CC=3)N=C2N2C=CN=C21 UOLZCRZBSIDSIC-UHFFFAOYSA-N 0.000 claims 1
ZPNSETQPCRFHOG-UHFFFAOYSA-N 12-[[2-(cyclopropylamino)-2,3-dihydro-1H-inden-5-yl]amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CC(CC4=CC=3)NC3CC3)N=C2N2C=CN=C21 ZPNSETQPCRFHOG-UHFFFAOYSA-N 0.000 claims 1
RBAMWXWJHPVUSG-UHFFFAOYSA-N 12-[[2-[(1-benzylpiperidin-4-yl)methyl]-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC(CC1)CCN1CC1=CC=CC=C1 RBAMWXWJHPVUSG-UHFFFAOYSA-N 0.000 claims 1
VIOAAWUARYASTN-UHFFFAOYSA-N 12-anilino-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC=CC=3)N=C2N2C=CN=C21 VIOAAWUARYASTN-UHFFFAOYSA-N 0.000 claims 1
LOVNSZMZEXLULX-UHFFFAOYSA-N 12-anilino-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC=CC=3)N=C2N2C=CN=C21 LOVNSZMZEXLULX-UHFFFAOYSA-N 0.000 claims 1
IGCUAUFPJNLDSO-UHFFFAOYSA-N 12-anilino-7-(3-hydroxyphenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound OC1=CC=CC(N2C(C3=CN=C(NC=4C=CC=CC=4)N=C3N3C=CN=C32)=O)=C1 IGCUAUFPJNLDSO-UHFFFAOYSA-N 0.000 claims 1
GFTMSJAEEHGADR-UHFFFAOYSA-N 12-anilino-7-(3-methoxy-2-methylphenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC1=CC=CC(N2C(C3=CN=C(NC=4C=CC=CC=4)N=C3N3C=CN=C32)=O)=C1C GFTMSJAEEHGADR-UHFFFAOYSA-N 0.000 claims 1
MEDXOIFKFTYQIH-UHFFFAOYSA-N 2-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-5-methyl-1,3-thiazolidin-4-one Chemical compound N1C(=O)C(C)SC1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 MEDXOIFKFTYQIH-UHFFFAOYSA-N 0.000 claims 1
HHIFFEAVUYQZLV-UHFFFAOYSA-N 2-[[7-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-4,4-dimethyl-1,3-dihydroisoquinolin-2-yl]methyl]benzonitrile Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC1=CC=CC=C1C#N HHIFFEAVUYQZLV-UHFFFAOYSA-N 0.000 claims 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
FCRXDUAFQRKDNB-UHFFFAOYSA-N 3-[4-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]piperazin-1-yl]propanenitrile Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CCC#N)CC3)N=C2N2C=CN=C21 FCRXDUAFQRKDNB-UHFFFAOYSA-N 0.000 claims 1
GZTCYQYXVYNDJM-UHFFFAOYSA-N 3-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-cyclopropylanilino]propanenitrile Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N(CCC#N)C3CC3)N=C2N2C=CN=C21 GZTCYQYXVYNDJM-UHFFFAOYSA-N 0.000 claims 1
VYVOWWGXHVELTL-UHFFFAOYSA-N 3-[[4-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]piperazin-1-yl]methyl]benzonitrile Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CC=4C=C(C=CC=4)C#N)CC3)N=C2N2C=CN=C21 VYVOWWGXHVELTL-UHFFFAOYSA-N 0.000 claims 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
FDYOQRGSQDHYPS-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N,N-diethylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N(CC)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 FDYOQRGSQDHYPS-UHFFFAOYSA-N 0.000 claims 1
PCLRXBXXCJHMTF-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-cyclohexylbenzamide Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C(=O)NC3CCCCC3)N=C2N2C=CN=C21 PCLRXBXXCJHMTF-UHFFFAOYSA-N 0.000 claims 1
NTFYGGCWWQYKAO-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-ethylbenzamide Chemical compound C1=CC(C(=O)NCC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 NTFYGGCWWQYKAO-UHFFFAOYSA-N 0.000 claims 1
SVUNWNBQQMXLGG-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SVUNWNBQQMXLGG-UHFFFAOYSA-N 0.000 claims 1
KCUNBCQXUBVYAX-UHFFFAOYSA-N 6-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-4H-1,4-benzoxazin-3-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4NC(=O)COC4=CC=3)N=C2N2C=CN=C21 KCUNBCQXUBVYAX-UHFFFAOYSA-N 0.000 claims 1
PBHVOWBAQKJIHE-UHFFFAOYSA-N 7-(2,4-dimethoxyphenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC1=CC(OC)=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(C)CC3)N=C2N2C=CN=C21 PBHVOWBAQKJIHE-UHFFFAOYSA-N 0.000 claims 1
MWFNJZACFYVWPD-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC(F)=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 MWFNJZACFYVWPD-UHFFFAOYSA-N 0.000 claims 1
ZEJFJEZCFFBWJX-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=C(F)C=C1Cl ZEJFJEZCFFBWJX-UHFFFAOYSA-N 0.000 claims 1
OXCFVBYWTGGOQB-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=C(F)C=C1Cl OXCFVBYWTGGOQB-UHFFFAOYSA-N 0.000 claims 1
JPETUTHBTHPCLP-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[(2-methylsulfonylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(S(=O)(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=C(F)C=C1Cl JPETUTHBTHPCLP-UHFFFAOYSA-N 0.000 claims 1
MHZZCSSVPOHYON-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[(6-piperazin-1-ylpyridin-3-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC(F)=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=NC(=CC=3)N3CCNCC3)N=C2N2C=CN=C21 MHZZCSSVPOHYON-UHFFFAOYSA-N 0.000 claims 1
VFZPAFOLJAQYOG-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[3-methyl-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(F)=CC=3Cl)Cl)C3=NC=CN3C2=N1 VFZPAFOLJAQYOG-UHFFFAOYSA-N 0.000 claims 1
COZUICJLJUGGAF-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(F)=CC=3Cl)Cl)C3=NC=CN3C2=N1 COZUICJLJUGGAF-UHFFFAOYSA-N 0.000 claims 1
ZFLFXSHMLQGSTN-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=C(F)C=C1Cl ZFLFXSHMLQGSTN-UHFFFAOYSA-N 0.000 claims 1
BLZMYIUFPQJWKP-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CCNCC4=CC=3)N=C2N2C=CN=C21 BLZMYIUFPQJWKP-UHFFFAOYSA-N 0.000 claims 1
WKWWMMXOLUAQNQ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(1,2,3,4-tetrahydroisoquinolin-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CNCCC4=CC=3)N=C2N2C=CN=C21 WKWWMMXOLUAQNQ-UHFFFAOYSA-N 0.000 claims 1
RGHKDYZHFCXXGZ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(1H-indazol-5-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C=NNC4=CC=3)N=C2N2C=CN=C21 RGHKDYZHFCXXGZ-UHFFFAOYSA-N 0.000 claims 1
SJKFRWBTYBCUGI-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(1H-indazol-6-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4NN=CC4=CC=3)N=C2N2C=CN=C21 SJKFRWBTYBCUGI-UHFFFAOYSA-N 0.000 claims 1
GGAQMONGBVYRHN-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(3,5-difluoro-4-piperazin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C(F)=C(N2CCNCC2)C(F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GGAQMONGBVYRHN-UHFFFAOYSA-N 0.000 claims 1
PLCPXNHZGVDLBL-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(3-methyl-4-piperazin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCC2)C(C)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl PLCPXNHZGVDLBL-UHFFFAOYSA-N 0.000 claims 1
SPYJRXAJCSHASW-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(4-piperidin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3NCCCC3)N=C2N2C=CN=C21 SPYJRXAJCSHASW-UHFFFAOYSA-N 0.000 claims 1
DNDPQMUPODMFQA-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(4-pyrrolidin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3NCCC3)N=C2N2C=CN=C21 DNDPQMUPODMFQA-UHFFFAOYSA-N 0.000 claims 1
PTLMFNDQOCVRNY-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(4-pyrrolidin-3-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3CNCC3)N=C2N2C=CN=C21 PTLMFNDQOCVRNY-UHFFFAOYSA-N 0.000 claims 1
XMFGSTRFDFIUBX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 XMFGSTRFDFIUBX-UHFFFAOYSA-N 0.000 claims 1
RVAPALZVDKEYRH-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(1,1,2,3,3-pentamethylisoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2C(C)(C)N(C)C(C)(C)C2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl RVAPALZVDKEYRH-UHFFFAOYSA-N 0.000 claims 1
XCRDWMSFUCDJCE-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(1,1,2-trimethyl-3,4-dihydroisoquinolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl XCRDWMSFUCDJCE-UHFFFAOYSA-N 0.000 claims 1
YZMCCFLYDCAMJE-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(1,1,2-trimethyl-3H-isoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl YZMCCFLYDCAMJE-UHFFFAOYSA-N 0.000 claims 1
FIEFUTLSNLZAGA-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl FIEFUTLSNLZAGA-UHFFFAOYSA-N 0.000 claims 1
GAGKTBMUQVXVFC-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-ethylsulfonyl-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(S(=O)(=O)CC)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GAGKTBMUQVXVFC-UHFFFAOYSA-N 0.000 claims 1
LVWGYVOYZGMKSJ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl LVWGYVOYZGMKSJ-UHFFFAOYSA-N 0.000 claims 1
KFMRHPXDYPAONS-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-methylsulfonylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(S(=O)(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl KFMRHPXDYPAONS-UHFFFAOYSA-N 0.000 claims 1
IWTDIBNESAUTDQ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-pyrrolidin-1-yl-2,3-dihydro-1H-inden-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CC(CC4=CC=3)N3CCCC3)N=C2N2C=CN=C21 IWTDIBNESAUTDQ-UHFFFAOYSA-N 0.000 claims 1
QSPFXHIREXUPNK-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(4,4-dimethyl-2,3-dihydro-1H-isoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CNCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl QSPFXHIREXUPNK-UHFFFAOYSA-N 0.000 claims 1
FSHSRWFNFYSCTH-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(4,4-dimethyl-2-methylsulfonyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(S(C)(=O)=O)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl FSHSRWFNFYSCTH-UHFFFAOYSA-N 0.000 claims 1
KIFSZOILSBLSKH-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(4-oxo-1H-cinnolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(=O)C=NNC4=CC=3)N=C2N2C=CN=C21 KIFSZOILSBLSKH-UHFFFAOYSA-N 0.000 claims 1
NZCPVWCJDIRVSB-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(6-piperazin-1-ylpyridin-3-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=NC(=CC=3)N3CCNCC3)N=C2N2C=CN=C21 NZCPVWCJDIRVSB-UHFFFAOYSA-N 0.000 claims 1
GTMOOJIZVADIIA-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-(hydroxymethyl)-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)CO)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 GTMOOJIZVADIIA-UHFFFAOYSA-N 0.000 claims 1
RBEVWQZQYFQXSN-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-ethyl-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(CC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl RBEVWQZQYFQXSN-UHFFFAOYSA-N 0.000 claims 1
RKLJXTZEJDSOEW-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-fluoro-4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(C)C)CCN1C(C(=C1)F)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 RKLJXTZEJDSOEW-UHFFFAOYSA-N 0.000 claims 1
IPAMMJLEAOPWRH-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(OC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl IPAMMJLEAOPWRH-UHFFFAOYSA-N 0.000 claims 1
KPKUEUCHTUVVJM-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-methoxy-4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(CC2)C(C)C)C(OC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl KPKUEUCHTUVVJM-UHFFFAOYSA-N 0.000 claims 1
KDULFSRPAJMGSJ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-methyl-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KDULFSRPAJMGSJ-UHFFFAOYSA-N 0.000 claims 1
XVONRMRAGIETCX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(2-methylsulfonyl-2,6-diazaspiro[3.3]heptan-6-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1N(S(=O)(=O)C)CC11CN(C=2C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=2)C1 XVONRMRAGIETCX-UHFFFAOYSA-N 0.000 claims 1
STAWYSSWADGLPY-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(2-methylsulfonyl-2,7-diazaspiro[3.5]nonan-7-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1N(S(=O)(=O)C)CC21CCN(C=1C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=1)CC2 STAWYSSWADGLPY-UHFFFAOYSA-N 0.000 claims 1
YUSACECZXYAHRO-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(3,3-difluoropiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C(F)(F)CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 YUSACECZXYAHRO-UHFFFAOYSA-N 0.000 claims 1
LVGYPHJTNLSONJ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4-piperidin-1-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCCCC3)N=C2N2C=CN=C21 LVGYPHJTNLSONJ-UHFFFAOYSA-N 0.000 claims 1
ALGSKGHDUKFHSW-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 ALGSKGHDUKFHSW-UHFFFAOYSA-N 0.000 claims 1
JUCXZLZNUPUMAX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCCC3)N=C2N2C=CN=C21 JUCXZLZNUPUMAX-UHFFFAOYSA-N 0.000 claims 1
MAIXOLYZPZODGD-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3CCC(=O)NN=3)N=C2N2C=CN=C21 MAIXOLYZPZODGD-UHFFFAOYSA-N 0.000 claims 1
FIZCVABTBXZLTR-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(7-methylsulfonyl-2,7-diazaspiro[3.4]octan-2-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1N(S(=O)(=O)C)CCC11CN(C=2C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=2)C1 FIZCVABTBXZLTR-UHFFFAOYSA-N 0.000 claims 1
ITBIXLURBFCVLL-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCC21CCN(C=1C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=1)CC2 ITBIXLURBFCVLL-UHFFFAOYSA-N 0.000 claims 1
LRGFEYBMQIRJDW-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(piperidin-4-ylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(NC4CCNCC4)=CC=3)N=C2N2C=CN=C21 LRGFEYBMQIRJDW-UHFFFAOYSA-N 0.000 claims 1
YAFZYVBNSGAZJR-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[(1-methylsulfonylpiperidin-4-yl)amino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(S(=O)(=O)C)CCC1NC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 YAFZYVBNSGAZJR-UHFFFAOYSA-N 0.000 claims 1
FEUICBMWYFHGDZ-KDURUIRLSA-N 7-(2,6-dichlorophenyl)-12-[4-[(1R,5S)-7-ethyl-3,7-diazabicyclo[3.3.1]nonane-3-carbonyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C([C@]1(CN(CC)C[C@@](C2)(C1)[H])[H])N2C(=O)C(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl FEUICBMWYFHGDZ-KDURUIRLSA-N 0.000 claims 1
KZXXQNYTTLEMPA-GOSISDBHSA-N 7-(2,6-dichlorophenyl)-12-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@H](N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KZXXQNYTTLEMPA-GOSISDBHSA-N 0.000 claims 1
JWZIHTRIINQCRU-GASCZTMLSA-N 7-(2,6-dichlorophenyl)-12-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C(C(=C1)F)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 JWZIHTRIINQCRU-GASCZTMLSA-N 0.000 claims 1
KZXXQNYTTLEMPA-SFHVURJKSA-N 7-(2,6-dichlorophenyl)-12-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@@H](N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KZXXQNYTTLEMPA-SFHVURJKSA-N 0.000 claims 1
QBLPXHRYUWXNIJ-JOCHJYFZSA-N 7-(2,6-dichlorophenyl)-12-[4-[(3S)-3-propan-2-ylpiperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN[C@@H](C(C)C)CN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 QBLPXHRYUWXNIJ-JOCHJYFZSA-N 0.000 claims 1
DLLLKSDEZLQJHT-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[(4-methylpiperazin-1-yl)methyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 DLLLKSDEZLQJHT-UHFFFAOYSA-N 0.000 claims 1
PJEIKZYPAJBYSN-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[1-[1-(dimethylamino)-3-methylbutyl]cyclobutyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(NC=2N=C3C(C(N(C=4C(=CC=CC=4Cl)Cl)C4=NC=CN43)=O)=CN=2)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 PJEIKZYPAJBYSN-UHFFFAOYSA-N 0.000 claims 1
VKZXXMSHMVGZMM-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[2-(4-methylpiperazin-1-yl)ethyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CCC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 VKZXXMSHMVGZMM-UHFFFAOYSA-N 0.000 claims 1
ZCMFFRXYWPAMAF-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[2-(dimethylamino)ethyl-ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(CCN(C)C)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 ZCMFFRXYWPAMAF-UHFFFAOYSA-N 0.000 claims 1
ZSNROWXRZIHBBO-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[2-(dimethylamino)ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(NCCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 ZSNROWXRZIHBBO-UHFFFAOYSA-N 0.000 claims 1
RCWBCGALBPUPRM-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[3-(diethylamino)propoxy]-3-fluoroanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(F)C(OCCCN(CC)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 RCWBCGALBPUPRM-UHFFFAOYSA-N 0.000 claims 1
KXAUNTOLVMSJKJ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[4-(dimethylamino)piperidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KXAUNTOLVMSJKJ-UHFFFAOYSA-N 0.000 claims 1
RSDUPIFHAPXDBX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[4-(dimethylamino)piperidine-1-carbonyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(N(C)C)CCN1C(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 RSDUPIFHAPXDBX-UHFFFAOYSA-N 0.000 claims 1
GNCAELHTYLWVAX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[propan-2-yl-[2-(propan-2-ylamino)ethyl]amino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(C(C)C)CCNC(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 GNCAELHTYLWVAX-UHFFFAOYSA-N 0.000 claims 1
BWUMKXXNVDKXLR-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCC2)C(C(F)(F)F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl BWUMKXXNVDKXLR-UHFFFAOYSA-N 0.000 claims 1
AZTYYNWSKUKKBY-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[1-[2-(dimethylamino)ethyl]-2,3-dihydroindol-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2N(CCN(C)C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl AZTYYNWSKUKKBY-UHFFFAOYSA-N 0.000 claims 1
DGXXKHUWNFRAAP-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[2-(2,2-dimethylpropanoyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C(C)(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl DGXXKHUWNFRAAP-UHFFFAOYSA-N 0.000 claims 1
AMBRIFCKYYVDGS-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[2-(2-methylpropanoyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl AMBRIFCKYYVDGS-UHFFFAOYSA-N 0.000 claims 1
GEPSQLANSSBBBA-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GEPSQLANSSBBBA-UHFFFAOYSA-N 0.000 claims 1
OFMHWUQCUJRJJD-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[2-(propylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(NCCC)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl OFMHWUQCUJRJJD-UHFFFAOYSA-N 0.000 claims 1
NMTKRBQZRMANMZ-KKFHFHRHSA-N 7-(2,6-dichlorophenyl)-12-[[2-[(3S)-3-fluoropyrrolidin-1-yl]-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@@H](F)CCN1C1CC2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C1 NMTKRBQZRMANMZ-KKFHFHRHSA-N 0.000 claims 1
AAXQXVYTVSHGLS-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[4,4-dimethyl-2-(2,2,2-trifluoroethyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CC(F)(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl AAXQXVYTVSHGLS-UHFFFAOYSA-N 0.000 claims 1
WLBVSRCBCIYMAZ-UHFFFAOYSA-N 7-(2,6-difluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)F)C3=NC=CN3C2=N1 WLBVSRCBCIYMAZ-UHFFFAOYSA-N 0.000 claims 1
SVFMGEMTWAECKS-UHFFFAOYSA-N 7-(2,6-dimethylphenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(C)C=CC=C1C SVFMGEMTWAECKS-UHFFFAOYSA-N 0.000 claims 1
GMKXOFPMGDEEAV-UHFFFAOYSA-N 7-(2-chloro-3-hydroxyphenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound OC1=CC=CC(N2C(C3=CN=C(NC=4C=C5C(C6(CC6)CNC5)=CC=4)N=C3N3C=CN=C32)=O)=C1Cl GMKXOFPMGDEEAV-UHFFFAOYSA-N 0.000 claims 1
MUBBWOHVMUIKIR-UHFFFAOYSA-N 7-(2-chloro-4,6-difluorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=C(F)C=C1Cl MUBBWOHVMUIKIR-UHFFFAOYSA-N 0.000 claims 1
MIUZKHQKIKYNFA-UHFFFAOYSA-N 7-(2-chloro-4,6-difluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(F)=CC=3F)Cl)C3=NC=CN3C2=N1 MIUZKHQKIKYNFA-UHFFFAOYSA-N 0.000 claims 1
DGMFLJDUBAOBPV-UHFFFAOYSA-N 7-(2-chloro-4,6-difluorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=C(F)C=C1Cl DGMFLJDUBAOBPV-UHFFFAOYSA-N 0.000 claims 1
FPMBIKCMUSPCLI-UHFFFAOYSA-N 7-(2-chloro-4-methylphenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(C)=CC=3)Cl)C3=NC=CN3C2=N1 FPMBIKCMUSPCLI-UHFFFAOYSA-N 0.000 claims 1
OUVGXWNTDFYUQR-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-(5,6,7,8-tetrahydro-1,6-naphthyridin-3-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CNCCC4=NC=3)N=C2N2C=CN=C21 OUVGXWNTDFYUQR-UHFFFAOYSA-N 0.000 claims 1
HZXKSYNUISSDRZ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 HZXKSYNUISSDRZ-UHFFFAOYSA-N 0.000 claims 1
USWYVRFQYIOSJC-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(1,1,2,3,3-pentamethylisoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2C(C)(C)N(C)C(C)(C)C2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl USWYVRFQYIOSJC-UHFFFAOYSA-N 0.000 claims 1
SSDVHDBNZJIQMX-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(1,1,2-trimethyl-3H-isoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl SSDVHDBNZJIQMX-UHFFFAOYSA-N 0.000 claims 1
LZNRTNXWTSKNMC-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl LZNRTNXWTSKNMC-UHFFFAOYSA-N 0.000 claims 1
YFRNHMAIZOCUPR-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl YFRNHMAIZOCUPR-UHFFFAOYSA-N 0.000 claims 1
ZSAHIYGOYSATRM-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(2-methylsulfonylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(S(=O)(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl ZSAHIYGOYSATRM-UHFFFAOYSA-N 0.000 claims 1
YBPDRUNRDRQNJG-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(2-pyrrolidin-1-yl-2,3-dihydro-1H-inden-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CC(CC4=CC=3)N3CCCC3)N=C2N2C=CN=C21 YBPDRUNRDRQNJG-UHFFFAOYSA-N 0.000 claims 1
PTVNEBPLXVYSBC-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(4,4-dimethyl-2,3-dihydro-1H-isoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CNCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl PTVNEBPLXVYSBC-UHFFFAOYSA-N 0.000 claims 1
VYCIWMBUYBPTLQ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(4,4-dimethyl-2-methylsulfonyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(S(C)(=O)=O)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl VYCIWMBUYBPTLQ-UHFFFAOYSA-N 0.000 claims 1
DJCAHZKZXWQRGB-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[3-methyl-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 DJCAHZKZXWQRGB-UHFFFAOYSA-N 0.000 claims 1
NWYGMUXHPKFFFX-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[4-(1,4-diazepan-1-yl)-3-methylanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCCC2)C(C)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl NWYGMUXHPKFFFX-UHFFFAOYSA-N 0.000 claims 1
DATCYIARXKPUBJ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[4-(1-methylpiperidin-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCC1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 DATCYIARXKPUBJ-UHFFFAOYSA-N 0.000 claims 1
QUTZVOUNNKGPFD-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 QUTZVOUNNKGPFD-UHFFFAOYSA-N 0.000 claims 1
IWQIFPYCRKJXGB-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[4-[4-(dimethylamino)piperidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 IWQIFPYCRKJXGB-UHFFFAOYSA-N 0.000 claims 1
BNQVPFAKFCJURC-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(2,2-dimethylpropanoyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C(C)(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl BNQVPFAKFCJURC-UHFFFAOYSA-N 0.000 claims 1
HKDAOTQPQFTQGZ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(2-hydroxyacetyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C(=O)CO)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl HKDAOTQPQFTQGZ-UHFFFAOYSA-N 0.000 claims 1
AKGKWVTWFBVCPK-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(2-methylpropanoyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl AKGKWVTWFBVCPK-UHFFFAOYSA-N 0.000 claims 1
JAQWMUMGNOQMGD-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(cyclopentanecarbonyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)C(=O)C4CCCC4)=CC=3)N=C2N2C=CN=C21 JAQWMUMGNOQMGD-UHFFFAOYSA-N 0.000 claims 1
SCGBGGVRWINOLJ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(cyclopropanecarbonyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C(=O)C3CC3)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl SCGBGGVRWINOLJ-UHFFFAOYSA-N 0.000 claims 1
PSVSKRQYABFVSD-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(cyclopropanecarbonyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)C(=O)C4CC4)=CC=3)N=C2N2C=CN=C21 PSVSKRQYABFVSD-UHFFFAOYSA-N 0.000 claims 1
PGUCIORNTUDLKU-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl PGUCIORNTUDLKU-UHFFFAOYSA-N 0.000 claims 1
TVROFKVTTFPOPR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(1,2,3,4-tetrahydroisoquinolin-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4CNCCC4=CC=3)N=C2N2C=CN=C21 TVROFKVTTFPOPR-UHFFFAOYSA-N 0.000 claims 1
DKKKDPUXHSCONL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(2,3,4,5-tetrahydro-1H-2-benzazepin-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4CCCNCC4=CC=3)N=C2N2C=CN=C21 DKKKDPUXHSCONL-UHFFFAOYSA-N 0.000 claims 1
XDSGNNMNHWMDOO-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(3,5-dichloro-4-piperazin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C(Cl)C(N4CCNCC4)=C(Cl)C=3)N=C2N2C=CN=C21 XDSGNNMNHWMDOO-UHFFFAOYSA-N 0.000 claims 1
BETMOIKLRDEYNF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(3,5-difluoro-4-piperazin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C(F)=C(N2CCNCC2)C(F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl BETMOIKLRDEYNF-UHFFFAOYSA-N 0.000 claims 1
QGTROLNLDGHKID-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-cyclohexylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3CCCCC3)N=C2N2C=CN=C21 QGTROLNLDGHKID-UHFFFAOYSA-N 0.000 claims 1
GRNBWTTUZPFZLG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-hydroxy-3-methylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(O)C(C)=CC(NC=2N=C3C(C(N(C=4C(=CC=CC=4)Cl)C4=NC=CN43)=O)=CN=2)=C1 GRNBWTTUZPFZLG-UHFFFAOYSA-N 0.000 claims 1
VQEUOEOBCQPYSX-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-imidazo[1,2-a]pyridin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=C4C=CC=CN4C=3)N=C2N2C=CN=C21 VQEUOEOBCQPYSX-UHFFFAOYSA-N 0.000 claims 1
NUEJBGYJOOBOHM-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-methylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 NUEJBGYJOOBOHM-UHFFFAOYSA-N 0.000 claims 1
IUMYMNAILOBLJL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-morpholin-4-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCOCC3)N=C2N2C=CN=C21 IUMYMNAILOBLJL-UHFFFAOYSA-N 0.000 claims 1
WJDVIVAHSHCRQL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-piperidin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCCCC3)N=C2N2C=CN=C21 WJDVIVAHSHCRQL-UHFFFAOYSA-N 0.000 claims 1
FNNOSSSVSACDCE-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-piperidin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3NCCCC3)N=C2N2C=CN=C21 FNNOSSSVSACDCE-UHFFFAOYSA-N 0.000 claims 1
QYRRHAFJBWVMFQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-piperidin-4-yloxyanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(OC4CCNCC4)=CC=3)N=C2N2C=CN=C21 QYRRHAFJBWVMFQ-UHFFFAOYSA-N 0.000 claims 1
ONHABPWAEIKIJU-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-pyrazol-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3N=CC=C3)N=C2N2C=CN=C21 ONHABPWAEIKIJU-UHFFFAOYSA-N 0.000 claims 1
XNDFLXRBPQEZDO-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-pyridin-3-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3C=NC=CC=3)N=C2N2C=CN=C21 XNDFLXRBPQEZDO-UHFFFAOYSA-N 0.000 claims 1
UFBLJWAOFPIERE-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-pyrrolidin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3NCCC3)N=C2N2C=CN=C21 UFBLJWAOFPIERE-UHFFFAOYSA-N 0.000 claims 1
JZRFEWFZXOSIDA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-pyrrolidin-3-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3CNCC3)N=C2N2C=CN=C21 JZRFEWFZXOSIDA-UHFFFAOYSA-N 0.000 claims 1
JIXLPAFSAYXLQW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-thiomorpholin-4-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCSCC3)N=C2N2C=CN=C21 JIXLPAFSAYXLQW-UHFFFAOYSA-N 0.000 claims 1
VCEWFIVEODTAPW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(5,6,7,8-tetrahydronaphthalen-2-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4CCCCC4=CC=3)N=C2N2C=CN=C21 VCEWFIVEODTAPW-UHFFFAOYSA-N 0.000 claims 1
NRAXTRPZXBZAAB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(pyridin-4-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CN=CC=3)N=C2N2C=CN=C21 NRAXTRPZXBZAAB-UHFFFAOYSA-N 0.000 claims 1
UDARXIKVYRTRBT-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 UDARXIKVYRTRBT-UHFFFAOYSA-N 0.000 claims 1
RXFZHVDTUZNUDK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1,1,2,3,3-pentamethylisoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2C(C)(C)N(C)C(C)(C)C2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl RXFZHVDTUZNUDK-UHFFFAOYSA-N 0.000 claims 1
CSGZSKJHPOJUBN-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1,1,2-trimethyl-3,4-dihydroisoquinolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl CSGZSKJHPOJUBN-UHFFFAOYSA-N 0.000 claims 1
QGYNNTMCLDQWJN-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1,1,2-trimethyl-3,4-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2C(C)(C)N(C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl QGYNNTMCLDQWJN-UHFFFAOYSA-N 0.000 claims 1
OZEBXGJIEWGDLG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1,1,2-trimethyl-3H-isoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl OZEBXGJIEWGDLG-UHFFFAOYSA-N 0.000 claims 1
FNGLHPVBGGVTRR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1-methyl-3,4-dihydro-2H-quinolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2N(C)CCCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl FNGLHPVBGGVTRR-UHFFFAOYSA-N 0.000 claims 1
JAFUBIPJLRMFCG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1-methyl-3,4-dihydro-2H-quinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2N(C)CCCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl JAFUBIPJLRMFCG-UHFFFAOYSA-N 0.000 claims 1
MUKWAQUSFPAUGU-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl MUKWAQUSFPAUGU-UHFFFAOYSA-N 0.000 claims 1
IEWDIQKMZRVANG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(2-ethyl-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CC)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl IEWDIQKMZRVANG-UHFFFAOYSA-N 0.000 claims 1
PFAIKAPJSZVPTC-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CN(C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl PFAIKAPJSZVPTC-UHFFFAOYSA-N 0.000 claims 1
UGDHRERXJQTXBB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl UGDHRERXJQTXBB-UHFFFAOYSA-N 0.000 claims 1
PEUULKFEGQHWFY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(3-cyclopropyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4CCN(CCC4=CC=3)C3CC3)N=C2N2C=CN=C21 PEUULKFEGQHWFY-UHFFFAOYSA-N 0.000 claims 1
YHQXNFMHVVJBPZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CCN(C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl YHQXNFMHVVJBPZ-UHFFFAOYSA-N 0.000 claims 1
ZGBTXCDUOKJJGB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(4,4-dimethyl-2-propan-2-yl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl ZGBTXCDUOKJJGB-UHFFFAOYSA-N 0.000 claims 1
YKCNYRMBKPOZJR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC1=CC(N2CCN(C)CC2)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl YKCNYRMBKPOZJR-UHFFFAOYSA-N 0.000 claims 1
CUJAWNMZKOEMSZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[2-methyl-4-[3-(4-methylpiperazin-1-yl)propoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CCCOC(C=C1C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 CUJAWNMZKOEMSZ-UHFFFAOYSA-N 0.000 claims 1
MLHGGHCZXJGZOR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3,5-difluoro-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C(=C1)F)=C(F)C=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 MLHGGHCZXJGZOR-UHFFFAOYSA-N 0.000 claims 1
XTNHIIWNDNCKKF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C1=CC=CC(NC=2N=C3C(C(N(C=4C(=CC=CC=4)Cl)C4=NC=CN43)=O)=CN=2)=C1 XTNHIIWNDNCKKF-UHFFFAOYSA-N 0.000 claims 1
GKAGRSUWJGSEAR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-(hydroxymethyl)-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)CO)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GKAGRSUWJGSEAR-UHFFFAOYSA-N 0.000 claims 1
MESANKRTXWTCGC-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-(pyrrolidin-1-ylmethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C(CN4CCCC4)C=CC=3)N=C2N2C=CN=C21 MESANKRTXWTCGC-UHFFFAOYSA-N 0.000 claims 1
MGQYJIGVHIABLP-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-[3-(4-methylpiperazin-1-yl)propoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CCCOC1=CC=CC(NC=2N=C3C(C(N(C=4C(=CC=CC=4)Cl)C4=NC=CN43)=O)=CN=2)=C1 MGQYJIGVHIABLP-UHFFFAOYSA-N 0.000 claims 1
NCSLSRHAGUPMIR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-chloro-4-[2-(propan-2-ylamino)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(Cl)C(OCCNC(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 NCSLSRHAGUPMIR-UHFFFAOYSA-N 0.000 claims 1
LTDJVNXPFRTHPR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-chloro-4-piperazin-1-yl-5-(trifluoromethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C(Cl)=C(N2CCNCC2)C(C(F)(F)F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl LTDJVNXPFRTHPR-UHFFFAOYSA-N 0.000 claims 1
QEQAQSMIISYCKJ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-ethyl-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(CC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl QEQAQSMIISYCKJ-UHFFFAOYSA-N 0.000 claims 1
SXKZCTYUUSMWNZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-fluoro-4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(C)C)CCN1C(C(=C1)F)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SXKZCTYUUSMWNZ-UHFFFAOYSA-N 0.000 claims 1
PLPDBCQEFQSXHI-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-fluoro-4-[2-(4-methylpiperazin-1-yl)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CCOC(C(=C1)F)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 PLPDBCQEFQSXHI-UHFFFAOYSA-N 0.000 claims 1
XQJXUOKWSDUBCA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(OC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl XQJXUOKWSDUBCA-UHFFFAOYSA-N 0.000 claims 1
SMINPGDPSAYJNB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methoxy-4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(CC2)C(C)C)C(OC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl SMINPGDPSAYJNB-UHFFFAOYSA-N 0.000 claims 1
XXVLURPBUPXZKD-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methoxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(OCCN2CCN(C)CC2)C(OC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl XXVLURPBUPXZKD-UHFFFAOYSA-N 0.000 claims 1
HWJXZCPWQIVHCB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methoxy-4-[2-(propan-2-ylamino)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(OCCNC(C)C)C(OC)=CC(NC=2N=C3C(C(N(C=4C(=CC=CC=4)Cl)C4=NC=CN43)=O)=CN=2)=C1 HWJXZCPWQIVHCB-UHFFFAOYSA-N 0.000 claims 1
GCFKMPJJZHGGAY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methyl-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GCFKMPJJZHGGAY-UHFFFAOYSA-N 0.000 claims 1
ODBWPJDXYDPWJA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ODBWPJDXYDPWJA-UHFFFAOYSA-N 0.000 claims 1
SUMCRTBWSMDICB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(1,4-diazepan-1-yl)-3-methylanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCCC2)C(C)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl SUMCRTBWSMDICB-UHFFFAOYSA-N 0.000 claims 1
HLCFJKUJLMXDCF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(1-methylpiperidin-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCC1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 HLCFJKUJLMXDCF-UHFFFAOYSA-N 0.000 claims 1
BSIGDYDOKKECNI-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(1H-pyrazol-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3=CNN=C3)N=C2N2C=CN=C21 BSIGDYDOKKECNI-UHFFFAOYSA-N 0.000 claims 1
HHSNMKMVCYOUFX-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=C4SCCN4C=3)N=C2N2C=CN=C21 HHSNMKMVCYOUFX-UHFFFAOYSA-N 0.000 claims 1
QQJLLPSWBNUDQY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=C(SC=3)N3CCOCC3)N=C2N2C=CN=C21 QQJLLPSWBNUDQY-UHFFFAOYSA-N 0.000 claims 1
YCJSWOWKXTVETQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2-morpholin-4-ylethylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCN4CCOCC4)=CC=3)N=C2N2C=CN=C21 YCJSWOWKXTVETQ-UHFFFAOYSA-N 0.000 claims 1
MKQPIHBOLOTWHR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2-pyrrolidin-1-ylethylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCN4CCCC4)=CC=3)N=C2N2C=CN=C21 MKQPIHBOLOTWHR-UHFFFAOYSA-N 0.000 claims 1
RZDUUOJUVMNMFW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(3-imidazol-1-ylpropylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCCN4C=NC=C4)=CC=3)N=C2N2C=CN=C21 RZDUUOJUVMNMFW-UHFFFAOYSA-N 0.000 claims 1
WRQLVOWKUUIYKQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(3-morpholin-4-ylpropylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCCN4CCOCC4)=CC=3)N=C2N2C=CN=C21 WRQLVOWKUUIYKQ-UHFFFAOYSA-N 0.000 claims 1
ICIOPPGTCQNTNY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(3-oxo-1,2-dihydroindazol-7-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3C4=C(C(NN4)=O)C=CC=3)N=C2N2C=CN=C21 ICIOPPGTCQNTNY-UHFFFAOYSA-N 0.000 claims 1
SCWRDQQXVOUYHS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-hydroxypiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(O)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SCWRDQQXVOUYHS-UHFFFAOYSA-N 0.000 claims 1
HVRSFBMFPRDHBS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-hydroxypiperidine-1-carbonyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(O)CCN1C(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 HVRSFBMFPRDHBS-UHFFFAOYSA-N 0.000 claims 1
FYUMRXXTENSYRF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)-3-propan-2-ylanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(C(C)C)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl FYUMRXXTENSYRF-UHFFFAOYSA-N 0.000 claims 1
YENWEOCDIMPAIL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,4,5,7,11,13-hexazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NN=CN3C2=N1 YENWEOCDIMPAIL-UHFFFAOYSA-N 0.000 claims 1
IICGNJDSNUEEHR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 IICGNJDSNUEEHR-UHFFFAOYSA-N 0.000 claims 1
SHECBVUSRYTIRU-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaene-8-thione Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=S)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SHECBVUSRYTIRU-UHFFFAOYSA-N 0.000 claims 1
QOZMDPNEYXJJHY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazine-1-carbonyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 QOZMDPNEYXJJHY-UHFFFAOYSA-N 0.000 claims 1
MFITWXWCJVWMHQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-morpholin-4-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCOCC3)N=C2N2C=CN=C21 MFITWXWCJVWMHQ-UHFFFAOYSA-N 0.000 claims 1
GCFBDNMUIHNLIV-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-piperidin-1-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCCCC3)N=C2N2C=CN=C21 GCFBDNMUIHNLIV-UHFFFAOYSA-N 0.000 claims 1
DPGFXRUPDBRYKG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 DPGFXRUPDBRYKG-UHFFFAOYSA-N 0.000 claims 1
XSFRKOIPMNHCSK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-pyridin-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CC3)C=3N=CC=CC=3)N=C2N2C=CN=C21 XSFRKOIPMNHCSK-UHFFFAOYSA-N 0.000 claims 1
WZRMRABHYLDJJF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCCC3)N=C2N2C=CN=C21 WZRMRABHYLDJJF-UHFFFAOYSA-N 0.000 claims 1
STJGZOBBYGZWPX-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(hydroxymethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(CO)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 STJGZOBBYGZWPX-UHFFFAOYSA-N 0.000 claims 1
SBFKEEHRFNMNNG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(imidazol-1-ylmethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(CN4C=NC=C4)=CC=3)N=C2N2C=CN=C21 SBFKEEHRFNMNNG-UHFFFAOYSA-N 0.000 claims 1
MJBJKFZMPBCFBE-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(morpholin-4-ylmethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(CN4CCOCC4)=CC=3)N=C2N2C=CN=C21 MJBJKFZMPBCFBE-UHFFFAOYSA-N 0.000 claims 1
GASZSOBCXYCKAV-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(piperidin-4-ylmethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(CC4CCNCC4)=CC=3)N=C2N2C=CN=C21 GASZSOBCXYCKAV-UHFFFAOYSA-N 0.000 claims 1
SHDASFTVMNGMQE-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(pyrazol-1-ylmethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(CN4N=CC=C4)=CC=3)N=C2N2C=CN=C21 SHDASFTVMNGMQE-UHFFFAOYSA-N 0.000 claims 1
LPILJTRIDGYRLT-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(pyrrolidin-1-ylmethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(CN4CCCC4)=CC=3)N=C2N2C=CN=C21 LPILJTRIDGYRLT-UHFFFAOYSA-N 0.000 claims 1
KRQQYGJSUNKQPS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(trifluoromethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(C(F)(F)F)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 KRQQYGJSUNKQPS-UHFFFAOYSA-N 0.000 claims 1
ZHZHDFPEDFXLKW-LJQANCHMSA-N 7-(2-chlorophenyl)-12-[4-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC[C@H]1CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ZHZHDFPEDFXLKW-LJQANCHMSA-N 0.000 claims 1
OOHKMENCNVDUEZ-FQEVSTJZSA-N 7-(2-chlorophenyl)-12-[4-[(2S)-2-(trifluoromethyl)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC(F)(F)[C@@H]1CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 OOHKMENCNVDUEZ-FQEVSTJZSA-N 0.000 claims 1
VHEALHXMBUECJS-LJQANCHMSA-N 7-(2-chlorophenyl)-12-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@H](N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 VHEALHXMBUECJS-LJQANCHMSA-N 0.000 claims 1
OCZSMSRPDZFEBY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(1-methylpyrrolidin-2-yl)ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound CN1CCCC1CCNC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 OCZSMSRPDZFEBY-UHFFFAOYSA-N 0.000 claims 1
AAZRWBWWHVIATQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(1H-imidazol-5-yl)ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCC=4N=CNC=4)=CC=3)N=C2N2C=CN=C21 AAZRWBWWHVIATQ-UHFFFAOYSA-N 0.000 claims 1
TUZDSLJKMWZQQS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(6-methylquinolin-2-yl)ethyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC2=CC(C)=CC=C2N=C1CCC(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl TUZDSLJKMWZQQS-UHFFFAOYSA-N 0.000 claims 1
SJAZUYFBVKZIHT-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(diethylamino)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(OCCN(CC)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SJAZUYFBVKZIHT-UHFFFAOYSA-N 0.000 claims 1
GCRIPFFAFGSGJZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(dimethylamino)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(OCCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GCRIPFFAFGSGJZ-UHFFFAOYSA-N 0.000 claims 1
FWVAXLUYFOSLLD-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(dimethylamino)ethyl-ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(CCN(C)C)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 FWVAXLUYFOSLLD-UHFFFAOYSA-N 0.000 claims 1
WOULXCXHUMPFBR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(dimethylamino)ethyl-methylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(C)CCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 WOULXCXHUMPFBR-UHFFFAOYSA-N 0.000 claims 1
OOHKMENCNVDUEZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(trifluoromethyl)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC(F)(F)C1CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 OOHKMENCNVDUEZ-UHFFFAOYSA-N 0.000 claims 1
QTUTZQJDHFNMIL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[3-(2-oxopyrrolidin-1-yl)propylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCCN4C(CCC4)=O)=CC=3)N=C2N2C=CN=C21 QTUTZQJDHFNMIL-UHFFFAOYSA-N 0.000 claims 1
SOZPDGNNIAKORH-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[3-(dimethylamino)propyl-methylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(C)CCCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SOZPDGNNIAKORH-UHFFFAOYSA-N 0.000 claims 1
JZMDEGGHLUISMB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[3-(trifluoromethyl)piperidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C(C(F)(F)F)CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 JZMDEGGHLUISMB-UHFFFAOYSA-N 0.000 claims 1
QDCUXXKOUNDUAS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(2-methoxyethyl)piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(CCOC)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 QDCUXXKOUNDUAS-UHFFFAOYSA-N 0.000 claims 1
YIFPUJOZGFNUSO-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(4-fluorophenyl)piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(F)=CC=C1N1CCN(C=2C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=2)CC1 YIFPUJOZGFNUSO-UHFFFAOYSA-N 0.000 claims 1
PMKVKTIUZFRYPK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(cyclohexylmethyl)piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CC4CCCCC4)CC3)N=C2N2C=CN=C21 PMKVKTIUZFRYPK-UHFFFAOYSA-N 0.000 claims 1
ICOWOOZKFOHYEH-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(dimethylamino)piperidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ICOWOOZKFOHYEH-UHFFFAOYSA-N 0.000 claims 1
ZIVISXMJPANONQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(oxetan-3-yl)piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CC3)C3COC3)N=C2N2C=CN=C21 ZIVISXMJPANONQ-UHFFFAOYSA-N 0.000 claims 1
GSDTYSPSQFWYBN-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-[(3-chlorophenyl)methyl]piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(CN2CCN(CC2)C=2C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=2)=C1 GSDTYSPSQFWYBN-UHFFFAOYSA-N 0.000 claims 1
DPYHKUBAWKDQGM-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(CCN(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 DPYHKUBAWKDQGM-UHFFFAOYSA-N 0.000 claims 1
GIZSAAKJRUZMGS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-[3-(dimethylamino)propyl]piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(CCCN(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GIZSAAKJRUZMGS-UHFFFAOYSA-N 0.000 claims 1
QLSQWQRZAPISIU-KRWDZBQOSA-N 7-(2-chlorophenyl)-12-[4-[[(2S)-pyrrolidin-2-yl]methoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(OC[C@H]4NCCC4)=CC=3)N=C2N2C=CN=C21 QLSQWQRZAPISIU-KRWDZBQOSA-N 0.000 claims 1
GYVYBZGLYXUARW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[propan-2-yl-[2-(propan-2-ylamino)ethyl]amino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(C(C)C)CCNC(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GYVYBZGLYXUARW-UHFFFAOYSA-N 0.000 claims 1
QPQHXCXOUDEHOR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCC2)C(C(F)(F)F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl QPQHXCXOUDEHOR-UHFFFAOYSA-N 0.000 claims 1
RWJCTWYINAYMFV-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[1-[2-(dimethylamino)ethyl]-2,3-dihydroindol-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2N(CCN(C)C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl RWJCTWYINAYMFV-UHFFFAOYSA-N 0.000 claims 1
ABALSCAZEPXGDF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(2-ethylbutyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CC(CC)CC)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl ABALSCAZEPXGDF-UHFFFAOYSA-N 0.000 claims 1
KKCUAASUFOILPL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(2-methoxyethyl)-3,4-dihydro-1H-isoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CN(CCOC)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl KKCUAASUFOILPL-UHFFFAOYSA-N 0.000 claims 1
LWKBFYGLHVKLIW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(cyclohexylmethyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC1CCCCC1 LWKBFYGLHVKLIW-UHFFFAOYSA-N 0.000 claims 1
PVJFQINWMUVXBI-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl PVJFQINWMUVXBI-UHFFFAOYSA-N 0.000 claims 1
OQHAWPBWPDOYBQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-[(4-imidazol-1-ylphenyl)methyl]-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC(C=C1)=CC=C1N1C=CN=C1 OQHAWPBWPDOYBQ-UHFFFAOYSA-N 0.000 claims 1
KTYKKSPOVNEULM-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC1=CC(F)=CC(C(F)(F)F)=C1 KTYKKSPOVNEULM-UHFFFAOYSA-N 0.000 claims 1
DKQPDIYSKXVOFA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-(2,2,2-trifluoroethyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CC(F)(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl DKQPDIYSKXVOFA-UHFFFAOYSA-N 0.000 claims 1
FMBORYIZQRKJLK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-(4,4,4-trifluorobutyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CCCC(F)(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl FMBORYIZQRKJLK-UHFFFAOYSA-N 0.000 claims 1
UXOLVCNWZNMQMB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-(pyridin-3-ylmethyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC1=CC=CN=C1 UXOLVCNWZNMQMB-UHFFFAOYSA-N 0.000 claims 1
HKBWWKPGTXQPIA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-(thiophen-3-ylmethyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC=1C=CSC=1 HKBWWKPGTXQPIA-UHFFFAOYSA-N 0.000 claims 1
XVLSHQPTPJYEAT-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-[(4-propoxyphenyl)methyl]-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(OCCC)=CC=C1CN1CC(C)(C)C2=CC=C(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)C=C2C1 XVLSHQPTPJYEAT-UHFFFAOYSA-N 0.000 claims 1
ZUOSENQRSAWNKY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(CC)CCN1C(C=N1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ZUOSENQRSAWNKY-UHFFFAOYSA-N 0.000 claims 1
LHLGMQAZACYFPV-UHFFFAOYSA-N 7-(2-chlorophenyl)-3-methyl-12-[4-(4-methylpiperazin-1-yl)anilino]-2,4,5,7,11,13-hexazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NN=C(C)N3C2=N1 LHLGMQAZACYFPV-UHFFFAOYSA-N 0.000 claims 1
XEYIRLOQTLKFHY-UHFFFAOYSA-N 7-(2-chlorophenyl)-3-methyl-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=C(C)N3C2=N1 XEYIRLOQTLKFHY-UHFFFAOYSA-N 0.000 claims 1
DVYLGXXGLPOVGT-UHFFFAOYSA-N 7-(2-chlorophenyl)-8-imino-N-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-amine Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=N)C=1N1C=CN=C1N2C1=CC=CC=C1Cl DVYLGXXGLPOVGT-UHFFFAOYSA-N 0.000 claims 1
XZVUXDVMSJADHH-UHFFFAOYSA-N 7-(2-methylphenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)C)C3=NC=CN3C2=N1 XZVUXDVMSJADHH-UHFFFAOYSA-N 0.000 claims 1
BVSHKIRKMXGZMN-UHFFFAOYSA-N 7-(3-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C=C(Cl)C=CC=3)C3=NC=CN3C2=N1 BVSHKIRKMXGZMN-UHFFFAOYSA-N 0.000 claims 1
GTVAFXIRKVPEGA-UHFFFAOYSA-N 7-(3-fluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C=C(F)C=CC=3)C3=NC=CN3C2=N1 GTVAFXIRKVPEGA-UHFFFAOYSA-N 0.000 claims 1
RRUCAEDSIJXSMT-UHFFFAOYSA-N 7-(4-hydroxy-2-methylphenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound CC1=CC(O)=CC=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 RRUCAEDSIJXSMT-UHFFFAOYSA-N 0.000 claims 1
ZLLWMXBDINIIFP-UHFFFAOYSA-N 7-(4-hydroxyphenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(O)=CC=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 ZLLWMXBDINIIFP-UHFFFAOYSA-N 0.000 claims 1
BUJBUAPLAJWDLH-UHFFFAOYSA-N 7-[2-chloro-4-(trifluoromethyl)phenyl]-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(=CC=3)C(F)(F)F)Cl)C3=NC=CN3C2=N1 BUJBUAPLAJWDLH-UHFFFAOYSA-N 0.000 claims 1
UFUYHRZIJHDGIT-UHFFFAOYSA-N 7-[[7-(2-chloro-6-fluorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-4,4-dimethyl-1,3-dihydroisoquinoline-2-sulfonamide Chemical compound C=1C=C2C(C)(C)CN(S(N)(=O)=O)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl UFUYHRZIJHDGIT-UHFFFAOYSA-N 0.000 claims 1
KYLYVGCGAVZINF-UHFFFAOYSA-N 7-[[7-(2-chloro-6-fluorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-2-carboxamide Chemical compound C=1C=C2C3(CC3)CN(C(=O)NC)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl KYLYVGCGAVZINF-UHFFFAOYSA-N 0.000 claims 1
SCWAHOJJUNVFNK-UHFFFAOYSA-N 7-[[7-(2-chloro-6-fluorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-propan-2-ylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-2-carboxamide Chemical compound C=1C=C2C3(CC3)CN(C(=O)NC(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl SCWAHOJJUNVFNK-UHFFFAOYSA-N 0.000 claims 1
WVNQOFKQYRFPIJ-UHFFFAOYSA-N 7-cyclohexyl-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C3CCCCC3)C3=NC=CN3C2=N1 WVNQOFKQYRFPIJ-UHFFFAOYSA-N 0.000 claims 1
CWWLREJNRGUASV-UHFFFAOYSA-N AKI00000020a Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCOCC3)N=C2N2C=CN=C21 CWWLREJNRGUASV-UHFFFAOYSA-N 0.000 claims 1
GKGDBNYEBLXRBK-UHFFFAOYSA-N C1=C2CC(NCCF)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl Chemical compound C1=C2CC(NCCF)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GKGDBNYEBLXRBK-UHFFFAOYSA-N 0.000 claims 1
MFQIKQJYFSEBDC-UHFFFAOYSA-N C1=C2CCN(CC(F)F)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl Chemical compound C1=C2CCN(CC(F)F)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl MFQIKQJYFSEBDC-UHFFFAOYSA-N 0.000 claims 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
QOWZEOJBRPFCFG-UHFFFAOYSA-N C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=S)C=1N1C=CN=C1N2C1=CC=CC=C1Cl Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=S)C=1N1C=CN=C1N2C1=CC=CC=C1Cl QOWZEOJBRPFCFG-UHFFFAOYSA-N 0.000 claims 1
MEJCDTUASJICTL-UHFFFAOYSA-N C=1C=C2C(C)(C)CN(CC(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl Chemical compound C=1C=C2C(C)(C)CN(CC(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl MEJCDTUASJICTL-UHFFFAOYSA-N 0.000 claims 1
MGKQCKFWFZVBNZ-UHFFFAOYSA-N C=1C=C2C(C)(C)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl Chemical compound C=1C=C2C(C)(C)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl MGKQCKFWFZVBNZ-UHFFFAOYSA-N 0.000 claims 1
DWRDTRFUFLBCNX-UHFFFAOYSA-N C=1C=C2C(C)(C)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl Chemical compound C=1C=C2C(C)(C)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl DWRDTRFUFLBCNX-UHFFFAOYSA-N 0.000 claims 1
YFXPXAIGNXNQIY-UHFFFAOYSA-N C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=S)C=1N1C=CN=C1N2C1=CC=CC=C1Cl Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=S)C=1N1C=CN=C1N2C1=CC=CC=C1Cl YFXPXAIGNXNQIY-UHFFFAOYSA-N 0.000 claims 1
HJTVIZPBTFNXGN-UHFFFAOYSA-N C=1C=C2C3(CC3)CN(CC(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl Chemical compound C=1C=C2C3(CC3)CN(CC(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl HJTVIZPBTFNXGN-UHFFFAOYSA-N 0.000 claims 1
XYSPAJYSNPKYPT-UHFFFAOYSA-N C=1C=C2C3(CC3)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl Chemical compound C=1C=C2C3(CC3)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl XYSPAJYSNPKYPT-UHFFFAOYSA-N 0.000 claims 1
SAMKOIRNJNKDSB-UHFFFAOYSA-N N-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-1-methylpiperidine-4-carboxamide Chemical compound C1CN(C)CCC1C(=O)NC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SAMKOIRNJNKDSB-UHFFFAOYSA-N 0.000 claims 1
OXRSDNJFGFDKCI-UHFFFAOYSA-N N-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-4-hydroxycyclohexane-1-carboxamide Chemical compound C1CC(O)CCC1C(=O)NC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 OXRSDNJFGFDKCI-UHFFFAOYSA-N 0.000 claims 1
ZSLIZCAXMMDJTD-UHFFFAOYSA-N N-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ZSLIZCAXMMDJTD-UHFFFAOYSA-N 0.000 claims 1
SOYSPINXUBJEKX-UHFFFAOYSA-N N-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]cyclopentanecarboxamide Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NC(=O)C4CCCC4)=CC=3)N=C2N2C=CN=C21 SOYSPINXUBJEKX-UHFFFAOYSA-N 0.000 claims 1
WUPJPYDSZZOXNN-UHFFFAOYSA-N N-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]pyridine-4-carboxamide Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NC(=O)C=4C=CN=CC=4)=CC=3)N=C2N2C=CN=C21 WUPJPYDSZZOXNN-UHFFFAOYSA-N 0.000 claims 1
JKPCLADUTSTTEJ-UHFFFAOYSA-N S1C(NC)=NC(C)=C1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 Chemical compound S1C(NC)=NC(C)=C1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 JKPCLADUTSTTEJ-UHFFFAOYSA-N 0.000 claims 1
CLMIGLFZQQFETA-UHFFFAOYSA-N S1CC(=O)N(C(C)C)C1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 Chemical compound S1CC(=O)N(C(C)C)C1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 CLMIGLFZQQFETA-UHFFFAOYSA-N 0.000 claims 1
125000003342 alkenyl group Chemical group 0.000 claims 1
125000004350 aryl cycloalkyl group Chemical group 0.000 claims 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
125000002619 bicyclic group Chemical group 0.000 claims 1
125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
125000001188 haloalkyl group Chemical group 0.000 claims 1
125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
INBLGJXWYYQNCP-UHFFFAOYSA-N methyl 4-[[7-(2,6-dichlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 INBLGJXWYYQNCP-UHFFFAOYSA-N 0.000 claims 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
125000002950 monocyclic group Chemical group 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
XMNVBOSLZWOYFC-UHFFFAOYSA-N pyrimido[4,5-d]pyrimidin-2-amine Chemical compound C1=NC=NC2=NC(N)=NC=C21 XMNVBOSLZWOYFC-UHFFFAOYSA-N 0.000 claims 1
239000012453 solvate Substances 0.000 claims 1
238000006467 substitution reaction Methods 0.000 claims 1
FHKMQEPNAVSOMS-UHFFFAOYSA-N tert-butyl 7-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-3,4-dihydro-1H-isoquinoline-2-carboxylate Chemical compound C1=C2CN(C(=O)OC(C)(C)C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl FHKMQEPNAVSOMS-UHFFFAOYSA-N 0.000 claims 1

JP2013556755A 2011-02-28 2012-02-27 三環式キナーゼ阻害薬 Expired - Fee Related JP5886326B2 (ja)