SG11202003974XA - Macrocyclic compound serving as weel inhibitor and applications thereof - Google Patents
Macrocyclic compound serving as weel inhibitor and applications thereofInfo
- Publication number
- SG11202003974XA SG11202003974XA SG11202003974XA SG11202003974XA SG11202003974XA SG 11202003974X A SG11202003974X A SG 11202003974XA SG 11202003974X A SG11202003974X A SG 11202003974XA SG 11202003974X A SG11202003974X A SG 11202003974XA SG 11202003974X A SG11202003974X A SG 11202003974XA
- Authority
- SG
- Singapore
- Prior art keywords
- applications
- macrocyclic compound
- compound serving
- weel inhibitor
- weel
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002678 macrocyclic compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711058653 | 2017-11-01 | ||
| PCT/CN2018/112909 WO2019085933A1 (en) | 2017-11-01 | 2018-10-31 | Macrocyclic compound serving as wee1 inhibitor and applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003974XA true SG11202003974XA (en) | 2020-05-28 |
Family
ID=66332843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003974XA SG11202003974XA (en) | 2017-11-01 | 2018-10-31 | Macrocyclic compound serving as weel inhibitor and applications thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11613545B2 (en) |
| EP (1) | EP3712150A4 (en) |
| JP (1) | JP7290638B2 (en) |
| CN (2) | CN111344290B (en) |
| AU (1) | AU2018361010B2 (en) |
| BR (1) | BR112020008664A8 (en) |
| CA (1) | CA3080842A1 (en) |
| IL (1) | IL274357B2 (en) |
| SG (1) | SG11202003974XA (en) |
| WO (1) | WO2019085933A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108623615B (en) * | 2017-03-23 | 2022-12-13 | 上海迪诺医药科技有限公司 | Macrocyclic derivatives of pyrazolo [3,4-d ] pyrimidin-3-one, pharmaceutical compositions and uses thereof |
| JP7481336B2 (en) | 2018-10-26 | 2024-05-10 | ウーシー・バイオシティ・バイオファーマシューティクス・カンパニー・リミテッド | Pyrimidopyrazolone derivatives as Wee1 inhibitors and their use |
| CA3138240A1 (en) * | 2019-04-30 | 2020-11-05 | Shijiazhuang Sagacity New Drug Development Co., Ltd. | Crystal forms of wee1 inhibitor coumpound and use thereof |
| CN112142763B (en) * | 2019-06-28 | 2024-01-26 | 上海医药集团股份有限公司 | Pyrazolopyrimidine compound, and preparation method and application thereof |
| WO2021127046A1 (en) * | 2019-12-20 | 2021-06-24 | Recurium Ip Holdings, Llc | Combinations |
| CA3165468A1 (en) * | 2019-12-20 | 2021-06-24 | Recurium Ip Holdings, Llc | Combinations |
| CN115197221B (en) * | 2021-04-02 | 2024-05-24 | 轩竹(北京)医药科技有限公司 | Dihydropyrazolopyrimidinone macrocyclic derivatives and their use |
| TW202328142A (en) * | 2021-09-18 | 2023-07-16 | 香港商優領醫藥科技(香港)有限公司 | Pyrimidino-dihydropyrazolone-containing derivative, pharmaceutically acceptable salt thereof, preparation method and application of pyrimidino-dihydropyrazolone-containing derivative |
| WO2023155892A1 (en) * | 2022-02-18 | 2023-08-24 | Insilico Medicine Ip Limited | Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase (pkmyt1) inhibitors and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7163939B2 (en) | 2003-11-05 | 2007-01-16 | Abbott Laboratories | Macrocyclic kinase inhibitors |
| PE20080695A1 (en) | 2006-04-27 | 2008-06-28 | Banyu Pharma Co Ltd | DIHYDROPIRAZOLOPYRIMIDINONE DERIVATIVES AS KINASE WEEL INHIBITORS |
| WO2008133866A1 (en) | 2007-04-25 | 2008-11-06 | Merck & Co., Inc. | Polymorph of dihydropyrazolopyrimidinone derivative as weel kinase.inhibitor |
| US8329711B2 (en) * | 2007-10-23 | 2012-12-11 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
| WO2010067886A1 (en) | 2008-12-12 | 2010-06-17 | Banyu Pharmaceutical Co.,Ltd. | Dihydropyrimidopyrimidine derivative |
| WO2011034743A1 (en) | 2009-09-15 | 2011-03-24 | Merck Sharp & Dohme Corp. | Preparation of crystalline forms of dihydropyrazolopyrimidinone |
| EP2491033A4 (en) | 2009-10-20 | 2013-03-13 | Eiger Biopharmaceuticals Inc | Azaindazoles to treat flaviviridae virus infection |
| TWI532742B (en) | 2011-02-28 | 2016-05-11 | 艾伯維有限公司 | Tricyclic inhibitors of kinases |
| CA2841629A1 (en) | 2011-07-15 | 2013-01-24 | Abbvie Inc. | Tricyclic inhibitors of kinases useful for the treatment of proliferative diseases |
| WO2013013031A1 (en) | 2011-07-19 | 2013-01-24 | Abbvie Inc. | Pyridazino [4, 5 -d] pyrimidin- (6h) -one inhibitors of wee - 1 kinase |
| CA2851640A1 (en) | 2011-10-20 | 2013-04-25 | Abbvie Inc. | Pyridopyrimidinone inhibitors of kinases |
| CN104271576A (en) | 2012-02-23 | 2015-01-07 | 艾伯维公司 | Pyridopyrimidinone inhibitors of kinases |
| GB201306610D0 (en) | 2013-04-11 | 2013-05-29 | Almac Discovery Ltd | Pharmaceutical compounds |
| EP3004096A1 (en) | 2013-06-06 | 2016-04-13 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
| WO2015019037A1 (en) | 2013-08-05 | 2015-02-12 | Almac Discovery Limited | Pharmaceutical compounds |
| GB201322602D0 (en) | 2013-12-19 | 2014-02-05 | Almac Discovery Ltd | Pharmaceutical compounds |
| AU2016344040B2 (en) | 2015-11-01 | 2020-12-10 | The Regents Of The University Of Colorado, A Body Corporate | Wee 1 kinase inhibitors and methods of making and using the same |
| CN108623615B (en) | 2017-03-23 | 2022-12-13 | 上海迪诺医药科技有限公司 | Macrocyclic derivatives of pyrazolo [3,4-d ] pyrimidin-3-one, pharmaceutical compositions and uses thereof |
| JP7481336B2 (en) * | 2018-10-26 | 2024-05-10 | ウーシー・バイオシティ・バイオファーマシューティクス・カンパニー・リミテッド | Pyrimidopyrazolone derivatives as Wee1 inhibitors and their use |
-
2018
- 2018-10-31 WO PCT/CN2018/112909 patent/WO2019085933A1/en active Application Filing
- 2018-10-31 CN CN201880071103.3A patent/CN111344290B/en active Active
- 2018-10-31 US US16/759,769 patent/US11613545B2/en active Active
- 2018-10-31 EP EP18874492.4A patent/EP3712150A4/en active Pending
- 2018-10-31 CA CA3080842A patent/CA3080842A1/en active Pending
- 2018-10-31 SG SG11202003974XA patent/SG11202003974XA/en unknown
- 2018-10-31 JP JP2020524447A patent/JP7290638B2/en active Active
- 2018-10-31 CN CN202311487748.4A patent/CN117534673A/en active Pending
- 2018-10-31 AU AU2018361010A patent/AU2018361010B2/en active Active
- 2018-10-31 BR BR112020008664A patent/BR112020008664A8/en unknown
-
2020
- 2020-04-30 IL IL274357A patent/IL274357B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3712150A4 (en) | 2021-03-10 |
| IL274357B1 (en) | 2023-01-01 |
| RU2020117443A (en) | 2021-12-01 |
| CN117534673A (en) | 2024-02-09 |
| US11613545B2 (en) | 2023-03-28 |
| CA3080842A1 (en) | 2019-05-09 |
| JP7290638B2 (en) | 2023-06-13 |
| AU2018361010B2 (en) | 2023-01-12 |
| CN111344290A (en) | 2020-06-26 |
| EP3712150A1 (en) | 2020-09-23 |
| BR112020008664A8 (en) | 2023-01-17 |
| BR112020008664A2 (en) | 2020-10-27 |
| WO2019085933A1 (en) | 2019-05-09 |
| JP2021501191A (en) | 2021-01-14 |
| US20200325145A1 (en) | 2020-10-15 |
| IL274357B2 (en) | 2023-05-01 |
| RU2020117443A3 (en) | 2021-12-01 |
| AU2018361010A1 (en) | 2020-06-11 |
| IL274357A (en) | 2020-06-30 |
| CN111344290B (en) | 2023-12-01 |
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