JPH10501535A - 発泡系及び製剤学的活性物質を含む顆粒状生成物又は錠剤並びにその調整方法 - Google Patents
発泡系及び製剤学的活性物質を含む顆粒状生成物又は錠剤並びにその調整方法Info
- Publication number
- JPH10501535A JPH10501535A JP8501534A JP50153496A JPH10501535A JP H10501535 A JPH10501535 A JP H10501535A JP 8501534 A JP8501534 A JP 8501534A JP 50153496 A JP50153496 A JP 50153496A JP H10501535 A JPH10501535 A JP H10501535A
- Authority
- JP
- Japan
- Prior art keywords
- active substance
- granules
- weight
- parts
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.一種の疎水性作用物質、特にロラタジン又はシサプリド、一種の界面活性剤 及び一種の発泡システムを含む薬剤学的製剤に於いて、前記製剤が少なくとも二 種の異なる界面活性剤乃至乳化剤を含むことを特徴とする前記製剤。 2.少なくとも一種の界面活性剤がドクセートナトリウム又はドデシル硫酸ナト リウムであり、少なくとも一種の乳化剤が糖エステル、ポリソルベート類及びリ ン脂質のグループから選ばれることを特徴とする請求の範囲第1項記載の製剤。 3.前記乳化剤の少なくとも一種が発泡システム及び/又は作用物質の顆粒とは 別の、混合物の中のそれ自体の顆粒の中に存在していることを特徴とする請求の 範囲第1項又は第2項記載の製剤。 記請求の範囲のいずれか1項記載の製剤。 5.前記作用物質の顆粒が、更に少なくとも一種の前記発泡成分及び/又は一種 の充填剤を含み、該充填剤が好ましくは次の化合物、即ちマンニトール、ソルビ トール又はラクトースのような高級アルコール、マルトデキストリン又はデキス トリンのようなヒドロコロイド、又はデンプンの内の少なくとも一種から成るこ とを特徴とする請求の範囲第4項記載の製剤。 6.少なくとも一種の乳化剤が前記発泡システムの成分の上に、或いは一種の発 泡成分を含む一種の顆粒の上に及び/又は前記作用物質の顆粒の上に沈着してい ることを特徴とする前記請求の範囲のいずれか1項記載の製剤。 ことを特徴とする請求の範囲第3項乃至第6項記載の製剤用の作用物質の顆粒を 調製する方法。 8.前記懸濁物質及び/又は充填剤と混合した前記作用物質を、少なくとも一種 の結合剤及び/又は少なくとも一種の乳化剤を含む一種の溶剤で湿潤して粒子 項乃至第6項記載の製剤用の作用物質の顆粒を調製する方法。 を特徴とする請求の範囲第3項乃至第6項記載の製剤用の乳化剤の顆粒を調製す る方法。 10.前記充填剤が次の化合物、即ちマンニトール、ソルビトール又はラクトース のような高級アルコール、マルトデキストリン又はデキストリンのようなヒドロ コロイド、又はデンプンの内の少なくとも一種から成ることを特徴とする請求の 範囲第7項乃至第9項記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH01890/94A CH686865A5 (de) | 1994-06-15 | 1994-06-15 | Pharmazeutische Zubereitung mit einem hydrophoben Wirkstoff und einem Brausesystem, sowie Verfahren zur Herstellung der Zubereitung. |
CH1890/94.0 | 1994-06-15 | ||
PCT/EP1995/001904 WO1995034284A1 (de) | 1994-06-15 | 1995-05-19 | Pharmazeutische zubereitung mit einem hydrophoben wirkstoff und einem brausesystem, sowie verfahren zur herstellung der zubereitung |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH10501535A true JPH10501535A (ja) | 1998-02-10 |
Family
ID=4221002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8501534A Ceased JPH10501535A (ja) | 1994-06-15 | 1995-05-19 | 発泡系及び製剤学的活性物質を含む顆粒状生成物又は錠剤並びにその調整方法 |
Country Status (26)
Country | Link |
---|---|
US (1) | US5834019A (ja) |
EP (1) | EP0768868B1 (ja) |
JP (1) | JPH10501535A (ja) |
KR (1) | KR100367302B1 (ja) |
CN (1) | CN1149071C (ja) |
AT (1) | ATE204744T1 (ja) |
AU (1) | AU684966B2 (ja) |
BR (1) | BR9508002A (ja) |
CA (1) | CA2191302C (ja) |
CH (1) | CH686865A5 (ja) |
CO (1) | CO4410175A1 (ja) |
CZ (1) | CZ287807B6 (ja) |
DE (1) | DE59509566D1 (ja) |
ES (1) | ES2161901T3 (ja) |
HU (1) | HU221680B1 (ja) |
IL (1) | IL114144A (ja) |
MX (1) | MX9606391A (ja) |
MY (1) | MY113718A (ja) |
NO (1) | NO314016B1 (ja) |
NZ (1) | NZ288208A (ja) |
PE (1) | PE42295A1 (ja) |
PL (1) | PL180135B1 (ja) |
SK (1) | SK281262B6 (ja) |
TW (1) | TW457097B (ja) |
WO (1) | WO1995034284A1 (ja) |
ZA (1) | ZA954932B (ja) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0803251B1 (en) * | 1996-04-23 | 2002-07-17 | Janssen Pharmaceutica N.V. | Immediate release pH-independent solid dosage form of cisapride |
DE69713948D1 (de) * | 1996-04-23 | 2002-08-22 | Janssen Pharmaceutica Nv | Rasch-freisetzende pH-unabhängige feste Dosisformen enthaltend Cisaprid |
JP2002504107A (ja) * | 1997-06-11 | 2002-02-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | (+)−または(−)−シサプリドの即時放出性pH非依存的固形投薬剤形 |
WO2002085337A1 (en) * | 2001-04-20 | 2002-10-31 | The University Of British Columbia | Micellar drug delivery systems for hydrophobic drugs |
US6589555B2 (en) | 1999-12-29 | 2003-07-08 | Mahendra Pandya | Effervescent vitaceutical compositions and related methods |
WO2002036077A2 (en) * | 2000-11-06 | 2002-05-10 | Andrx Pharmaceuticals, Inc. | Once a day antihistamine and decongestant formulation |
US20030157170A1 (en) * | 2001-03-13 | 2003-08-21 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
AU2002240755B2 (en) * | 2001-03-13 | 2007-07-05 | Angiotech International Ag | Micellar drug delivery vehicles and uses thereof |
AR036852A1 (es) * | 2001-10-19 | 2004-10-06 | Isotechnika Inc | Preconcentrado de una microemulsion de analogos de ciclosporina, su metodo de preparacion y metodos para producir inmunosupresion |
US8092831B2 (en) * | 2002-11-08 | 2012-01-10 | Andrx Pharmaceuticals, Llc | Antihistamine and decongestant system |
US20050069590A1 (en) * | 2003-09-30 | 2005-03-31 | Buehler Gail K. | Stable suspensions for medicinal dosages |
CN100381123C (zh) * | 2005-01-12 | 2008-04-16 | 南京亿华药业有限公司 | 一种氯雷他定颗粒剂及其制法 |
CN101897732B (zh) * | 2009-05-27 | 2013-01-30 | 北京因科瑞斯医药科技有限公司 | 一种中药泡腾片剂及其制备方法 |
CN106236713B (zh) * | 2016-08-30 | 2018-11-09 | 林州中农颖泰生物肽有限公司 | 一种七清败毒泡腾颗粒及其制备方法 |
CN107296800A (zh) * | 2017-06-01 | 2017-10-27 | 江苏黄河药业股份有限公司 | 一种氯雷他定泡腾片及其制备方法 |
CN112741841A (zh) * | 2019-10-29 | 2021-05-04 | 湖北真奥医药研究院有限公司 | 三维钙自乳化泡腾剂组合物及其制剂的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3584522D1 (de) * | 1984-12-14 | 1991-11-28 | Gergely Gerhard | Teilchen aus einer hydrophoben oder schwerloeslichen substanz und verfahren zu ihrer hydrophilisierung. |
GB8528195D0 (en) * | 1985-11-15 | 1985-12-18 | Boots Co Plc | Therapeutic compositions |
GB9224021D0 (en) * | 1992-11-16 | 1993-01-06 | Boots Co Plc | Effervescent compositions |
US5646131A (en) * | 1994-02-22 | 1997-07-08 | The Arab Company For Drug Industries And Medical Applicances (Acdima) | Method for solubilizing drugs using cyclodextrins and carboxylic acids |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
-
1994
- 1994-06-15 CH CH01890/94A patent/CH686865A5/de not_active IP Right Cessation
-
1995
- 1995-05-19 BR BR9508002-3A patent/BR9508002A/pt active Search and Examination
- 1995-05-19 CN CNB95193578XA patent/CN1149071C/zh not_active Expired - Fee Related
- 1995-05-19 AU AU27497/95A patent/AU684966B2/en not_active Ceased
- 1995-05-19 CZ CZ19963672A patent/CZ287807B6/cs not_active IP Right Cessation
- 1995-05-19 DE DE59509566T patent/DE59509566D1/de not_active Expired - Lifetime
- 1995-05-19 KR KR1019960706945A patent/KR100367302B1/ko not_active IP Right Cessation
- 1995-05-19 CA CA2191302A patent/CA2191302C/en not_active Expired - Fee Related
- 1995-05-19 AT AT95922463T patent/ATE204744T1/de active
- 1995-05-19 SK SK1593-96A patent/SK281262B6/sk unknown
- 1995-05-19 EP EP95922463A patent/EP0768868B1/de not_active Expired - Lifetime
- 1995-05-19 NZ NZ288208A patent/NZ288208A/en unknown
- 1995-05-19 JP JP8501534A patent/JPH10501535A/ja not_active Ceased
- 1995-05-19 WO PCT/EP1995/001904 patent/WO1995034284A1/de active IP Right Grant
- 1995-05-19 PL PL95317856A patent/PL180135B1/pl unknown
- 1995-05-19 HU HU9603452A patent/HU221680B1/hu not_active IP Right Cessation
- 1995-05-19 MX MX9606391A patent/MX9606391A/es not_active IP Right Cessation
- 1995-05-19 ES ES95922463T patent/ES2161901T3/es not_active Expired - Lifetime
- 1995-05-19 US US08/737,580 patent/US5834019A/en not_active Expired - Lifetime
- 1995-06-14 CO CO95026284A patent/CO4410175A1/es unknown
- 1995-06-14 IL IL11414495A patent/IL114144A/xx not_active IP Right Cessation
- 1995-06-14 PE PE1995271312A patent/PE42295A1/es not_active Application Discontinuation
- 1995-06-14 ZA ZA954932A patent/ZA954932B/xx unknown
- 1995-06-15 TW TW084106115A patent/TW457097B/zh not_active IP Right Cessation
- 1995-06-15 MY MYPI95001623A patent/MY113718A/en unknown
-
1996
- 1996-12-09 NO NO19965244A patent/NO314016B1/no unknown
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