YU46223B - Postupak za dobivanje 1-/4-aminofenil/-4-metil-7,8-metilendioksi-3,4-dihid ro-5h-2,3-benzodiazepina - Google Patents

Postupak za dobivanje 1-/4-aminofenil/-4-metil-7,8-metilendioksi-3,4-dihid ro-5h-2,3-benzodiazepina

Info

Publication number
YU46223B
YU46223B YU151487A YU151487A YU46223B YU 46223 B YU46223 B YU 46223B YU 151487 A YU151487 A YU 151487A YU 151487 A YU151487 A YU 151487A YU 46223 B YU46223 B YU 46223B
Authority
YU
Yugoslavia
Prior art keywords
benzodiazepine
methylenedioxy
aminophenyl
methyl
preparation
Prior art date
Application number
YU151487A
Other languages
English (en)
Other versions
YU151487A (en
Inventor
J. Koerosi
T. Lang
F. Andrasi
P. Berzsenyi
P. Botka
T. Haemori
K. Goldschmidt
J. Borsy
I. Elekes
Z. Lang
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of YU151487A publication Critical patent/YU151487A/xx
Publication of YU46223B publication Critical patent/YU46223B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

POSTUPAK ZA DOBIVANJE 1-/4-AMINOFENIL/-4-METIL-7,8-METILENDIOKSI-3,4-DIHID RO-5H-2,3-BENZODIAZEPINA formule (I) i njegovih optički aktivnih izomera kao i adicionih soli sa kiselinama ovih jedinjenja, naznačen time, što se redukuje 1-/4-aminofenil/-4-metil-7,8-metilendioksi-5H-2,3-benzodiazepin formule (II): u nekom podesnom rastvaraču sa neorganskimj ili organsko-neorganskim i/ili kompleksnim metalnim hidridom i, prema potrebi, odvajaju se optički aktivni oblici jedinjenja formule (I) koji su tako dobiveni i, prema potrebi, prevodi se u baze ili baze u adicione soli sa kiselinama ili se prevode soli u slobodnu bazu. Prijava sadrži još 2 patentna zahteva.
YU151487A 1986-08-15 1987-08-13 Postupak za dobivanje 1-/4-aminofenil/-4-metil-7,8-metilendioksi-3,4-dihid ro-5h-2,3-benzodiazepina YU46223B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU863594A HU198494B (en) 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
YU151487A YU151487A (en) 1988-12-31
YU46223B true YU46223B (sh) 1993-05-28

Family

ID=10964707

Family Applications (1)

Application Number Title Priority Date Filing Date
YU151487A YU46223B (sh) 1986-08-15 1987-08-13 Postupak za dobivanje 1-/4-aminofenil/-4-metil-7,8-metilendioksi-3,4-dihid ro-5h-2,3-benzodiazepina

Country Status (23)

Country Link
US (1) US4835152A (sh)
JP (1) JPS6399073A (sh)
AT (1) ATA202187A (sh)
AU (1) AU596206B2 (sh)
BE (1) BE1002415A4 (sh)
CA (1) CA1284322C (sh)
CH (1) CH673652A5 (sh)
CS (1) CS264150B2 (sh)
DD (1) DD265627A5 (sh)
DE (1) DE3727226A1 (sh)
DK (1) DK164555C (sh)
ES (1) ES2004985A6 (sh)
FI (1) FI85706C (sh)
FR (1) FR2602773B1 (sh)
GB (1) GB2194236B (sh)
HU (1) HU198494B (sh)
IT (1) IT1222508B (sh)
NL (1) NL8701909A (sh)
NO (1) NO164656C (sh)
PL (1) PL148535B1 (sh)
RU (1) RU1779251C (sh)
SE (1) SE467357B (sh)
YU (1) YU46223B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
US6329364B1 (en) * 1994-08-31 2001-12-11 Eli Lilly And Company Crystalline form of dihydro-2,3-benzodiazepine derivative
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
WO2004069155A2 (en) * 2002-12-03 2004-08-19 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
MXPA05005895A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3, 4-dimetoxifenil)-4 -metil-5-etil -7-metoxi-8 -hidroxi- 5h-2, 3-benzodiacepina y usos de la misma.
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
WO2004103154A2 (en) * 2003-05-16 2004-12-02 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US20050096464A1 (en) * 2003-10-30 2005-05-05 Heikki Heikkila Separation process
EP4197536A1 (en) * 2021-12-20 2023-06-21 Universitat de València Haloperidol for use in the treatment of spinal muscular atrophy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
DE3319491A1 (de) * 1982-06-19 1983-10-13 Alps Electric Co., Ltd., Tokyo Papierfuehrungsmechanismus fuer schreibgeraete
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
JPS6399073A (ja) 1988-04-30
SE467357B (sv) 1992-07-06
NO164656B (no) 1990-07-23
NO873426D0 (no) 1987-08-14
FR2602773B1 (fr) 1990-11-02
US4835152A (en) 1989-05-30
IT8721667A0 (it) 1987-08-14
RU1779251C (ru) 1992-11-30
DK164555C (da) 1992-11-30
AU596206B2 (en) 1990-04-26
DK424887A (da) 1988-02-16
CS600787A2 (en) 1988-08-16
SE8703169L (sv) 1988-02-16
BE1002415A4 (fr) 1991-02-05
YU151487A (en) 1988-12-31
ATA202187A (de) 1993-06-15
CS264150B2 (en) 1989-06-13
ES2004985A6 (es) 1989-02-16
DK424887D0 (da) 1987-08-14
HUT47287A (en) 1989-02-28
HU198494B (en) 1989-10-30
NO164656C (no) 1990-10-31
FI85706B (fi) 1992-02-14
FI873525A0 (fi) 1987-08-14
GB2194236B (en) 1990-03-21
CH673652A5 (sh) 1990-03-30
CA1284322C (en) 1991-05-21
NL8701909A (nl) 1988-03-01
FI873525A (fi) 1988-02-16
PL148535B1 (en) 1989-10-31
FR2602773A1 (fr) 1988-02-19
DD265627A5 (de) 1989-03-08
AU7688087A (en) 1988-02-18
GB8719265D0 (en) 1987-09-23
FI85706C (fi) 1992-05-25
GB2194236A (en) 1988-03-02
SE8703169D0 (sv) 1987-08-14
NO873426L (no) 1988-02-16
IT1222508B (it) 1990-09-05
DK164555B (da) 1992-07-13
DE3727226A1 (de) 1988-02-18

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