CR20220170A - Aminas bicíclicas como inhibidoras de la cdk2 - Google Patents

Aminas bicíclicas como inhibidoras de la cdk2

Info

Publication number
CR20220170A
CR20220170A CR20220170A CR20220170A CR20220170A CR 20220170 A CR20220170 A CR 20220170A CR 20220170 A CR20220170 A CR 20220170A CR 20220170 A CR20220170 A CR 20220170A CR 20220170 A CR20220170 A CR 20220170A
Authority
CR
Costa Rica
Prior art keywords
bicyclic amines
cdk2 inhibitors
cdk2
inhibitors
amines
Prior art date
Application number
CR20220170A
Other languages
English (en)
Spanish (es)
Inventor
Joshua Hummel
Min Ye
Ding-Quan Qian
Meizhong Xu
Sarah Winterton
Kaijiong Xiao
Wenqing Yao
Margaret Favata
Zhenwu Li
Liangxing Wu
Yingda Ye
Yingnan Chen
Yvonne Lo
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CR20220170A publication Critical patent/CR20220170A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CR20220170A 2019-10-11 2020-10-09 Aminas bicíclicas como inhibidoras de la cdk2 CR20220170A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962914114P 2019-10-11 2019-10-11
PCT/US2020/055033 WO2021072232A1 (en) 2019-10-11 2020-10-09 Bicyclic amines as cdk2 inhibitors

Publications (1)

Publication Number Publication Date
CR20220170A true CR20220170A (es) 2022-10-10

Family

ID=73040280

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20220170A CR20220170A (es) 2019-10-11 2020-10-09 Aminas bicíclicas como inhibidoras de la cdk2
CR20250191A CR20250191A (es) 2019-10-11 2020-10-09 AMINAS BICÍCLICAS COMO INHIBIDORAS DE LA CDK2 (Divisional expediente 2022-0170)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20250191A CR20250191A (es) 2019-10-11 2020-10-09 AMINAS BICÍCLICAS COMO INHIBIDORAS DE LA CDK2 (Divisional expediente 2022-0170)

Country Status (29)

Country Link
US (3) US11851426B2 (OSRAM)
EP (2) EP4736856A2 (OSRAM)
JP (2) JP7693656B2 (OSRAM)
KR (1) KR20220099970A (OSRAM)
CN (3) CN119930611A (OSRAM)
AR (1) AR120184A1 (OSRAM)
AU (1) AU2020364007A1 (OSRAM)
BR (1) BR112022006977A2 (OSRAM)
CA (1) CA3157681A1 (OSRAM)
CL (1) CL2022000922A1 (OSRAM)
CO (1) CO2022004595A2 (OSRAM)
CR (2) CR20220170A (OSRAM)
DK (1) DK4041731T3 (OSRAM)
DO (1) DOP2022000077A (OSRAM)
EC (1) ECSP22029193A (OSRAM)
FI (1) FI4041731T3 (OSRAM)
GE (1) GEAP202516803A (OSRAM)
IL (1) IL292116A (OSRAM)
JO (1) JOP20220087A1 (OSRAM)
LT (1) LT4041731T (OSRAM)
MA (1) MA62580B1 (OSRAM)
MX (3) MX2022004390A (OSRAM)
PE (1) PE20221905A1 (OSRAM)
PH (1) PH12022550884A1 (OSRAM)
RS (1) RS67953B1 (OSRAM)
SA (1) SA522432225B1 (OSRAM)
SM (1) SMT202600187T1 (OSRAM)
TW (1) TW202128684A (OSRAM)
WO (1) WO2021072232A1 (OSRAM)

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EA202191170A1 (ru) 2018-10-31 2021-07-27 Инсайт Корпорейшн Комбинированная терапия для лечения гематологических заболеваний
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
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WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
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WO2026024674A1 (en) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Methods of treating skp2-associated cancers
WO2026026768A1 (zh) * 2024-07-29 2026-02-05 浙江扬厉医药技术有限公司 杂环取代磺酰胺类化合物、其药物组合物及应用
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