JP7693656B2 - Ｃｄｋ２阻害剤としての二環式アミン - Google Patents

Ｃｄｋ２阻害剤としての二環式アミン Download PDF

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Publication number
JP7693656B2
JP7693656B2 JP2022522033A JP2022522033A JP7693656B2 JP 7693656 B2 JP7693656 B2 JP 7693656B2 JP 2022522033 A JP2022522033 A JP 2022522033A JP 2022522033 A JP2022522033 A JP 2022522033A JP 7693656 B2 JP7693656 B2 JP 7693656B2
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alkyl
pyrazol
triazolo
cycloalkyl
cancer
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Japanese (ja)
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JP2022551668A5 (OSRAM
JP2022551668A (ja
Inventor
ハメル，ジョシュア
シュー，メイジョン
イェ，ミン
チェン，インナン
ファヴァータ，マーガレット
ロ，イヴォンヌ
イェ，インダ
リィ，ジェンウー
チエン，ディン－チュエン
ウィンタートン，サラ
シャオ，カイジオン
ウー，リアンシン
ヤオ，ウェンチン
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Incyte Corp
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Incyte Corp
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Priority to JP2025094180A priority Critical patent/JP7833597B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2022522033A 2019-10-11 2020-10-09 Ｃｄｋ２阻害剤としての二環式アミン Active JP7693656B2 (ja)

Priority Applications (1)

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JP2025094180A JP7833597B2 (ja) 2019-10-11 2025-06-05 Ｃｄｋ２阻害剤としての二環式アミン

Applications Claiming Priority (3)

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US201962914114P 2019-10-11 2019-10-11
US62/914,114 2019-10-11
PCT/US2020/055033 WO2021072232A1 (en) 2019-10-11 2020-10-09 Bicyclic amines as cdk2 inhibitors

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JP2022551668A JP2022551668A (ja) 2022-12-12
JP2022551668A5 JP2022551668A5 (OSRAM) 2023-10-16
JP7693656B2 true JP7693656B2 (ja) 2025-06-17

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US (3) US11851426B2 (OSRAM)
EP (2) EP4736856A2 (OSRAM)
JP (2) JP7693656B2 (OSRAM)
KR (1) KR20220099970A (OSRAM)
CN (3) CN119930611A (OSRAM)
AR (1) AR120184A1 (OSRAM)
AU (1) AU2020364007A1 (OSRAM)
BR (1) BR112022006977A2 (OSRAM)
CA (1) CA3157681A1 (OSRAM)
CL (1) CL2022000922A1 (OSRAM)
CO (1) CO2022004595A2 (OSRAM)
CR (2) CR20220170A (OSRAM)
DK (1) DK4041731T3 (OSRAM)
DO (1) DOP2022000077A (OSRAM)
EC (1) ECSP22029193A (OSRAM)
FI (1) FI4041731T3 (OSRAM)
GE (1) GEAP202516803A (OSRAM)
IL (1) IL292116A (OSRAM)
JO (1) JOP20220087A1 (OSRAM)
LT (1) LT4041731T (OSRAM)
MA (1) MA62580B1 (OSRAM)
MX (3) MX2022004390A (OSRAM)
PE (1) PE20221905A1 (OSRAM)
PH (1) PH12022550884A1 (OSRAM)
RS (1) RS67953B1 (OSRAM)
SA (1) SA522432225B1 (OSRAM)
SM (1) SMT202600187T1 (OSRAM)
TW (1) TW202128684A (OSRAM)
WO (1) WO2021072232A1 (OSRAM)

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US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
EA202191170A1 (ru) 2018-10-31 2021-07-27 Инсайт Корпорейшн Комбинированная терапия для лечения гематологических заболеваний
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
CN116348458A (zh) 2019-08-14 2023-06-27 因赛特公司 作为cdk2抑制剂的咪唑基嘧啶基胺化合物
CN119930611A (zh) 2019-10-11 2025-05-06 因赛特公司 作为cdk2抑制剂的双环胺
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US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
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EP4673449A1 (en) * 2023-02-28 2026-01-07 Differentiated Therapeutics Inc Cyclin dependent kinase degraders and methods of use thereof
TW202517253A (zh) 2023-09-08 2025-05-01 美商奧迪希治療公司 Cdk2抑制劑及其用途
WO2025103502A1 (en) * 2023-11-16 2025-05-22 Cullgen Inc. Compounds and methods of treating cancers
WO2026024674A1 (en) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Methods of treating skp2-associated cancers
WO2026026768A1 (zh) * 2024-07-29 2026-02-05 浙江扬厉医药技术有限公司 杂环取代磺酰胺类化合物、其药物组合物及应用
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