JP5886326B2 - 三環式キナーゼ阻害薬 - Google Patents

三環式キナーゼ阻害薬 Download PDF

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Publication number
JP5886326B2
JP5886326B2 JP2013556755A JP2013556755A JP5886326B2 JP 5886326 B2 JP5886326 B2 JP 5886326B2 JP 2013556755 A JP2013556755 A JP 2013556755A JP 2013556755 A JP2013556755 A JP 2013556755A JP 5886326 B2 JP5886326 B2 JP 5886326B2
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Japan
Prior art keywords
pyrimido
amino
imidazo
pyrimidin
phenyl
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Japanese (ja)
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JP2014506929A (ja
JP2014506929A5 (enExample
Inventor
トン，ユンソン
ペニング，トーマス・デイー
フロールジヤンシツク，アラン
ミヤシロ，ジユリー
ウツズ，キース・ダブリユ
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AbbVie Inc
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AbbVie Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2013556755A 2011-02-28 2012-02-27 三環式キナーゼ阻害薬 Expired - Fee Related JP5886326B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161447405P 2011-02-28 2011-02-28
US61/447,405 2011-02-28
PCT/US2012/026685 WO2012161812A1 (en) 2011-02-28 2012-02-27 Tricyclic inhibitors of kinases

Publications (3)

Publication Number Publication Date
JP2014506929A JP2014506929A (ja) 2014-03-20
JP2014506929A5 JP2014506929A5 (enExample) 2015-04-16
JP5886326B2 true JP5886326B2 (ja) 2016-03-16

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JP2013556755A Expired - Fee Related JP5886326B2 (ja) 2011-02-28 2012-02-27 三環式キナーゼ阻害薬

Country Status (11)

Country Link
US (1) US8710065B2 (enExample)
EP (1) EP2681221B1 (enExample)
JP (1) JP5886326B2 (enExample)
CN (1) CN103703005A (enExample)
AR (1) AR085502A1 (enExample)
CA (1) CA2827648A1 (enExample)
ES (1) ES2587514T3 (enExample)
MX (1) MX340402B (enExample)
TW (1) TWI532742B (enExample)
UY (1) UY33925A (enExample)
WO (1) WO2012161812A1 (enExample)

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CN108727249A (zh) * 2018-07-07 2018-11-02 台州学院 3-二氟甲基哌啶盐酸盐及其衍生物的合成方法
KR20210066839A (ko) * 2018-09-27 2021-06-07 베타 파머수티컬 컴퍼니 리미티드 Fgfr4 저해제 및 그것의 용도
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
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TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
SI3964510T1 (sl) 2019-04-30 2024-10-30 Wuxi Biocity Biopharmaceutics Co., Ltd. Kristalna oblika WEE1 inhibitorske spojine in njena uporaba
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WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3150681A1 (en) 2019-08-14 2021-02-18 Incyte Corporation Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
CN112442049A (zh) * 2019-09-03 2021-03-05 微境生物医药科技(上海)有限公司 作为Wee1抑制剂的嘧啶衍生物
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Also Published As

Publication number Publication date
JP2014506929A (ja) 2014-03-20
US20120220572A1 (en) 2012-08-30
MX340402B (es) 2016-07-07
UY33925A (es) 2012-09-28
CN103703005A (zh) 2014-04-02
WO2012161812A1 (en) 2012-11-29
TWI532742B (zh) 2016-05-11
MX2013009873A (es) 2014-03-12
US8710065B2 (en) 2014-04-29
CA2827648A1 (en) 2012-11-29
EP2681221B1 (en) 2016-05-18
ES2587514T3 (es) 2016-10-25
EP2681221A1 (en) 2014-01-08
AR085502A1 (es) 2013-10-09
TW201247675A (en) 2012-12-01

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