CA2827648A1 - Tricyclic inhibitors of kinases - Google Patents

Info

Publication number

CA2827648A1

CA2827648A1 CA2827648A CA2827648A CA2827648A1 CA 2827648 A1 CA2827648 A1 CA 2827648A1 CA 2827648 A CA2827648 A CA 2827648A CA 2827648 A CA2827648 A CA 2827648A CA 2827648 A1 CA2827648 A1 CA 2827648A1

Authority

CA

Canada

Prior art keywords

pyrimido

pyrimidin

amino

imidazo

phenyl

Prior art date

2011-02-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 108091000080 Phosphotransferase Proteins 0.000 title abstract description 15
• 102000020233 phosphotransferase Human genes 0.000 title abstract description 15
• 239000003112 inhibitor Substances 0.000 title description 35
• 150000001875 compounds Chemical class 0.000 claims abstract description 368
• 150000003839 salts Chemical class 0.000 claims abstract description 39
• 238000000034 method Methods 0.000 claims abstract description 20
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 19
• 201000011510 cancer Diseases 0.000 claims abstract description 10
• -1 {4- [4-(2-methoxyethyl)piperazin-1-yl]phenyl} amino Chemical group 0.000 claims description 504
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 233
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 194
• 125000001072 heteroaryl group Chemical group 0.000 claims description 187
• 125000003118 aryl group Chemical group 0.000 claims description 184
• 125000005843 halogen group Chemical group 0.000 claims description 179
• 125000001424 substituent group Chemical group 0.000 claims description 168
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 145
• FAPREGZSIDHQBT-UHFFFAOYSA-N C1=NC=C2C(=O)NC3=NC=CN3C2=N1 Chemical compound C1=NC=C2C(=O)NC3=NC=CN3C2=N1 FAPREGZSIDHQBT-UHFFFAOYSA-N 0.000 claims description 133
• UTCSSFWDNNEEBH-UHFFFAOYSA-N imidazo[1,2-a]pyridine Chemical compound C1=CC=CC2=NC=CN21 UTCSSFWDNNEEBH-UHFFFAOYSA-N 0.000 claims description 131
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 115
• 125000000217 alkyl group Chemical group 0.000 claims description 105
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 81
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 76
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 71
• 229910052736 halogen Inorganic materials 0.000 claims description 57
• 150000002367 halogens Chemical group 0.000 claims description 48
• 229910052739 hydrogen Inorganic materials 0.000 claims description 47
• 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 47
• JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 41
• 125000001624 naphthyl group Chemical group 0.000 claims description 38
• YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims description 37
• 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 37
• 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 37
• 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims description 36
• 125000000623 heterocyclic group Chemical group 0.000 claims description 34
• 125000001188 haloalkyl group Chemical group 0.000 claims description 33
• 125000004043 oxo group Chemical group O=* 0.000 claims description 31
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 22
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 22
• 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims description 18
• 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 18
• 229910052757 nitrogen Inorganic materials 0.000 claims description 17
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 16
• 125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 15
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 12
• 229910052799 carbon Inorganic materials 0.000 claims description 11
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 11
• 125000002619 bicyclic group Chemical group 0.000 claims description 10
• 229910052717 sulfur Inorganic materials 0.000 claims description 10
• 125000002950 monocyclic group Chemical group 0.000 claims description 9
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
• 241000124008 Mammalia Species 0.000 claims description 6
• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzenecarbonitrile Natural products N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 6
• 229910052727 yttrium Inorganic materials 0.000 claims description 6
• 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 5
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 4
• AOFIYKYYKPEQEY-UHFFFAOYSA-N 12-(4-aminoanilino)-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 AOFIYKYYKPEQEY-UHFFFAOYSA-N 0.000 claims description 4
• DVCFSMPQEKMGAH-UHFFFAOYSA-N 12-[4-(4-methylpiperazin-1-yl)anilino]-7-phenyl-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C=CC=CC=3)C3=NC=CN3C2=N1 DVCFSMPQEKMGAH-UHFFFAOYSA-N 0.000 claims description 3
• VJRKBAPOWFAEMZ-RDJZCZTQSA-N 12-[4-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C([C@]1(NC[C@]2([H])C1)[H])N2C(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl VJRKBAPOWFAEMZ-RDJZCZTQSA-N 0.000 claims description 3
• LOVNSZMZEXLULX-UHFFFAOYSA-N 12-anilino-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC=CC=3)N=C2N2C=CN=C21 LOVNSZMZEXLULX-UHFFFAOYSA-N 0.000 claims description 3
• GSDTYSPSQFWYBN-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-[(3-chlorophenyl)methyl]piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(CN2CCN(CC2)C=2C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=2)=C1 GSDTYSPSQFWYBN-UHFFFAOYSA-N 0.000 claims description 3
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 3
• 229910052740 iodine Inorganic materials 0.000 claims description 3
• 229910052760 oxygen Inorganic materials 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims description 3
• WSTMFUSTYZOYDL-UHFFFAOYSA-N 12-(1,2,3-benzothiadiazol-5-ylamino)-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4N=NSC4=CC=3)N=C2N2C=CN=C21 WSTMFUSTYZOYDL-UHFFFAOYSA-N 0.000 claims description 2
• CFYZZUMUBPACPF-UHFFFAOYSA-N 12-(1,3-benzothiazol-6-ylamino)-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4SC=NC4=CC=3)N=C2N2C=CN=C21 CFYZZUMUBPACPF-UHFFFAOYSA-N 0.000 claims description 2
• LPWIXQTVUKDQPE-UHFFFAOYSA-N 12-(4-bromoanilino)-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(Br)=CC=3)N=C2N2C=CN=C21 LPWIXQTVUKDQPE-UHFFFAOYSA-N 0.000 claims description 2
• XBXHHAXUUZSAER-UHFFFAOYSA-N 12-(4-cyclohexylanilino)-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3CCCCC3)N=C2N2C=CN=C21 XBXHHAXUUZSAER-UHFFFAOYSA-N 0.000 claims description 2
• XQCSSURHRLCVFQ-UHFFFAOYSA-N 12-[(2-acetyl-3,4-dihydro-1H-isoquinolin-6-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2CN(C(=O)C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl XQCSSURHRLCVFQ-UHFFFAOYSA-N 0.000 claims description 2
• ZOERDVHQLNAKHE-UHFFFAOYSA-N 12-[(2-acetyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CN(C(=O)C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl ZOERDVHQLNAKHE-UHFFFAOYSA-N 0.000 claims description 2
• QAHYGGLTHWWEOT-UHFFFAOYSA-N 12-[(2-acetyl-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl)amino]-7-(2-chloro-6-fluorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl QAHYGGLTHWWEOT-UHFFFAOYSA-N 0.000 claims description 2
• CWGJVAOSKXUZTO-UHFFFAOYSA-N 12-[(2-acetylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2-chloro-6-fluorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl CWGJVAOSKXUZTO-UHFFFAOYSA-N 0.000 claims description 2
• WJRROINZDMTREW-UHFFFAOYSA-N 12-[(2-acetylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl WJRROINZDMTREW-UHFFFAOYSA-N 0.000 claims description 2
• CQQNPOAQLYKSME-UHFFFAOYSA-N 12-[4-(2-acetyl-2,7-diazaspiro[3.5]nonan-7-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1N(C(=O)C)CC21CCN(C=1C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=1)CC2 CQQNPOAQLYKSME-UHFFFAOYSA-N 0.000 claims description 2
• GSNIAXMXBBAXNE-UHFFFAOYSA-N 12-[4-[(1-acetylpiperidin-4-yl)amino]anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(=O)C)CCC1NC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 GSNIAXMXBBAXNE-UHFFFAOYSA-N 0.000 claims description 2
• VJRKBAPOWFAEMZ-NVXWUHKLSA-N 12-[4-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C([C@@]1(NC[C@@]2([H])C1)[H])N2C(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl VJRKBAPOWFAEMZ-NVXWUHKLSA-N 0.000 claims description 2
• BESVCKOFTCVZIZ-QFIPXVFZSA-N 12-[4-[[(3R)-1-azabicyclo[2.2.2]octan-3-yl]amino]anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(N[C@@H]4C5CCN(CC5)C4)=CC=3)N=C2N2C=CN=C21 BESVCKOFTCVZIZ-QFIPXVFZSA-N 0.000 claims description 2
• ZFECWWBXIJRTEA-UHFFFAOYSA-N 12-[4-[bis(2-methoxyethyl)amino]anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(CCOC)CCOC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ZFECWWBXIJRTEA-UHFFFAOYSA-N 0.000 claims description 2
• RBAMWXWJHPVUSG-UHFFFAOYSA-N 12-[[2-[(1-benzylpiperidin-4-yl)methyl]-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC(CC1)CCN1CC1=CC=CC=C1 RBAMWXWJHPVUSG-UHFFFAOYSA-N 0.000 claims description 2
• SVUNWNBQQMXLGG-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SVUNWNBQQMXLGG-UHFFFAOYSA-N 0.000 claims description 2
• RRUCAEDSIJXSMT-UHFFFAOYSA-N 7-(4-hydroxy-2-methylphenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound CC1=CC(O)=CC=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 RRUCAEDSIJXSMT-UHFFFAOYSA-N 0.000 claims description 2
• ZLLWMXBDINIIFP-UHFFFAOYSA-N 7-(4-hydroxyphenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(O)=CC=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 ZLLWMXBDINIIFP-UHFFFAOYSA-N 0.000 claims description 2
• 230000003247 decreasing effect Effects 0.000 claims description 2
• 239000012453 solvate Substances 0.000 claims description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 20
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 3
• NNQKGOSIJAERJY-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(cyclopropylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CC(CC4=CC=3)NC3CC3)N=C2N2C=CN=C21 NNQKGOSIJAERJY-UHFFFAOYSA-N 0.000 claims 2
• QXZZUBFQRVTJCD-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(diethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(CC)CC)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl QXZZUBFQRVTJCD-UHFFFAOYSA-N 0.000 claims 2
• VEYHNBOUKBIXHN-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(propylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(NCCC)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl VEYHNBOUKBIXHN-UHFFFAOYSA-N 0.000 claims 2
• LAMLNRBJGRMUNN-KKFHFHRHSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-[(3S)-3-fluoropyrrolidin-1-yl]-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@@H](F)CCN1C1CC2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5F)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C1 LAMLNRBJGRMUNN-KKFHFHRHSA-N 0.000 claims 2
• XYSPAJYSNPKYPT-UHFFFAOYSA-N C=1C=C2C3(CC3)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl Chemical compound C=1C=C2C3(CC3)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl XYSPAJYSNPKYPT-UHFFFAOYSA-N 0.000 claims 2
• JHJDVNFDEKIOSO-GDBMZVCRSA-N (3aS,10aS)-8-[[7-(2,6-dichlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-2,3,3a,5,10,10a-hexahydro-1H-pyrrolo[3,4-c][1]benzazepin-4-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C[C@@H]5CNC[C@H]5C(=O)NC4=CC=3)N=C2N2C=CN=C21 JHJDVNFDEKIOSO-GDBMZVCRSA-N 0.000 claims 1
• MXNPKUQHTFLYOQ-UHFFFAOYSA-N 1-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-N,N-diethylpiperidine-3-carboxamide Chemical compound C1C(C(=O)N(CC)CC)CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 MXNPKUQHTFLYOQ-UHFFFAOYSA-N 0.000 claims 1
• WSKYCBFAXMTTQI-UHFFFAOYSA-N 1-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-N-methylmethanesulfonamide Chemical compound C1=CC(CS(=O)(=O)NC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 WSKYCBFAXMTTQI-UHFFFAOYSA-N 0.000 claims 1
• SHIGBOIFLLIYCS-UHFFFAOYSA-N 1-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]piperidine-3-carboxamide Chemical compound C1C(C(=O)N)CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SHIGBOIFLLIYCS-UHFFFAOYSA-N 0.000 claims 1
• KJXAQJXSJOHHLL-UHFFFAOYSA-N 1-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]piperidine-4-carboxamide Chemical compound C1CC(C(=O)N)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 KJXAQJXSJOHHLL-UHFFFAOYSA-N 0.000 claims 1
• ZQLRREONZSVIQO-UHFFFAOYSA-N 12-[(1-acetyl-2,3-dihydroindol-6-yl)amino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2N(C(=O)C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl ZQLRREONZSVIQO-UHFFFAOYSA-N 0.000 claims 1
• GKAIUFLVMQMDHO-UHFFFAOYSA-N 12-[(2-acetylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GKAIUFLVMQMDHO-UHFFFAOYSA-N 0.000 claims 1
• IDVBIPAGPCIDPV-UHFFFAOYSA-N 12-[(2-cyclopropylsulfonylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)S(=O)(=O)C4CC4)=CC=3)N=C2N2C=CN=C21 IDVBIPAGPCIDPV-UHFFFAOYSA-N 0.000 claims 1
• LDPUHXKJRAXDON-UHFFFAOYSA-N 12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-7-propan-2-yl-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound N=1C=C2C(=O)N(C(C)C)C3=NC=CN3C2=NC=1NC(C=1)=CC=C2C=1CN(C)CC21CC1 LDPUHXKJRAXDON-UHFFFAOYSA-N 0.000 claims 1
• QVYKKSXEJXHNGJ-UHFFFAOYSA-N 12-[3-chloro-4-(4-methylpiperazin-1-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C(=C1)Cl)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 QVYKKSXEJXHNGJ-UHFFFAOYSA-N 0.000 claims 1
• PWNBRPDHBMSFSF-UHFFFAOYSA-N 12-[4-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4CCCCN4CC3)N=C2N2C=CN=C21 PWNBRPDHBMSFSF-UHFFFAOYSA-N 0.000 claims 1
• LLLNFIQZWRXVLO-UHFFFAOYSA-N 12-[4-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4CNCC4C3)N=C2N2C=CN=C21 LLLNFIQZWRXVLO-UHFFFAOYSA-N 0.000 claims 1
• SARRXSLLADDAOE-UHFFFAOYSA-N 12-[4-(2,7-diazaspiro[3.4]octan-2-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4(C3)CNCC4)N=C2N2C=CN=C21 SARRXSLLADDAOE-UHFFFAOYSA-N 0.000 claims 1
• KWDCBYJISYZLLU-UHFFFAOYSA-N 12-[4-(2,7-diazaspiro[3.5]nonan-2-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4(C3)CCNCC4)N=C2N2C=CN=C21 KWDCBYJISYZLLU-UHFFFAOYSA-N 0.000 claims 1
• PMWSRMFYNLXUOL-UHFFFAOYSA-N 12-[4-(2,7-diazaspiro[3.5]nonan-7-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC4(CNC4)CC3)N=C2N2C=CN=C21 PMWSRMFYNLXUOL-UHFFFAOYSA-N 0.000 claims 1
• ZJEYDTIPPFWMNI-UHFFFAOYSA-N 12-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4CCCN4CC3)N=C2N2C=CN=C21 ZJEYDTIPPFWMNI-UHFFFAOYSA-N 0.000 claims 1
• CAFTYPPLMPBFKG-UHFFFAOYSA-N 12-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC4CCCN4CC3)N=C2N2C=CN=C21 CAFTYPPLMPBFKG-UHFFFAOYSA-N 0.000 claims 1
• JPQMJYUOSIHHNT-UHFFFAOYSA-N 12-[4-(4-acetylpiperazin-1-yl)anilino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 JPQMJYUOSIHHNT-UHFFFAOYSA-N 0.000 claims 1
• BQXGAXHVZLYFLW-UHFFFAOYSA-N 12-[4-(4-acetylpiperazin-1-yl)anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 BQXGAXHVZLYFLW-UHFFFAOYSA-N 0.000 claims 1
• RAOFCVHAVATOES-UHFFFAOYSA-N 12-[4-(4-methylpiperazin-1-yl)anilino]-7-[2-(trifluoromethoxy)phenyl]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)OC(F)(F)F)C3=NC=CN3C2=N1 RAOFCVHAVATOES-UHFFFAOYSA-N 0.000 claims 1
• ABVBVZIBDDRXHB-UHFFFAOYSA-N 12-[4-(4-methylpiperazin-1-yl)anilino]-7-[2-(trifluoromethyl)phenyl]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)C(F)(F)F)C3=NC=CN3C2=N1 ABVBVZIBDDRXHB-UHFFFAOYSA-N 0.000 claims 1
• LTLLXUSSJDQDHM-LJQANCHMSA-N 12-[4-[(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]anilino]-7-(2-chloro-6-fluorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3C[C@H]4CCCN4CC3)N=C2N2C=CN=C21 LTLLXUSSJDQDHM-LJQANCHMSA-N 0.000 claims 1
• CAFTYPPLMPBFKG-HXUWFJFHSA-N 12-[4-[(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3C[C@H]4CCCN4CC3)N=C2N2C=CN=C21 CAFTYPPLMPBFKG-HXUWFJFHSA-N 0.000 claims 1
• CAFTYPPLMPBFKG-FQEVSTJZSA-N 12-[4-[(8aS)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]anilino]-7-(2-chlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3C[C@@H]4CCCN4CC3)N=C2N2C=CN=C21 CAFTYPPLMPBFKG-FQEVSTJZSA-N 0.000 claims 1
• UOLZCRZBSIDSIC-UHFFFAOYSA-N 12-[[2-(cyclopropanecarbonyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)C(=O)C4CC4)=CC=3)N=C2N2C=CN=C21 UOLZCRZBSIDSIC-UHFFFAOYSA-N 0.000 claims 1
• ZPNSETQPCRFHOG-UHFFFAOYSA-N 12-[[2-(cyclopropylamino)-2,3-dihydro-1H-inden-5-yl]amino]-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CC(CC4=CC=3)NC3CC3)N=C2N2C=CN=C21 ZPNSETQPCRFHOG-UHFFFAOYSA-N 0.000 claims 1
• VIOAAWUARYASTN-UHFFFAOYSA-N 12-anilino-7-(2,6-dichlorophenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC=CC=3)N=C2N2C=CN=C21 VIOAAWUARYASTN-UHFFFAOYSA-N 0.000 claims 1
• QIBUEKFLXRFNOZ-UHFFFAOYSA-N 12-anilino-7-(3-hydroxy-2-methylphenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound CC1=C(O)C=CC=C1N1C(=O)C2=CN=C(NC=3C=CC=CC=3)N=C2N2C=CN=C21 QIBUEKFLXRFNOZ-UHFFFAOYSA-N 0.000 claims 1
• IGCUAUFPJNLDSO-UHFFFAOYSA-N 12-anilino-7-(3-hydroxyphenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound OC1=CC=CC(N2C(C3=CN=C(NC=4C=CC=CC=4)N=C3N3C=CN=C32)=O)=C1 IGCUAUFPJNLDSO-UHFFFAOYSA-N 0.000 claims 1
• GFTMSJAEEHGADR-UHFFFAOYSA-N 12-anilino-7-(3-methoxy-2-methylphenyl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC1=CC=CC(N2C(C3=CN=C(NC=4C=CC=CC=4)N=C3N3C=CN=C32)=O)=C1C GFTMSJAEEHGADR-UHFFFAOYSA-N 0.000 claims 1
• MEDXOIFKFTYQIH-UHFFFAOYSA-N 2-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-5-methyl-1,3-thiazolidin-4-one Chemical compound N1C(=O)C(C)SC1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 MEDXOIFKFTYQIH-UHFFFAOYSA-N 0.000 claims 1
• RAOAJMDTFNJCGT-UHFFFAOYSA-N 2-[cyclopropyl(methyl)amino]ethyl 4-[[7-(2,6-dichlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]benzoate Chemical compound C1CC1N(C)CCOC(=O)C(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl RAOAJMDTFNJCGT-UHFFFAOYSA-N 0.000 claims 1
• FCRXDUAFQRKDNB-UHFFFAOYSA-N 3-[4-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]piperazin-1-yl]propanenitrile Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CCC#N)CC3)N=C2N2C=CN=C21 FCRXDUAFQRKDNB-UHFFFAOYSA-N 0.000 claims 1
• GZTCYQYXVYNDJM-UHFFFAOYSA-N 3-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-cyclopropylanilino]propanenitrile Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N(CCC#N)C3CC3)N=C2N2C=CN=C21 GZTCYQYXVYNDJM-UHFFFAOYSA-N 0.000 claims 1
• VYVOWWGXHVELTL-UHFFFAOYSA-N 3-[[4-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]piperazin-1-yl]methyl]benzonitrile Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CC=4C=C(C=CC=4)C#N)CC3)N=C2N2C=CN=C21 VYVOWWGXHVELTL-UHFFFAOYSA-N 0.000 claims 1
• CFYRYYVJZSDUJU-UHFFFAOYSA-N 4-[[7-(2,6-dichlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-(1-methylpiperidin-4-yl)benzamide Chemical compound C1CN(C)CCC1NC(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 CFYRYYVJZSDUJU-UHFFFAOYSA-N 0.000 claims 1
• KSELMXMUDGOLFH-UHFFFAOYSA-N 4-[[7-(2,6-dichlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-[4-(dimethylamino)cyclohexyl]benzamide Chemical compound C1CC(N(C)C)CCC1NC(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KSELMXMUDGOLFH-UHFFFAOYSA-N 0.000 claims 1
• FDYOQRGSQDHYPS-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N,N-diethylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N(CC)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 FDYOQRGSQDHYPS-UHFFFAOYSA-N 0.000 claims 1
• PCLRXBXXCJHMTF-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-cyclohexylbenzamide Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C(=O)NC3CCCCC3)N=C2N2C=CN=C21 PCLRXBXXCJHMTF-UHFFFAOYSA-N 0.000 claims 1
• NTFYGGCWWQYKAO-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-ethylbenzamide Chemical compound C1=CC(C(=O)NCC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 NTFYGGCWWQYKAO-UHFFFAOYSA-N 0.000 claims 1
• VVRKDJOZLXFMBL-UHFFFAOYSA-N 4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-pyridin-4-ylbenzamide Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C(=O)NC=3C=CN=CC=3)N=C2N2C=CN=C21 VVRKDJOZLXFMBL-UHFFFAOYSA-N 0.000 claims 1
• KCUNBCQXUBVYAX-UHFFFAOYSA-N 6-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-4H-1,4-benzoxazin-3-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4NC(=O)COC4=CC=3)N=C2N2C=CN=C21 KCUNBCQXUBVYAX-UHFFFAOYSA-N 0.000 claims 1
• PBHVOWBAQKJIHE-UHFFFAOYSA-N 7-(2,4-dimethoxyphenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC1=CC(OC)=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(C)CC3)N=C2N2C=CN=C21 PBHVOWBAQKJIHE-UHFFFAOYSA-N 0.000 claims 1
• MWFNJZACFYVWPD-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC(F)=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 MWFNJZACFYVWPD-UHFFFAOYSA-N 0.000 claims 1
• ZEJFJEZCFFBWJX-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=C(F)C=C1Cl ZEJFJEZCFFBWJX-UHFFFAOYSA-N 0.000 claims 1
• OXCFVBYWTGGOQB-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=C(F)C=C1Cl OXCFVBYWTGGOQB-UHFFFAOYSA-N 0.000 claims 1
• MHZZCSSVPOHYON-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[(6-piperazin-1-ylpyridin-3-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC(F)=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=NC(=CC=3)N3CCNCC3)N=C2N2C=CN=C21 MHZZCSSVPOHYON-UHFFFAOYSA-N 0.000 claims 1
• VFZPAFOLJAQYOG-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[3-methyl-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(F)=CC=3Cl)Cl)C3=NC=CN3C2=N1 VFZPAFOLJAQYOG-UHFFFAOYSA-N 0.000 claims 1
• COZUICJLJUGGAF-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(F)=CC=3Cl)Cl)C3=NC=CN3C2=N1 COZUICJLJUGGAF-UHFFFAOYSA-N 0.000 claims 1
• ZFLFXSHMLQGSTN-UHFFFAOYSA-N 7-(2,6-dichloro-4-fluorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=C(F)C=C1Cl ZFLFXSHMLQGSTN-UHFFFAOYSA-N 0.000 claims 1
• BLZMYIUFPQJWKP-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CCNCC4=CC=3)N=C2N2C=CN=C21 BLZMYIUFPQJWKP-UHFFFAOYSA-N 0.000 claims 1
• RGHKDYZHFCXXGZ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(1H-indazol-5-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C=NNC4=CC=3)N=C2N2C=CN=C21 RGHKDYZHFCXXGZ-UHFFFAOYSA-N 0.000 claims 1
• SJKFRWBTYBCUGI-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(1H-indazol-6-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4NN=CC4=CC=3)N=C2N2C=CN=C21 SJKFRWBTYBCUGI-UHFFFAOYSA-N 0.000 claims 1
• GGAQMONGBVYRHN-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(3,5-difluoro-4-piperazin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C(F)=C(N2CCNCC2)C(F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GGAQMONGBVYRHN-UHFFFAOYSA-N 0.000 claims 1
• SPYJRXAJCSHASW-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(4-piperidin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3NCCCC3)N=C2N2C=CN=C21 SPYJRXAJCSHASW-UHFFFAOYSA-N 0.000 claims 1
• DNDPQMUPODMFQA-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(4-pyrrolidin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3NCCC3)N=C2N2C=CN=C21 DNDPQMUPODMFQA-UHFFFAOYSA-N 0.000 claims 1
• XMFGSTRFDFIUBX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 XMFGSTRFDFIUBX-UHFFFAOYSA-N 0.000 claims 1
• RVAPALZVDKEYRH-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(1,1,2,3,3-pentamethylisoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2C(C)(C)N(C)C(C)(C)C2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl RVAPALZVDKEYRH-UHFFFAOYSA-N 0.000 claims 1
• XCRDWMSFUCDJCE-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(1,1,2-trimethyl-3,4-dihydroisoquinolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl XCRDWMSFUCDJCE-UHFFFAOYSA-N 0.000 claims 1
• YZMCCFLYDCAMJE-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(1,1,2-trimethyl-3H-isoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl YZMCCFLYDCAMJE-UHFFFAOYSA-N 0.000 claims 1
• FIEFUTLSNLZAGA-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl FIEFUTLSNLZAGA-UHFFFAOYSA-N 0.000 claims 1
• GAGKTBMUQVXVFC-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-ethylsulfonyl-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(S(=O)(=O)CC)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GAGKTBMUQVXVFC-UHFFFAOYSA-N 0.000 claims 1
• LVWGYVOYZGMKSJ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl LVWGYVOYZGMKSJ-UHFFFAOYSA-N 0.000 claims 1
• KFMRHPXDYPAONS-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-methylsulfonylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(S(=O)(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl KFMRHPXDYPAONS-UHFFFAOYSA-N 0.000 claims 1
• YNJPXSBWVLFYNW-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-propan-2-ylsulfonylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(S(=O)(=O)C(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl YNJPXSBWVLFYNW-UHFFFAOYSA-N 0.000 claims 1
• IWTDIBNESAUTDQ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(2-pyrrolidin-1-yl-2,3-dihydro-1H-inden-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CC(CC4=CC=3)N3CCCC3)N=C2N2C=CN=C21 IWTDIBNESAUTDQ-UHFFFAOYSA-N 0.000 claims 1
• QSPFXHIREXUPNK-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(4,4-dimethyl-2,3-dihydro-1H-isoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CNCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl QSPFXHIREXUPNK-UHFFFAOYSA-N 0.000 claims 1
• FSHSRWFNFYSCTH-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(4,4-dimethyl-2-methylsulfonyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(S(C)(=O)=O)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl FSHSRWFNFYSCTH-UHFFFAOYSA-N 0.000 claims 1
• KIFSZOILSBLSKH-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(4-oxo-1H-cinnolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(=O)C=NNC4=CC=3)N=C2N2C=CN=C21 KIFSZOILSBLSKH-UHFFFAOYSA-N 0.000 claims 1
• NZCPVWCJDIRVSB-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[(6-piperazin-1-ylpyridin-3-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=NC(=CC=3)N3CCNCC3)N=C2N2C=CN=C21 NZCPVWCJDIRVSB-UHFFFAOYSA-N 0.000 claims 1
• GTMOOJIZVADIIA-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-(hydroxymethyl)-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)CO)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 GTMOOJIZVADIIA-UHFFFAOYSA-N 0.000 claims 1
• RBEVWQZQYFQXSN-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-ethyl-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(CC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl RBEVWQZQYFQXSN-UHFFFAOYSA-N 0.000 claims 1
• IPAMMJLEAOPWRH-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(OC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl IPAMMJLEAOPWRH-UHFFFAOYSA-N 0.000 claims 1
• KDULFSRPAJMGSJ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[3-methyl-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KDULFSRPAJMGSJ-UHFFFAOYSA-N 0.000 claims 1
• LTOCMASZGWESMF-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(1-methylpiperidin-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCC1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 LTOCMASZGWESMF-UHFFFAOYSA-N 0.000 claims 1
• STAWYSSWADGLPY-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(2-methylsulfonyl-2,7-diazaspiro[3.5]nonan-7-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1N(S(=O)(=O)C)CC21CCN(C=1C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=1)CC2 STAWYSSWADGLPY-UHFFFAOYSA-N 0.000 claims 1
• YUSACECZXYAHRO-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(3,3-difluoropiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C(F)(F)CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 YUSACECZXYAHRO-UHFFFAOYSA-N 0.000 claims 1
• UYFFZUITWKYKDZ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(3-oxopiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CC(=O)NCC3)N=C2N2C=CN=C21 UYFFZUITWKYKDZ-UHFFFAOYSA-N 0.000 claims 1
• JPLBPJNNOXQWAL-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4,4-difluoropiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(F)(F)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 JPLBPJNNOXQWAL-UHFFFAOYSA-N 0.000 claims 1
• ZFFLPGAASPARKM-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4-methylpiperazin-1-yl)-3-propan-2-ylanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(C(C)C)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl ZFFLPGAASPARKM-UHFFFAOYSA-N 0.000 claims 1
• LYCVEVRCMPEROG-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 LYCVEVRCMPEROG-UHFFFAOYSA-N 0.000 claims 1
• LVGYPHJTNLSONJ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4-piperidin-1-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCCCC3)N=C2N2C=CN=C21 LVGYPHJTNLSONJ-UHFFFAOYSA-N 0.000 claims 1
• ALGSKGHDUKFHSW-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 ALGSKGHDUKFHSW-UHFFFAOYSA-N 0.000 claims 1
• JUCXZLZNUPUMAX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCCC3)N=C2N2C=CN=C21 JUCXZLZNUPUMAX-UHFFFAOYSA-N 0.000 claims 1
• MAIXOLYZPZODGD-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3CCC(=O)NN=3)N=C2N2C=CN=C21 MAIXOLYZPZODGD-UHFFFAOYSA-N 0.000 claims 1
• ITBIXLURBFCVLL-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCC21CCN(C=1C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=1)CC2 ITBIXLURBFCVLL-UHFFFAOYSA-N 0.000 claims 1
• LRGFEYBMQIRJDW-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-(piperidin-4-ylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(NC4CCNCC4)=CC=3)N=C2N2C=CN=C21 LRGFEYBMQIRJDW-UHFFFAOYSA-N 0.000 claims 1
• YAFZYVBNSGAZJR-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[(1-methylsulfonylpiperidin-4-yl)amino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(S(=O)(=O)C)CCC1NC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 YAFZYVBNSGAZJR-UHFFFAOYSA-N 0.000 claims 1
• FEUICBMWYFHGDZ-KDURUIRLSA-N 7-(2,6-dichlorophenyl)-12-[4-[(1R,5S)-7-ethyl-3,7-diazabicyclo[3.3.1]nonane-3-carbonyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C([C@]1(CN(CC)C[C@@](C2)(C1)[H])[H])N2C(=O)C(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl FEUICBMWYFHGDZ-KDURUIRLSA-N 0.000 claims 1
• KZXXQNYTTLEMPA-GOSISDBHSA-N 7-(2,6-dichlorophenyl)-12-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@H](N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KZXXQNYTTLEMPA-GOSISDBHSA-N 0.000 claims 1
• JWZIHTRIINQCRU-GASCZTMLSA-N 7-(2,6-dichlorophenyl)-12-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@@H](C)N[C@@H](C)CN1C(C(=C1)F)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 JWZIHTRIINQCRU-GASCZTMLSA-N 0.000 claims 1
• KZXXQNYTTLEMPA-SFHVURJKSA-N 7-(2,6-dichlorophenyl)-12-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@@H](N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KZXXQNYTTLEMPA-SFHVURJKSA-N 0.000 claims 1
• QBLPXHRYUWXNIJ-JOCHJYFZSA-N 7-(2,6-dichlorophenyl)-12-[4-[(3S)-3-propan-2-ylpiperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN[C@@H](C(C)C)CN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 QBLPXHRYUWXNIJ-JOCHJYFZSA-N 0.000 claims 1
• DLLLKSDEZLQJHT-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[(4-methylpiperazin-1-yl)methyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 DLLLKSDEZLQJHT-UHFFFAOYSA-N 0.000 claims 1
• PJEIKZYPAJBYSN-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[1-[1-(dimethylamino)-3-methylbutyl]cyclobutyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(NC=2N=C3C(C(N(C=4C(=CC=CC=4Cl)Cl)C4=NC=CN43)=O)=CN=2)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 PJEIKZYPAJBYSN-UHFFFAOYSA-N 0.000 claims 1
• BXLDGIOMGQRMTF-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[2-(1-methylpyrrolidin-2-yl)ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound CN1CCCC1CCNC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 BXLDGIOMGQRMTF-UHFFFAOYSA-N 0.000 claims 1
• VKZXXMSHMVGZMM-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[2-(4-methylpiperazin-1-yl)ethyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CCC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 VKZXXMSHMVGZMM-UHFFFAOYSA-N 0.000 claims 1
• ZCMFFRXYWPAMAF-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[2-(dimethylamino)ethyl-ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(CCN(C)C)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 ZCMFFRXYWPAMAF-UHFFFAOYSA-N 0.000 claims 1
• ZSNROWXRZIHBBO-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[2-(dimethylamino)ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(NCCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 ZSNROWXRZIHBBO-UHFFFAOYSA-N 0.000 claims 1
• RCWBCGALBPUPRM-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[3-(diethylamino)propoxy]-3-fluoroanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(F)C(OCCCN(CC)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 RCWBCGALBPUPRM-UHFFFAOYSA-N 0.000 claims 1
• KXAUNTOLVMSJKJ-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[4-(dimethylamino)piperidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 KXAUNTOLVMSJKJ-UHFFFAOYSA-N 0.000 claims 1
• RSDUPIFHAPXDBX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[4-(dimethylamino)piperidine-1-carbonyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(N(C)C)CCN1C(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 RSDUPIFHAPXDBX-UHFFFAOYSA-N 0.000 claims 1
• GNCAELHTYLWVAX-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-[propan-2-yl-[2-(propan-2-ylamino)ethyl]amino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(C(C)C)CCNC(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3Cl)Cl)C3=NC=CN3C2=N1 GNCAELHTYLWVAX-UHFFFAOYSA-N 0.000 claims 1
• BWUMKXXNVDKXLR-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCC2)C(C(F)(F)F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl BWUMKXXNVDKXLR-UHFFFAOYSA-N 0.000 claims 1
• AZTYYNWSKUKKBY-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[1-[2-(dimethylamino)ethyl]-2,3-dihydroindol-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2N(CCN(C)C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl AZTYYNWSKUKKBY-UHFFFAOYSA-N 0.000 claims 1
• DGXXKHUWNFRAAP-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[2-(2,2-dimethylpropanoyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C(C)(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl DGXXKHUWNFRAAP-UHFFFAOYSA-N 0.000 claims 1
• AMBRIFCKYYVDGS-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[2-(2-methylpropanoyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl AMBRIFCKYYVDGS-UHFFFAOYSA-N 0.000 claims 1
• GEPSQLANSSBBBA-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GEPSQLANSSBBBA-UHFFFAOYSA-N 0.000 claims 1
• OFMHWUQCUJRJJD-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[2-(propylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(NCCC)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl OFMHWUQCUJRJJD-UHFFFAOYSA-N 0.000 claims 1
• NMTKRBQZRMANMZ-KKFHFHRHSA-N 7-(2,6-dichlorophenyl)-12-[[2-[(3S)-3-fluoropyrrolidin-1-yl]-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@@H](F)CCN1C1CC2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5Cl)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C1 NMTKRBQZRMANMZ-KKFHFHRHSA-N 0.000 claims 1
• AAXQXVYTVSHGLS-UHFFFAOYSA-N 7-(2,6-dichlorophenyl)-12-[[4,4-dimethyl-2-(2,2,2-trifluoroethyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CC(F)(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl AAXQXVYTVSHGLS-UHFFFAOYSA-N 0.000 claims 1
• WLBVSRCBCIYMAZ-UHFFFAOYSA-N 7-(2,6-difluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)F)C3=NC=CN3C2=N1 WLBVSRCBCIYMAZ-UHFFFAOYSA-N 0.000 claims 1
• SVFMGEMTWAECKS-UHFFFAOYSA-N 7-(2,6-dimethylphenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(C)C=CC=C1C SVFMGEMTWAECKS-UHFFFAOYSA-N 0.000 claims 1
• GMKXOFPMGDEEAV-UHFFFAOYSA-N 7-(2-chloro-3-hydroxyphenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound OC1=CC=CC(N2C(C3=CN=C(NC=4C=C5C(C6(CC6)CNC5)=CC=4)N=C3N3C=CN=C32)=O)=C1Cl GMKXOFPMGDEEAV-UHFFFAOYSA-N 0.000 claims 1
• MUBBWOHVMUIKIR-UHFFFAOYSA-N 7-(2-chloro-4,6-difluorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=C(F)C=C1Cl MUBBWOHVMUIKIR-UHFFFAOYSA-N 0.000 claims 1
• MIUZKHQKIKYNFA-UHFFFAOYSA-N 7-(2-chloro-4,6-difluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(F)=CC=3F)Cl)C3=NC=CN3C2=N1 MIUZKHQKIKYNFA-UHFFFAOYSA-N 0.000 claims 1
• FPMBIKCMUSPCLI-UHFFFAOYSA-N 7-(2-chloro-4-methylphenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(C)=CC=3)Cl)C3=NC=CN3C2=N1 FPMBIKCMUSPCLI-UHFFFAOYSA-N 0.000 claims 1
• OUVGXWNTDFYUQR-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-(5,6,7,8-tetrahydro-1,6-naphthyridin-3-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CNCCC4=NC=3)N=C2N2C=CN=C21 OUVGXWNTDFYUQR-UHFFFAOYSA-N 0.000 claims 1
• HZXKSYNUISSDRZ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 HZXKSYNUISSDRZ-UHFFFAOYSA-N 0.000 claims 1
• SSDVHDBNZJIQMX-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(1,1,2-trimethyl-3H-isoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl SSDVHDBNZJIQMX-UHFFFAOYSA-N 0.000 claims 1
• YFRNHMAIZOCUPR-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl YFRNHMAIZOCUPR-UHFFFAOYSA-N 0.000 claims 1
• ZSAHIYGOYSATRM-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(2-methylsulfonylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(S(=O)(=O)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl ZSAHIYGOYSATRM-UHFFFAOYSA-N 0.000 claims 1
• YBPDRUNRDRQNJG-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(2-pyrrolidin-1-yl-2,3-dihydro-1H-inden-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4CC(CC4=CC=3)N3CCCC3)N=C2N2C=CN=C21 YBPDRUNRDRQNJG-UHFFFAOYSA-N 0.000 claims 1
• VYCIWMBUYBPTLQ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[(4,4-dimethyl-2-methylsulfonyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(S(C)(=O)=O)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl VYCIWMBUYBPTLQ-UHFFFAOYSA-N 0.000 claims 1
• DJCAHZKZXWQRGB-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[3-methyl-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 DJCAHZKZXWQRGB-UHFFFAOYSA-N 0.000 claims 1
• NWYGMUXHPKFFFX-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[4-(1,4-diazepan-1-yl)-3-methylanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCCC2)C(C)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl NWYGMUXHPKFFFX-UHFFFAOYSA-N 0.000 claims 1
• DATCYIARXKPUBJ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[4-(1-methylpiperidin-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCC1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 DATCYIARXKPUBJ-UHFFFAOYSA-N 0.000 claims 1
• QUTZVOUNNKGPFD-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 QUTZVOUNNKGPFD-UHFFFAOYSA-N 0.000 claims 1
• IWQIFPYCRKJXGB-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[4-[4-(dimethylamino)piperidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3F)Cl)C3=NC=CN3C2=N1 IWQIFPYCRKJXGB-UHFFFAOYSA-N 0.000 claims 1
• BNQVPFAKFCJURC-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(2,2-dimethylpropanoyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C(C)(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl BNQVPFAKFCJURC-UHFFFAOYSA-N 0.000 claims 1
• HKDAOTQPQFTQGZ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(2-hydroxyacetyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C(=O)CO)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl HKDAOTQPQFTQGZ-UHFFFAOYSA-N 0.000 claims 1
• AKGKWVTWFBVCPK-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(2-methylpropanoyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C(=O)C(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl AKGKWVTWFBVCPK-UHFFFAOYSA-N 0.000 claims 1
• JAQWMUMGNOQMGD-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(cyclopentanecarbonyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)C(=O)C4CCCC4)=CC=3)N=C2N2C=CN=C21 JAQWMUMGNOQMGD-UHFFFAOYSA-N 0.000 claims 1
• SCGBGGVRWINOLJ-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(cyclopropanecarbonyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C(=O)C3CC3)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl SCGBGGVRWINOLJ-UHFFFAOYSA-N 0.000 claims 1
• PSVSKRQYABFVSD-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(cyclopropanecarbonyl)spiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CN(C4)C(=O)C4CC4)=CC=3)N=C2N2C=CN=C21 PSVSKRQYABFVSD-UHFFFAOYSA-N 0.000 claims 1
• PGUCIORNTUDLKU-UHFFFAOYSA-N 7-(2-chloro-6-fluorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl PGUCIORNTUDLKU-UHFFFAOYSA-N 0.000 claims 1
• TVROFKVTTFPOPR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(1,2,3,4-tetrahydroisoquinolin-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4CNCCC4=CC=3)N=C2N2C=CN=C21 TVROFKVTTFPOPR-UHFFFAOYSA-N 0.000 claims 1
• XDSGNNMNHWMDOO-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(3,5-dichloro-4-piperazin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C(Cl)C(N4CCNCC4)=C(Cl)C=3)N=C2N2C=CN=C21 XDSGNNMNHWMDOO-UHFFFAOYSA-N 0.000 claims 1
• BETMOIKLRDEYNF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(3,5-difluoro-4-piperazin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C(F)=C(N2CCNCC2)C(F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl BETMOIKLRDEYNF-UHFFFAOYSA-N 0.000 claims 1
• QGTROLNLDGHKID-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-cyclohexylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3CCCCC3)N=C2N2C=CN=C21 QGTROLNLDGHKID-UHFFFAOYSA-N 0.000 claims 1
• GRNBWTTUZPFZLG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-hydroxy-3-methylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(O)C(C)=CC(NC=2N=C3C(C(N(C=4C(=CC=CC=4)Cl)C4=NC=CN43)=O)=CN=2)=C1 GRNBWTTUZPFZLG-UHFFFAOYSA-N 0.000 claims 1
• VQEUOEOBCQPYSX-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-imidazo[1,2-a]pyridin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=C4C=CC=CN4C=3)N=C2N2C=CN=C21 VQEUOEOBCQPYSX-UHFFFAOYSA-N 0.000 claims 1
• ILPBXCNMMNQGRT-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-imidazo[2,1-b][1,3]thiazol-6-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=C4SC=CN4C=3)N=C2N2C=CN=C21 ILPBXCNMMNQGRT-UHFFFAOYSA-N 0.000 claims 1
• ABMZDXLRRXTPDN-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-imidazol-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3C=NC=C3)N=C2N2C=CN=C21 ABMZDXLRRXTPDN-UHFFFAOYSA-N 0.000 claims 1
• NUEJBGYJOOBOHM-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-methylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 NUEJBGYJOOBOHM-UHFFFAOYSA-N 0.000 claims 1
• IUMYMNAILOBLJL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-morpholin-4-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCOCC3)N=C2N2C=CN=C21 IUMYMNAILOBLJL-UHFFFAOYSA-N 0.000 claims 1
• WJDVIVAHSHCRQL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-piperidin-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCCCC3)N=C2N2C=CN=C21 WJDVIVAHSHCRQL-UHFFFAOYSA-N 0.000 claims 1
• FNNOSSSVSACDCE-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-piperidin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3NCCCC3)N=C2N2C=CN=C21 FNNOSSSVSACDCE-UHFFFAOYSA-N 0.000 claims 1
• QYRRHAFJBWVMFQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-piperidin-4-yloxyanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(OC4CCNCC4)=CC=3)N=C2N2C=CN=C21 QYRRHAFJBWVMFQ-UHFFFAOYSA-N 0.000 claims 1
• ONHABPWAEIKIJU-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-pyrazol-1-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3N=CC=C3)N=C2N2C=CN=C21 ONHABPWAEIKIJU-UHFFFAOYSA-N 0.000 claims 1
• XNDFLXRBPQEZDO-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-pyridin-3-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3C=NC=CC=3)N=C2N2C=CN=C21 XNDFLXRBPQEZDO-UHFFFAOYSA-N 0.000 claims 1
• UFBLJWAOFPIERE-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-pyrrolidin-2-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3NCCC3)N=C2N2C=CN=C21 UFBLJWAOFPIERE-UHFFFAOYSA-N 0.000 claims 1
• JZRFEWFZXOSIDA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-pyrrolidin-3-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3CNCC3)N=C2N2C=CN=C21 JZRFEWFZXOSIDA-UHFFFAOYSA-N 0.000 claims 1
• JIXLPAFSAYXLQW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(4-thiomorpholin-4-ylanilino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCSCC3)N=C2N2C=CN=C21 JIXLPAFSAYXLQW-UHFFFAOYSA-N 0.000 claims 1
• VCEWFIVEODTAPW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(5,6,7,8-tetrahydronaphthalen-2-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4CCCCC4=CC=3)N=C2N2C=CN=C21 VCEWFIVEODTAPW-UHFFFAOYSA-N 0.000 claims 1
• NRAXTRPZXBZAAB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(pyridin-4-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CN=CC=3)N=C2N2C=CN=C21 NRAXTRPZXBZAAB-UHFFFAOYSA-N 0.000 claims 1
• UDARXIKVYRTRBT-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-(spiro[2,3-dihydro-1H-isoquinoline-4,1'-cyclopropane]-7-ylamino)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4C(C5(CC5)CNC4)=CC=3)N=C2N2C=CN=C21 UDARXIKVYRTRBT-UHFFFAOYSA-N 0.000 claims 1
• RXFZHVDTUZNUDK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1,1,2,3,3-pentamethylisoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2C(C)(C)N(C)C(C)(C)C2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl RXFZHVDTUZNUDK-UHFFFAOYSA-N 0.000 claims 1
• CSGZSKJHPOJUBN-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1,1,2-trimethyl-3,4-dihydroisoquinolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl CSGZSKJHPOJUBN-UHFFFAOYSA-N 0.000 claims 1
• QGYNNTMCLDQWJN-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1,1,2-trimethyl-3,4-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2C(C)(C)N(C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl QGYNNTMCLDQWJN-UHFFFAOYSA-N 0.000 claims 1
• OZEBXGJIEWGDLG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1,1,2-trimethyl-3H-isoindol-5-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)N(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl OZEBXGJIEWGDLG-UHFFFAOYSA-N 0.000 claims 1
• FNGLHPVBGGVTRR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1-methyl-3,4-dihydro-2H-quinolin-6-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2N(C)CCCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl FNGLHPVBGGVTRR-UHFFFAOYSA-N 0.000 claims 1
• JAFUBIPJLRMFCG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(1-methyl-3,4-dihydro-2H-quinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2N(C)CCCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl JAFUBIPJLRMFCG-UHFFFAOYSA-N 0.000 claims 1
• MUKWAQUSFPAUGU-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl MUKWAQUSFPAUGU-UHFFFAOYSA-N 0.000 claims 1
• IEWDIQKMZRVANG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(2-ethyl-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CC)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl IEWDIQKMZRVANG-UHFFFAOYSA-N 0.000 claims 1
• PFAIKAPJSZVPTC-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CN(C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl PFAIKAPJSZVPTC-UHFFFAOYSA-N 0.000 claims 1
• UGDHRERXJQTXBB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl UGDHRERXJQTXBB-UHFFFAOYSA-N 0.000 claims 1
• PEUULKFEGQHWFY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(3-cyclopropyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C4CCN(CCC4=CC=3)C3CC3)N=C2N2C=CN=C21 PEUULKFEGQHWFY-UHFFFAOYSA-N 0.000 claims 1
• YHQXNFMHVVJBPZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CCN(C)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl YHQXNFMHVVJBPZ-UHFFFAOYSA-N 0.000 claims 1
• ZGBTXCDUOKJJGB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(4,4-dimethyl-2-propan-2-yl-1,3-dihydroisoquinolin-7-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(C(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl ZGBTXCDUOKJJGB-UHFFFAOYSA-N 0.000 claims 1
• SRCDFSLLQZAPHB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[(6-piperazin-1-ylpyridin-3-yl)amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=NC(=CC=3)N3CCNCC3)N=C2N2C=CN=C21 SRCDFSLLQZAPHB-UHFFFAOYSA-N 0.000 claims 1
• YKCNYRMBKPOZJR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC1=CC(N2CCN(C)CC2)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl YKCNYRMBKPOZJR-UHFFFAOYSA-N 0.000 claims 1
• CUJAWNMZKOEMSZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[2-methyl-4-[3-(4-methylpiperazin-1-yl)propoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CCCOC(C=C1C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 CUJAWNMZKOEMSZ-UHFFFAOYSA-N 0.000 claims 1
• MLHGGHCZXJGZOR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3,5-difluoro-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C(=C1)F)=C(F)C=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 MLHGGHCZXJGZOR-UHFFFAOYSA-N 0.000 claims 1
• NBWFIGVYZCDJNB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-(3-piperidin-1-ylpropoxy)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C(OCCCN4CCCCC4)C=CC=3)N=C2N2C=CN=C21 NBWFIGVYZCDJNB-UHFFFAOYSA-N 0.000 claims 1
• XTNHIIWNDNCKKF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C1=CC=CC(NC=2N=C3C(C(N(C=4C(=CC=CC=4)Cl)C4=NC=CN43)=O)=CN=2)=C1 XTNHIIWNDNCKKF-UHFFFAOYSA-N 0.000 claims 1
• GKAGRSUWJGSEAR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-(hydroxymethyl)-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)CO)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GKAGRSUWJGSEAR-UHFFFAOYSA-N 0.000 claims 1
• MESANKRTXWTCGC-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-(pyrrolidin-1-ylmethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=C(CN4CCCC4)C=CC=3)N=C2N2C=CN=C21 MESANKRTXWTCGC-UHFFFAOYSA-N 0.000 claims 1
• MGQYJIGVHIABLP-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-[3-(4-methylpiperazin-1-yl)propoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CCCOC1=CC=CC(NC=2N=C3C(C(N(C=4C(=CC=CC=4)Cl)C4=NC=CN43)=O)=CN=2)=C1 MGQYJIGVHIABLP-UHFFFAOYSA-N 0.000 claims 1
• NCSLSRHAGUPMIR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-chloro-4-[2-(propan-2-ylamino)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(Cl)C(OCCNC(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 NCSLSRHAGUPMIR-UHFFFAOYSA-N 0.000 claims 1
• LTDJVNXPFRTHPR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-chloro-4-piperazin-1-yl-5-(trifluoromethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C(Cl)=C(N2CCNCC2)C(C(F)(F)F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl LTDJVNXPFRTHPR-UHFFFAOYSA-N 0.000 claims 1
• QEQAQSMIISYCKJ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-ethyl-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(CC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl QEQAQSMIISYCKJ-UHFFFAOYSA-N 0.000 claims 1
• SXKZCTYUUSMWNZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-fluoro-4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(C)C)CCN1C(C(=C1)F)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SXKZCTYUUSMWNZ-UHFFFAOYSA-N 0.000 claims 1
• PLPDBCQEFQSXHI-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-fluoro-4-[2-(4-methylpiperazin-1-yl)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1CCOC(C(=C1)F)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 PLPDBCQEFQSXHI-UHFFFAOYSA-N 0.000 claims 1
• XQJXUOKWSDUBCA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(OC)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl XQJXUOKWSDUBCA-UHFFFAOYSA-N 0.000 claims 1
• HWJXZCPWQIVHCB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methoxy-4-[2-(propan-2-ylamino)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(OCCNC(C)C)C(OC)=CC(NC=2N=C3C(C(N(C=4C(=CC=CC=4)Cl)C4=NC=CN43)=O)=CN=2)=C1 HWJXZCPWQIVHCB-UHFFFAOYSA-N 0.000 claims 1
• GCFKMPJJZHGGAY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methyl-4-(4-methyl-1,4-diazepan-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GCFKMPJJZHGGAY-UHFFFAOYSA-N 0.000 claims 1
• ODBWPJDXYDPWJA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C(=C1)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ODBWPJDXYDPWJA-UHFFFAOYSA-N 0.000 claims 1
• HZLADDZBGLEJJV-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(1,3-thiazol-2-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3SC=CN=3)N=C2N2C=CN=C21 HZLADDZBGLEJJV-UHFFFAOYSA-N 0.000 claims 1
• PAMCBQTYCXAOMS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(1,3-thiazol-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=CSC=3)N=C2N2C=CN=C21 PAMCBQTYCXAOMS-UHFFFAOYSA-N 0.000 claims 1
• OONVXTKZKIAQMC-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(1,8-naphthyridin-2-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=C4N=CC=CC4=CC=3)N=C2N2C=CN=C21 OONVXTKZKIAQMC-UHFFFAOYSA-N 0.000 claims 1
• HLCFJKUJLMXDCF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(1-methylpiperidin-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCC1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 HLCFJKUJLMXDCF-UHFFFAOYSA-N 0.000 claims 1
• BSIGDYDOKKECNI-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(1H-pyrazol-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C3=CNN=C3)N=C2N2C=CN=C21 BSIGDYDOKKECNI-UHFFFAOYSA-N 0.000 claims 1
• HHSNMKMVCYOUFX-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=C4SCCN4C=3)N=C2N2C=CN=C21 HHSNMKMVCYOUFX-UHFFFAOYSA-N 0.000 claims 1
• QQJLLPSWBNUDQY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3N=C(SC=3)N3CCOCC3)N=C2N2C=CN=C21 QQJLLPSWBNUDQY-UHFFFAOYSA-N 0.000 claims 1
• CKXFGVRIQGJCTK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2-morpholin-4-ylethoxy)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(OCCN4CCOCC4)=CC=3)N=C2N2C=CN=C21 CKXFGVRIQGJCTK-UHFFFAOYSA-N 0.000 claims 1
• YCJSWOWKXTVETQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2-morpholin-4-ylethylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCN4CCOCC4)=CC=3)N=C2N2C=CN=C21 YCJSWOWKXTVETQ-UHFFFAOYSA-N 0.000 claims 1
• MKQPIHBOLOTWHR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(2-pyrrolidin-1-ylethylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCN4CCCC4)=CC=3)N=C2N2C=CN=C21 MKQPIHBOLOTWHR-UHFFFAOYSA-N 0.000 claims 1
• RZDUUOJUVMNMFW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(3-imidazol-1-ylpropylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCCN4C=NC=C4)=CC=3)N=C2N2C=CN=C21 RZDUUOJUVMNMFW-UHFFFAOYSA-N 0.000 claims 1
• WRQLVOWKUUIYKQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(3-morpholin-4-ylpropylamino)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCCN4CCOCC4)=CC=3)N=C2N2C=CN=C21 WRQLVOWKUUIYKQ-UHFFFAOYSA-N 0.000 claims 1
• ICIOPPGTCQNTNY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(3-oxo-1,2-dihydroindazol-7-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)C=3C4=C(C(NN4)=O)C=CC=3)N=C2N2C=CN=C21 ICIOPPGTCQNTNY-UHFFFAOYSA-N 0.000 claims 1
• SCWRDQQXVOUYHS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-hydroxypiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(O)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SCWRDQQXVOUYHS-UHFFFAOYSA-N 0.000 claims 1
• HVRSFBMFPRDHBS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-hydroxypiperidine-1-carbonyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(O)CCN1C(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 HVRSFBMFPRDHBS-UHFFFAOYSA-N 0.000 claims 1
• FYUMRXXTENSYRF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)-3-propan-2-ylanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCN(C)CC2)C(C(C)C)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl FYUMRXXTENSYRF-UHFFFAOYSA-N 0.000 claims 1
• OFLUWBFGEJMLNG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,3,4,5,7,11,13-heptazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NN=NN3C2=N1 OFLUWBFGEJMLNG-UHFFFAOYSA-N 0.000 claims 1
• YENWEOCDIMPAIL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,4,5,7,11,13-hexazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NN=CN3C2=N1 YENWEOCDIMPAIL-UHFFFAOYSA-N 0.000 claims 1
• IICGNJDSNUEEHR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 IICGNJDSNUEEHR-UHFFFAOYSA-N 0.000 claims 1
• SHECBVUSRYTIRU-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaene-8-thione Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=S)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SHECBVUSRYTIRU-UHFFFAOYSA-N 0.000 claims 1
• QOZMDPNEYXJJHY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-methylpiperazine-1-carbonyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 QOZMDPNEYXJJHY-UHFFFAOYSA-N 0.000 claims 1
• MFITWXWCJVWMHQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-morpholin-4-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCOCC3)N=C2N2C=CN=C21 MFITWXWCJVWMHQ-UHFFFAOYSA-N 0.000 claims 1
• GCFBDNMUIHNLIV-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-piperidin-1-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCCCC3)N=C2N2C=CN=C21 GCFBDNMUIHNLIV-UHFFFAOYSA-N 0.000 claims 1
• DPGFXRUPDBRYKG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-propan-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 DPGFXRUPDBRYKG-UHFFFAOYSA-N 0.000 claims 1
• XSFRKOIPMNHCSK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-pyridin-2-ylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CC3)C=3N=CC=CC=3)N=C2N2C=CN=C21 XSFRKOIPMNHCSK-UHFFFAOYSA-N 0.000 claims 1
• WZRMRABHYLDJJF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(4-pyrrolidin-1-ylpiperidin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCC(CC3)N3CCCC3)N=C2N2C=CN=C21 WZRMRABHYLDJJF-UHFFFAOYSA-N 0.000 claims 1
• STJGZOBBYGZWPX-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(hydroxymethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(CO)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 STJGZOBBYGZWPX-UHFFFAOYSA-N 0.000 claims 1
• SBFKEEHRFNMNNG-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-(imidazol-1-ylmethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(CN4C=NC=C4)=CC=3)N=C2N2C=CN=C21 SBFKEEHRFNMNNG-UHFFFAOYSA-N 0.000 claims 1
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• ZHZHDFPEDFXLKW-LJQANCHMSA-N 7-(2-chlorophenyl)-12-[4-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC[C@H]1CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ZHZHDFPEDFXLKW-LJQANCHMSA-N 0.000 claims 1
• ZHZHDFPEDFXLKW-IBGZPJMESA-N 7-(2-chlorophenyl)-12-[4-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC[C@@H]1CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ZHZHDFPEDFXLKW-IBGZPJMESA-N 0.000 claims 1
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• VHEALHXMBUECJS-LJQANCHMSA-N 7-(2-chlorophenyl)-12-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1[C@H](N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 VHEALHXMBUECJS-LJQANCHMSA-N 0.000 claims 1
• OCZSMSRPDZFEBY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(1-methylpyrrolidin-2-yl)ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound CN1CCCC1CCNC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 OCZSMSRPDZFEBY-UHFFFAOYSA-N 0.000 claims 1
• AAZRWBWWHVIATQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(1H-imidazol-5-yl)ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCC=4N=CNC=4)=CC=3)N=C2N2C=CN=C21 AAZRWBWWHVIATQ-UHFFFAOYSA-N 0.000 claims 1
• TUZDSLJKMWZQQS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(6-methylquinolin-2-yl)ethyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC2=CC(C)=CC=C2N=C1CCC(C=C1)=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl TUZDSLJKMWZQQS-UHFFFAOYSA-N 0.000 claims 1
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• GCRIPFFAFGSGJZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(dimethylamino)ethoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(OCCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GCRIPFFAFGSGJZ-UHFFFAOYSA-N 0.000 claims 1
• FWVAXLUYFOSLLD-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(dimethylamino)ethyl-ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(CCN(C)C)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 FWVAXLUYFOSLLD-UHFFFAOYSA-N 0.000 claims 1
• WOULXCXHUMPFBR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(dimethylamino)ethyl-methylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(C)CCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 WOULXCXHUMPFBR-UHFFFAOYSA-N 0.000 claims 1
• GVACRQGZFUXYFH-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(dimethylamino)ethylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(NCCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GVACRQGZFUXYFH-UHFFFAOYSA-N 0.000 claims 1
• OOHKMENCNVDUEZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[2-(trifluoromethyl)pyrrolidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound FC(F)(F)C1CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 OOHKMENCNVDUEZ-UHFFFAOYSA-N 0.000 claims 1
• SYMCJHNCSLFDEE-GOSISDBHSA-N 7-(2-chlorophenyl)-12-[4-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C[C@@H]1CCCN1CCC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SYMCJHNCSLFDEE-GOSISDBHSA-N 0.000 claims 1
• QTUTZQJDHFNMIL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[3-(2-oxopyrrolidin-1-yl)propylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(NCCCN4C(CCC4)=O)=CC=3)N=C2N2C=CN=C21 QTUTZQJDHFNMIL-UHFFFAOYSA-N 0.000 claims 1
• KTBMIBCGXFCLPU-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[3-(diethylamino)propoxy]-3-fluoroanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(F)C(OCCCN(CC)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 KTBMIBCGXFCLPU-UHFFFAOYSA-N 0.000 claims 1
• XFQKZYWBZGCPLZ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[3-(diethylamino)propoxy]-3-methylanilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C(C)C(OCCCN(CC)CC)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 XFQKZYWBZGCPLZ-UHFFFAOYSA-N 0.000 claims 1
• SOZPDGNNIAKORH-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[3-(dimethylamino)propyl-methylamino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(C)CCCN(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SOZPDGNNIAKORH-UHFFFAOYSA-N 0.000 claims 1
• JZMDEGGHLUISMB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[3-(trifluoromethyl)piperidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C(C(F)(F)F)CCCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 JZMDEGGHLUISMB-UHFFFAOYSA-N 0.000 claims 1
• YIFPUJOZGFNUSO-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(4-fluorophenyl)piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(F)=CC=C1N1CCN(C=2C=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=2)CC1 YIFPUJOZGFNUSO-UHFFFAOYSA-N 0.000 claims 1
• PMKVKTIUZFRYPK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(cyclohexylmethyl)piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CC4CCCCC4)CC3)N=C2N2C=CN=C21 PMKVKTIUZFRYPK-UHFFFAOYSA-N 0.000 claims 1
• ICOWOOZKFOHYEH-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(dimethylamino)piperidin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CC(N(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ICOWOOZKFOHYEH-UHFFFAOYSA-N 0.000 claims 1
• ZIVISXMJPANONQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-(oxetan-3-yl)piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(CC3)C3COC3)N=C2N2C=CN=C21 ZIVISXMJPANONQ-UHFFFAOYSA-N 0.000 claims 1
• DPYHKUBAWKDQGM-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(CCN(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 DPYHKUBAWKDQGM-UHFFFAOYSA-N 0.000 claims 1
• GIZSAAKJRUZMGS-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[4-[3-(dimethylamino)propyl]piperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(CCCN(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GIZSAAKJRUZMGS-UHFFFAOYSA-N 0.000 claims 1
• QLSQWQRZAPISIU-KRWDZBQOSA-N 7-(2-chlorophenyl)-12-[4-[[(2S)-pyrrolidin-2-yl]methoxy]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound ClC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(OC[C@H]4NCCC4)=CC=3)N=C2N2C=CN=C21 QLSQWQRZAPISIU-KRWDZBQOSA-N 0.000 claims 1
• GYVYBZGLYXUARW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-[propan-2-yl-[2-(propan-2-ylamino)ethyl]amino]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(N(C(C)C)CCNC(C)C)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 GYVYBZGLYXUARW-UHFFFAOYSA-N 0.000 claims 1
• QPQHXCXOUDEHOR-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C(N2CCNCC2)C(C(F)(F)F)=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl QPQHXCXOUDEHOR-UHFFFAOYSA-N 0.000 claims 1
• RWJCTWYINAYMFV-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[1-[2-(dimethylamino)ethyl]-2,3-dihydroindol-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2N(CCN(C)C)CCC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl RWJCTWYINAYMFV-UHFFFAOYSA-N 0.000 claims 1
• ABALSCAZEPXGDF-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(2-ethylbutyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CC(CC)CC)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl ABALSCAZEPXGDF-UHFFFAOYSA-N 0.000 claims 1
• XTNWAFVIHYHKCI-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(2-hydroxyethyl)-3,4-dihydro-1H-isoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CN(CCO)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl XTNWAFVIHYHKCI-UHFFFAOYSA-N 0.000 claims 1
• KKCUAASUFOILPL-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(2-methoxyethyl)-3,4-dihydro-1H-isoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CN(CCOC)CCC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl KKCUAASUFOILPL-UHFFFAOYSA-N 0.000 claims 1
• LWKBFYGLHVKLIW-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(cyclohexylmethyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC1CCCCC1 LWKBFYGLHVKLIW-UHFFFAOYSA-N 0.000 claims 1
• GWNIPMQQLSAOTM-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(cyclopropylmethyl)-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC1CC1 GWNIPMQQLSAOTM-UHFFFAOYSA-N 0.000 claims 1
• PVJFQINWMUVXBI-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=C2CC(N(C)C)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl PVJFQINWMUVXBI-UHFFFAOYSA-N 0.000 claims 1
• OQHAWPBWPDOYBQ-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[2-[(4-imidazol-1-ylphenyl)methyl]-4,4-dimethyl-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC(C=C1)=CC=C1N1C=CN=C1 OQHAWPBWPDOYBQ-UHFFFAOYSA-N 0.000 claims 1
• DKQPDIYSKXVOFA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-(2,2,2-trifluoroethyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CC(F)(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl DKQPDIYSKXVOFA-UHFFFAOYSA-N 0.000 claims 1
• FMBORYIZQRKJLK-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-(4,4,4-trifluorobutyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C=1C=C2C(C)(C)CN(CCCC(F)(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=CC=CC=C1Cl FMBORYIZQRKJLK-UHFFFAOYSA-N 0.000 claims 1
• UXOLVCNWZNMQMB-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-(pyridin-3-ylmethyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC1=CC=CN=C1 UXOLVCNWZNMQMB-UHFFFAOYSA-N 0.000 claims 1
• HKBWWKPGTXQPIA-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-(thiophen-3-ylmethyl)-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1C2=CC(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)=CC=C2C(C)(C)CN1CC=1C=CSC=1 HKBWWKPGTXQPIA-UHFFFAOYSA-N 0.000 claims 1
• XVLSHQPTPJYEAT-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[4,4-dimethyl-2-[(4-propoxyphenyl)methyl]-1,3-dihydroisoquinolin-7-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1=CC(OCCC)=CC=C1CN1CC(C)(C)C2=CC=C(NC=3N=C4C(C(N(C=5C(=CC=CC=5)Cl)C5=NC=CN54)=O)=CN=3)C=C2C1 XVLSHQPTPJYEAT-UHFFFAOYSA-N 0.000 claims 1
• ZUOSENQRSAWNKY-UHFFFAOYSA-N 7-(2-chlorophenyl)-12-[[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(CC)CCN1C(C=N1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 ZUOSENQRSAWNKY-UHFFFAOYSA-N 0.000 claims 1
• LHLGMQAZACYFPV-UHFFFAOYSA-N 7-(2-chlorophenyl)-3-methyl-12-[4-(4-methylpiperazin-1-yl)anilino]-2,4,5,7,11,13-hexazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NN=C(C)N3C2=N1 LHLGMQAZACYFPV-UHFFFAOYSA-N 0.000 claims 1
• XEYIRLOQTLKFHY-UHFFFAOYSA-N 7-(2-chlorophenyl)-3-methyl-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=C(C)N3C2=N1 XEYIRLOQTLKFHY-UHFFFAOYSA-N 0.000 claims 1
• DVYLGXXGLPOVGT-UHFFFAOYSA-N 7-(2-chlorophenyl)-8-imino-N-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-amine Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=N)C=1N1C=CN=C1N2C1=CC=CC=C1Cl DVYLGXXGLPOVGT-UHFFFAOYSA-N 0.000 claims 1
• KEPDHUGTPHFUOM-UHFFFAOYSA-N 7-(2-chlorophenyl)-8-imino-N-[4-(4-methylpiperazin-1-yl)phenyl]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-amine Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=N)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 KEPDHUGTPHFUOM-UHFFFAOYSA-N 0.000 claims 1
• MFDOYNTUZCCLIV-UHFFFAOYSA-N 7-(2-methoxyphenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound COC1=CC=CC=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCN(C)CC3)N=C2N2C=CN=C21 MFDOYNTUZCCLIV-UHFFFAOYSA-N 0.000 claims 1
• XZVUXDVMSJADHH-UHFFFAOYSA-N 7-(2-methylphenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)C)C3=NC=CN3C2=N1 XZVUXDVMSJADHH-UHFFFAOYSA-N 0.000 claims 1
• BVSHKIRKMXGZMN-UHFFFAOYSA-N 7-(3-chlorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C=C(Cl)C=CC=3)C3=NC=CN3C2=N1 BVSHKIRKMXGZMN-UHFFFAOYSA-N 0.000 claims 1
• GTVAFXIRKVPEGA-UHFFFAOYSA-N 7-(3-fluorophenyl)-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C=C(F)C=CC=3)C3=NC=CN3C2=N1 GTVAFXIRKVPEGA-UHFFFAOYSA-N 0.000 claims 1
• BUJBUAPLAJWDLH-UHFFFAOYSA-N 7-[2-chloro-4-(trifluoromethyl)phenyl]-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC(=CC=3)C(F)(F)F)Cl)C3=NC=CN3C2=N1 BUJBUAPLAJWDLH-UHFFFAOYSA-N 0.000 claims 1
• UFUYHRZIJHDGIT-UHFFFAOYSA-N 7-[[7-(2-chloro-6-fluorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-4,4-dimethyl-1,3-dihydroisoquinoline-2-sulfonamide Chemical compound C=1C=C2C(C)(C)CN(S(N)(=O)=O)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl UFUYHRZIJHDGIT-UHFFFAOYSA-N 0.000 claims 1
• KYLYVGCGAVZINF-UHFFFAOYSA-N 7-[[7-(2-chloro-6-fluorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-2-carboxamide Chemical compound C=1C=C2C3(CC3)CN(C(=O)NC)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl KYLYVGCGAVZINF-UHFFFAOYSA-N 0.000 claims 1
• SCWAHOJJUNVFNK-UHFFFAOYSA-N 7-[[7-(2-chloro-6-fluorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]-N-propan-2-ylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-2-carboxamide Chemical compound C=1C=C2C3(CC3)CN(C(=O)NC(C)C)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl SCWAHOJJUNVFNK-UHFFFAOYSA-N 0.000 claims 1
• WVNQOFKQYRFPIJ-UHFFFAOYSA-N 7-cyclohexyl-12-[4-(4-methylpiperazin-1-yl)anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-8-one Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C3CCCCC3)C3=NC=CN3C2=N1 WVNQOFKQYRFPIJ-UHFFFAOYSA-N 0.000 claims 1
• CWWLREJNRGUASV-UHFFFAOYSA-N AKI00000020a Chemical compound ClC1=CC=CC(Cl)=C1N1C(=O)C2=CN=C(NC=3C=CC(=CC=3)N3CCOCC3)N=C2N2C=CN=C21 CWWLREJNRGUASV-UHFFFAOYSA-N 0.000 claims 1
• GKGDBNYEBLXRBK-UHFFFAOYSA-N C1=C2CC(NCCF)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl Chemical compound C1=C2CC(NCCF)CC2=CC=C1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(Cl)C=CC=C1Cl GKGDBNYEBLXRBK-UHFFFAOYSA-N 0.000 claims 1
• JFAMEOZAQRJLBS-UAPYVXQJSA-N C1C[C@@H](O)CC[C@@H]1NC(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 Chemical compound C1C[C@@H](O)CC[C@@H]1NC(=O)C(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 JFAMEOZAQRJLBS-UAPYVXQJSA-N 0.000 claims 1
• QOWZEOJBRPFCFG-UHFFFAOYSA-N C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=S)C=1N1C=CN=C1N2C1=CC=CC=C1Cl Chemical compound C=1C=C2C(C)(C)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=S)C=1N1C=CN=C1N2C1=CC=CC=C1Cl QOWZEOJBRPFCFG-UHFFFAOYSA-N 0.000 claims 1
• MEJCDTUASJICTL-UHFFFAOYSA-N C=1C=C2C(C)(C)CN(CC(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl Chemical compound C=1C=C2C(C)(C)CN(CC(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl MEJCDTUASJICTL-UHFFFAOYSA-N 0.000 claims 1
• DWRDTRFUFLBCNX-UHFFFAOYSA-N C=1C=C2C(C)(C)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl Chemical compound C=1C=C2C(C)(C)CN(CCF)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl DWRDTRFUFLBCNX-UHFFFAOYSA-N 0.000 claims 1
• YFXPXAIGNXNQIY-UHFFFAOYSA-N C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=S)C=1N1C=CN=C1N2C1=CC=CC=C1Cl Chemical compound C=1C=C2C3(CC3)CN(C)CC2=CC=1NC(N=1)=NC=C(C2=S)C=1N1C=CN=C1N2C1=CC=CC=C1Cl YFXPXAIGNXNQIY-UHFFFAOYSA-N 0.000 claims 1
• HJTVIZPBTFNXGN-UHFFFAOYSA-N C=1C=C2C3(CC3)CN(CC(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl Chemical compound C=1C=C2C3(CC3)CN(CC(F)F)CC2=CC=1NC(N=1)=NC=C(C2=O)C=1N1C=CN=C1N2C1=C(F)C=CC=C1Cl HJTVIZPBTFNXGN-UHFFFAOYSA-N 0.000 claims 1
• SAMKOIRNJNKDSB-UHFFFAOYSA-N N-[4-[[7-(2-chlorophenyl)-8-oxo-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),3,5,9,11-pentaen-12-yl]amino]phenyl]-1-methylpiperidine-4-carboxamide Chemical compound C1CN(C)CCC1C(=O)NC(C=C1)=CC=C1NC1=NC=C2C(=O)N(C=3C(=CC=CC=3)Cl)C3=NC=CN3C2=N1 SAMKOIRNJNKDSB-UHFFFAOYSA-N 0.000 claims 1
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