|
NL297170A
(enExample)
|
1963-04-04 |
1900-01-01 |
|
|
|
US3558618A
(en)
|
1968-04-01 |
1971-01-26 |
Dow Chemical Co |
Novel 4h-pyrazino(1,2-a)pyrimidine-4-ones
|
|
GB1383409A
(en)
|
1972-09-09 |
1974-02-12 |
Pfizer Ltd |
Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
|
|
US4122274A
(en)
|
1977-05-25 |
1978-10-24 |
Bristol-Myers Company |
3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
|
|
JPS56150091A
(en)
|
1980-03-28 |
1981-11-20 |
Janssen Pharmaceutica Nv |
3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidine- 4-one derivative and its manufacture
|
|
US4342870A
(en)
|
1980-03-28 |
1982-08-03 |
Janssen Pharmaceutica N.V. |
Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
|
|
FR2567518B1
(fr)
|
1984-07-11 |
1987-11-13 |
Sanofi Sa |
Nouveaux composes a noyau heterocyclique azote, leur preparation et les medicaments qui en contiennent
|
|
US5089633A
(en)
|
1987-04-28 |
1992-02-18 |
Georgia Tech Research Corporation |
Substituted isocoumarins
|
|
US5726182A
(en)
|
1990-05-02 |
1998-03-10 |
Abbott Laboratories |
Quinolizinone type compounds
|
|
WO1993023398A1
(en)
|
1992-05-13 |
1993-11-25 |
E.I. Du Pont De Nemours And Company |
Substituted pyrido[1,2-a]pyrimidinone derivatives as fungicides
|
|
NZ266386A
(en)
|
1993-05-11 |
1997-11-24 |
Univ North Carolina |
Use of antisense rna oligonucleotides in regulating gene expression
|
|
JPH11510478A
(ja)
|
1995-06-06 |
1999-09-14 |
アボツト・ラボラトリーズ |
キノリジノン型化合物
|
|
US5916916A
(en)
|
1996-10-10 |
1999-06-29 |
Eli Lilly And Company |
1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
|
|
US5869500A
(en)
|
1996-12-13 |
1999-02-09 |
Hoffmann-La Roche Inc. |
Pyridone compounds useful in treating Alzheimer's disease
|
|
CA2269561C
(en)
|
1998-04-22 |
2007-06-05 |
Dainippon Ink And Chemicals, Inc. |
Naphthalene derivative and liquid crystal composition comprising the same
|
|
WO2000017197A1
(en)
|
1998-09-21 |
2000-03-30 |
Biochem Pharma Inc. |
Quinolizinones as integrin inhibitors
|
|
US6172216B1
(en)
|
1998-10-07 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of BCL-X expression
|
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
|
US6214986B1
(en)
|
1998-10-07 |
2001-04-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of bcl-x expression
|
|
AU7961100A
(en)
|
1999-10-28 |
2001-05-08 |
Daiichi Pharmaceutical Co., Ltd. |
Drug discharge pump inhibitors
|
|
DE60128655T2
(de)
|
2000-01-24 |
2008-02-07 |
Astrazeneca Ab |
Durch einen morpholinrest substituierte therapeutische verbindungen
|
|
CA2437942C
(en)
|
2000-11-09 |
2013-06-11 |
Cold Spring Harbor Laboratory |
Chimeric molecules to modulate gene expression
|
|
US6774134B2
(en)
|
2000-12-20 |
2004-08-10 |
Bristol-Myers Squibb Company |
Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
|
|
WO2002068415A1
(en)
|
2000-12-21 |
2002-09-06 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
GB0100624D0
(en)
*
|
2001-01-10 |
2001-02-21 |
Vernalis Res Ltd |
Chemical compounds VII
|
|
EP1389463A4
(en)
|
2001-04-26 |
2008-09-17 |
Daiichi Seiyaku Co |
MEDICAMENT FOR INHIBITING A DRUG REMOVAL PUMP
|
|
EP2198867A1
(en)
|
2001-12-07 |
2010-06-23 |
Vertex Pharmaceuticals, Inc. |
Pyrimidine-based compounds useful as GSK-3 inhibitors
|
|
GB0205281D0
(en)
|
2002-03-06 |
2002-04-17 |
Novartis Ag |
Organic compounds
|
|
CA2493458A1
(en)
|
2002-07-24 |
2004-01-29 |
Ptc Therapeutics, Inc. |
Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations
|
|
WO2004019002A2
(en)
|
2002-08-23 |
2004-03-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Fluorescent glycosides and methods for their use
|
|
US7220741B2
(en)
|
2002-09-30 |
2007-05-22 |
Neurosearch A/S |
1,4-diazabicycloalkane derivatives, their preparation and use
|
|
US20070078144A1
(en)
|
2003-01-29 |
2007-04-05 |
Stockwell Brent R |
Agents for treating neurodegenerative diseases
|
|
MXPA05013142A
(es)
|
2003-06-20 |
2006-03-17 |
Chiron Corp |
Compuestos de piridinio [1,2-a]pirimidin-4-ona como agentes anticancer.
|
|
GB0315494D0
(en)
|
2003-07-02 |
2003-08-06 |
Biofocus Plc |
Compounds which bind to the active site of protein kinase enzymes
|
|
ZA200600424B
(en)
|
2003-08-01 |
2007-05-30 |
Genelabs Tech Inc |
Bicyclic imidazol derivatives against flaviviridae
|
|
US7160888B2
(en)
|
2003-08-22 |
2007-01-09 |
Warner Lambert Company Llc |
[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
|
|
US20050074801A1
(en)
|
2003-09-09 |
2005-04-07 |
Monia Brett P. |
Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
|
|
US7309699B2
(en)
|
2003-12-22 |
2007-12-18 |
Abbott Laboratories |
3-Quinuclidinyl amino-substituted biaryl derivatives
|
|
US20050137203A1
(en)
|
2003-12-22 |
2005-06-23 |
Jianguo Ji |
3-quinuclidinyl amino-substituted biaryl derivatives
|
|
US7655657B2
(en)
|
2003-12-22 |
2010-02-02 |
Abbott Laboratories |
Fused bicycloheterocycle substituted quinuclidine derivatives
|
|
US20050245531A1
(en)
|
2003-12-22 |
2005-11-03 |
Abbott Laboratories |
Fused bicycloheterocycle substituted quinuclidine derivatives
|
|
US8598193B2
(en)
|
2003-12-24 |
2013-12-03 |
Biota Scientific Management Pty Ltd. |
Polycyclic agents for the treatment of respiratory syncytial virus infections
|
|
SE0400184D0
(sv)
|
2004-01-30 |
2004-01-30 |
Fyrkloevern Scandinavia Ab |
New therapeutical use
|
|
TW200536830A
(en)
|
2004-02-06 |
2005-11-16 |
Chugai Pharmaceutical Co Ltd |
1-(2H)-isoquinolone derivative
|
|
CN1964717A
(zh)
|
2004-04-08 |
2007-05-16 |
神经能质公司 |
经取代∴啉-4-基胺
|
|
DE602005002562T2
(de)
|
2004-05-04 |
2008-01-31 |
Warner-Lambert Company Llc |
Pyrrolylsubstituierte pyridoä2,3-düpyrimidin-7-one und derivate davon als therapeutische mittel
|
|
CA2595477A1
(en)
|
2005-01-21 |
2006-07-27 |
Janssen Pharmaceutica N.V. |
Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors
|
|
US7879992B2
(en)
|
2005-01-31 |
2011-02-01 |
Isis Pharmaceuticals, Inc. |
Modification of MyD88 splicing using modified oligonucleotides
|
|
GB0501999D0
(en)
|
2005-02-01 |
2005-03-09 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
JP2006219453A
(ja)
|
2005-02-14 |
2006-08-24 |
Tokyo Univ Of Pharmacy & Life Science |
キノリン環を母核とする金属識別型二波長性蛍光分子
|
|
US7563601B1
(en)
|
2005-06-01 |
2009-07-21 |
City Of Hope |
Artificial riboswitch for controlling pre-mRNA splicing
|
|
WO2006138418A2
(en)
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
CA2614116A1
(en)
|
2005-07-04 |
2007-01-11 |
Novo Nordisk A/S |
Novel medicaments
|
|
US7473784B2
(en)
|
2005-08-01 |
2009-01-06 |
Bristol-Myers Squibb Company |
Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
|
|
US8258109B2
(en)
|
2005-10-20 |
2012-09-04 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of LMNA expression
|
|
EP2535413A3
(en)
|
2005-11-10 |
2016-04-13 |
Roche Innovation Center Copenhagen A/S |
Splice switching oligomers for the TNF superfamily receptors and their use in treatment of disease
|
|
US8173658B2
(en)
|
2005-12-06 |
2012-05-08 |
Neurosearch A/S |
Diazabicycylic aryl derivatives and their medical use
|
|
CN101360738A
(zh)
|
2005-12-21 |
2009-02-04 |
佩因赛普托药物公司 |
调节门控离子通道的组合物和方法
|
|
WO2007089611A2
(en)
|
2006-01-26 |
2007-08-09 |
Isis Pharmaceuticals Inc. |
Compositions and their uses directed to huntingtin
|
|
EP1984499B1
(en)
|
2006-01-27 |
2015-05-27 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
|
AR059339A1
(es)
|
2006-02-09 |
2008-03-26 |
Chugai Pharmaceutical Co Ltd |
Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
|
|
US8110681B2
(en)
|
2006-03-17 |
2012-02-07 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Compounds for the treatment of spinal muscular atrophy and other uses
|
|
CA2645581A1
(en)
|
2006-03-28 |
2007-10-04 |
High Point Pharmaceuticals, Llc |
Benzothiazoles having histamine h3 receptor activity
|
|
WO2007130383A2
(en)
|
2006-04-28 |
2007-11-15 |
Northwestern University |
Compositions and treatments using pyridazine compounds and secretases
|
|
US20080247964A1
(en)
|
2006-05-08 |
2008-10-09 |
Yuelian Xu |
Substituted azaspiro derivatives
|
|
WO2007133756A2
(en)
|
2006-05-15 |
2007-11-22 |
Neurogen Corporation |
Crf1 receptor ligands comprising heteroaryl fused bicycles
|
|
JP2009537599A
(ja)
|
2006-05-23 |
2009-10-29 |
ノイロサーチ アクティーゼルスカブ |
新規8,10−ジアザ−ビシクロ[4.3.1]デカン誘導体及びそれらの医学的使用
|
|
EP2079724B1
(en)
|
2006-07-20 |
2010-05-26 |
Amgen Inc. |
Substituted pyridone compounds and methods of use
|
|
US8337941B2
(en)
|
2006-07-27 |
2012-12-25 |
The Trustees Of Columbia University In The City Of New York |
Fluorescent substrates for monoamine transporters as optical false neurotransmitters
|
|
DK2066653T3
(da)
|
2006-08-03 |
2012-12-10 |
Rottapharm Spa |
6-1H-Imidazoquinazolin- og -quinolinderivater, nye stærke analgetika og antiinflammatoriske midler
|
|
US20100029685A1
(en)
|
2006-10-25 |
2010-02-04 |
Neurosearch A/S |
Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
|
|
US8314119B2
(en)
|
2006-11-06 |
2012-11-20 |
Abbvie Inc. |
Azaadamantane derivatives and methods of use
|
|
EP2269992A1
(en)
|
2006-12-22 |
2011-01-05 |
Avexa Limited |
Bicyclic pyrimidinones for the treatment of viral infections
|
|
US20080171792A1
(en)
|
2006-12-28 |
2008-07-17 |
Jobdevairakkam Christopher New |
Use of highly concentrated formulations of 4-phenylbutyrate for treatment of certain disorders
|
|
FR2914188B1
(fr)
|
2007-03-28 |
2012-06-22 |
Trophos |
Nouvelle composition a base d'oxime de cholest-4-en-3-one
|
|
EP2014656A3
(en)
|
2007-06-11 |
2011-08-24 |
High Point Pharmaceuticals, LLC |
New heteocyclic h3 antagonists
|
|
US20100267712A1
(en)
|
2007-09-27 |
2010-10-21 |
The United States of America, as represented by the Secretary, Department of Health and |
Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
|
|
DK2193133T3
(en)
|
2007-09-27 |
2015-10-05 |
Fundacion Ct Nac Investigaciones Oncologicas Carlos Iii |
IMIDAZOLOTHIADIAZOLES USED AS PROTEINKINASE INHIBITORS
|
|
US8153813B2
(en)
|
2007-12-20 |
2012-04-10 |
Abbott Laboratories |
Benzothiazole and benzooxazole derivatives and methods of use
|
|
WO2009114874A2
(en)
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Benzothiazole kinase inhibitors and methods of use
|
|
WO2009126635A1
(en)
|
2008-04-09 |
2009-10-15 |
Abbott Laboratories |
2-amino-benzothiazole derivates useful as inhibitors of rock kinases
|
|
WO2009131958A2
(en)
|
2008-04-21 |
2009-10-29 |
Institute For Oneworld Health |
Compounds, compositions and methods comprising triazine derivatives
|
|
WO2009151546A2
(en)
|
2008-05-27 |
2009-12-17 |
Ptc Therapeutics, Inc. |
Methods for treating spinal muscular atrophy
|
|
CA2728376C
(en)
|
2008-06-20 |
2015-05-12 |
Rottapharm S.P.A. |
6-1h-imidazo-quinazoline and quinolines derivatives/mao inhibitors for treating depression
|
|
EP2138493A1
(en)
|
2008-06-26 |
2009-12-30 |
Sanofi-Aventis |
Substituted pyrimidone derivatives
|
|
AU2009266421B2
(en)
|
2008-07-02 |
2013-07-11 |
Avexa Limited |
Compounds having antiviral properties
|
|
US8932818B2
(en)
|
2008-08-13 |
2015-01-13 |
Ptc Therapeutics, Inc. |
Screening assays for compounds that modulate programmed ribosomal frameshifting
|
|
WO2010024903A1
(en)
|
2008-08-29 |
2010-03-04 |
Yangbo Feng |
BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS
|
|
JP2012505898A
(ja)
|
2008-10-16 |
2012-03-08 |
シェーリング コーポレイション |
ピロリジン、ピペリジンおよびピペラジン誘導体ならびにそれらの使用方法
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
US8283360B2
(en)
|
2008-12-19 |
2012-10-09 |
Merck Sharp & Dohme Corp. |
Bicyclic heterocyclic derivatives and methods of use thereof
|
|
KR20110132564A
(ko)
|
2009-02-11 |
2011-12-08 |
선오비온 파마슈티컬스 인코포레이티드 |
히스타민 h3 역 작용제 및 길항제, 및 이의 사용 방법
|
|
FR2945289A1
(fr)
|
2009-05-11 |
2010-11-12 |
Sanofi Aventis |
Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique
|
|
BRPI1015043A2
(pt)
|
2009-06-19 |
2019-07-09 |
Abbott Lab |
derivados de diazahomoadamantano e métodos de uso dos mesmos
|
|
KR102279458B1
(ko)
|
2009-09-11 |
2021-07-21 |
아이오니스 파마수티컬즈, 인코포레이티드 |
헌팅틴 발현의 조절
|
|
WO2011050245A1
(en)
|
2009-10-23 |
2011-04-28 |
Yangbo Feng |
Bicyclic heteroaryls as kinase inhibitors
|
|
WO2011057204A2
(en)
|
2009-11-06 |
2011-05-12 |
The Johns Hopkins University |
Lrrk2-mediated neuronal toxicity
|
|
WO2011062853A1
(en)
|
2009-11-20 |
2011-05-26 |
Merck Sharp & Dohme Corp. |
Quinolizidinone carboxamide m1 receptor positive allosteric modulators
|
|
JP2013517233A
(ja)
|
2010-01-13 |
2013-05-16 |
インスティチュート・パスツール・コリア |
抗感染ピリド(1,2−a)ピリミジン
|
|
EP2536738A4
(en)
|
2010-02-08 |
2014-09-17 |
Isis Pharmaceuticals Inc |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES OR SUFFERING IN CONNECTION WITH REPEAT EXTENSIONS
|
|
US9006198B2
(en)
|
2010-02-08 |
2015-04-14 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
EP3561060A1
(en)
|
2010-02-08 |
2019-10-30 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
EP2575866A4
(en)
|
2010-05-24 |
2013-10-16 |
Presidio Pharmaceuticals Inc |
HCV NS5A INHIBITORS
|
|
CN103167883B
(zh)
|
2010-07-19 |
2016-08-03 |
F·C·贝内特 |
肌强直性营养障碍蛋白激酶(dmpk)表达的调节
|
|
WO2012019106A2
(en)
|
2010-08-06 |
2012-02-09 |
Board Of Regents Of The University Of Nebraska |
Positive and negative modulators of nmda receptors
|
|
WO2012075393A2
(en)
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
CN102617548A
(zh)
|
2011-01-31 |
2012-08-01 |
北京赛林泰医药技术有限公司 |
作为gpr受体激动剂的双环杂芳基化合物及其组合物和应用
|
|
WO2012104823A2
(en)
|
2011-02-04 |
2012-08-09 |
Novartis Ag |
Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
|
|
EP3467109A1
(en)
|
2011-02-08 |
2019-04-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
US8703763B2
(en)
|
2011-03-02 |
2014-04-22 |
Hoffmann-La Roche Inc. |
Bridged piperidine derivatives
|
|
WO2013019938A1
(en)
|
2011-08-02 |
2013-02-07 |
The Brigham And Women's Hospital, Inc. |
Pyridazine derivatives as eaat2 activators
|
|
US20140303235A1
(en)
|
2011-08-11 |
2014-10-09 |
Isis Pharmaceuticals, Inc. |
Linkage modified gapped oligomeric compounds and uses thereof
|
|
US8871756B2
(en)
|
2011-08-11 |
2014-10-28 |
Hoffmann-La Roche Inc. |
Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
|
|
EP2560008B1
(en)
|
2011-08-18 |
2016-11-30 |
Korea Institute of Science and Technology |
Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
|
|
WO2013033223A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
US9662314B2
(en)
|
2011-10-21 |
2017-05-30 |
Tufts Medical Center, Inc. |
Compounds and methods for the treatment of muscular disease, and related screening methods
|
|
GB201119538D0
(en)
|
2011-11-10 |
2011-12-21 |
Viral Ltd |
Pharmaceutical compounds
|
|
ES2606630T3
(es)
|
2011-11-28 |
2017-03-24 |
Novartis Ag |
Derivados de trifluorometil-oxadiazol novedosos y su uso en el tratamiento de enfermedad
|
|
USRE47689E1
(en)
|
2011-12-30 |
2019-11-05 |
Ptc Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
CA2862084C
(en)
|
2012-01-26 |
2021-05-11 |
Ptc Therapeutics, Inc. |
1h-isochromen-1-one derivatives and compositions thereof for treating spinal muscular atrophy
|
|
EA037123B1
(ru)
|
2012-02-10 |
2021-02-09 |
ПиТиСи ТЕРАПЬЮТИКС, ИНК. |
Соединения для лечения спинальной мышечной атрофии
|
|
WO2013130689A1
(en)
|
2012-03-01 |
2013-09-06 |
Ptc Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
EP2828247B1
(en)
|
2012-03-23 |
2019-01-16 |
PTC Therapeutics, Inc. |
4h-chromen-4-one derivatives for treating spinal muscular atrophy
|
|
US9296701B2
(en)
*
|
2012-04-24 |
2016-03-29 |
Vertex Pharmaceuticals Incorporated |
DNA-PK inhibitors
|
|
US9212209B2
(en)
|
2012-07-13 |
2015-12-15 |
Indiana University Research And Technology Corporation |
Screening methods for spinal muscular atrophy
|
|
US8729263B2
(en)
|
2012-08-13 |
2014-05-20 |
Novartis Ag |
1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
|
|
EP4086347A3
(en)
|
2012-10-12 |
2023-01-11 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
EP4144845B1
(en)
|
2012-10-12 |
2024-04-24 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
|
PL2911671T3
(pl)
|
2012-10-25 |
2018-11-30 |
Usher Iii Initiative, Inc. |
Pirazolopirydazyny oraz sposoby leczenia zwyrodnieniowych chorób siatkówki i utraty słuchu związanych z zespołem ushera
|
|
US9227976B2
(en)
*
|
2012-10-25 |
2016-01-05 |
Usher Iii Initiative, Inc. |
Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
|
|
JP6255711B2
(ja)
|
2012-11-01 |
2018-01-10 |
株式会社リコー |
エレクトロクロミック化合物、エレクトロクロミック組成物及び表示素子
|
|
US9040712B2
(en)
|
2013-01-23 |
2015-05-26 |
Novartis Ag |
Thiadiazole analogs thereof and methods for treating SMN-deficiency-related-conditions
|
|
US10260069B2
(en)
|
2013-02-04 |
2019-04-16 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
CN105026398B
(zh)
|
2013-03-05 |
2018-05-18 |
默克专利股份公司 |
用于治疗疾病诸如癌症的三唑并[4,5-d]嘧啶衍生物
|
|
BR112015028475A2
(pt)
|
2013-05-14 |
2017-07-25 |
Hoffmann La Roche |
novos aza-oxo-indois para o tratamento ou profilaxia de infecção virótica respiratória sincitial
|
|
KR102314290B1
(ko)
|
2013-06-25 |
2021-10-21 |
에프. 호프만-라 로슈 아게 |
척수성 근위축증을 치료하기 위한 화합물
|
|
CN105636953B
(zh)
|
2013-07-31 |
2018-01-02 |
诺华股份有限公司 |
1,4‑二取代的哒嗪衍生物及其用于治疗与smn缺乏相关的病症的用途
|
|
JP6689197B2
(ja)
|
2013-08-19 |
2020-04-28 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
スクリーニング方法
|
|
WO2015095449A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount rna transcripts
|
|
WO2015095446A1
(en)
|
2013-12-19 |
2015-06-25 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount of rna transcripts
|
|
EP3082820B1
(en)
|
2013-12-19 |
2022-07-20 |
PTC Therapeutics, Inc. |
Methods for modulating the amount of rna transcripts
|
|
US9624170B2
(en)
*
|
2013-12-26 |
2017-04-18 |
Takeda Pharmaceutical Company Limited |
4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors
|
|
EP4137572A1
(en)
|
2014-01-16 |
2023-02-22 |
Wave Life Sciences Ltd. |
Chiral design
|
|
EP3094629B1
(en)
|
2014-01-17 |
2018-08-22 |
Novartis AG |
1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions thereof for inhibiting the activity of shp2
|
|
AR099134A1
(es)
|
2014-01-24 |
2016-06-29 |
Hoffmann La Roche |
Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
|
|
RU2683309C2
(ru)
|
2014-03-14 |
2019-03-28 |
Раквалиа Фарма Инк. |
Азаспиропроизводные в качестве антагонистов trpm8
|
|
US10005745B2
(en)
|
2014-03-19 |
2018-06-26 |
The Regents Of The University Of California |
Amyloid targeting agents and methods of using the same
|
|
RS59718B1
(sr)
|
2014-05-15 |
2020-01-31 |
Hoffmann La Roche |
Jedinjenja za lečenje spinalne mišićne atrofije
|
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
|
EP3157875A2
(en)
|
2014-06-17 |
2017-04-26 |
Novozymes A/S |
Biological phosphorus removal from wastewater
|
|
BR112016026951B1
(pt)
|
2014-06-25 |
2022-09-20 |
F. Hoffmann-La Roche Ag |
Imidazo[1,2-a]pirazin-1-il-benzamida, seu uso, e composições farmacêuticas
|
|
WO2016087417A1
(de)
|
2014-12-02 |
2016-06-09 |
Bayer Cropscience Aktiengesellschaft |
Bicyclische verbindungen als schädlingsbekämpfungsmittel
|
|
SMT201900347T1
(it)
|
2014-12-24 |
2019-07-11 |
Uniqure Ip Bv |
Soppressione del gene huntingtina indotta da rnai
|
|
CA2973949C
(en)
|
2015-01-16 |
2023-07-11 |
The General Hospital Corporation |
Compounds for improving mrna splicing
|
|
JP6884102B2
(ja)
|
2015-02-09 |
2021-06-09 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
がんの治療のための化合物
|
|
GB201502567D0
(en)
|
2015-02-16 |
2015-04-01 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
CN112679467B
(zh)
|
2015-03-11 |
2024-11-01 |
Fmc公司 |
杂环取代的二环唑杀有害生物剂
|
|
GB201506933D0
(en)
|
2015-04-23 |
2015-06-10 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
EP3298017B1
(en)
|
2015-05-20 |
2019-08-14 |
H. Hoffnabb-La Roche Ag |
Compounds for treating spinal muscular atrophy
|
|
EP3310169B1
(en)
|
2015-05-30 |
2023-05-17 |
PTC Therapeutics, Inc. |
Methods for modulating rna splicing
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
US10226448B2
(en)
|
2015-08-03 |
2019-03-12 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
|
|
TW201718546A
(zh)
|
2015-10-02 |
2017-06-01 |
英塞特公司 |
適用作pim激酶抑制劑之雜環化合物
|
|
BR112018009281B1
(pt)
|
2015-11-12 |
2023-10-31 |
F. Hoffmann-La Roche Ag |
Composições para tratar atrofia muscular espinhal e seu uso
|
|
AR106652A1
(es)
|
2015-11-12 |
2018-02-07 |
Hoffmann La Roche |
Compuestos para tratar la esclerosis lateral amiotrófica
|
|
US10383867B2
(en)
|
2015-11-28 |
2019-08-20 |
Russell Dahl |
Quinoline derivatives and their use for treating endoplasmic reticulum stress-related diseases and disorders
|
|
MX382671B
(es)
*
|
2015-12-10 |
2025-03-13 |
Ptc Therapeutics Inc |
Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington
|
|
JP6872550B2
(ja)
|
2015-12-10 |
2021-05-19 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
架橋されたピペリジン誘導体
|
|
US10526345B2
(en)
|
2016-04-08 |
2020-01-07 |
Mankind Pharma Ltd. |
Compounds as GPR119 agonists
|
|
AR108325A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
|
MA45270A
(fr)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
JP7044375B2
(ja)
*
|
2016-05-31 |
2022-03-30 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
Ptpn11の複素環式阻害剤
|
|
US20190264267A1
(en)
|
2016-07-25 |
2019-08-29 |
Wave Life Sciences Ltd. |
Phasing
|
|
TWI848901B
(zh)
*
|
2016-10-24 |
2024-07-21 |
美商傳達治療有限公司 |
Shp2磷酸酶抑制劑及其使用方法
|
|
US11857599B2
(en)
|
2017-04-03 |
2024-01-02 |
Acceleron Pharma Inc. |
Compositions and methods for treating spinal muscular atrophy
|
|
US11591336B2
(en)
*
|
2017-05-26 |
2023-02-28 |
D. E. Shaw Research, Llc |
Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
|
|
JP7376471B2
(ja)
|
2017-06-05 |
2023-11-08 |
ピーティーシー セラピューティクス, インコーポレイテッド |
ハンチントン病を処置するための化合物
|
|
MX2019015578A
(es)
|
2017-06-28 |
2020-07-28 |
Ptc Therapeutics Inc |
Metodos para tratar la enfermedad de huntington.
|
|
MX2019015580A
(es)
|
2017-06-28 |
2020-07-28 |
Ptc Therapeutics Inc |
Metodos para tratar la enfermedad de huntington.
|
|
MY201938A
(en)
|
2017-08-04 |
2024-03-25 |
Skyhawk Therapeutics Inc |
Methods and compositions for modulating splicing
|
|
WO2019165073A1
(en)
|
2018-02-21 |
2019-08-29 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of use thereof
|
|
EP4506035A3
(en)
|
2018-03-21 |
2025-04-16 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of use thereof
|
|
EP3768680A1
(en)
*
|
2018-03-21 |
2021-01-27 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
|
|
JP7399870B2
(ja)
|
2018-03-27 |
2023-12-18 |
ピーティーシー セラピューティクス, インコーポレイテッド |
ハンチントン病を処置するための化合物
|
|
LT3814357T
(lt)
|
2018-06-27 |
2024-06-25 |
Ptc Therapeutics, Inc. |
Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui
|
|
US11685746B2
(en)
|
2018-06-27 |
2023-06-27 |
Ptc Therapeutics, Inc. |
Heteroaryl compounds for treating Huntington's disease
|
|
EA202092899A1
(ru)
|
2018-06-27 |
2021-05-14 |
ПиТиСи ТЕРАПЬЮТИКС, ИНК. |
Гетероарильные соединения для лечения болезни гентингтона
|
|
KR20210151823A
(ko)
|
2019-03-15 |
2021-12-14 |
스카이호크 테라퓨틱스, 인코포레이티드 |
비정상적인 스플라이싱을 보정하기 위한 조성물 및 방법
|
|
AU2020277027A1
(en)
|
2019-05-13 |
2021-12-09 |
Ptc Therapeutics, Inc. |
Compounds for treating huntington's disease
|
|
WO2021007378A1
(en)
|
2019-07-11 |
2021-01-14 |
Ptc Therapeutics, Inc. |
Compounds for use in treating huntington's disease
|
|
CN114650822A
(zh)
|
2019-11-01 |
2022-06-21 |
诺华股份有限公司 |
剪接调节子用于减慢亨廷顿氏病进展的治疗的用途
|
|
JP2023522177A
(ja)
|
2020-04-09 |
2023-05-29 |
ピーティーシー セラピューティクス, インコーポレイテッド |
ハンチントン病を処置するための化合物
|
|
IL302839A
(en)
|
2020-11-12 |
2023-07-01 |
Ptc Therapeutics Inc |
Novel rna transcript
|
|
KR20240054264A
(ko)
|
2021-07-30 |
2024-04-25 |
피티씨 테라퓨틱스, 인크. |
Heteroaryl compounds for treating huntington's disease
|