CN106236713B - 一种七清败毒泡腾颗粒及其制备方法 - Google Patents
一种七清败毒泡腾颗粒及其制备方法 Download PDFInfo
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Abstract
一种七清败毒泡腾颗粒，由以下重量份的原料和辅料制成，原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众60份、大青叶40份；辅料：枸橼酸40‑60份、NaHCO340‑60份、糖精钠8‑12份、食用香精8‑12份、乳糖200‑400份、微粉硅胶5‑10份、麦芽糊精20‑30份。本发明提供的泡腾颗粒，以枸橼酸为酸性剂，碳酸氢钠为碱性剂，糖精钠和食用香精为主要矫味剂，乳糖为主要稀释剂，微粉硅胶为主要抗粘着剂，麦芽糊精为主要分散剂、粘合剂，以65%的乙醇为润湿剂，制得泡腾颗粒溶解速度快，无结块粘连，可以掩盖七清败毒中药的不良气味，便于畜禽、宠物的口服给药。
Description
技术领域
本发明属于兽药加工技术领域，具体涉及一种七清败毒泡腾颗粒及其制备方法。
背景技术
七清败毒泡腾颗粒由黄芩、虎杖、白头翁、苦参、板蓝根、绵马贯众、大青叶七味中药经提取加工而成，具有清热解毒，燥湿止泻的功能，主治湿热泄泻，雏鸡白痢，被收录于中华人民共和国兽药典2005版2部；但七清败毒颗粒使用时具有一定的苦味，适口性差，且溶解速度慢，不利于畜禽的经口给药，延缓了对疾病的治疗效果。泡腾颗粒是利用有机酸与弱碱遇水作用产生二氧化碳，使液体产生气泡呈泡腾状态的一种颗粒剂，由于酸和碱的中和反应，产生的二氧化碳使颗粒疏松、崩裂、具速溶性。同时，二氧化碳溶于水后呈酸性，能刺激味蕾，因而可达到矫味的作用；专利CN200910066082.9公开了一种七清败毒泡腾颗粒及其制备方法，并具体公开了以富马酸为酸源、以碳酸氢钠为碳源，以葡萄糖、蔗糖、可溶性淀粉、等为稀释剂，以甜菊素、香兰素等为矫味剂；制得的泡腾颗粒易成型、不易吸湿、泡腾速度快、泡腾效果好、溶化性好，泡腾后药液澄清度好，无焦屑异物等，但是其酸性剂采用富马酸。柠檬酸作为酸性剂，相比富马酸，具有易溶于水、口感好的优点，对于带有苦味的七清败毒浸膏，柠檬酸的矫味作用更为重要，因此，开发一种以柠檬酸为主要酸性剂的七清败毒泡腾颗粒，也是目前兽药市场的迫切需求。
发明内容
本发明的目的就在于提供一种以柠檬酸为酸性剂的七清败毒泡腾颗粒及其制备方法。
本发明的目的是以下述方式实现的：
一种七清败毒泡腾颗粒，由以下重量份的原料和辅料制备而成：
原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众 60份、大青叶40份；
辅料：枸橼酸40-60份、NaHCO3 40-60份、糖精钠8-12份、食用香精8-12份、乳糖200-400份、微粉硅胶5-10份、麦芽糊精20-30份。
优选的，由以下重量份的原料和辅料制备而成：
原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众 60份、大青叶40份；
辅料：枸橼酸50份、NaHCO3 50份、糖精钠10份、食用香精10份、乳糖300份、微粉硅胶7份、麦芽糊精25份。
如上所述的七清败毒泡腾颗粒的制备方法，包括以下步骤：
（1）七清败毒浸膏的制备：取原料加水浸提，取滤液浓缩至相对密度为1.25-1.35的浸膏，备用；
（2）酸性颗粒的制备：取全部的枸橼酸、糖精钠总量的45-55%、食用香精总量的45-55%、乳糖总量的45-55%、全部的微粉硅胶和麦芽糊精混合均匀，然后加入浸膏总量的45-55%，采用240-400重量份60-70%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于40-60℃条件下干燥至含水量在6.0%以下；
（3）碱性颗粒的制备：取全部的NaHCO3、步骤（2）剩余的糖精钠、食用香精、乳糖、浸膏；采用240-400重量份60-70%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于40-60℃条件下干燥至含水量在6.0%以下；
（4）将步骤（2）制备的酸性颗粒和步骤（3）制备的碱性颗粒混合均匀，即得七清败毒泡腾颗粒。
步骤（1）具体为：取原料加8-12倍质量的水，浸泡20-40min，然后煎煮1-2h，过滤；取第一次煎煮后的滤渣加3-5倍质量的水，煎煮0.5-1.5h，重复此步骤2-3次；将上述煎煮过滤滤液合并，进行减压浓缩，在75-85℃条件下浓缩至相对密度为1.25-1.35的浸膏。
本发明提供的七清败毒泡腾颗粒，以枸橼酸（无水柠檬酸）为酸性剂，碳酸氢钠为碱性剂，糖精钠和食用香精为主要矫味剂，乳糖为主要稀释剂，微粉硅胶为主要抗粘着剂，麦芽糊精为主要分散剂、粘合剂，以65%的乙醇为润湿剂，制得的七清败毒泡腾颗粒溶解速度快，无结块粘连，可以掩盖七清败毒中药的不良气味，便于畜禽、宠物的口服给药。
具体实施方式
实施例1
一种七清败毒泡腾颗粒，由以下重量份的原料和辅料制备而成：
原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众 60份、大青叶40份；
辅料：枸橼酸40-60份、NaHCO3 40-60份、糖精钠8-12份、食用香精8-12份、乳糖200-400份、微粉硅胶5-10份、麦芽糊精20-30份。
如上所述的七清败毒泡腾颗粒的制备方法，包括以下步骤：
（1）七清败毒浸膏的制备：取7味中药原料加8-12倍质量的水，浸泡20-40min，然后煎煮1-2h，过滤；取第一次煎煮后的滤渣加3-5倍质量的水，煎煮0.5-1.5h，重复此步骤2-3次；将上述煎煮过滤滤液合并，进行减压浓缩，在75-85℃条件下浓缩至相对密度为1.25-1.35的浸膏，备用；
（2）酸性颗粒的制备：取全部的枸橼酸、糖精钠总量的45-55%、食用香精总量的45-55%、乳糖总量的45-55%、全部的微粉硅胶和麦芽糊精混合均匀，然后加入浸膏总量的45-55%，采用240-400重量份60-70%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于40-60℃条件下干燥至含水量在6.0%以下；
（3）碱性颗粒的制备：取全部的NaHCO3、步骤（2）剩余的糖精钠、食用香精、乳糖、浸膏；采用240-400重量份60-70%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于40-60℃条件下干燥至含水量在6.0%以下；
（4）将步骤（2）制备的酸性颗粒和步骤（3）制备的碱性颗粒混合均匀，即得七清败毒泡腾颗粒。
试验例
由于柠檬酸作为酸性剂，易吸潮结块，因此经过先期预实验，初步选定了采用添加微粉硅胶、麦芽糊精、乳糖、甘露醇、微晶纤维素、CMC作为辅料，具体配方与实验结果如表1所示。
从表2可知，采用乳糖比甘露醇易制粒，并且泡腾效果好，将微粉硅胶和麦芽糊精配合使用可以良好的防止七清败毒泡腾颗粒结块粘连等不良现象，配方2制粒和泡腾效果好，溶解彻底无残留，确定为本发明的配方；再加入糖精钠和食用香精进一步增强七清败毒泡腾颗粒的适口性，使获得的泡腾颗粒产品速溶性好，溶解速度快，可以掩盖中药的不良气味，对动物用药可饮水或拌料使用，便于畜禽、宠物的口服给药。
实施例2
一种七清败毒泡腾颗粒，由以下重量份的原料和辅料制备而成：
原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众 60份、大青叶40份；
辅料：枸橼酸50份、NaHCO3 50份、糖精钠10份、食用香精10份、乳糖300份、微粉硅胶7.5份、麦芽糊精25份。
如上所述的七清败毒泡腾颗粒的制备方法，包括以下步骤：
（1）七清败毒浸膏的制备：取7味中药原料加10倍质量的水，浸泡30min，然后煎煮1.5h，过滤；取第一次煎煮后的滤渣加4倍质量的水，煎煮1h，重复此步骤2次；将上述煎煮过滤滤液合并，进行减压浓缩，在80℃条件下浓缩至相对密度为1.3的浸膏，备用；
（2）酸性颗粒的制备：取全部的枸橼酸、糖精钠总量的50%、食用香精总量的50%、乳糖总量的50%、全部的微粉硅胶和麦芽糊精混合均匀，然后加入浸膏总量的50%，采用320重量份65%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于50℃条件下干燥至含水量在6.0%以下；
（3）碱性颗粒的制备：取全部的NaHCO3、糖精钠总量的50%、食用香精总量的50%、乳糖总量的50%混合均匀，然后加入浸膏总量的50%，采用320重量份65%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于50℃条件下干燥至含水量在6.0%以下；
（4）将步骤（2）制备的酸性颗粒和步骤（3）制备的碱性颗粒混合均匀，即得七清败毒泡腾颗粒。
实施例3
一种七清败毒泡腾颗粒，由以下重量份的原料和辅料制备而成：
原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众 60份、大青叶40份；
辅料：枸橼酸55份、NaHCO3 50份、糖精钠12份、食用香精10份、乳糖350份、微粉硅胶10份、麦芽糊精25份。
如上所述的七清败毒泡腾颗粒的制备方法，包括以下步骤：
（1）七清败毒浸膏的制备：取7味中药原料加12倍质量的水，浸泡20min，然后煎煮1h，过滤；取第一次煎煮后的滤渣加5倍质量的水，煎煮1.5h，重复此步骤2次；将上述煎煮过滤滤液合并，进行减压浓缩，在85℃条件下浓缩至相对密度为1.35的浸膏，备用；
（2）酸性颗粒的制备：取全部的枸橼酸、糖精钠总量的55%、食用香精总量的55%、乳糖总量的55%、全部的微粉硅胶和麦芽糊精混合均匀，然后加入浸膏总量的55%，采用400重量份70%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于60℃条件下干燥至含水量在6.0%以下；
（3）碱性颗粒的制备：取全部的NaHCO3、糖精钠总量的45%、食用香精总量的45%、乳糖总量的45%混合均匀，然后加入浸膏总量的45%，采用240重量份70%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于60℃条件下干燥至含水量在6.0%以下；
（4）将步骤（2）制备的酸性颗粒和步骤（3）制备的碱性颗粒混合均匀，即得七清败毒泡腾颗粒。
实施例4
一种七清败毒泡腾颗粒，由以下重量份的原料和辅料制备而成：
原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众 60份、大青叶40份；
辅料：枸橼酸50份、NaHCO3 50份、糖精钠10份、食用香精12份、乳糖300份、微粉硅胶8份、麦芽糊精30份。
如上所述的七清败毒泡腾颗粒的制备方法，包括以下步骤：
（1）七清败毒浸膏的制备：取7味中药原料加8倍质量的水，浸泡40min，然后煎煮2h，过滤；取第一次煎煮后的滤渣加3倍质量的水，煎煮0.5h，重复此步骤3次；将上述煎煮过滤滤液合并，进行减压浓缩，在75℃条件下浓缩至相对密度为1.25的浸膏，备用；
（2）酸性颗粒的制备：取全部的枸橼酸、糖精钠总量的45%、食用香精总量的45%、乳糖总量的45%、全部的微粉硅胶和麦芽糊精混合均匀，然后加入浸膏总量的45%，采用240重量份60%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于40℃条件下干燥至含水量在6.0%以下；
（3）碱性颗粒的制备：取全部的NaHCO3、糖精钠总量的55%、食用香精总量的55%、乳糖总量的55%混合均匀，然后加入浸膏总量的55%，采用400重量份60%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于40℃条件下干燥至含水量在6.0%以下；
（4）将步骤（2）制备的酸性颗粒和步骤（3）制备的碱性颗粒混合均匀，即得七清败毒泡腾颗粒。
本发明实施例5-18七清败毒泡腾颗粒辅料配方见表3-4，其他同实施例2。
以上所述的仅是本发明的优选实施方式，应当指出，对于本领域的技术人员来说，在不脱离本发明整体构思前提下，还可以作出若干改变和改进，这些也应该视为本发明的保护范围。
Claims (2)
1.一种七清败毒泡腾颗粒，其特征在于：由以下重量份的原料和辅料制备而成：
原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众 60份、大青叶40份；
辅料：枸橼酸40-60份、NaHCO3 40-60份、糖精钠8-12份、食用香精8-12份、乳糖200-400份、微粉硅胶5-10份、麦芽糊精20-30份；
如上述的七清败毒泡腾颗粒的制备方法，包括以下步骤：
（1）七清败毒浸膏的制备：取原料加8-12倍质量的水，浸泡20-40min，然后煎煮1-2h，过滤；取第一次煎煮后的滤渣加3-5倍质量的水，煎煮0.5-1.5h，重复此步骤2-3次；将上述煎煮过滤滤液合并，进行减压浓缩，在75-85℃条件下浓缩至相对密度为1.25-1.35的浸膏；
（2）酸性颗粒的制备：取全部的枸橼酸、糖精钠总量的45-55%、食用香精总量的45-55%、乳糖总量的45-55%、全部的微粉硅胶和麦芽糊精混合均匀，然后加入浸膏总量的45-55%，采用240-400重量份60-70%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于40-60℃条件下干燥至含水量在6.0%以下；
（3）碱性颗粒的制备：取全部的NaHCO3、步骤（2）剩余的糖精钠、食用香精、乳糖、浸膏；采用240-400重量份60-70%体积比的乙醇作润湿剂，制成软材；然后采用湿法制粒，然后于40-60℃条件下干燥至含水量在6.0%以下；
（4）将步骤（2）制备的酸性颗粒和步骤（3）制备的碱性颗粒混合均匀，即得七清败毒泡腾颗粒。
2.如权利要求1所述的七清败毒泡腾颗粒，其特征在于：由以下重量份的原料和辅料制备而成：
原料：黄芩100份、虎杖100份、白头翁80份、苦参80份、板蓝根100份、绵马贯众 60份、大青叶40份；
辅料：枸橼酸50份、NaHCO3 50份、糖精钠10份、食用香精10份、乳糖300份、微粉硅胶7份、麦芽糊精25份。
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