JPWO2020005877A5 - - Google Patents

Claims (13)

The compound of the formula (I) or the formula (II), or a form thereof, the form of the compound is a salt, a hydrate, a solvate, a racemic compound, a mirror image isomer, a diastereoisomer, a stereoisomer thereof. And compounds selected from the group consisting of tautomeric morphology.

(In the equation, W ₁ , W ₂ and W ₃ are independently CR _a or N,
R _a is hydrogen, cyano, halogen, hydroxy, C _1-6 alkyl, halo-C _1-6 alkyl, C _1-6 alkyl-carbonyl, C _1-6 alkoxy, halo-C _1-6 in each example. Alkoxy, C _1-6 Alkoxy-C _1-6 Alkoxy, C _1-6 Alkoxy-carbonyl, Amino, C _1-6 Alkoxy-Amino, (C _1-6 Alkoxy) ₂ -Amino, Amino-C _1-6 Alkoxy And independently selected from the group consisting of hydroxy-C _1-6 alkyl
X is selected from the group consisting of N-R _b , O and binding.
R _b is selected from the group consisting of hydrogen and C _1-6 alkyl.
R ₁ is selected from the group consisting of C _3-10 cycloalkyl and heterocyclyl.
Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6-10-membered ring with 1, 2 or 3 heteroatom rings independently selected from N, O or S. Bicyclic or 13-16 membered polycyclic ring system,
Each example of C _3-10 cycloalkyl and heterocyclyl may be substituted with 1, 2, 3 or 4 R ₃ substituents or with one additional R ₄ substituent. ,or,
Alternatively, each example of C _3-10 cycloalkyl and heterocyclyl may be substituted with 1, 2, 3, 4 or 5 R ₃ substituents.
R ₂ is selected from the group consisting of phenyl and heteroaryl,
Heteroaryl is a 3- to 7-membered monocyclic or 6 to 10-membered bicyclic ring with 1, 2, 3 or 4 heteroatom rings independently selected from N, O or S. It is a cyclic system
Each example of phenyl and heteroaryl may be substituted with 1, 2 or 3 R ₅ substituents, with one additional R ₆ substituent, or
Alternatively, each example of phenyl and heteroaryl may be substituted with 1, 2, 3 or 4 R ₅ substituents.
R ₃ is, in each example, cyano, halogen, hydroxy, C _1-6 alkyl, halo-C _1-6 alkyl, C _1-6 alkyl-carbonyl, C _1-6 alkoxy, halo-C _1-6 alkoxy, C _1-6 Alkoxy-C _1-6 Alkoxy, C _1-6 Alkoxy-carbonyl, Amino, C _1-6 Alkoxy-Amino, (C _1-6 Alkyl) ₂ -Amino, Amino-C _1-6 Alkyl and Hydroxy -Selected independently from the group consisting of C _1-6 alkyl,
R ₄ is selected from the group consisting of C _3-10 cycloalkyl, phenyl, heterocyclyl and heteroaryl.
Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6-10-membered ring with 1, 2 or 3 heteroatom rings independently selected from N, O or S. Bicyclic or 13-16 membered polycyclic ring system,
Heteroaryl is a 3- to 7-membered monocyclic or 6 to 10-membered bicyclic ring with 1, 2, 3 or 4 heteroatom rings independently selected from N, O or S. It is a cyclic system
Examples of C _3-10 cycloalkyl, phenyl, heterocyclyl and heteroaryl may be substituted with 1, 2 or 3 R ₇ substituents .
R ₅ is, in each example, cyano, halogen, hydroxy, C _1-6 alkyl, halo-C _1-6 alkyl, C _1-6 alkyl-carbonyl, C _1-6 alkoxy, halo-C _1-6 alkoxy, C _1-6 Alkoxy-C _1-6 Alkoxy, C _1-6 Alkoxy-Carbonyl, C _1-6 Alkoxy-Carbonyl-C _1-6 Alkoxy, Carboxamide, C _1-6 Alkoxy-Carboxyl, Amino, C _1-6 Selected independently from the group consisting of alkyl-amino, (C _1-6 alkyl) ₂ -amino, amino-C _1-6 alkyl, amino-carbonyl and hydroxy-C _1-6 alkyl,
R ₆ is selected from the group consisting of C _3-10 cycloalkyl, phenyl, phenyl-C _1-6 alkoxy, phenyl-oxy, heterocyclyl and heteroaryl.
Heterocyclyl is a saturated or partially unsaturated 3- to 7-membered monocyclic, 6-10-membered ring with 1, 2 or 3 heteroatom rings independently selected from N, O or S. Bicyclic or 13-16 membered polycyclic ring system,
Heteroaryl is a 3- to 7-membered monocyclic or 6 to 10-membered bicyclic ring with 1, 2, 3 or 4 heteroatom rings independently selected from N, O or S. It is a cyclic system
Examples of C _3-10 cycloalkyl, phenyl, heterocyclyl and heteroaryl may be substituted with 1, 2 or 3 R ₇ substituents.
R ₇ is, in each example, cyano, halogen, hydroxy, C _1-6 alkyl, halo-C _1-6 alkyl, C _1-6 alkyl-carbonyl, C _1-6 alkoxy, halo-C _1-6 alkoxy, C _1-6 Alkoxy-C _1-6 Alkoxy, C _1-6 Alkoxy-carbonyl, Amino, C _1-6 Alkoxy-Amino, (C _1-6 Alkyl) ₂ -Amino, Amino-C _1-6 Alkyl and Hydroxy -Selected independently from the group consisting of C _1-6 alkyl) The compound according to claim 1, which is a compound of the formula (I) or a form thereof.

R ₁ is azetidinyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, piperazinyl, 1H-azepinyl, 2,3,6,7-tetrahydro-1H-azepinyl, azepanyl, 1,4-diazepanyl, 1,2,5,6-tetrahydro. Pyrizinyl, 1,2,3,6-tetrahydropyridinyl, octahydroindridinyl, octahydro-1H-pyrrolo [3,2-c] pyridinyl, (3aS, 7aR) -octahydro-1H-pyrrolo [3] , 2-c] pyridinyl, 1-azabicyclo [2.2.2] octyl, 3-azabicyclo [3.1.0] hexyl, (1R, 5S) -3-azabicyclo [3.1.0] hexyl, 3 -Azabicyclo [3.2.1] octyl, 8-Azabicyclo [3.2.1] octyl, (1R, 5S) -8-Azabicyclo [3.2.1] octyl, 8-Azabicyclo [3.2.1] ] Octa-2-en-yl, (1R, 5S) -8-azabicyclo [3.2.1] Oct-2-en-il, 9-azabicyclo [3.3.1] nonyl, (1R, 5S) -9-Azabicyclo [3.3.1] nonyl, 2,5-diazabicyclo [2.2.1] heptyl, (1S, 4S) -2,5-diazabicyclo [2.2.1] heptyl, 1,4 -Diazabicyclo [3.1.1] heptyl, 3,6-diazabicyclo [3.2.0] heptyl, 2,5-diazabicyclo [2.2.2] octyl, 1,4-diazabicyclo [3.2.1] ] Octyl, 3,8-diazabicyclo [3.2.1] octyl, (1R, 5S) -3,8-diazabicyclo [3.2.1] octyl, 1,4-diazabicyclo [3.2.2] nonyl , 3,8-diazabicyclo [4.2.0] octyl, (1S, 6R) -3,8-diazabicyclo [4.2.0] octyl, (1R, 6S) -3,8-diazabicyclo [4.2] .0] octyl, 2-azaspiro [3.3] heptyl, 4,7-diazaspiro [2.5] octyl, 2,6-diazaspiro [3.3] heptyl, 2,6-diazaspiro [3.4] octyl , 1,6-diazaspiro [3.5] nonyl, 1,7-diazaspiro [3.5] nonyl, 2,6-diazaspiro [3.5] nonyl, 2,7-diazaspiro [3.5] nonyl, 5 , 8-diazaspiro [3.5] nonyl, 1,7-diazaspiro [4.4] nonyl, 2,7-diazaspiro [4.4] nonyl, 2,7-diazaspiro [4.5] decyl and 6,9 -Ziazas It is a heterocyclyl selected from the group consisting of pyro [4.5] decyl, which may be substituted with 1, 2 , 3 or 4 R ₃ substituents and 1 additional R ₄ substitution. The compound according to claim 1, wherein the heterocyclyl may be substituted with 1, 2, 3, 4 or 5 R ₃ substituents. R ₂ is furanyl, 1H-pyrazolyl, 1H-imidazolyl, 1H-1,2,3-triazolyl, 4H-1,2,4-triazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, Pyrizinyl, pyridazinyl, pyrimidinyl, pyrazinyl, 1H-indazole, 2H-indrill, 1H-indazolyl, 2H-indazolyl, indridinyl, benzofuranyl, 1H-benzimidazolyl, 1,3-benzoxazolyl, flo [2,3-b] Pyridinyl, Flo [2,3-c] Pyridinyl, Flo [3,2-b] Pyridinyl, Flo [3,2-c] Pyridinyl, 1H-Pyrrolo [2,3-b] Pyridinyl, 1H-Pyrrolo [2, 3-c] pyrizinyl, pyrolo [1,2-α] pyrimidinyl, pyrrolho [1,2-α] pyrazinyl, pyrrolo [1,2-b] pyridadinyl, pyrazolo [1,5-α] pyrizinyl, 1H-pyrazolo [ 4,3-b] pyrizinyl, 2H-pyrazolo [4,3-b] pyrizinyl, 2H-pyrazolo [4,3-c] pyrizinyl, pyrazolo [1,5-α] pyrazinyl, pyrazolo [1,5-a] Pyrimidinyl, imidazole [1,2-α] pyridinyl, imidazole [1,2-α] pyrimidinyl, imidazole [1,2-α] pyrazinyl, imidazole [1,2-b] pyridadinyl, imidazole [1,2-c] Pyrimidinyl, imidazole [1,5-α] pyridinyl, imidazole [2,1-b] [1,3] thiazolyl, imidazole [2,1-b] [1,3,4] thiadiazolyl, [1,3] oxazolo Selected from the group consisting of [4,5-b] pyridinyl, [1,2,4] triazolo [1,5-a] pyrizinyl, [1,2,4] triazolo [1,5-b] pyridadinyl and quinolinyl. Heteroaryl may be substituted with 1, 2 or 3 R ₅ substituents, with one additional R ₆ substituent, or otherwise. The compound according to claim 1, wherein the heteroaryl may be substituted with 1, 2, 3 or 4 R ₅ substituents. The compound according to claim 1, wherein the form of the compound is a compound salt selected from the group consisting of hydrochloride, hydrobromide, trifluoroacetate, formate and dihydrochloride. 6- (2-Methyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
6- (2-Methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
6- (2-Methyl-2H-Indazole-5-yl) -2- (1-Methyl-1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
2- (2-Methyl-2H-indazole-5-yl) -6- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
2- (2-Methyl-2H-indazole-5-yl) -6- (piperidine-4-yl) -1,3-benzothiazole;
2- (2-Methyl-2H-indazole-5-yl) -6- (1-methyl-1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
6- (2-Methyl-2H-indazole-5-yl) -2- (piperazine-1-yl) -1,3-benzothiazole;
N-methyl-6- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-2-amine;
6- (2-Methyl-2H-Indazole-5-yl) -2- (1-Methylpiperidin-4-yl) -1,3-Benzothiazole;
2- (2-Methyl-2H-indazole-5-yl) -6- (1-methylpiperidin-4-yl) -1,3-benzothiazole;
N-Methyl-2- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-6-amine;
N-methyl-6- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridin-2-amine;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridin-2-amine;
6- (2,7-dimethyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridin-2-amine;
6- (2-Methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridin-2-amine;
N-Methyl-6- (2-Methyl-2H-Indazole-5-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] Thiazolo [4,5-yl] b] Pyridine-2-amine;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [4, 5-b] Pyridine-2-amine;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
2- (2-Methyl-2H-indazole-5-yl) -6- (1,2,3,6-tetrahydropyridine-4-yl) [1,3] thiazolo [4,5-b] pyridine;
N-Methyl-6- (2-Methyl-2H-Indazole-5-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzothiazole-2-amine ;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidin-4-yl) -1,3-benzothiazole-2 -Amine;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole
4-Fluoro-N-methyl-6- (2-methyl-2H-indazole-5-yl) -N- (2,2,6,6-tetramethylpiperidin-4-yl) -1,3-benzothiazole -2-Amine;
6- (2,7-dimethyl-2H-indazole-5-yl) -4-fluoro-N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3- Benzothiazole-2-amine;
N-Methyl-5- (2-Methyl-2H-Indazole-5-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] Thiazolo [5,4-Il] b] Pyridine-2-amine;
N-methyl-5- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [5,4-b] pyridin-2-amine;
N-methyl-6- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridin-2-amine;
N, N-dimethyl-1- [6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole-2-yl] piperidine-4-amine;
1- [6- (2-Methyl-2H-indazole-5-yl) -1,3-benzothiazole-2-yl] piperidine-4-amine;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridin-2-amine;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [4, 5-c] Pyridine-2-amine;
N-Methyl-6- (2-Methyl-2H-Indazole-5-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] Thiazolo [4,5-yl] c] Pyridine-2-amine;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3 -Benzothiazole-2-amine;
6- (1H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzothiazole-2-amine;
6- (2-Methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-2-amine;
5- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [5,4-b] pyridin-2-amine;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) -1 , 3-Benzothiazole-2-amine;
N-Methyl-6- (2-Methyl-2H-Indazole-5-yl) -N- (Pyrrolidine-3-yl) -1,3-Benzothiazole-2-amine;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -4-fluoro-N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-Benzothiazole-2-amine;
N-Methyl-6- (2-Methylimidazole [1,2-b] pyridazine-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzo Thiazole-2-amine;
2- (4-Fluoropiperidin-4-yl) -6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole;
2- (azepan-4-yl) -6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole;
2- (2-Methyl-2H-indazole-5-yl) -6- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridine;
6- [4-Fluor-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine ;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine;
6- [4-Fluor-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] ] Pyridazine;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine;
N-Methyl-6- (2-methyl [1,2,4] triazolo [1,5-b] pyridazine-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) )-1,3-Benzothiazole-2-amine;
2- (2,7-dimethyl-2H-indazole-5-yl) -6- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
2- (2,7-dimethyl-2H-indazole-5-yl) -6- (piperidine-4-yl) -1,3-benzothiazole;
N-Methyl-6- [2-Methyl-7- (trifluoromethyl) -2H-indazole-5-yl] -N- (2,2,6,6-tetramethylpiperidine-4-yl) -1, 3-Benzothiazole-2-amine;
6- (2-Methyl-2H-Indazole-5-yl) -2- (2,2,6,6-tetramethylpiperidin-4-yl) -1,3-benzothiazole;
6- [4-Fluor-2- (1,2,3,6-tetrahydropyridin-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-a] ] Pyrazine;
6- (7-Ethyl-2-methyl-2H-Indazole-5-yl) -N-Methyl-N- (2,2,6,6-tetramethylpiperidin-4-yl) -1,3-benzothiazole -2-Amine;
6- (1,3-dimethylpyrrolo [1,2-a] pyrazine-7-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3 -Benzothiazole-2-amine;
6- (2-Methyl-2H-Indazole-5-yl) -2- (2,3,6,7-tetrahydro-1H-azepine-4-yl) -1,3-benzothiazole;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N-Methyl-N- (2,2,6,6-tetramethylpiperidin-4-yl) -1,3-benzothiazole -2-Amine;
6- (2-Methyl-2H-Indazole-5-yl) -2- (2-Methylpiperidine-4-yl) -1,3-benzothiazole;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine;
6- [2-Methyl-7- (trifluoromethyl) -2H-indazole-5-yl] -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridine;
2-Methyl-5-{2- [Methyl (2,2,6,6-Tetramethylpiperidin-4-yl) Amino] -1,3-Benzothiazole-6-yl} -2H-Indazole-7-Carbo Nitrile;
N-Methyl-6- (2-methylimidazole [1,2-a] pyridin-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzo Thiazole-2-amine;
6- (2-Methyl-2H-Indazole-5-yl) -2-[(2,2,6,6-tetramethylpiperidin-4-yl) oxy] -1,3-benzothiazole;
6- (2-Methyl-2H-Indazole-5-yl) -2- (2-Methyl-1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (2-methylpiperidin-4-yl) -1,3-benzothiazole-2-amine;
6- (2-Methyl-2H-Indazole-5-yl) -2- (6-Methyl-1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
6- (2,7-dimethyl-2H-indazole-5-yl) -2-[(2,2,6,6-tetramethylpiperidine-4-yl) oxy] -1,3-benzothiazole;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-1,3-benzoxazole;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -4-fluoro-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3- Benzothiazole;
4-Fluoro-6- (2-methyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
4-Fluoro-6- (2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
2-Methyl-5- [2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridin-6-yl] -2H-indazole-7-carbonitrile;
6- (7-Ethyl-2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine;
6- (7-Fluoro-2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine;
6- (2-Methylimidazole [1,2-a] pyridin-6-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine
5- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -1H-pyrazolo [4,3-b] pyridine
5- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-pyrazolo [4,3-b] pyridine;
6- (7-Cyclopropyl-2-methyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzo Thiazole-2-amine;
N-Methyl-6- (2-Methyl-2H-Indazole-5-yl) -N- (2-Methylpiperidin-4-yl) -1,3-Benzothiazole-2-amine;
6- (2-Methylimidazole [1,2-a] pyridin-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
6- (7-Fluoro-2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
2-Methyl-5- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2H-indazole-7-carbonitrile;
6- (7-Ethyl-2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N-Methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] Thiazolo [ 4,5-c] Pyridine-2-amine;
N-Methyl-6- (2-methylimidazole [1,2-a] pyridin-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [4,5-c] Pyridine-2-amine;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-c] Pyridine-2-amine;
N-Methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [4,5-c] Pyridine-2-amine;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-c] Pyridine-2-amine;
5- {4-Fluor-2- [methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] -1,3-benzothiazole-6-yl} -2-methyl-2H-indazole -7-Carbonitrile;
6- [4-Fluoro-2- (1-methylpiperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine;
6- (8-Ethyl-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1 , 3-Benzothiazole-2-amine;
6- (2,4-dimethyl-1H-benzimidazole-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
6- (2-Methyl-1H-benzimidazole-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
N-Methyl-6- [2-Methyl-8- (Trifluoromethyl) Imidazo [1,2-a] Pyridine-6-yl] -N- (2,2,6,6-Tetramethylpiperidine-4- Ill) -1,3-benzothiazole-2-amine;
2-Methyl-6- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] imidazole [1,2-b] pyridazine;
6- (2,7-dimethyl-2H-indazole-5-yl) -4-methoxy-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole
6- (2,7-dimethyl-2H-indazole-5-yl) -4-methoxy-2- (piperidine-4-yl) -1,3-benzothiazole;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-4-ol;
6- (2,7-dimethyl-2H-indazole-5-yl) -7-fluoro-N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] Thiazolo [4,5-c] Pyridine-2-amine;
5- [4-Fluoro-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-indazole-7-carbonitrile ;
1- {5- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-indazole-7-yl} methaneamine;
5- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-indazole-7-carbonitrile;
N-Methyl-6- (2-methylimidazole [1,2-a] pyrimidin-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [4,5-c] Pyridine-2-amine;
6- [2- (1-Ethylpiperidin-4-yl) -4-fluoro-1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine;
6- [4-Fluoro-2- (1-methylpiperidine-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine;
6- (2,7-dimethyl-2H-indazole-5-yl) -N- (1,2-dimethylpiperidine-4-yl) -N-methyl-1,3-benzothiazole-2-amine;
2-Methyl-5- [2- (piperidine-4-yl) [1,3] thiazolo [5,4-d] pyrimidin-5-yl] -2H-indazole-7-carbonitrile;
5- (2,7-dimethyl-2H-indazole-5-yl) -2- (piperidine-4-yl) [1,3] thiazolo [5,4-d] pyrimidine;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1 , 3-Benzothiazole-2-amine;
2-Methyl-6- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -1,3-benzoxazole;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
2- (2,2-Dimethylpiperidine-4-yl) -6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole;
N-Methyl-6- [2-Methyl-8- (Trifluoromethyl) Imidazo [1,2-a] Pyridine-6-yl] -N- (2,2,6,6-Tetramethylpiperidine-4- Il) [1,3] thiazolo [4,5-c] pyridin-2-amine;
2-Methyl-5-{2- [Methyl (2,2,6,6-Tetramethylpiperidine-4-yl) Amino] [1,3] Thiazolo [4,5-c] Pyridine-6-yl}- 2H-indazole-7-carbonitrile;
3- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpyridazine-4-yl) [1,3] thiazolo [4, 5-c] Pyridazine-6-amine;
2- {6- [Methyl (2,2,6,6-Tetramethylpiperidin-4-yl) Amino] [1,3] Thiazolo [4,5-c] Pyridazine-3-yl} -5- (1H) -Pyrazole-4-yl) Phenol;
6- [4-Fluoro-2- (piperazine-1-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine;
6- [2- (1,4-Diazepan-1-yl) -4-fluoro-1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine;
5- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpyrimidine-4-yl) [1,3] thiazolo [5, 4-d] Pyrimidine-2-amine;
2-Methyl-5-{2- [Methyl (2,2,6,6-Tetramethylpiperidin-4-yl) Amino] [1,3] Thiazolo [5,4-d] Pyrimidine-5-yl}- 2H-indazole-7-carbonitrile;
5- (7-Fluoro-2-methyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpyrimidine-4-yl) [1,3] thiazolo [ 5,4-d] Pyrimidine-2-amine;
6- [2- (4,7-Diazaspiro [2.5] octa-7-yl) -4-fluoro-1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-yl] b] Pyridazine;
4-Fluoro-6- (7-fluoro-2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4-fluoro-N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-Benzothiazole-2-amine;
5- (7-Fluoro-2-methyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [ 5,4-b] Pyridine-2-amine;
N-Methyl-5- (2-methylimidazole [1,2-a] pyridin-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [5,4-b] Pyridine-2-amine;
2- {2- [Methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-b] pyrazine-6-yl} -5- (1H) -Pyrazole-4-yl) phenol;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [4, 5-b] Pyrazine-2-amine;
6- [2- (3,5-dimethylpiperazine-1-yl) -4-fluoro-1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine;
6- {4-fluoro-2-[(2,2,6,6-tetramethylpyridazine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2,8-dimethylimidazole [1] , 2-b] Pyridazine;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole-4-ol;
6- {2-[(2,6-Dimethylpiperidine-4-yl) oxy] -4-fluoro-1,3-benzothiazole-6-yl} -2,8-dimethylimidazole [1,2-b] Pyridazine;
N-Methyl-6- (2-Methyl [1,2,4] Triazolo [1,5-a] Pyridine-6-yl) -N- (2,2,6,6-Tetramethylpiperidine-4-yl) ) [1,3] Thiazolo [4,5-c] Pyridine-2-amine;
2- {2- [Methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] Thiazolo [4,5-c] Pyridine-6-yl} -5- (1H) -Pyrazole-4-yl) phenol;
2-Methyl-6- {2- [methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] -1,3-benzothiazole-6-yl} imidazole [1,2-a] Pyridine-8-carbonitrile;
2,8-dimethyl-6- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] imidazole [1,2-b] pyridazine;
2-Methyl-5-{2- [Methyl (2,2,6,6-Tetramethylpiperidine-4-yl) Amino] [1,3] Thiazolo [4,5-b] Pyrazine-6-yl}- 2H-indazole-7-carbonitrile;
N-Methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [4,5-b] Pyridazine-2-amine;
2- {2- [Methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl} -5- (1H) -Pyrazole-4-yl) phenol;
1- [6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4-fluoro-1,3-benzothiazole-2-yl] piperidine-4-ol;
6- {4-fluoro-2-[(2R) -2-methylpiperidine-4-yl] -1,3-benzothiazole-6-yl} -2-methylimidazole [1,2-b] pyridazine;
6- [4-Fluor-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -8-methoxy-2-methylimidazole [1,2] -B] Pyridazine;
6- (2,7-dimethyl-2H-indazole-5-yl) -N- (2,2-dimethylpiperidine-4-yl) -N-methyl-1,3-benzothiazole-2-amine;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1 , 3] Thiazolo [4,5-c] Pyridine-2-amine;
2-Methyl-5-{2- [methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl}- 2H-indazole-7-carbonitrile;
2- {2- [Methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] Thiazolo [5,4-b] Pyridine-5-yl} -5- (1H) -Pyrazole-4-yl) phenol;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N-Methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] Thiazolo [ 4,5-b] Pyrazine-2-amine;
6- [4-Fluor-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -8-methoxy-2-methylimidazole [1,2-b] pyridazine;
4-Fluoro-6- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole;
4-Chloro-6- (7-fluoro-2-methyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole;
5- [4-Chloro-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-indazole-7-carbonitrile ;
N- (2,2-dimethylpiperidine-4-yl) -N-methyl-6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole-2-amine;
2-Methyl-6- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] imidazole [1,2-a] pyrimidine;
3- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1 , 3] Thiazolo [4,5-c] pyridazine-6-amine;
2-Methyl-5-{6- [Methyl (2,2,6,6-Tetramethylpiperidin-4-yl) Amino] [1,3] Thiazolo [4,5-c] Pyridazine-3-yl}- 2H-indazole-7-carbonitrile;
6- [2,3-difluoro-4- (1H-pyrazole-4-yl) phenyl] -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-b] pyrazine-2-amine;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-b] pyrazine-2-amine;
2-Methyl-6- {2- [methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-b] pyrazine-6-yl} imidazole [1,2-a] Pyrazine-8-carbonitrile;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N-[(2S) -2-methylpiperidine-4-yl] -1,3- Benzothiazole-2-amine;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4-fluoro-N-methyl-N-[(2S) -2-methylpiperidine-4-yl] -1, 3-Benzothiazole-2-amine;
6- [4-Fluoro-2- (octahydroindolizine-7-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -N, 2-dimethylimidazole [1,2-b] pyridazine-8-amine;
6- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -N, N, 2-trimethylimidazole [1,2-b] pyridazine-8-amine;
2-Methyl-6- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] imidazole [1,2-a] pyrazine;
2-Methyl-6- {2- [methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl} imidazole [1,2-a] Pyridine-8-carbonitrile;
5- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1 , 3] Thiazolo [5,4-d] pyrimidin-2-amine;
6- (7-Cyano-2-methyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-4-carbonitrile ;
2-Methyl-6- [2- (piperazine-1-yl) [1,3] thiazolo [4,5-b] pyrazine-6-yl] imidazole [1,2-a] pyridin-8-carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2- (piperazine-1-yl) [1,3] thiazolo [4,5-b] pyrazine;
6- (2,7-dimethyl-2H-indazole-5-yl) -N- (2,6-dimethylpiperidine-4-yl) -N-methyl-1,3-benzothiazole-2-amine;
N- (2,6-dimethylpiperidine-4-yl) -N-methyl-6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole-2-amine;
5- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1 , 3] Thiazolo [5,4-b] Pyridine-2-amine;
2-Methyl-6- {2- [methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl} imidazole [1,2-a] Pyridine-8-carbonitrile;
2-Methyl-6- {2- [Methyl (2,2,6,6-Tetramethylpiperidine-4-yl) Amino] [1,3] Thiazolo [4,5-c] Pyridine-6-yl} Imidazo [1,2-a] Pyridine-8-carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2-[(2,2,6,6-tetramethylpiperidine-4-yl) oxy] [1, 3] Thiazolo [4,5-b] pyrazine;
2-Methyl-6- {2-[(2,2,6,6-tetramethylpiperidine-4-yl) oxy] [1,3] thiazolo [4,5-b] pyrazine-6-yl} imidazole [ 1,2-a] Pyrazine-8-carbonitrile;
6- (2-Methylimidazole [1,2-b] pyridazine-6-yl) -2- (piperazine-1-yl) [1,3] thiazolo [4,5-b] pyrazine;
5- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [5,4-d] pyrimidin-2-amine;
5- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [5,4-d] pyrimidin-2-amine;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-2-amine;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4-fluoro-N-methyl-N- (piperidine-4-yl) -1,3-benzothiazole-2- Amine;
8- (benzyloxy) -6- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-amine;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-ol;
2- (2,6-Dimethylpiperidine-4-yl) -6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole;
4-Fluoro-6- (4-fluoro-3-methoxyphenyl) -2- (piperidine-4-yl) -1,3-benzothiazole;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4 -Fluoro-N-methyl-1,3-benzothiazole-2-amine;
2-Methyl-5-{2- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl} -2H-indazole-7-carbonitrile;
6- [2- (1-azabicyclo [2.2.2] octa-4-yl) -4-fluoro-1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-yl] b] Pyridazine;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-8-phenoxyimidazole [1,2-b] pyridazine;
2-Methyl-6- {2- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl} imidazole [1,2-a] pyridine-8 -Carbonitrile;
5- (7-Methoxy-2-methyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpyrimidine-4-yl) [1,3] thiazolo [ 5,4-d] Pyrimidine-2-amine;
2-Methyl-6- {2- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} imidazole [1,2-a] pyridine-8 -Carbonitrile;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-ylamino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2- Methylimidazole [1,2-a] pyridin-8-carbonitrile;
4-Fluoro-6- (8-Methoxy-2-methylimidazole [1,2-b] pyridazine-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) Ill) -1,3-benzothiazole-2-amine;
6- {4-fluoro-2- [methyl (2,2,6,6-tetramethylpyridazine-4-yl) amino] -1,3-benzothiazole-6-yl} -2-methylimidazole [1, 2-b] Pyridazine-8-amine;
4-Fluoro-6- (8-Methoxy-2-methylimidazole [1,2-b] pyridazine-6-yl) -N-methyl-N- (piperidine-4-yl) -1,3-benzothiazole- 2-Amine;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [4,5-c] pyridin-2-amine;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [ 1,3] Thiazolo [4,5-c] Pyridine-2-amine;
5- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl } -2-Methyl-2H-Indazole-7-Carbonitrile;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile;
5- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl } -2-Methyl-2H-Indazole-7-Carbonitrile;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -4-fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine- 6-yl) -1,3-benzothiazole-2-amine;
6- [4-Fluoro-2- (4-methylpiperidine-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (7-fluoro-2-methyl-2H-indazole-5-yl) [1,3] Thiazolo [4,5-c] Pyridine-2-amine;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) [1,3] Thiazolo [4,5-c] Pyridine-2-amine;
5- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-ylamino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2- Methyl-2H-indazole-7-carbonitrile;
2-Methyl-5-{2- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridin-6-yl} -2H-indazole-7-carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-c ] Pyridine-2-amine;
6- (7-Fluoro-2-methyl-2H-indazole-5-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridin-2- Amine;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -5- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [ 1,3] Thiazolo [5,4-d] pyrimidin-2-amine;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-carboxylic acid;
Methyl {6- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-yl} acetate;
{6- [4-Fluor-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-yl} acetic acid;
2-Methyl-6- {2-[(2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} imidazole [ 1,2-a] Pyridine-8-carbonitrile;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yloxy] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2- Methylimidazole [1,2-a] pyridin-8-carbonitrile;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-carboxamide;
6- (1,3-dimethylpyrrolo [1,2-a] pyrazine-7-yl) -4-fluoro-N-methyl-N- (piperidine-4-yl) -1,3-benzothiazole-2- Amine;
6- {4-fluoro-2- [methyl (piperidine-4-yl) amino] -1,3-benzothiazole-6-yl} -2-methylimidazole [1,2-a] pyridin-8-carbonitrile ;
N-[(8-anti) -3-azabicyclo [3.2.1] octa-8-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine;
6- {2-[(8-anti) -3-azabicyclo [3.2.1] octa-8-yl (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile;
2- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -6,8-dimethylimidazole [1,2-a] pyrazine;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-carbonitrile;
6- {4-Fluor-2- [methyl (piperidine-4-yl) amino] -1,3-benzothiazole-6-yl} -2-methylimidazole [1,2-b] pyridazine-8-carbonitrile ;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] Thiazolo [4,5-yl] c] Pyridine-2-amine;
2-Methyl-5-{2-[(2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2H -Indazole-7-Carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3] thiazolo [4,5-c] Pyridine-2-amine;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] -4-fluoro-1,3-benzothiazole-6-yl} -2 -Methylimidazole [1,2-b] pyridazine-8-carbonitrile;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] -4-fluoro-1,3-benzothiazole-6-yl} -2 -Methylimidazole [1,2-b] pyridazine-8-carboxamide;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -4-fluoro-N-methyl-6- (2-methyl-2H-pyrazolo [4,3-b] ] Pyridine-5-yl) -1,3-benzothiazole-2-amine;
2-Methyl-5-(2- {methyl [(3-exo) -8-methyl-8-azabicyclo [3.2.1] octa-3-yl] amino} [1,3] thiazolo [4,5] -C] Pyridine-6-yl) -2H-indazole-7-carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N-[(3-exo) -8-methyl-8-azabicyclo [3.2. 1] Octa-3-yl] [1,3] Thiazolo [4,5-c] Pyridine-2-amine;
2-Methyl-6-(2- {methyl [(3-exo) -8-methyl-8-azabicyclo [3.2.1] octa-3-yl] amino} [1,3] thiazolo [4,5] -C] Pyridine-6-yl) Imidazo [1,2-a] Pyridine-8-carbonitrile;
6- (7-Fluoro-2-Methyl-2H-Indazole-5-yl) -N-Methyl-N-[(3-exo) -8-Methyl-8-Azabicyclo [3.2.1] Octa-3 -Il] [1,3] thiazolo [4,5-c] pyridin-2-amine;
6- {2- [Ethyl (2,2,6,6-Tetramethylpiperidine-4-yl) Amino] [1,3] Thiazolo [5,4-d] Pyrimidine-5-yl} -2-Methylimidazole [1,2-a] Pyridine-8-carbonitrile;
N-Ethyl-5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [1 , 3] Thiazolo [5,4-d] pyrimidin-2-amine;
2-Methyl-5-(2-{[(3-exo) -8-methyl-8-azabicyclo [3.2.1] octa-3-yl] amino} [1,3] thiazolo [4,5- c] Pyridine-6-yl) -2H-indazole-7-carbonitrile;
2-Methyl-6-(2-{[(3-exo) -8-methyl-8-azabicyclo [3.2.1] octa-3-yl] amino} [1,3] thiazolo [4,5- c] Pyridine-6-yl) Imidazo [1,2-a] Pyridine-8-carbonitrile;
6- (7-Fluoro-2-methyl-2H-indazole-5-yl) -N-[(3-exo) -8-methyl-8-azabicyclo [3.2.1] octa-3-yl] [ 1,3] Thiazolo [4,5-c] Pyridine-2-amine;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-[(3-exo) -8-methyl-8-azabicyclo [3.2.1] octa- 3-yl] [1,3] thiazolo [4,5-c] pyridin-2-amine;
N- (azetidine-3-yl) -6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4-fluoro-N-methyl-1,3-benzothiazole-2- Amine;
5- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylpyrazolo [1,5-a] pyrimidine;
4-Fluoro-N-methyl-6- (2-methylpyrazolo [1,5-a] pyrimidin-5-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-2-amine;
6- {2- [9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [4,5-c] pyridin-6-yl} -2-methylimidazole [1,2-a] Pyridine-8-carbonitrile;
5- {2- [9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2-methyl- 2H-indazole-7-carbonitrile;
N- (9-azabicyclo [3.3.1] nona-3-yl) -6- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [ 4,5-c] Pyridine-2-amine;
5- {2-[(1,5-dimethyl-8-azabicyclo [3.2.1] octa-3-yl) (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidine-5 -Il} -2-methyl-2H-indazole-7-carbonitrile;
6-(2-{[(1R) -1,5-dimethyl-8-azabicyclo [3.2.1] octa-3-yl] (methyl) amino} [1,3] thiazolo [5,4-d ] Pyrimidine-5-yl) -2-methylimidazole [1,2-a] Pyridine-8-carbonitrile;
6- {2-[(1R, 5S) -9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile;
N-[(1R, 5S) -9-azabicyclo [3.3.1] nona-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N-[(2S, 4S) -2-methylpiperidine-4-yl] -1, 3-Benzothiazole-2-amine;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N-[(2S, 4R) -2-methylpiperidine-4-yl] -1, 3-Benzothiazole-2-amine;
N- (9-azabicyclo [3.3.1] nona-3-yl) -N-methyl-6- (2-methylimidazole [1,2-a] pyridin-6-yl) [1,3] thiazolo [4,5-c] Pyridine-2-amine;
N- (9-azabicyclo [3.3.1] nona-3-yl) -6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -N-methyl [1,3 ] Thiazolo [4,5-c] Pyridine-2-amine;
N- (9-azabicyclo [3.3.1] nona-3-yl) -N-methyl-6- (2-methyl-2H-indazole-5-yl) [1,3] thiazolo [4,5-yl) c] Pyridine-2-amine;
N- (9-azabicyclo [3.3.1] nona-3-yl) -6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [4, 5-c] Pyridine-2-amine;
N- (9-azabicyclo [3.3.1] nona-3-yl) -6- (7-methoxy-2-methyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [ 4,5-c] Pyridine-2-amine;
5- (1,3-dimethylpyrrolo [1,2-a] pyrazine-7-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [5,4-d] pyrimidine-2-amine;
2-Methyl-6- {2-[(1,2,2,6,6-pentamethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} Imidazo [1,2-a] Pyridine-8-Carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N- (1,2,2,6,6-pentamethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-c] Pyridine-2-amine;
2-Methyl-5-{2-[(1,2,2,6,6-pentamethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2H-Indazole-7-Carbonitrile;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N- (1,2,2,6,6-pentamethylpiperidin-4-yl) [1,3] Thiazolo [4, 5-c] Pyridine-2-amine;
2-Methyl-6- {2- [Methyl (9-Methyl-9-Azabicyclo [3.3.1] Nona-3-yl) Amino] [1,3] Thiazolo [4,5-c] Pyridine-6 -Il} Imidazo [1,2-a] Pyridine-8-Carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (9-methyl-9-azabicyclo [3.3.1] nona-3- Ill) [1,3] thiazolo [4,5-c] pyridin-2-amine;
2-Methyl-5-{2- [Methyl (9-Methyl-9-Azabicyclo [3.3.1] Nona-3-yl) Amino] [1,3] Thiazolo [4,5-c] Pyridine-6 -Il} -2H-indazole-7-carbonitrile;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N-Methyl-N- (9-Methyl-9-Azabicyclo [3.3.1] Nona-3-yl) [1, 3] Thiazolo [4,5-c] Pyridine-2-amine;
2- {2- [Methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-b] pyrazine-6-yl} -5- (1H-pyrazole-4-yl) phenol;
2-Methyl-6- {2- [Methyl (2,2,6,6-Tetramethylpiperidin-4-yl) Amino] [1,3] Thiazolo [5,4-d] Pyrimidine-5-yl}- 1,3-Benzoxazole-4-carbonitrile;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-b] pyridin-2-amine;
5- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl } -2-Methyl-2H-Indazole-7-Carbonitrile
6- {2-[(3-exo) -9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile;
N-[(3-exo) -9-azabicyclo [3.3.1] nona-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-b] pyridin-2-amine;
5- {2-[(3-exo) -9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl } -2-Methyl-2H-Indazole-7-Carbonitrile;
2- {6- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) phenol;
2- {6- [Methyl (1-methylpiperidine-4-yl) amino] [1,3] Thiazolo [4,5-c] Pyridazine-3-yl} -5- (1H-pyrazole-4-yl) Phenol;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-] a] Pyridine-6-yl) -N-methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine;
6-(2-{[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] (methyl) amino} [1,3] thiazolo [4] , 5-c] Pyridine-6-yl) -2-methylimidazole [1,2-a] Pyridine-8-carbonitrile;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -6- (8-fluoro-2-methylimidazole [1,2-] a] Pyridine-6-yl) -N-methyl [1,3] thiazolo [4,5-c] pyridin-2-amine;
5-(2-{[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] (methyl) amino} [1,3] thiazolo [4] , 5-c] Pyridine-6-yl) -2-methyl-2H-indazole-7-carbonitrile;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyrazine -2-Amine;
N-[(1R) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -5- (7-fluoro-2-methyl-2H-indazole-5-yl)- N-Methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine;
6-(2-{[(1R) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] (methyl) amino} [1,3] thiazolo [5,4-d ] Pyrimidine-5-yl) -2-methyl-1,3-benzoxazole-4-carbonitrile;
6-(2-{[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] (methyl) amino} [1,3] thiazolo [5] , 4-b] Pyridine-5-yl) -2-Methylimidazole [1,2-a] Pyridine-8-carbonitrile;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-] a] Pyridine-6-yl) -N-methyl [1,3] thiazolo [5,4-b] pyridin-2-amine;
5- (2-{[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] (methyl) amino} [1,3] thiazolo [5] , 4-b] Pyridine-5-yl) -2-Methyl-2H-indazole-7-carbonitrile;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -5- (7-fluoro-2-methyl-2H-indazole-5) -Il) -N-methyl [1,3] thiazolo [5,4-b] pyridin-2-amine;
N- (9-azabicyclo [3.3.1] nonane-3-yl) -5- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [ 5,4-b] Pyridine-2-amine;
6- (6,8-dimethylimidazole [1,2-a] pyrazine-2-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-c] Pyrazine-2-amine;
6- (1,3-dimethylpyrrolo [1,2-a] pyrazine-7-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-c] Pyrazine-2-amine;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -6- (7-fluoro-2-methyl-2H-indazole-5) -Il) -N-methyl [1,3] thiazolo [4,5-c] pyridin-2-amine;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -6- (2,8-dimethylimidazole [1,2-a]] Pyridine-6-yl) -N-methyl [1,3] thiazolo [4,5-c] pyridin-2-amine;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -N-methyl-6- (2-methylimidazole [1,2-) a] Pyridine-6-yl) [1,3] Thiazolo [4,5-c] Pyridine-2-amine;
6-(2-{[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] (methyl) amino} [1,3] thiazolo [4] , 5-c] Pyridine-6-yl) -2-methyl-1,3-benzoxazole-4-carbonitrile;
N-Methyl-6- (2-methylimidazole [2,1-b] [1,3] thiazole-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [ 1,3] Thiazolo [4,5-c] Pyridine-2-amine;
6-(2-{[(1R, 3r, 5S) -1,5-diethyl-8-azabicyclo [3.2.1] octane-3-yl] (methyl) amino} [1,3] thiazolo [5] , 4-d] Pyrimidine-5-yl) -2-Methylimidazole [1,2-a] Pyridine-8-carbonitrile;
N-[(1R, 3r, 5S) -1,5-diethyl-8-azabicyclo [3.2.1] octane-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-] a] Pyridine-6-yl) -N-methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine;
N-Methyl-6- (3-Methylimidazole [2,1-b] [1,3] Thiazole-6-yl) -N- (2,2,6,6-Tetramethylpiperidine-4-yl) [ 1,3] Thiazolo [4,5-c] Pyridine-2-amine;
6- {4-fluoro-2-[(piperidine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2,8-dimethylimidazole [1,2-b] pyridazine;
4-Fluoro-6- (7-fluoro-2-methyl-2H-indazole-5-yl) -2-[(piperidine-4-yl) oxy] -1,3-benzothiazole;
N-Methyl-6- (2-Methylimidazole [2,1-b] [1,3,4] thiadiazole-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) ) [1,3] Thiadiazole [4,5-c] Pyridine-2-amine;
2-Methyl-6- {2-[(2,2,6,6-tetramethylpiperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] pyridine-6-yl} imidazole [ 1,2-a] Pyridine-8-carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2-[(2,2,6,6-tetramethylpiperidine-4-yl) oxy] [1, 3] Thiazolo [4,5-c] pyridine;
2-Methyl-5-{2-[(2,2,6,6-tetramethylpiperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2H -Indazole-7-Carbonitrile;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -2-[(2,2,6,6-tetramethylpiperidine-4-yl) oxy] [1,3] Thiazolo [4] , 5-c] Pyridine;
2-Methyl-6- {2-[(piperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] pyridine-6-yl} imidazole [1,2-a] pyridine-8- Carbonitrile;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2-[(piperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] Pyridine;
2-Methyl-5-{2-[(piperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] pyridin-6-yl} -2H-indazole-7-carbonitrile;
6- (7-Fluoro-2-methyl-2H-indazole-5-yl) -2-[(piperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] pyridine;
6- {4-fluoro-2-[(piperidine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2-methylimidazole [1,2-a] pyridine-8-carbonitrile;
5- {4-Fluoro-2-[(piperidine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2-methyl-2H-indazole-7-carbonitrile;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -4-fluoro-2-[(piperidine-4-yl) oxy] -1,3-benzothiazole;
6- {4-fluoro-2-[(1-methylpiperidine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2,8-dimethylimidazole [1,2-b] pyridazine;
6- {2-[(1-Ethylpiperidin-4-yl) oxy] -4-fluoro-1,3-benzothiazole-6-yl} -2,8-dimethylimidazole [1,2-b] pyridazine;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -6- (6,8-dimethylimidazole [1,2-a]] Pyrazine-2-yl) -N-methyl [1,3] thiazolo [4,5-c] pyridin-2-amine;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -5- (1,3-dimethylpyrrolo [1,2-a] Pyrazine-7-yl) -N-methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine;
6-(2-{[(3R, 4R) -3-fluoro-2,2,6,6-tetramethylpiperidine-4-yl] (methyl) amino} [1,3] thiazolo [5,4-d] ] Pyrimidine-5-yl) -2-methylimidazole [1,2-a] Pyridine-8-carbonitrile;
6-(2-{[(3R, 4R) -3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] ] Pyridine-6-yl) -2-methylimidazole [1,2-a] Pyridine-8-carbonitrile;
N-[(1R, 2S, 3S, 5S) -2-fluoro-1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -6- (8-fluoro-2-methyl) Imidazo [1,2-a] Pyridine-6-yl) -N-methyl [1,3] thiazolo [4,5-c] Pyridine-2-amine;
5- (1H-imidazol-1-yl) -2- {6- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} phenol;
3- [2,5-difluoro-4- (1H-pyrazole-4-yl) phenyl] -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridazine -6-amine;
5- (3-Fluoro-1H-pyrazole-4-yl) -2-{6- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl } Phenol;
5- (1H-imidazol-1-yl) -2- {6- [methyl (1-methylpiperidin-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} Phenol;
3- [2,5-difluoro-4- (3-fluoro-1H-pyrazole-4-yl) phenyl] -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5] -C] Pyridazine-6-amine;
5- (3-Fluoro-1H-pyrazole-4-yl) -2-{6- [methyl (1-methylpiperidin-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine- 3-Il} Phenol;
2- {6-[(3R, 5S) -3,5-dimethylpiperazine-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-) 4-Il) Phenol;
2- [6- (Piperazine-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H-pyrazole-4-yl) phenol;
5- (1H-Pyrazole-4-yl) -2- [6- (1,2,3,6-tetrahydropyridine-4-yl) [1,3] thiazolo [4,5-c] pyridin-2- Il] Phenol;
2- (6-{[(3R, 4S) -4-fluoro-1-methylpyrrolidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5 (1H-pyrazole-4-yl) phenol;
5- (1H-Pyrazole-4-yl) -2- [6- (2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine-4-yl) [1,3] thiazolo [4,5-c] Pyridine-2-yl] Phenol;
2- [6- (2,6-diazaspiro [3.5] nonane-2-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H-pyrazole-4) -Il) Phenol;
2- [6- (7-Methyl-1,7-diazaspiro [3.5] nonane-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H) -Pyrazole-4-yl) Phenol;
2- [6- (7-Methyl-2,7-diazaspiro [4.4] nonane-2-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H) -Pyrazole-4-yl) Phenol;
2- [6- (2,7-Diazaspiro [3.5] Nonane-2-yl) [1,3] Thiazolo [4,5-c] Pyridazine-3-yl] -5- (3-Fluoro-1H) -Pyrazole-4-yl) Phenol;
2- (6-{[(3S, 4S) -4-fluoro-1-methylpyrrolidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5 (1H-pyrazole-4-yl) phenol;
2- {6- [methyl (1-methylazetidine-3-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) ) Phenol;
2- {6-[(3aS, 7aR) -octahydro-1H-pyrolo [3,2-c] pyridin-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl}- 5- (1H-pyrazole-4-yl) phenol;
2- (6- {Methyl [(1s, 4s) -4- (methylamino) cyclohexyl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole) -4-yl) Phenol;
2- (6-{[(3R, 4S) -4-fluoropyrrolidine-3-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5-( 1H-pyrazole-4-yl) phenol;
2- {6-[(3aS, 7aR) -5-methyloctahydro-1H-pyrolo [3,2-c] pyridin-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3 -Il} -5- (1H-pyrazole-4-yl) phenol;
2- (6- {Methyl [(3R) -piperidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-4-yl) ) Phenol;
2- (6- {Methyl [(3S) -piperidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-4-yl) ) Phenol;
2- (6- {Methyl [3- (methylamino) cyclobutyl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-4-yl) phenol ;
2- (6-{[(1r, 4r) -4- (dimethylamino) cyclohexyl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H) -Pyrazole-4-yl) Phenol;
2- (6- {Methyl [(3S) -1-methylpiperidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-) 4-Il) Phenol;
2- {6-[(azetidine-3-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) phenol ;
2- [6- (1,7-Diazaspiro [3.5] nonane-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H-pyrazole-4) -Il) Phenol;
2- {6-[(3,3-Dimethylpiperidine-4-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-) 4-yl) phenol;
2- {6-[(2-azaspiro [3.3] heptane-6-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H) -Pyrazole-4-yl) Phenol;
2- {6-[(Piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) phenol;
2- (6-{[(3R, 4S) -3-fluoropiperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5-( 1H-pyrazole-4-yl) phenol;
5- {2-[(2R, 4r, 6S) -2,6-dimethylpiperidine-4-yl] -4-fluoro-1,3-benzothiazole-6-yl} -2,7-dimethyl [1, 3] Oxazolo [5,4-b] pyridine;
2- {6- [methyl (1,3,3-trimethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-) 4-Il) Phenol;
2- (6- {Methyl [(1s, 3s) -3- (methylamino) cyclobutyl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole) -4-yl) Phenol;
2- {6-[(3aR, 7aS) -octahydro-1H-pyrolo [2,3-c] pyridin-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl}- 5- (1H-pyrazole-4-yl) phenol;
2- [6- (1,6-diazaspiro [3.5] nonane-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H-pyrazole-4) -Il) Phenol;
2- (6-{[(1s, 3s) -3- (dimethylamino) cyclobutyl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H) -Pyrazole-4-yl) Phenol;
2- (6-{[(3R, 4R) -3-fluoropiperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5-( 1H-pyrazole-4-yl) phenol;
2-{6-[(1-Methylpiperidin-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) phenol ;
5- (1H-pyrazole-4-yl) -2- {6-[(pyrrolidin-3-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} phenol;
2- [6- (2,6-diazaspiro [3.3] heptane-2-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (3-fluoro-1H) -Pyrazole-4-yl) Phenol;
2- {6-[(3aR, 7aS) -6-methyloctahydro-1H-pyrolo [2,3-c] pyridin-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3 -Il} -5- (1H-pyrazole-4-yl) phenol;
2- [6- (6-Methyl-1,6-diazaspiro [3.5] nonane-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H) -Pyrazole-4-yl) Phenol;
2- (6-{[(2S, 4S) -2- (hydroxymethyl) piperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl)- 5- (1H-pyrazole-4-yl) phenol;
2- (6-{[(2S, 4S) -2- (hydroxymethyl) -1-methylpiperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3 -Il) -5- (1H-pyrazole-4-yl) phenol;
2- {6-[(1-Methylpyrrolidine-3-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) phenol ;
2- {6- [methyl (pyrrolidine-3-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) phenol;
2- {6- [methyl (1-methylpyrrolidine-3-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) Phenol;
2- (6- {Methyl [(1r, 3r) -3- (methylamino) cyclobutyl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole) -4-yl) Phenol;
5- {2-[(1,2-Dimethylpiperidine-4-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2-methyl-2H-indazole -7-Carbonitrile;
N- (1,2-dimethylpiperidine-4-yl) -6- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [4,5-c ] Pyridine-2-amine;
6- {2-[(1,2-dimethylpiperidine-4-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridin-6-yl} -2-methylimidazole [1, 2-a] Pyridine-8-carbonitrile;
N- (1,2-dimethylpiperidine-4-yl) -6- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl [1,3] thiazolo [ 4,5-c] Pyridine-2-amine;
2- (6-{[(3S, 4S) -4-fluoropyrrolidine-3-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5-( 1H-pyrazole-4-yl) phenol;
2- (6-{[(3S, 4S) -4-fluoro-1-methylpyrrolidine-3-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-4-yl) phenol;
2- {6-[(1-Cyclopropylpiperidin-4-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4) -Il) Phenol;
2- (6-{[1- (2-Fluoroethyl) piperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H) -Pyrazole-4-yl) phenol;
5- (3-Fluoro-1H-pyrazole-4-yl) -2- [6- (6-methyl-2,6-diazaspiro [3.3] heptane-2-yl) [1,3] thiazolo [4] , 5-c] pyridazine-3-yl] phenol;
2- {6-[(1S, 6R) -3,8-diazabicyclo [4.2.0] octane-8-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl}- 5- (1H-pyrazole-4-yl) phenol;
5- (3-Fluoro-1H-pyrazole-4-yl) -2-{6- [methyl (pyrrolidin-3-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl } Phenol;
2- {6-[(1S, 6R) -3-methyl-3,8-diazabicyclo [4.2.0] octane-8-yl] [1,3] thiazolo [4,5-c] pyridazine-3 -Il} -5- (1H-pyrazole-4-yl) phenol;
2- {6-[(1R, 6S) -3,8-diazabicyclo [4.2.0] octane-8-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl}- 5- (1H-pyrazole-4-yl) phenol;
2- {6-[(1R, 6S) -3-methyl-3,8-diazabicyclo [4.2.0] octane-8-yl] [1,3] thiazolo [4,5-c] pyridazine-3 -Il} -5- (1H-pyrazole-4-yl) phenol;
5- (3-Fluoro-1H-pyrazole-4-yl) -2-{6- [methyl (1-methylpyrrolidin-3-yl) amino] [1,3] thiazolo [4,5-c] pyridazine- 3-Il} Phenol;
5- (3-Fluoro-1H-pyrazole-4-yl) -2- [6- (7-methyl-2,7-diazaspiro [3.5] nonane-2-yl) [1,3] thiazolo [4] , 5-c] pyridazine-3-yl] phenol;
2- {6- [Methyl (1-propylpiperidin-4-yl) Amino] [1,3] Thiazolo [4,5-c] Pyridazine-3-yl} -5- (1H-Pyrazole-4-yl) Phenol;
2- (6- {Methyl [(2S, 4S) -2-methylpiperidine-4-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-) Pyrazole-4-yl) phenol;
2- (6-{[(2S, 4S) -1,2-dimethylpiperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5 -(1H-pyrazole-4-yl) phenol;
2- (6- {Methyl [(2R, 4S) -2-methylpiperidine-4-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-) Pyrazole-4-yl) phenol;
2- (6-{[(2R, 4S) -1,2-dimethylpiperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5 -(1H-pyrazole-4-yl) phenol;
2- {6- [(azepan-4-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (3-fluoro-1H-pyrazole-4) -Il) Phenol; and
2- (6-{[1- (2-Hydroxyethyl) piperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H) -Pyrazole-4-yl) Phenol; a compound selected from the group consisting of, or a form thereof. A compound whose morphology is selected from the group consisting of its salts, hydrates, solvates, racemic compounds, mirror isomers, diastereoisomers, stereoisomers and homomorphic forms. .. 2- (2-Methyl-2H-indazole-5-yl) -6- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride;
2- (2-Methyl-2H-indazole-5-yl) -6- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
2- (2-Methyl-2H-indazole-5-yl) -6- (1-methyl-1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride;
N-Methyl-6- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-2-amine hydrochloride;
2- (2-Methyl-2H-indazole-5-yl) -6- (1-methylpiperidin-4-yl) -1,3-benzothiazole hydrochloride;
N-Methyl-2- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-6-amine hydrochloride;
N-Methyl-6- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridin-2-amine hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridin-2-amine hydrochloride salt;
6- (2,7-dimethyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridin-2-amine hydrochloride;
6- (2-Methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridin-2-amine hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride;
2- (2-Methyl-2H-indazole-5-yl) -6- (1,2,3,6-tetrahydropyridine-4-yl) [1,3] thiazolo [4,5-b] pyridine hydrochloride ;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
N-Methyl-5- (2-Methyl-2H-Indazole-5-yl) -N- (2,2,6,6-tetramethylpiperidin-4-yl) [1,3] Thiazolo [5,4-Il] b] Pyridine-2-amine hydrochloride;
N-Methyl-5- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [5,4-b] pyridin-2-amine hydrochloride;
N-methyl-6- (2-methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridin-2-amine hydrochloride;
N, N-dimethyl-1- [6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole-2-yl] piperidine-4-amine hydrochloride;
1- [6- (2-Methyl-2H-indazole-5-yl) -1,3-benzothiazole-2-yl] piperidine-4-amine hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridin-2-amine hydrochloride salt;
6- (1H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzothiazole-2-amine hydrochloride;
6- (2-Methyl-2H-indazole-5-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-2-amine hydrochloride;
5- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [5,4-b] pyridin-2-amine hydrochloride salt;
N-Methyl-6- (2-Methyl-2H-Indazole-5-yl) -N- (Pyrrolidine-3-yl) -1,3-Benzothiazole-2-amine hydrochloride;
N-Methyl-6- (2-Methylimidazole [1,2-b] pyridazine-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzo Thiazole-2-amine hydrochloride;
2- (4-Fluoropiperidin-4-yl) -6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole hydrochloride;
2- (azepan-4-yl) -6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole hydrochloride;
2- (2-Methyl-2H-indazole-5-yl) -6- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridine hydrochloride;
6- [4-Fluor-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine Hydrochloride;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine hydrochloride;
6- [4-Fluor-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] ] Pyridazine hydrochloride;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine hydrochloride;
2- (2,7-dimethyl-2H-indazole-5-yl) -6- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride;
2- (2,7-dimethyl-2H-indazole-5-yl) -6- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
N-Methyl-6- [2-Methyl-7- (trifluoromethyl) -2H-indazole-5-yl] -N- (2,2,6,6-tetramethylpiperidine-4-yl) -1, 3-Benzothiazole-2-amine hydrochloride;
6- [4-Fluor-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-a] ] Pyrazine hydrochloride;
6- (1,3-dimethylpyrrolo [1,2-a] pyrazine-7-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3 -Benzothiazole-2-amine hydrochloride;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N-Methyl-N- (2,2,6,6-tetramethylpiperidin-4-yl) -1,3-benzothiazole -2-Amine hydrochloride;
6- (2-Methyl-2H-Indazole-5-yl) -2- (2-Methylpiperidin-4-yl) -1,3-benzothiazole hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine hydrochloride;
6- [2-Methyl-7- (trifluoromethyl) -2H-indazole-5-yl] -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine hydrochloride;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyridine hydrochloride;
2-Methyl-5-{2- [Methyl (2,2,6,6-Tetramethylpiperidin-4-yl) Amino] -1,3-Benzothiazole-6-yl} -2H-Indazole-7-Carbo Nitrile hydrochloride;
N-Methyl-6- (2-methylimidazole [1,2-a] pyridin-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzo Thiazole-2-amine hydrochloride;
6- (2-Methyl-2H-Indazole-5-yl) -2- (2-Methyl-1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl-N- (2-methylpiperidin-4-yl) -1,3-benzothiazole-2-amine hydrochloride;
6- (2-Methyl-2H-Indazole-5-yl) -2- (6-Methyl-1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -2-[(2,2,6,6-tetramethylpiperidine-4-yl) oxy] -1,3-benzothiazole hydrochloride;
6- [4-Fluor-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-1,3-benzoxazole hydrochloride;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -4-fluoro-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3- Benzothiazole hydrochloride;
4-Fluoro-6- (2-methyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride;
4-Fluoro-6- (2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
2-Methyl-5- [2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridin-6-yl] -2H-indazole-7-carbonitrile hydrochloride;
6- (7-Ethyl-2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine hydrochloride;
6- (7-Fluoro-2-methyl-2H-indazole-5-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine hydrochloride;
6- (2-Methylimidazole [1,2-a] pyridine-6-yl) -2- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridine hydrochloride;
5- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -1H-pyrazolo [4,3-b] pyridine hydrochloride;
5- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-pyrazolo [4,3-b] pyridine hydrochloride;
6- (7-Cyclopropyl-2-methyl-2H-indazole-5-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1,3-benzo Thiazole-2-amine hydrochloride;
N-Methyl-6- (2-Methyl-2H-Indazole-5-yl) -N- (2-Methylpiperidin-4-yl) -1,3-Benzothiazole-2-amine hydrochloride;
2-Methyl-5- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2H-indazole-7-carbonitrile hydrochloride;
6- (8-Ethyl-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1 , 3-Benzothiazole-2-amine hydrochloride;
6- (2,4-dimethyl-1H-benzimidazole-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
6- (2-Methyl-1H-benzimidazole-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole dihydrochloride;
2-Methyl-6- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] imidazole [1,2-b] pyridazine hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -4-methoxy-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -4-methoxy-2- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-4-all hydrochloride 5 -[4-Fluor-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-indazole-7-carbonitrile hydrochloride salt;
1- {5- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-indazole-7-yl} methaneamine dihydrochloride;
5- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-indazole-7-carbonitrile hydrochloride;
2-Methyl-5- [2- (piperidine-4-yl) [1,3] thiazolo [5,4-d] pyrimidin-5-yl] -2H-indazole-7-carbonitrile hydrochloride;
5- (2,7-dimethyl-2H-indazole-5-yl) -2- (piperidine-4-yl) [1,3] thiazolo [5,4-d] pyrimidine hydrochloride;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) -1 , 3-Benzothiazole-2-amine hydrochloride;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
2- (2,2-Dimethylpiperidine-4-yl) -6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole hydrochloride;
2- {6- [methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H) -Pyrazole-4-yl) Phenolic hydrochloride;
2- {2- [Methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] Thiazolo [4,5-b] Pyrazine-6-yl} -5- (1H) -Pyrazole-4-yl) phenol hydrochloride;
6- [2- (3,5-dimethylpiperazine-1-yl) -4-fluoro-1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine hydrochloride ;
6- {4-fluoro-2-[(2,2,6,6-tetramethylpyridazine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2,8-dimethylimidazole [1] , 2-b] Pyridazine hydrochloride;
6- {2-[(2,6-Dimethylpiperidine-4-yl) oxy] -4-fluoro-1,3-benzothiazole-6-yl} -2,8-dimethylimidazole [1,2-b] Pyridazine hydrochloride;
2- {2- [Methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] Thiazolo [4,5-c] Pyridine-6-yl} -5- (1H) -Pyrazole-4-yl) Phenolic hydrochloride;
2-Methyl-6- {2- [methyl (2,2,6,6-tetramethylpiperidin-4-yl) amino] -1,3-benzothiazole-6-yl} imidazole [1,2-a] Pyridine-8-carbonitrile hydrochloride;
2,8-dimethyl-6- [2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] imidazole [1,2-b] pyridazine hydrochloride;
2- {2- [Methyl (2,2,6,6-tetramethylpiperidin-4-yl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl} -5- (1H) -Pyrazole-4-yl) Phenolic hydrochloride;
6- {4-fluoro-2-[(2R) -2-methylpiperidine-4-yl] -1,3-benzothiazole-6-yl} -2-methylimidazole [1,2-b] pyridazine hydrochloride ;
6- [4-Fluor-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -8-methoxy-2-methylimidazole [1,2] -B] Pyridazine hydrochloride;
6- (2,7-dimethyl-2H-indazole-5-yl) -N- (2,2-dimethylpiperidine-4-yl) -N-methyl-1,3-benzothiazole-2-amine hydrochloride;
2- {2- [Methyl (2,2,6,6-tetramethylpiperidine-4-yl) amino] [1,3] Thiazolo [5,4-b] Pyridine-5-yl} -5- (1H) -Pyrazole-4-yl) Phenolic hydrochloride;
6- [4-Fluor-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -8-methoxy-2-methylimidazole [1,2-b] pyridazine hydrochloride;
4-Fluoro-6- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
4-Chloro-6- (7-fluoro-2-methyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole hydrochloride salt;
5- [4-Chloro-2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-2H-indazole-7-carbonitrile Hydrochloride;
N- (2,2-dimethylpiperidine-4-yl) -N-methyl-6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole-2-amine hydrochloride;
6- [2,3-difluoro-4- (1H-pyrazole-4-yl) phenyl] -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-b] pyrazine-2-amine hydrochloride;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N-[(2S) -2-methylpiperidine-4-yl] -1,3- Benzothiazole-2-amine hydrochloride;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4-fluoro-N-methyl-N-[(2S) -2-methylpiperidine-4-yl] -1, 3-Benzothiazole-2-amine hydrochloride;
6- [4-Fluoro-2- (octahydroindolizine-7-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine hydrochloride;
6- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -N, 2-dimethylimidazole [1,2-b] pyridazine-8-amine hydrochloride;
6- [4-Fluor-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -N, N, 2-trimethylimidazole [1,2-b] pyridazine-8-amine hydrochloride salt;
6- (7-Cyano-2-methyl-2H-indazole-5-yl) -2- (1,2,3,6-tetrahydropyridine-4-yl) -1,3-benzothiazole-4-carbonitrile Hydrochloride;
2-Methyl-6- [2- (piperazine-1-yl) [1,3] thiazolo [4,5-b] pyrazine-6-yl] imidazole [1,2-a] pyridin-8-carbonitrile hydrochloride salt;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2- (piperazine-1-yl) [1,3] thiazolo [4,5-b] pyrazine hydrochloride ;
6- (2,7-dimethyl-2H-indazole-5-yl) -N- (2,6-dimethylpiperidine-4-yl) -N-methyl-1,3-benzothiazole-2-amine hydrochloride;
N- (2,6-dimethylpiperidine-4-yl) -N-methyl-6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole-2-amine hydrochloride;
6- (2-Methylimidazole [1,2-b] pyridazine-6-yl) -2- (piperazine-1-yl) [1,3] thiazolo [4,5-b] pyrazine hydrochloride;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N- (piperidine-4-yl) -1,3-benzothiazole-2-amine hydrochloride salt;
6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4-fluoro-N-methyl-N- (piperidine-4-yl) -1,3-benzothiazole-2- Amine hydrochloride;
8- (Benzyloxy) -6- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine hydrochloride ;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-amine hydrochloride;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-all hydrochloride;
2- (2,6-Dimethylpiperidine-4-yl) -6- (2-methyl-2H-indazole-5-yl) -1,3-benzothiazole hydrochloride;
4-Fluoro-6- (4-fluoro-3-methoxyphenyl) -2- (piperidine-4-yl) -1,3-benzothiazole hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4 -Fluoro-N-methyl-1,3-benzothiazole-2-amine hydrochloride;
2-Methyl-5-{2- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl} -2H-indazole-7-carbonitrile hydrochloride ;
6- [2- (1-Azabicyclo [2.2.2] octa-4-yl) -4-fluoro-1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-yl] b] Pyridazine hydrochloride;
6- [4-Fluor-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methyl-8-phenoxyimidazole [1,2-b] pyridazine hydrochloride;
2-Methyl-6- {2- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl} imidazole [1,2-a] pyridine-8 -Carbonitrile hydrochloride;
2-Methyl-6- {2- [Methyl (piperidine-4-yl) amino] [1,3] Thiazolo [4,5-c] Pyridine-6-yl} Imidazo [1,2-a] Pyridine-8 -Carbonitrile hydrochloride;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-ylamino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2- Methylimidazole [1,2-a] pyridin-8-carbonitrile hydrochloride;
6- {4-fluoro-2- [methyl (2,2,6,6-tetramethylpyridazine-4-yl) amino] -1,3-benzothiazole-6-yl} -2-methylimidazole [1, 2-b] Pyridazine-8-amine hydrochloride;
4-Fluoro-6- (8-Methoxy-2-methylimidazole [1,2-b] pyridazine-6-yl) -N-methyl-N- (piperidine-4-yl) -1,3-benzothiazole- 2-amine hydrochloride;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile Hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [4,5-c] pyridin-2-amine hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [ 1,3] Thiazolo [4,5-c] Pyridine-2-amine hydrochloride;
5- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl } -2-Methyl-2H-Indazole-7-Carbonitrile Hydrochloride;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-carbonitrile hydrochloride;
5- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl } -2-Methyl-2H-Indazole-7-Carbonitrile Hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -4-fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine- 6-yl) -1,3-benzothiazole-2-amine hydrochloride;
6- [4-Fluoro-2- (4-Methylpiperidin-4-yl) -1,3-benzothiazole-6-yl] -2,8-dimethylimidazole [1,2-b] pyridazine hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (7-fluoro-2-methyl-2H-indazole-5-yl) [1,3] Thiazolo [4,5-c] Pyridine-2-amine Hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -6- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) [1,3] Thiazolo [4,5-c] Pyridine-2-amine hydrochloride;
5- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-ylamino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2- Methyl-2H-indazole-7-carbonitrile hydrochloride;
2-Methyl-5-{2- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridin-6-yl} -2H-indazole-7-carbonitrile hydrochloride ;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-c ] Pyridine-2-amine hydrochloride;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N-Methyl-N- (Piperidin-4-yl) [1,3] Thiazolo [4,5-c] Pyridine-2- Amine hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -5- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [ 1,3] Thiazolo [5,4-d] pyrimidin-2-amine hydrochloride;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-carboxylate acid salt;
Methyl {6- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-yl} acetate hydrochloride salt;
{6- [4-Fluor-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-yl} acetate hydrochloride ;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yloxy] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2- Methylimidazole [1,2-a] pyridin-8-carbonitrile hydrochloride;
6- [4-fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-carboxamide trifluoroacetate;
6- {4-Fluoro-2- [methyl (piperidine-4-yl) amino] -1,3-benzothiazole-6-yl} -2-methylimidazole [1,2-a] pyridine-8-carbonitrile Hydrochloride;
N-[(8-anti) -3-azabicyclo [3.2.1] octa-8-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine hydrochloride;
6- {2-[(8-anti) -3-azabicyclo [3.2.1] octa-8-yl (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-carbonitrile hydrochloride;
2- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -6,8-dimethylimidazole [1,2-a] pyrazine hydrochloride;
6- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylimidazole [1,2-b] pyridazine-8-carbonitrile hydrochloride;
6- {4-fluoro-2- [methyl (piperidine-4-yl) amino] -1,3-benzothiazole-6-yl} -2-methylimidazole [1,2-b] pyridazine-8-carbonitrile Hydrochloride;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N- (2,2,6,6-tetramethylpiperidin-4-yl) [1,3] Thiazolo [4,5-yl] c] Pyridine-2-amine hydrochloride;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] -4-fluoro-1,3-benzothiazole-6-yl} -2 -Methylimidazole [1,2-b] pyridazine-8-carbonitrile hydrochloride;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] -4-fluoro-1,3-benzothiazole-6-yl} -2 -Methylimidazole [1,2-b] pyridazine-8-carboxamide hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -4-fluoro-N-methyl-6- (2-methyl-2H-pyrazolo [4,3-b] ] Pyridine-5-yl) -1,3-benzothiazole-2-amine hydrochloride;
N- (azetidine-3-yl) -6- (2,8-dimethylimidazole [1,2-b] pyridazine-6-yl) -4-fluoro-N-methyl-1,3-benzothiazole-2- Amine hydrochloride;
5- [4-Fluoro-2- (piperidine-4-yl) -1,3-benzothiazole-6-yl] -2-methylpyrazolo [1,5-a] pyrimidine hydrochloride;
4-Fluoro-N-methyl-6- (2-methylpyrazolo [1,5-a] pyrimidin-5-yl) -N- (piperidine-4-yl)-, 3-benzothiazole-2-amine hydrochloride;
6- {2- [9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [4,5-c] pyridin-6-yl} -2-methylimidazole [1,2-a] Pyridine-8-carbonitrile hydrochloride;
5- {2- [9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2-methyl- 2H-Indazole-7-Carbonitrile Hydrochloride;
N- (9-azabicyclo [3.3.1] nona-3-yl) -6- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [ 4,5-c] Pyridine-2-amine hydrochloride;
6- {2-[(1R, 5S) -9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [5,4-d] pyrimidin-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-carbonitrile hydrochloride;
N-[(1R, 5S) -9-azabicyclo [3.3.1] nona-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-d] pyrimidin-2-amine hydrochloride;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N-[(2S, 4S) -2-methylpiperidine-4-yl] -1, 3-Benzothiazole-2-amine hydrochloride;
4-Fluoro-N-methyl-6- (2-methylimidazole [1,2-b] pyridazine-6-yl) -N-[(2S, 4R) -2-methylpiperidine-4-yl] -1, 3-Benzothiazole-2-amine hydrochloride;
N- (9-azabicyclo [3.3.1] nona-3-yl) -N-methyl-6- (2-methylimidazole [1,2-a] pyridin-6-yl) [1,3] thiazolo [4,5-c] Pyridine-2-amine hydrochloride;
N- (9-azabicyclo [3.3.1] nona-3-yl) -6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -N-methyl [1,3 ] Thiazolo [4,5-c] Pyridine-2-amine hydrochloride;
N- (9-azabicyclo [3.3.1] nona-3-yl) -N-methyl-6- (2-methyl-2H-indazole-5-yl) [1,3] thiazolo [4,5-yl) c] Pyridine-2-amine hydrochloride;
N- (9-azabicyclo [3.3.1] nona-3-yl) -6- (2,7-dimethyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [4, 5-c] Pyridine-2-amine hydrochloride;
N- (9-azabicyclo [3.3.1] nona-3-yl) -6- (7-methoxy-2-methyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [ 4,5-c] Pyridine-2-amine hydrochloride;
2-Methyl-6- {2-[(1,2,2,6,6-pentamethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} Imidazo [1,2-a] Pyridine-8-Carbonitrile Hydrochloride;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N- (1,2,2,6,6-pentamethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-c] Pyridine-2-amine hydrochloride;
2-Methyl-5-{2-[(1,2,2,6,6-pentamethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridine-6-yl} -2H-Indazole-7-Carbonitrile Hydrochloride;
6- (7-Fluoro-2-methyl-2H-Indazole-5-yl) -N- (1,2,2,6,6-pentamethylpiperidin-4-yl) [1,3] Thiazolo [4, 5-c] Pyridine-2-amine hydrochloride;
2- {2- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-b] pyrazine-6-yl} -5- (1H-pyrazole-4-yl) phenol hydrochloride ;
6- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile Hydrochloride;
N-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-b] pyridin-2-amine hydrochloride;
5- {2-[(3-exo) -8-azabicyclo [3.2.1] octa-3-yl (methyl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl } -2-Methyl-2H-Indazole-7-Carbonitrile Hydrochloride;
6- {2-[(3-exo) -9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl } -2-Methylimidazole [1,2-a] Pyridine-8-Carbonitrile Hydrochloride;
N-[(3-exo) -9-azabicyclo [3.3.1] nona-3-yl] -5- (8-fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -N-Methyl [1,3] thiazolo [5,4-b] pyridin-2-amine hydrochloride;
5- {2-[(3-exo) -9-azabicyclo [3.3.1] nona-3-yl (methyl) amino] [1,3] thiazolo [5,4-b] pyridine-5-yl } -2-Methyl-2H-Indazole-7-Carbonitrile Hydrochloride;
2- {6- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) phenol hydrochloride ;
2- {6- [methyl (1-methylpiperidin-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) Phenolic hydrochloride;
N-[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -6- (8-fluoro-2-methylimidazole [1,2-] a] Pyridine-6-yl) -N-methyl [1,3] thiazolo [4,5-c] pyridin-2-amine hydrochloride;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-b] pyrazine -2-Amine hydrochloride;
N- (9-azabicyclo [3.3.1] nonane-3-yl) -5- (7-fluoro-2-methyl-2H-indazole-5-yl) -N-methyl [1,3] thiazolo [ 5,4-b] Pyridine-2-amine hydrochloride;
6- (6,8-dimethylimidazole [1,2-a] pyrazine-2-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-c] Pyrazine-2-amine hydrochloride;
6- (1,3-dimethylpyrrolo [1,2-a] pyrazine-7-yl) -N-methyl-N- (2,2,6,6-tetramethylpiperidine-4-yl) [1,3 ] Thiazolo [4,5-c] Pyrazine-2-amine hydrochloride;
6-(2-{[(1R, 3s, 5S) -1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] (methyl) amino} [1,3] thiazolo [4] , 5-c] Pyridine-6-yl) -2-methyl-1,3-benzoxazole-4-carbonitrile trifluoroacetate;
N-Methyl-6- (2-methylimidazole [2,1-b] [1,3] thiazole-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) [ 1,3] Thiazolo [4,5-c] Pyridine-2-amine hydrochloride;
6- {4-fluoro-2-[(piperidine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2,8-dimethylimidazole [1,2-b] pyridazine hydrochloride;
4-Fluoro-6- (7-fluoro-2-methyl-2H-indazole-5-yl) -2-[(piperidine-4-yl) oxy] -1,3-benzothiazole hydrochloride;
N-Methyl-6- (2-methylimidazole [2,1-b] [1,3,4] thiadiazole-6-yl) -N- (2,2,6,6-tetramethylpiperidine-4-yl) ) [1,3] Thiadiazole [4,5-c] Pyridine-2-amine hydrochloride;
2-Methyl-6- {2-[(piperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] pyridine-6-yl} imidazole [1,2-a] pyridine-8- Carbonitrile hydrochloride;
6- (8-Fluoro-2-methylimidazole [1,2-a] pyridin-6-yl) -2-[(piperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] Pyridine hydrochloride;
2-Methyl-5-{2-[(piperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] pyridin-6-yl} -2H-indazole-7-carbonitrile hydrochloride;
6- (7-Fluoro-2-methyl-2H-indazole-5-yl) -2-[(piperidine-4-yl) oxy] [1,3] thiazolo [4,5-c] pyridine hydrochloride;
6- {4-fluoro-2-[(piperidine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2-methylimidazole [1,2-a] pyridin-8-carbonitrile hydrochloride salt;
5- {4-Fluor-2-[(piperidine-4-yl) oxy] -1,3-benzothiazole-6-yl} -2-methyl-2H-indazole-7-carbonitrile hydrochloride;
6- (2,8-dimethylimidazole [1,2-a] pyridin-6-yl) -4-fluoro-2-[(piperidine-4-yl) oxy] -1,3-benzothiazole hydrochloride;
6-(2-{[(3R, 4R) -3-fluoro-2,2,6,6-tetramethylpiperidine-4-yl] (methyl) amino} [1,3] thiazolo [5,4-d] ] Pyrimidine-5-yl) -2-methylimidazole [1,2-a] Pyridine-8-carbonitrile dihydrochloride;
6-(2-{[(3R, 4R) -3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] ] Pyridine-6-yl) -2-methylimidazole [1,2-a] Pyridine-8-carbonitrile dihydrochloride;
N-[(1R, 2S, 3S, 5S) -2-fluoro-1,5-dimethyl-8-azabicyclo [3.2.1] octane-3-yl] -6- (8-fluoro-2-methyl) Imidazo [1,2-a] Pyridine-6-yl) -N-methyl [1,3] thiazolo [4,5-c] Pyridine-2-amine dihydrochloride;
5- (1H-imidazol-1-yl) -2-{6- [methyl (piperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} phenol formate ;
3- [2,5-difluoro-4- (1H-pyrazole-4-yl) phenyl] -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5-c] pyridazine -6-Aminite;
3- [2,5-difluoro-4- (3-fluoro-1H-pyrazole-4-yl) phenyl] -N-methyl-N- (piperidine-4-yl) [1,3] thiazolo [4,5] -C] Pyridazine-6-amine hydrochloride;
2- [6- (Piperazine-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H-pyrazole-4-yl) phenol formate;
5- (1H-Pyrazole-4-yl) -2- [6- (1,2,3,6-tetrahydropyridine-4-yl) [1,3] thiazolo [4,5-c] pyridin-2- Il] Phenolic hydrochloride;
2- (6-{[(3R, 4S) -4-fluoro-1-methylpyrrolidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5 (1H-pyrazole-4-yl) phenol formate;
5- (1H-Pyrazole-4-yl) -2- [6- (2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine-4-yl) [1,3] thiazolo [4,5-c] Pyridine-2-yl] Phenolic hydrochloride;
2- [6- (2,6-diazaspiro [3.5] nonane-2-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H-pyrazole-4) -Il) Phenol dihydrochloride;
2- [6- (7-Methyl-1,7-diazaspiro [3.5] nonane-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H) -Pyrazole-4-yl) Phenol dihydrochloride;
2- [6- (7-Methyl-2,7-diazaspiro [4.4] nonane-2-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H) -Pyrazole-4-yl) Phenol dihydrochloride;
2- [6- (2,7-Diazaspiro [3.5] nonane-2-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (3-fluoro-1H) -Pyrazole-4-yl) phenol formate;
2- (6-{[(3S, 4S) -4-fluoro-1-methylpyrrolidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5 (1H-pyrazole-4-yl) phenol formate;
2- {6-[(3aS, 7aR) -octahydro-1H-pyrolo [3,2-c] pyridin-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl}- 5- (1H-pyrazole-4-yl) phenol dihydrochloride;
2- (6- {Methyl [(1s, 4s) -4- (methylamino) cyclohexyl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole) -4-yl) Phenol dihydrochloride;
2- (6-{[(3R, 4S) -4-fluoropyrrolidine-3-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5-( 1H-pyrazole-4-yl) phenol formate;
2- {6-[(3aS, 7aR) -5-methyloctahydro-1H-pyrolo [3,2-c] pyridin-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3 -Il} -5- (1H-pyrazole-4-yl) phenol dihydrochloride;
2- (6- {Methyl [(3R) -piperidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-4-yl) ) Phenolic dihydrochloride;
2- (6- {Methyl [(3S) -piperidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-4-yl) ) Phenolic dihydrochloride;
2- (6- {Methyl [3- (methylamino) cyclobutyl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-4-yl) phenol Ditrifluoroacetic acid salt;
2- (6-{[(1r, 4r) -4- (dimethylamino) cyclohexyl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H) -Pyrazole-4-yl) Phenol dihydrochloride;
2- (6- {Methyl [(3S) -1-methylpiperidine-3-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole-) 4-Il) Phenol dihydrochloride;
2- {6-[(azetidine-3-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-4-yl) phenol Dihydrochloride;
2- [6- (1,7-Diazaspiro [3.5] nonane-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H-pyrazole-4) -Il) Phenol dihydrochloride;
2- {6-[(3,3-Dimethylpiperidine-4-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-) 4-yl) Phenol dihydrochloride;
2- {6-[(2-azaspiro [3.3] heptane-6-yl) (methyl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H) -Pyrazole-4-yl) Phenol dihydrochloride;
5- {2-[(2R, 4r, 6S) -2,6-dimethylpiperidine-4-yl] -4-fluoro-1,3-benzothiazole-6-yl} -2,7-dimethyl [1, 3] Oxazolo [5,4-b] pyridine hydrochloride;
2- {6- [methyl (1,3,3-trimethylpiperidine-4-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} -5- (1H-pyrazole-) 4-Il) Phenol dihydrochloride;
2- (6- {Methyl [(1s, 3s) -3- (methylamino) cyclobutyl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole) -4-yl) Phenol dihydrochloride;
2- {6-[(3aR, 7aS) -octahydro-1H-pyrolo [2,3-c] pyridin-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl}- 5- (1H-pyrazole-4-yl) phenol dihydrochloride;
2- [6- (1,6-diazaspiro [3.5] nonane-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H-pyrazole-4) -Il) Phenol dihydrochloride;
2- (6-{[(1s, 3s) -3- (dimethylamino) cyclobutyl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H) -Pyrazole-4-yl) Phenol dihydrochloride;
2- (6-{[(3R, 4R) -3-fluoropiperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5-( 1H-pyrazole-4-yl) phenol formate;
5- (1H-pyrazole-4-yl) -2- {6-[(pyrrolidin-3-yl) amino] [1,3] thiazolo [4,5-c] pyridazine-3-yl} phenol formate;
2- [6- (2,6-diazaspiro [3.3] heptane-2-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (3-fluoro-1H) -Pyrazole-4-yl) Phenol formate;
2- {6-[(3aR, 7aS) -6-methyloctahydro-1H-pyrolo [2,3-c] pyridin-1-yl] [1,3] thiazolo [4,5-c] pyridazine-3 -Il} -5- (1H-pyrazole-4-yl) phenol dihydrochloride;
2- [6- (6-Methyl-1,6-diazaspiro [3.5] nonane-1-yl) [1,3] thiazolo [4,5-c] pyridazine-3-yl] -5- (1H) -Pyrazole-4-yl) Phenol dihydrochloride;
2- (6-{[(2S, 4S) -2- (hydroxymethyl) piperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl)- 5- (1H-pyrazole-4-yl) phenol dihydrochloride;
2- (6-{[(2S, 4S) -2- (hydroxymethyl) -1-methylpiperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3 -Il) -5- (1H-pyrazole-4-yl) phenol dihydrochloride;
2- (6- {Methyl [(1r, 3r) -3- (methylamino) cyclobutyl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-pyrazole) -4-yl) Phenol dihydrochloride;
N- (1,2-dimethylpiperidine-4-yl) -6- (8-fluoro-2-methylimidazo [1,2-a] pyridin-6-yl) -N-methyl [1,3] thiazolo [ 4,5-c] Pyridine-2-aminetrifluoroacetate;
2- {6-[(1S, 6R) -3,8-diazabicyclo [4.2.0] octane-8-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl}- 5- (1H-Pyrazole-4-yl) phenol trifluoroacetate;
2- {6-[(1S, 6R) -3-methyl-3,8-diazabicyclo [4.2.0] octane-8-yl] [1,3] thiazolo [4,5-c] pyridazine-3 -Il} -5- (1H-pyrazole-4-yl) phenol trifluoroacetate;
2- {6-[(1R, 6S) -3,8-diazabicyclo [4.2.0] octane-8-yl] [1,3] thiazolo [4,5-c] pyridazine-3-yl}- 5- (1H-Pyrazole-4-yl) phenol trifluoroacetate;
2- {6-[(1R, 6S) -3-methyl-3,8-diazabicyclo [4.2.0] octane-8-yl] [1,3] thiazolo [4,5-c] pyridazine-3 -Il} -5- (1H-pyrazole-4-yl) phenol trifluoroacetate;
2- (6- {Methyl [(2S, 4S) -2-methylpiperidine-4-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-) Pyrazole-4-yl) Phenolic trifluoroacetic acid salt;
2- (6-{[(2S, 4S) -1,2-dimethylpiperidine-4-yl] (methyl) amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5 -(1H-Pyrazole-4-yl) phenol trifluoroacetate;
2- (6- {Methyl [(2R, 4S) -2-methylpiperidin-4-yl] amino} [1,3] thiazolo [4,5-c] pyridazine-3-yl) -5- (1H-) Pyrazole-4-yl) phenol trifluoroacetate, and 2- (6-{[(2R, 4S) -1,2-dimethylpiperidin-4-yl] (methyl) amino} [1,3] thiazolo [4] , 5-c] Pyridazine-3-yl) -5- (1H-pyrazol-4-yl) phenoltrifluoroacetate ; the compound salt according to claim 6 , or in its form, selected from the group. A compound in which the form of the compound salt is selected from the group consisting of its hydrate, solvates, racemic compounds, mirror isomers, diastereoisomers, stereoisomers and tautomer forms . A pharmaceutical composition comprising an effective amount of the compound according to any one of claims 1 to 7 for treating or ameliorating HD in a subject in need thereof. The pharmaceutical composition according to claim 8, wherein the effective amount of the compound is in the range of about 0.001 mg / kg / day to about 500 mg / kg / day. Use of the compound according to any one of claims 1 to 7 in the manufacture of a pharmaceutical for treating or ameliorating HD in a subject in need thereof . A pharmaceutical composition comprising the compound according to any one of claims 1 to 5 and at least one pharmaceutically acceptable excipient. A pharmaceutical composition comprising the compound according to claim 6 or 7 and at least one pharmaceutically acceptable excipient. The compound according to claim 1, which is a compound of the formula (II).