RU1779251C - Способ получени 1-(4-аминофенил)-4-метил-7,8-метилендиокси-3,4-дигидро-5Н-2,3-бензодиазепина или его кислотно-аддитивных солей - Google Patents

Способ получени 1-(4-аминофенил)-4-метил-7,8-метилендиокси-3,4-дигидро-5Н-2,3-бензодиазепина или его кислотно-аддитивных солей

Info

Publication number
RU1779251C
RU1779251C SU874203196A SU4203196A RU1779251C RU 1779251 C RU1779251 C RU 1779251C SU 874203196 A SU874203196 A SU 874203196A SU 4203196 A SU4203196 A SU 4203196A RU 1779251 C RU1779251 C RU 1779251C
Authority
RU
Russia
Prior art keywords
methylenedioxy
aminophenyl
methyl
benzodiazepine
acid addition
Prior art date
Application number
SU874203196A
Other languages
English (en)
Russian (ru)
Inventor
Кереши Йене
Ланг Тибор
Андраши Ференц
Берженьи Пал
Ботка Петер
Хамори Тамаш
Гольдшмидт Каталин
Борши Йожеф
Элекеш Иштван
Ланг Жужа
Original Assignee
Биогал Дьедьсердьяр
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Биогал Дьедьсердьяр filed Critical Биогал Дьедьсердьяр
Application granted granted Critical
Publication of RU1779251C publication Critical patent/RU1779251C/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
SU874203196A 1986-08-15 1987-08-14 Способ получени 1-(4-аминофенил)-4-метил-7,8-метилендиокси-3,4-дигидро-5Н-2,3-бензодиазепина или его кислотно-аддитивных солей RU1779251C (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU863594A HU198494B (en) 1986-08-15 1986-08-15 Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same

Publications (1)

Publication Number Publication Date
RU1779251C true RU1779251C (ru) 1992-11-30

Family

ID=10964707

Family Applications (1)

Application Number Title Priority Date Filing Date
SU874203196A RU1779251C (ru) 1986-08-15 1987-08-14 Способ получени 1-(4-аминофенил)-4-метил-7,8-метилендиокси-3,4-дигидро-5Н-2,3-бензодиазепина или его кислотно-аддитивных солей

Country Status (23)

Country Link
US (1) US4835152A (enExample)
JP (1) JPS6399073A (enExample)
AT (1) ATA202187A (enExample)
AU (1) AU596206B2 (enExample)
BE (1) BE1002415A4 (enExample)
CA (1) CA1284322C (enExample)
CH (1) CH673652A5 (enExample)
CS (1) CS264150B2 (enExample)
DD (1) DD265627A5 (enExample)
DE (1) DE3727226A1 (enExample)
DK (1) DK164555C (enExample)
ES (1) ES2004985A6 (enExample)
FI (1) FI85706C (enExample)
FR (1) FR2602773B1 (enExample)
GB (1) GB2194236B (enExample)
HU (1) HU198494B (enExample)
IT (1) IT1222508B (enExample)
NL (1) NL8701909A (enExample)
NO (1) NO164656C (enExample)
PL (1) PL148535B1 (enExample)
RU (1) RU1779251C (enExample)
SE (1) SE467357B (enExample)
YU (1) YU46223B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
US6329364B1 (en) * 1994-08-31 2001-12-11 Eli Lilly And Company Crystalline form of dihydro-2,3-benzodiazepine derivative
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
RU2146677C1 (ru) * 1995-03-28 2000-03-20 Эли Лилли Энд Компани Физическая форма (r)-7-ацетил-5-(4-аминофенил)-8,9-дигидро-8-метил-7н-1,3- диоксоло[4,5-h]-[2,3]-бензодиазепина, способ ее получения и фармацевтическая композиция
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
UA67749C2 (uk) 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
WO2004050040A2 (en) * 2002-12-03 2004-06-17 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
WO2004069155A2 (en) * 2002-12-03 2004-08-19 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
JP4611308B2 (ja) * 2003-05-16 2011-01-12 ヴェラ アクイジション コーポレイション 鏡像的に純粋な（ｒ）２，３−ベンゾジアゼピンを使用する胃腸の機能不全及び関連するストレスの治療
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US20050096464A1 (en) * 2003-10-30 2005-05-05 Heikki Heikkila Separation process
EP4197536A1 (en) * 2021-12-20 2023-06-21 Universitat de València Haloperidol for use in the treatment of spinal muscular atrophy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
DE3319491A1 (de) * 1982-06-19 1983-10-13 Alps Electric Co., Ltd., Tokyo Papierfuehrungsmechanismus fuer schreibgeraete
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Машковский М.Д. Лекарственные средства. М.: Медицина, 1987, т. 1, с. 110. *

Also Published As

Publication number Publication date
DK164555C (da) 1992-11-30
US4835152A (en) 1989-05-30
DK424887A (da) 1988-02-16
FI873525A7 (fi) 1988-02-16
AU7688087A (en) 1988-02-18
NO873426D0 (no) 1987-08-14
CS600787A2 (en) 1988-08-16
YU151487A (en) 1988-12-31
AU596206B2 (en) 1990-04-26
FI873525A0 (fi) 1987-08-14
PL148535B1 (en) 1989-10-31
HUT47287A (en) 1989-02-28
CH673652A5 (enExample) 1990-03-30
NO164656B (no) 1990-07-23
CS264150B2 (en) 1989-06-13
DD265627A5 (de) 1989-03-08
SE467357B (sv) 1992-07-06
HU198494B (en) 1989-10-30
GB8719265D0 (en) 1987-09-23
DK424887D0 (da) 1987-08-14
FR2602773B1 (fr) 1990-11-02
BE1002415A4 (fr) 1991-02-05
SE8703169D0 (sv) 1987-08-14
IT1222508B (it) 1990-09-05
GB2194236A (en) 1988-03-02
NO164656C (no) 1990-10-31
ATA202187A (de) 1993-06-15
JPS6399073A (ja) 1988-04-30
YU46223B (sh) 1993-05-28
NL8701909A (nl) 1988-03-01
FI85706B (fi) 1992-02-14
DE3727226A1 (de) 1988-02-18
NO873426L (no) 1988-02-16
FI85706C (fi) 1992-05-25
FR2602773A1 (fr) 1988-02-19
ES2004985A6 (es) 1989-02-16
GB2194236B (en) 1990-03-21
CA1284322C (en) 1991-05-21
SE8703169L (sv) 1988-02-16
DK164555B (da) 1992-07-13
IT8721667A0 (it) 1987-08-14

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