JP7749319B2 - Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用 - Google Patents

Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用

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Publication number
JP7749319B2
JP7749319B2 JP2020520253A JP2020520253A JP7749319B2 JP 7749319 B2 JP7749319 B2 JP 7749319B2 JP 2020520253 A JP2020520253 A JP 2020520253A JP 2020520253 A JP2020520253 A JP 2020520253A JP 7749319 B2 JP7749319 B2 JP 7749319B2
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ctla
polypeptide
seq
amino acid
domain
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JP2020536552A (ja
JP2020536552A5 (enExample
Inventor
ローレンス エバンス
ジョセフ エル． クイーパー
ライアン スワンソン
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アルパイン イミューン サイエンシズ インコーポレイテッド
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Publication of JP2020536552A5 publication Critical patent/JP2020536552A5/ja
Priority to JP2023104092A priority Critical patent/JP2023138962A/ja
Priority to JP2025116732A priority patent/JP2025148471A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020520253A 2017-10-10 2018-10-09 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用 Active JP7749319B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023104092A JP2023138962A (ja) 2017-10-10 2023-06-26 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
JP2025116732A JP2025148471A (ja) 2017-10-10 2025-07-10 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762570619P 2017-10-10 2017-10-10
US62/570,619 2017-10-10
US201862613379P 2018-01-03 2018-01-03
US62/613,379 2018-01-03
US201862733615P 2018-09-19 2018-09-19
US62/733,615 2018-09-19
PCT/US2018/055095 WO2019074983A1 (en) 2017-10-10 2018-10-09 CTLA-4 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2023104092A Division JP2023138962A (ja) 2017-10-10 2023-06-26 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
JP2025116732A Division JP2025148471A (ja) 2017-10-10 2025-07-10 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用

Publications (3)

Publication Number Publication Date
JP2020536552A JP2020536552A (ja) 2020-12-17
JP2020536552A5 JP2020536552A5 (enExample) 2021-11-25
JP7749319B2 true JP7749319B2 (ja) 2025-10-06

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JP2020520253A Active JP7749319B2 (ja) 2017-10-10 2018-10-09 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
JP2023104092A Pending JP2023138962A (ja) 2017-10-10 2023-06-26 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
JP2025116732A Pending JP2025148471A (ja) 2017-10-10 2025-07-10 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用

Family Applications After (2)

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JP2023104092A Pending JP2023138962A (ja) 2017-10-10 2023-06-26 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
JP2025116732A Pending JP2025148471A (ja) 2017-10-10 2025-07-10 Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用

Country Status (8)

Country Link
US (4) US11753458B2 (enExample)
EP (3) EP3694870A1 (enExample)
JP (3) JP7749319B2 (enExample)
KR (3) KR102813968B1 (enExample)
CN (2) CN111801347A (enExample)
CA (2) CA3077509A1 (enExample)
MA (1) MA50360A (enExample)
WO (1) WO2019074983A1 (enExample)

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EP3283508B1 (en) 2015-04-17 2021-03-17 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
KR102813968B1 (ko) 2017-10-10 2025-05-29 알파인 이뮨 사이언시즈, 인코포레이티드 Ctla-4 변이체 면역조절 단백질 및 이의 용도
EP3735417A1 (en) 2018-01-03 2020-11-11 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
CN112638419B (zh) * 2018-11-02 2022-06-24 北京伟德杰生物科技有限公司 修饰的ctla4及其使用方法
JP7650047B2 (ja) * 2019-11-27 2025-03-24 株式会社 MiyaCare Therapeutics 変異型結合性タンパク質の製造方法及び変異型ｐｄ－１
CN111592580A (zh) * 2020-05-08 2020-08-28 中国药科大学 一种具有免疫检查点ctla-4抑制活性的多肽及其应用
CN115812077A (zh) 2020-05-08 2023-03-17 高山免疫科学股份有限公司 April和baff抑制性免疫调节蛋白及其使用方法
WO2023205796A2 (en) * 2022-04-21 2023-10-26 Ohio State Innovation Foundation Human ctla-4 peptide vaccines and uses thereof
CN119679395B (zh) * 2024-12-04 2025-09-23 山东大学 一种基于动力学图融合的腺样体肥大辅助检测系统及方法

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