JPS6399073A - １−（４−アミノフェニル）−４−メチル−７，８−メチレンジオキシ−３，４−ジヒドロ−５ｈ−２，３−ベンゾジアゼピン、その光学活性体およびラセミ体、および前記化合物の酸付加塩、その製造方法、並びに前記化合物を含む薬剤、その製造方法、およびそれによる治療方法 - Google Patents

１−（４−アミノフェニル）−４−メチル−７，８−メチレンジオキシ−３，４−ジヒドロ−５ｈ−２，３−ベンゾジアゼピン、その光学活性体およびラセミ体、および前記化合物の酸付加塩、その製造方法、並びに前記化合物を含む薬剤、その製造方法、およびそれによる治療方法

Info

Publication number
JPS6399073A
JPS6399073A JP62201967A JP20196787A JPS6399073A JP S6399073 A JPS6399073 A JP S6399073A JP 62201967 A JP62201967 A JP 62201967A JP 20196787 A JP20196787 A JP 20196787A JP S6399073 A JPS6399073 A JP S6399073A
Authority
JP
Japan
Prior art keywords
compound
dihydro
benzodiazepine
methylenedioxy
aminophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62201967A
Other languages
English (en)
Japanese (ja)
Inventor
エノェー　コェーロェシ
ティボル　ラーング
フェレンツ　アンドラーシ
パール　ベルゼニィ
ペーテル　ボトゥカ
タマーシュ　ハーモリ
カタリン　ゴルドシュミット　ネーエ　ホルヴァート
ヨージェフ　ボルシィ
イシュトヴァーン　エレケシュ
ズザ　ラーング　ネーエ　リーメル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of JPS6399073A publication Critical patent/JPS6399073A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP62201967A 1986-08-15 1987-08-14 １−（４−アミノフェニル）−４−メチル−７，８−メチレンジオキシ−３，４−ジヒドロ−５ｈ−２，３−ベンゾジアゼピン、その光学活性体およびラセミ体、および前記化合物の酸付加塩、その製造方法、並びに前記化合物を含む薬剤、その製造方法、およびそれによる治療方法 Pending JPS6399073A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU2251-3594/86 1986-08-15
HU863594A HU198494B (en) 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same

Publications (1)

Publication Number Publication Date
JPS6399073A true JPS6399073A (ja) 1988-04-30

Family

ID=10964707

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62201967A Pending JPS6399073A (ja) 1986-08-15 1987-08-14 １−（４−アミノフェニル）−４−メチル−７，８−メチレンジオキシ−３，４−ジヒドロ−５ｈ−２，３−ベンゾジアゼピン、その光学活性体およびラセミ体、および前記化合物の酸付加塩、その製造方法、並びに前記化合物を含む薬剤、その製造方法、およびそれによる治療方法

Country Status (23)

Country Link
US (1) US4835152A (enExample)
JP (1) JPS6399073A (enExample)
AT (1) ATA202187A (enExample)
AU (1) AU596206B2 (enExample)
BE (1) BE1002415A4 (enExample)
CA (1) CA1284322C (enExample)
CH (1) CH673652A5 (enExample)
CS (1) CS264150B2 (enExample)
DD (1) DD265627A5 (enExample)
DE (1) DE3727226A1 (enExample)
DK (1) DK164555C (enExample)
ES (1) ES2004985A6 (enExample)
FI (1) FI85706C (enExample)
FR (1) FR2602773B1 (enExample)
GB (1) GB2194236B (enExample)
HU (1) HU198494B (enExample)
IT (1) IT1222508B (enExample)
NL (1) NL8701909A (enExample)
NO (1) NO164656C (enExample)
PL (1) PL148535B1 (enExample)
RU (1) RU1779251C (enExample)
SE (1) SE467357B (enExample)
YU (1) YU46223B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
US6329364B1 (en) * 1994-08-31 2001-12-11 Eli Lilly And Company Crystalline form of dihydro-2,3-benzodiazepine derivative
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
PL181112B1 (pl) * 1995-03-28 2001-05-31 Eli Lilly & Co Nowa fizyczna postać (R)-7-acetylo-5-(4-aminofenylo)-8,9-dihydro-8-metylo-7H-1,3-dioksolo[4,5-h] [2,3]-benzodiazepiny, sposób jej otrzymywania oraz kompozycja farmaceutyczna
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
WO2004069155A2 (en) * 2002-12-03 2004-08-19 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
WO2004050040A2 (en) * 2002-12-03 2004-06-17 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
CA2525273C (en) * 2003-05-16 2012-04-17 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US20050096464A1 (en) * 2003-10-30 2005-05-05 Heikki Heikkila Separation process
EP4197536A1 (en) * 2021-12-20 2023-06-21 Universitat de València Haloperidol for use in the treatment of spinal muscular atrophy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
DE3319491A1 (de) * 1982-06-19 1983-10-13 Alps Electric Co., Ltd., Tokyo Papierfuehrungsmechanismus fuer schreibgeraete
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
NO873426L (no) 1988-02-16
RU1779251C (ru) 1992-11-30
IT1222508B (it) 1990-09-05
YU151487A (en) 1988-12-31
DK164555C (da) 1992-11-30
DK164555B (da) 1992-07-13
GB8719265D0 (en) 1987-09-23
HU198494B (en) 1989-10-30
PL148535B1 (en) 1989-10-31
AU7688087A (en) 1988-02-18
IT8721667A0 (it) 1987-08-14
SE8703169L (sv) 1988-02-16
FI85706C (fi) 1992-05-25
NO164656C (no) 1990-10-31
GB2194236B (en) 1990-03-21
CS264150B2 (en) 1989-06-13
HUT47287A (en) 1989-02-28
YU46223B (sh) 1993-05-28
FI85706B (fi) 1992-02-14
DK424887D0 (da) 1987-08-14
ES2004985A6 (es) 1989-02-16
GB2194236A (en) 1988-03-02
AU596206B2 (en) 1990-04-26
FR2602773B1 (fr) 1990-11-02
SE8703169D0 (sv) 1987-08-14
FI873525A0 (fi) 1987-08-14
ATA202187A (de) 1993-06-15
US4835152A (en) 1989-05-30
BE1002415A4 (fr) 1991-02-05
DD265627A5 (de) 1989-03-08
NO873426D0 (no) 1987-08-14
NO164656B (no) 1990-07-23
DE3727226A1 (de) 1988-02-18
DK424887A (da) 1988-02-16
FI873525A7 (fi) 1988-02-16
FR2602773A1 (fr) 1988-02-19
CS600787A2 (en) 1988-08-16
CH673652A5 (enExample) 1990-03-30
CA1284322C (en) 1991-05-21
SE467357B (sv) 1992-07-06
NL8701909A (nl) 1988-03-01

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